Alternative promoter usage represents a regulatory mechanism of let-7c expression in different tissues. Mol Cancer Res; 12(6); ... Gene Expression Regulation, Leukemic Actions. * Search in PubMed * Search in MeSH * Add to Search ... Dual promoter usage as regulatory mechanism of let-7c expression in leukemic and solid tumors Andrea Pelosi 1 , Silvia Careccia ... Dual promoter usage as regulatory mechanism of let-7c expression in leukemic and solid tumors Andrea Pelosi et al. Mol Cancer ...

Aberrantly spliced genes included a number of oncogenes, tumor suppressor genes, and genes involved … ... Gene Expression Profiling * Gene Expression Regulation, Leukemic * Humans * Leukemia, Myeloid, Acute / diagnosis ... Aberrantly spliced genes included a number of oncogenes, tumor suppressor genes, and genes involved in regulation of apoptosis ... NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in ...

Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins. Mol Cancer Ther 2009;8(3):615-25. ...

Leukemic Gene Expression Regulation. *Brain, Astrocytoma, Childhood. *Cell Proliferation. Tag cloud generated 31 August, 2019 ... Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. ... METHODS: The protein coding genes (PCGs) and long non-coding RNA (lncRNA) gene expression profiles of 233 GBM postoperative ... Gene expression profiles that divide MDS into two major categories identify a progenitor gene signature subtype associated with ...

Gene Expression Regulation, Leukemic*; HEK293 Cells; Humans; Mutation; Phosphorylation/genetics; Precursor Cell Lymphoblastic ... of DNA methylation status at the PTPRG locus in human samples with levels of PTPRG gene expression as well as with RAS gene ... In addition, PTPRG expression is upregulated by RAS activation under DNA hypomethylating conditions. An element within the ... In the 293 cell line, we found that PTPRG expression induces dephosphorylation of ERK, a downstream RAS target that may be ...

"Allele-specific gene expression patterns in primary leukemic cells reveal regulation of gene expression by CpG site methylation ... indicate its expression in almost all tissues. One peculiar expression pattern of CARKD is its differential expression through ... Human CARKD gene has 10 exons and resides on Chromosome 13 at q34. The following genes are near CARKD on the chromosome: COL4A2 ... "Identification of novel candidate target genes in amplicons of Glioblastoma multiforme tumors detected by expression and CGH ...

... differential expression of HOX genes in chordomas of the clivus and sacrum suggests an oncofetal mechanism in gene regulation ... Each of the four genes was knocked down separately in the human precursor B-cell leukemic line RS4;11 expressing MLL-AF4. The ... Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. ... Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis ...

In light of recent evidence that the control of key genes depends on chromosome structures called insulated neighborhoods, we ... Oncogenes are activated through well-known chromosomal alterations such as gene fusion, translocation, and focal amplification ... Gene Expression Regulation, Leukemic* Actions. * Search in PubMed * Search in MeSH * Add to Search ... Proto-oncogenes, growth factor genes, receptor genes, differentiation genes and structural rearrangements in human cancer. De ...

Regulation of leukemic cell differentiation and retinoid-induced gene expression by statins. Mol Cancer Ther 2009;8(3):615-25. ...

Inducers of leukemic cell differentiation cause down-regulation of RB gene expression.. Yen A; Chandler S. Proc Soc Exp Biol ... Differences in expression of transcription factor AP-1 in human promyelocytic HL-60 cells during differentiation towards ... 6. Relationship of calcitonin mRNA expression to the differentiation state of HL 60 cells.. Kiefer P; Bacher M; Pflüger KH. ... Expression of GPI-80, a beta2-integrin-associated glycosylphosphatidylinositol-anchored protein, requires neutrophil ...

miRNAs are small noncoding RNA sequences that hybridize to mRNA resulting in the regulation of gene expression.[82] ... targeting the expression of specific miRNAs have been proposed as a novel class of therapy with potential anti-leukemic ... Risk categorization of AML based on karyotyping of leukemic blasts has become routine. ... including various leukemic resistance mechanisms, difficulty in achieving consistent serum levels of the drug and elevated ...

Transcriptional regulation of acetyl coenzyme A carboxylase gene expression by tumor necrosis factor in 30A-5 preadipocytes. ... Studies on some lipogenic enzymes of cultured myeloid leukemic cells. Okuma, M., Ichikawa, Y., Yamashita, S., Kitajima, K., ... Regulation of ob gene mRNA levels in cultured adipocytes. Rentsch, J., Chiesi, M. FEBS Lett. (1996) [Pubmed] ... Glycerol metabolism of Lactobacillus rhamnosus ATCC 7469: cloning and expression of two glycerol kinase genes. Alvarez, M.d.e ...

Gene Expression Regulation, Leukemic. dc.subject. Genes, myb. dc.subject. Humans. dc.subject. Jurkat Cells. ... while clarifying mechanisms of gene regulation and identifying new targets for therapeutic intervention. Here we report a C-to- ... APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL. ... leading to the formation of an aberrant transcriptional enhancer complex that drives high levels of expression of the LMO1 ...

Interestingly, the gene expression profile of NPMc AML is characterized by up-regulation of genes involved in stem cell ... Figure 4.Aberrant cytoplasmic expression of NPM in NPMc+ AML. (Top) Nuclear plus cytoplasmic expression of NPM in leukemic ... 12 as was subsequently confirmed by gene expression profiling143 which also showed CD133/PROM1 gene down-regulation. Another ... shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. Blood. 2005 ...

... affects gene expression regulation, and produces DNA-damaging free radicals. Absorption. Peak plasma concentration. * ... selectively ingested by leukemic cells, enhancing efficacy and increasing therapeutic index ...

Leukemic Gene Expression Regulation Regulation of Gene Expression, Leukemic Regulation, Gene Expression, Leukemic Previous ... Gene Expression Regulation [G05.308] * Gene Expression Regulation, Neoplastic [G05.308.370] * Gene Expression Regulation, ... Gene Expression Regulation, Leukemic Preferred Term Term UI T047383. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1990). ... Regulation of Gene Expression, Leukemic Term UI T047382. Date04/27/1989. LexicalTag NON. ThesaurusID NLM (1990). ...

Leukemic Gene Expression Regulation Regulation of Gene Expression, Leukemic Regulation, Gene Expression, Leukemic Previous ... Gene Expression Regulation [G05.308] * Gene Expression Regulation, Neoplastic [G05.308.370] * Gene Expression Regulation, ... Gene Expression Regulation, Leukemic Preferred Term Term UI T047383. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1990). ... Regulation of Gene Expression, Leukemic Term UI T047382. Date04/27/1989. LexicalTag NON. ThesaurusID NLM (1990). ...

Leukemic Gene Expression Regulation 37% 266 Citaten (Scopus) * Interactions among Polycomb Domains Are Guided by Chromosome ... RNAi genes pave their own way. Kamminga, L. M. & Ketting, R. F., 2011, In: Genes & Development. 25, 6, blz. 529-533. ... Neuronal activity regulates hippocampal miRNA expression. Eacker, S. M., Keuss, M. J., Berezikov, E., Dawson, V. L. & Dawson, T ... Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43. Boogerd, C. J., Wong, L. Y., van den Boogaard, ...

... we tested loss-of-function of 22 recurrently mutated ML-DS genes. Loss of 18 different genes produced leukemias that ... To define mechanisms of leukemic transformation, we combined exome and targeted resequencing of 111 TAM and 141 ML-DS samples ... Gene Expression Regulation, Leukemic, Genetic Predisposition to Disease, HEK293 Cells, Humans, Leukemia, Myeloid, Leukemoid ... we tested loss-of-function of 22 recurrently mutated ML-DS genes. Loss of 18 different genes produced leukemias that ...

A small molecule inhibitor of the Wnt pathway, PKF 115-584, decreases Wnt target gene expression, induces in vitro cytotoxicity ... However, the BMI-1-deficient leukemic stem cells were unable to produce AML in secondary transplant recipients. Thus, BMI-1 is ... Another example of the similarities between normal and tumor stem cell regulation is the shared importance of the WNT/ ß- ... Among those genes are BMI-1, WNT, ß-catenin, Notch, Hedgehog, and members of the HOX gene family. Interestingly, alterations in ...

... which may be key players in the regulation of differential gene expression in treatment responders and non-responders. Taken ... Differential expression-based analyses of treatment-naive, baseline gene expression profiles revealed that molecular functions ... In independent validation cohorts of MDS patients, the expression of gene sets specific to non-responders and responders ... identifying the gene expression signature may advance our understanding of the molecular mechanisms of azacitidine and may also ...

Histone acetylation and deacetylation are essential processes for the regulation of gene expression. Acetylation of histones ... Rearrangements of the mixed lineage leukemic (MLL) gene at the 11q23 chromosome locus are present in 5-10% of AML cases and ... Mutations in these genes often lead directly to aberrant gene expression in AML [23]. Currently, these mutations represent a ... On the other hand, deacetylation catalyzed by histone deacetylases (HDACs) results in gene silencing [23]. In leukemic cells, ...

2) Regulation of gene expression by F54 and FS. Regulation of gene expression by FS, a member of the F70 family, is responsible ... are needed for full leukemic transformation. Since this discovery, we have identified such cooperating genetic changes using a ... CBF genes encode transcription factors that associate with other nuclear proteins and regulate expression of target genes. We ... is located and involved in the regulation of gene expression. Using transgenic mouse models, we demonstrated recently that CBFB ...

We then analysed data from gene expression studies. These included 312 AML samples in the Microarray Innovations In Leukemia ( ... search tool for recurring instances of neighbouring genes (STRING), WEB-based Gene Set Analysis Toolkit, Bloodspot and ... but high expression levels of BIRC5 correlated with worse survival in inv(16) patients (p = 0.077) which was highly significant ... This study has shown that BIRC5 expression plays a role in the survival of AML patients, this association is not apparent when ...

... including down-regulation of Polycomb repressive complex 2 target genes. Significantly reduced cell growth and increased ... which lacks ASXL1 protein expression. CRISPR/Cas9-mediated ASXL1 homozygous correction resulted in protein re-expression with ... This study provides proof-of-concept for driver gene mutation correction via CRISPR/Cas9 technology in human leukemia cells and ... Gene Expression Regulation, Leukemic, Genetic Predisposition to Disease, Heterografts, Homozygote, Humans, Interleukin Receptor ...

... including down-regulation of Polycomb repressive complex 2 target genes. Significantly reduced cell growth and increased ... which lacks ASXL1 protein expression. CRISPR/Cas9-mediated ASXL1 homozygous correction resulted in protein re-expression with ... This study provides proof-of-concept for driver gene mutation correction via CRISPR/Cas9 technology in human leukemia cells and ... Gene Expression Regulation, Leukemic, Genetic Predisposition to Disease, Heterografts, Homozygote, Humans, Interleukin Receptor ...

Notably, resveratrol has been found to affect the expression of several genes including cytokine coding genes, caspases, matrix ... we summarize the results of studies that reported modulatory effects of resveratrol on the expression of genes and the activity ... Concurrent treatment of leukemic cells with bestatin and resveratrol has decreased IC50 values of bestatin and increased ... Disease-associated regulation of gene expression by resveratrol: Special focus on the PI3K/AKT signaling pathway. *Soudeh ...