Loading...
*  Dosage Compensation Regulatory Proteins and the Evolution of Sex Chromosomes in Drosophila | Genetics
The MSL proteins are thought to interact with cis-acting sites that confer dosage compensation to nearby genes, as they are ... In the fruitfly Drosophila melanogaster, the four male-specific lethal (msl) genes are required to achieve dosage compensation ... Dosage Compensation Regulatory Proteins and the Evolution of Sex Chromosomes in Drosophila. James R. Bone and Mitzi I. Kuroda ... Dosage Compensation Regulatory Proteins and the Evolution of Sex Chromosomes in Drosophila. James R. Bone and Mitzi I. Kuroda ...
  http://www.genetics.org/content/144/2/705
*  A non-canonical role for the C. elegans dosage compensation complex in growth and metabolic regulation downstream of TOR...
X chromosomal dosage compensation (DC) has evolved in order to equalize the expression of the X-linked genes between males and ... If RNAi to dpy-21 was suppressing rict-1 phenotypes by its canonical role in X chromosomal gene dosage, rict-1 male growth ... 2012). H4K20me1 contributes to downregulation of X-linked genes for C. elegans dosage compensation. PLoS Genet. 8, e1002933. ... 1994). The dpy-30 gene encodes an essential component of the Caenorhabditis elegans dosage compensation machinery. Genetics 137 ...
  http://dev.biologists.org/content/140/17/3601
*  The androgen receptor and DXS15-134 markers show a high rate of discordance for germline X chromosome inactivation | Journal of...
... equalisation of X chromosome gene expression between male and female cells and is therefore considered a mechanism for dosage ... This mechanism does not inactivate all genes on the inactive X chromosome. A number of genes localised to a limited number of ... The AR gene (CAG)n trinucleotide repeats fall within exon 1 and are polymorphic in 90% of females from all racial groups.24 The ... 1961) Gene action in the X chromosome of the mouse (Mus musculus L) Nature 190:372-373. ...
  http://jmg.bmj.com/content/38/7/474
*  Patente US4462839 - Enteric coating for pharmaceutical dosage forms - Google Patentes
... which is readily dispersible in water to provide a composition useful for forming an enteric coating on pharmaceutical dosage ... B squeda Im genes Maps Play YouTube Noticias Gmail Drive M s » ... Oral dosage forms of water insoluble drugs and methods of ... Gastric retained gabapentin dosage form. US8231905. 21 Nov 2011. 31 Jul 2012. Depomed, Inc.. Gastric retained gabapentin dosage ... Gastric retained gabapentin dosage form. US8333991. 19 Jul 2012. 18 Dic 2012. Depomed, Inc.. Gastric retained gabapentin dosage ...
  http://www.google.es/patents/US4462839?dq=flatulence
*  The Caenorhabditis elegans Dosage Compensation Machinery Is Recruited to X Chromosome DNA Attached to an Autosome | Genetics
1994 Sex-specific regulation of the male-specific lethal-1 dosage compensation gene in Drosophila. Genes Dev. 8: 698-706. ... 1983 X chromosome dosage and gene expression in Caenorhabditis elegans: two unusual dumpy genes. Mol. Gen. Genet. 192: 452-458 ... the DCC is prevented from associating with X because the male-specific xol-1 gene represses sdc gene activity. X-linked genes ... 1989 Genes that implement the hermaphrodite mode of dosage compensation in Caenorhabditis elegans. Genetics 121: 57-76. ...
  http://www.genetics.org/content/156/4/1603
*  Chromosomal amplifications, 3q gain and deletions of 2q33-q37 are the frequent genetic changes in cervical carcinoma | BMC...
Increase in gene dosage by DNA amplification is a common mechanism to achieve over-expression of genes in tumors. Gene ... which harbor the MYC gene and was previously shown as a candidate amplified gene in CC by Southern blot analysis [36]. A ... Genes Dev. 2002, 16: 984-93. 10.1101/gad.973602.View ArticlePubMedPubMed CentralGoogle Scholar. ... Genes Chromosomes Cancer. 1997, 19: 233-240. 10.1002/(SICI)1098-2264(199708)19:4,233::AID-GCC5,3.3.CO;2-K.View ArticlePubMed ...
  https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-4-5
*  Gene duplication - Wikipedia
Aneuploidy often alters gene dosage in ways that are detrimental to the organism; therefore, it is unlikely to spread through ... Experiments on human gene function can often be carried out on other species if a homolog to a human gene can be found in the ... greatly facilitating the evolutionary studies of gene regulation after gene duplication or speciation. Gene duplications can ... Whole genome duplications are thought to be less detrimental than aneuploidy as the relative dosage of individual genes should ...
  https://en.wikipedia.org/wiki/Gene_duplication
*  Gene Dosage and Gene Duplicability | Genetics
The previous test of the dosage hypothesis of gene duplication assumes that if halving the gene dosage is deleterious ( ... The dosage effect refers to an insufficient amount of gene product when one allele of a gene is deleted, whereas the dosage ... the gene dosage hypothesis), because haploinsufficient genes were reported to have more paralogs than haplosufficient genes in ... Genomic test of the gene dosage hypothesis in yeast:. One disadvantage of the above analysis is that haploinsufficient genes ...
  http://www.genetics.org/content/179/4/2319
*  Gene dosage - Wikipedia
Gene dosage is the number of copies of a particular gene present in a genome. Gene dosage is known to be related to the amount ... These slight gene dosage differences are responsible for variation in gene expression depending on the position on the ... Nonetheless, changes in gene dosage (copy number variations) due to gene insertions or deletions can have significant ... The bacterial chromosome is present only in one copy per cell, but there can still be variation in gene dosage due to DNA ...
  https://en.wikipedia.org/wiki/Gene_dosage
*  Mapping 22q11.2 Gene Dosage Effects on Brain Morphometry | Journal of Neuroscience
Mapping 22q11.2 Gene Dosage Effects on Brain Morphometry. Amy Lin, Christopher R. K. Ching, Ariana Vajdi, Daqiang Sun, Rachel K ... Mapping 22q11.2 Gene Dosage Effects on Brain Morphometry. Amy Lin, Christopher R. K. Ching, Ariana Vajdi, Daqiang Sun, Rachel K ... Mapping 22q11.2 Gene Dosage Effects on Brain Morphometry. Amy Lin, Christopher R. K. Ching, Ariana Vajdi, Daqiang Sun, Rachel K ... Mapping 22q11.2 Gene Dosage Effects on Brain Morphometry Message Subject (Your Name) has forwarded a page to you from Journal ...
  http://www.jneurosci.org/content/early/2017/05/23/JNEUROSCI.3759-16.2017
*  Direct autoregulation and gene dosage compensation by POU-domain transcription factor Brn3a.
... Trieu M., Ma A., Eng S.R., ... Conversely, transgenic overexpression of Brn3a in the trigeminal ganglion suppresses the expression of the endogenous gene. ... demonstrating that autoregulation can compensate for the loss of one allele by increasing transcription of the remaining gene ...
  http://www.uniprot.org/citations/12441296
*  ACE gene dosage determines additional autonomic dysfunction and increases renal angiotensin II levels in diabetic mice
Diabetic Nephropathy Induced by Increased Ace Gene Dosage Is Associated with High Renal Levels of Angiotensin (1-7) and ... ACE gene polymorphisms might also account for these discrepancies since ACE gene variance is associated with increased risk of ... or insert an extra copy of a gene adjacent to the existing gene (knock in). ... ACE gene titration in mice uncovers a new mechanism for ACE on the control of body weight. Physiol Genomics. 2005;20(2):173-82 ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100245&lng=es&nrm=iso&tlng=es
*  Gli2 gene dosage and gene-environment interaction illuminate the etiological complexity of holoprosencephaly | Disease Models &...
Gli2 gene dosage and gene-environment interaction illuminate the etiological complexity of holoprosencephaly ... Gli2 gene dosage and gene-environment interaction illuminate the etiological complexity of holoprosencephaly ... Gli2 gene dosage and gene-environment interaction illuminate the etiological complexity of holoprosencephaly ... Gli2 gene dosage and gene-environment interaction illuminate the etiological complexity of holoprosencephaly ...
  http://dmm.biologists.org/content/early/2016/08/26/dmm.026328
*  Lirias: Development and characterization of a linear human chromosomal vector to study increased gene dosage in mice
Recently, we identified in the lab a new gene dosage-sensitive ID-candidate gene, HUWE1. The latter was present in the minimal ... Development and characterization of a linear human chromosomal vector to study increased gene dosage in mice. ... To study in mice the consequences of gene duplications, transgenic mice overexpressing these genes can be generated. Current ... allows for the site specific insertion of genes and displays the physiological expression of human genes. In this thesis, we ...
  https://lirias.kuleuven.be/handle/123456789/349277
*  Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development, Mammalian Genome | 10.1007...
"Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development, Mammalian Genome" on ... Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development. Combined gene dosage ... Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development. Smith-Roe, Stephanie; ... This was most pronounced at the top and bottom of the gene dosage hierarchy, with a 1.5-fold overrepresentation of Brg1 +/+ ; ...
  https://www.deepdyve.com/lp/springer_journal/combined-gene-dosage-requirement-for-swi-snf-catalytic-subunits-during-DLCTuC28a5
*  Distinct disease mechanisms in peripheral neuropathies due to altered peripheral myelin protein 22 gene dosage or a Pmp22 point...
Distinct disease mechanisms in peripheral neuropathies due to altered peripheral myelin protein 22 gene dosage or a Pmp22 point ... Distinct disease mechanisms in peripheral neuropathies due to altered peripheral myelin protein 22 gene dosage or a Pmp22 point ... Increased expression of genes involved in cell cycle regulation and DNA replication is characteristic and specific for the ... Increased expression of genes involved in cell cycle regulation and DNA replication is characteristic and specific for the ...
  https://www.zora.uzh.ch/id/eprint/116005/
*  Distinct disease mechanisms in peripheral neuropathies due to altered |ce:italic|peripheral myelin protein 22|/ce:italic| gene...
Increased expression of genes involved in cell cycle regulation and DNA replication is characteristic and specific for the ... In the Tr mutant, a distinguishing feature is the high expression of stress response genes. Both Tr and Pmp22 mice show ... Finally, we have identified a number of candidate genes that may play important roles in the disease process or in myelination ... Interestingly, the three Pmp22 mutants exhibited distinct profiles of gene expression, suggesting different disease mechanisms ...
  https://www.semanticscholar.org/paper/Distinct-disease-mechanisms-in-peripheral-due-to-or-Giambonini-Brugnoli-Buchstaller/8c50da9f8ccc4a28348fd0de0b83b7c259aa9b80
*  Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage. - Semantic...
Collectively, we propose that a reduction in the sf-1 gene dosage directly affects BDNF levels in the VMH and disrupts normal ... we asked how sf-1 gene dosage affects VMH function. Despite an apparent normal VMH cytoarchitecture, sf-1 heterozygous (+/-) ... On the basis of previous findings suggesting brain-derived neurotrophic factor (bdnf) as an SF-1 target gene, we assessed the ... Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage.. @article{ ...
  https://www.semanticscholar.org/paper/Diminished-hypothalamic-bdnf-expression-and-VMH-are-Tran-Akana/285985c92fb94383a42021c84cd8b65a67424fbe
*  Analysis of gene dosage aberrations of ErbB oncogene family in endometrial cancer | OncologyPRO
Gene dosages of individual ERBB genes correlated with each other. Particularly strong correlation occurred in case of ERBB2 and ... The purpose of this study was to determine the gene dosages of all the ERBB genes in endometrial cancer in the context of ... 970PD - Analysis of gene dosage aberrations of ErbB oncogene family in endometrial cancer. ... Relative gene dosages of ERBB1, ERBB2, ERBB3 and ERBB4 were assessed by SYBR Green-based quantitative PCR, using ΔΔCt method. ...
  http://oncologypro.esmo.org/Topics/Translational-Research/Analysis-of-gene-dosage-aberrations-of-ErbB-oncogene-family-in-endometrial-cancer
*  Clinically reported heterozygous mutations in the PINK1 kinase domain exert a gene dosage effect | ScholarBank@NUS
We provided the first experimental evidence that clinically reported PINK1 heterozygous mutations exert a gene dosage effect, ... Clinically reported heterozygous mutations in the PINK1 kinase domain exert a gene dosage effect. ... Clinically reported heterozygous mutations in the PINK1 kinase domain exert a gene dosage effect. Human Mutation 30 (11) : 1551 ... Mutations in the gene encoding phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) have been associated with the ...
  http://scholarbank.nus.edu.sg/handle/10635/110507
*  ATR functions as a gene dosage‐dependent tumor suppressor on a mismatch repair‐deficient background | The EMBO Journal
To examine more specifically the impact of ATR gene dosage on gene amplification frequencies in HCT 116 cells, we performed an ... ATR functions as a gene dosage‐dependent tumor suppressor on a mismatch repair‐deficient background. Yanan Fang, Cheng‐Chung ... The results of this study indicate that a defect in the MMR machinery unmasks a strong gene dosage effect for ATR in the ... the p21/WAF1 gene and the CAD gene complex were rearranged and/or amplified at increased frequencies after monoallelic ATR gene ...
  http://emboj.embopress.org/content/23/15/3164
*  Increasing gene dosage greatly enhances recombinant expression of aquaporins in Pichia pastoris | BMC Biotechnology | Full Text
... folded and targeted aquaporins is strongly dependent on recombinant gene dosage and also that increasing the gene dosage could ... to ensure that the selection is efficient and that satisfactory gene dosage is obtained. If, as in the case with SoPIP1;2, gene ... The big advantage of this new method as compared with other qPCR based methods used to verify recombinant gene dosage in P. ... We report a convenient and robust method based on qPCR to determine recombinant gene dosage. The method is generic for all ...
  https://bmcbiotechnol.biomedcentral.com/articles/10.1186/1472-6750-11-47
*  Chloride conductance in mouse muscle is subject to post-transcriptional compensation of the functional Cl- channel 1 gene dosage
3. Despite a halved functional gene dosage, heterozygous muscles display an average G(Cl), which is not significantly different ... channel 1 gene dosage. Chen MF, Niggeweg R, Iaizzo PA, LehmannHorn F, Jockusch H (1997) JOURNAL OF PHYSIOLOGY-LONDON 504(1): 75 ... channel 1 gene dosage. JOURNAL OF PHYSIOLOGY-LONDON 504, 75-81.. Chen, M.F., et al., 1997. Chloride conductance in mouse muscle ... channel 1 gene dosage. JOURNAL OF PHYSIOLOGY-LONDON, 504(1), 75-81. doi:10.1111/j.1469-7793.1997.075bf.x ...
  https://pub.uni-bielefeld.de/record/1627314
*  Gene dosage defects in primary immunodeficiencies and related disorders: a pilot study
... publishes articles related to Single gene disorders, rare genetic disease, specific genetic syndromes, complex disease, etc. ... Gene dosage defects in primary immunodeficiencies and related disorders: a pilot study Lisa Dyer1,2, Xia Li1,2, James Denton1, ... Single gene CNV assessment of FAS was ordered for this patient after negative sequencing of FAS, FASLG, and CASP10 genes. This ... Meaningfully, we identified 3 novel CNVs in the FAS gene. Heterozygous mutations in the FAS gene cause autoimmune ...
  http://jtggjournal.com/article/view/2333/1816
*  University of Antwerp - Role of gene dosage in the acquisition of antimony resistance in Leishmania donovani: experimental...
Role of gene dosage in the acquisition of antimony resistance in Leishmania donovani: experimental evidence. Date: 16 January ... Gene dosage is thus a very important mechanism for the acquisition of antimony resistance and MRPA amplification is the first ... The main hypothesis of this PhD was that gene dosage would play a major role in the development of antimonial resistance in the ... This was highly correlated with transcription levels, supporting the adaptive function of gene dosage. Secondly, I analysed the ...
  https://www.uantwerpen.be/popup/kalenderonderdeel.aspx?calitem_id=6079&c=LANDP667&n=113498