*  Galectin-3 Detection: ELISAs and Antibodies
0.1% cross‑reactivity with human galectin-1 and mouse galectin-3; 0.21% cross-reactivity with human galectin-4. ... Galectin-3 belongs to a family of carbohydrate-binding proteins known as lectins. In humans, it is encoded by the LGALS3 gene ... Galectin3. 27755A. ELISA. Human. Capture:. (50A3). Mouse IgG MoAb. Detect: HRP (87B5). Mouse IgG MoAb. ≤ ... Galectin-3 has an N-terminal proline-rich tandem repeat domain, which allows it to self-associate, and a single C-terminal ...
  http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Cancer_and_Inflammation/Galectin-3?sitex=10020:22372:US&PEBCL1=Dm7FTxG1FysZdkrBbUhf5DYMmG&PEBCL1_pses=ZGC4A6FA625F7A680505A469470BE11678F412EBC881A2F2AF1B86A6E123958A18D38BCB6D5BF3FB3075DA61477DCD2CD4A82AFC1EAC80FE84
*  Protein and mRNA galectin-3 expression are up regulated | Open-i
Protein and mRNA galectin-3 expression are up regulated in tumor cells surrounding necrotic areas of CMT-U27 mice xenografts. ... Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis. de Oliveira JT, Ribeiro C, Barros R, Gomes C, de ... Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis. de Oliveira JT, Ribeiro C, Barros R, Gomes C, de ... High levels of galectin-3 expression were found in tumor areas surrounding necrotic tissue (Fig 5A) as well as in lung micro ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4519331_pone.0134458.g005&req=4
*  A Novel Function for Galectin-1 at the Crossroad of Innate and Adaptive Immunity: Galectin-1 Regulates Monocyte/Macrophage...
Galectin-1 does not affect the survival of human monocytes. Since galectin-1 has been implicated in the regulation of T cell ... Preparation of recombinant galectin-1 and the monomeric mutant N-Gal-1. Recombinant galectin-1 was produced and purified as ... Since galectin-1 is abundant at inflammatory foci and sites of T cell activation, these results provide evidence that galectin- ... Since galectin-1 expression is up-regulated during macrophage activation (23, 52), we might speculate that galectin-1 could ...
  http://www.jimmunol.org/content/178/1/436
*  Galectin-3, Clone 9C4 Antibody
3. We reserve the right to change prices or alter packaging at any time without prior notification. Warranties Genemed ...
  http://genemed.com/products/Primary-Antibodies_2/Galectin-3-Clone-9C4-Antibody.html
*  Prospect Therapeutics' In Vitro Studies Demonstrate that GCS-100 Drug Binds to and Blocks the Effects of ... ( WELLESLEY HILLS...
Galectin-3,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news ... Prospect's lead product candidate, GCS-100, is a carbohydrate molecule designed to inhibit the activity of galectin-3, a ... Prospect Therapeutics' In Vitro Studies Demonstrate that GCS-100 Drug Binds to and Blocks the Effects of Galectin-3 ... Galectin-3 plays an important role in tumor cell survival, new blood vessel growth, cell proliferation and tumor metastasis, ...
  http://www.bio-medicine.org/medicine-news-1/Prospect-Therapeutics-In-Vitro-Studies-Demonstrate-that-GCS-100-Drug-Binds-to-and-Blocks-the-Effects-of-Galectin-3-48875-1/
*  Galectin-3 regulates myofibroblast activation and hepatic fibrosis | PNAS
Galectins are members of a growing family of animal lectins (5-8). Galectin-3 is a β-galactoside-binding animal lectin of ≈30 ... A Novel Function for Galectin-1 at the Crossroad of Innate and Adaptive Immunity: Galectin-1 Regulates Monocyte/Macrophage ... Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Neil C. Henderson, Alison C. Mackinnon, Sarah L. Farnworth ... Galectin-3 regulates myofibroblast activation and hepatic fibrosis. Neil C. Henderson, Alison C. Mackinnon, Sarah L. Farnworth ...
  http://www.pnas.org/content/103/13/5060
*  Mouse Galectin 3 ELISA Kit (ab113343) | Abcam
Abcam's Galectin 3 ELISA Kit suitable for Cell culture supernatant, Serum, Plasma in mouse. Reliably quantify 6 pg/ml of ... Abcam's Galectin 3 Mouse ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the ... Standards and samples are pipetted into the wells and Galectin 3 present in a sample is bound to the wells by the immobilized ... The wells are washed and biotinylated anti-Mouse Galectin 3 antibody is added. After washing away unbound biotinylated antibody ...
  http://www.abcam.com/mouse-galectin-3-elisa-kit-ab113343.html
*  Galectin 3 293T transfected lysate (ab94225) | Abcam
Buy our Galectin 3 293T transfected lysate (positive control). ab94225 has been validated in western blot. Abcam now offers a ... Galectin 3 overexpression 293T lysate (whole cell) (ab94225). Lane 2 : 293T Non Transfected Lysate. Lysates/proteins at 25 µg ... ab94225 is a 293T cell transfected lysate in which Human Galectin 3 has been transiently over-expressed using a pCMV-Galectin 3 ... All lanes : Anti-Galectin 3 antibody (ab58086) at 1/500 dilution. Lane 1 : ...
  http://www.abcam.com/galectin-3-overexpression-293t-lysate-whole-cell-ab94225.html
*  Circulating galectin-3 promotes m... preview & related info | Mendeley
We show in this study that galectin-3, the concentration of which is greatly increased i... ... These effects of galectin-3 are shown to be a consequence of its interaction with cancer-associated MUC1, which breaks the ' ... Circulating galectin-3 promotes metastasis by modifying MUC1 localization on cancer cell surface. *Zhao Q ... We show in this study that galectin-3, the concentration of which is greatly increased in the circulation of cancer patients, ...
  https://www.mendeley.com/research-papers/circulating-galectin3-promotes-metastasis-modifying-muc1-localization-cancer-cell-surface/
*  Galectin-3 Antibody Pairs: Novus Biologicals
Browse our Galectin-3 Antibody Pair catalog backed by our Guarantee+. ... Our Galectin-3 Antibody Pairs can be used in a variety of model species: Human. Use the list below to choose the Galectin-3 ... Each Galectin-3 Antibody Pair is fully covered by our Guarantee+, to give you complete peace of mind and the support when you ... Alternate Names for Galectin-3 Antibody Pairs. Galectin-3 antibody pair, LGALS3 antibody pair, Carbohydrate-binding protein 35 ...
  https://www.novusbio.com/antibody-pairs/galectin-3
*  Lgals3 - Galectin-3 - Rattus norvegicus (Rat) - Lgals3 gene & protein
May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. In the nucleus: acts as ... Galectin. ,p>Manual validated information which has been generated by the UniProtKB automatic annotation system.,/p> ,p>,a href ... "Ly6 family member C4.4A binds laminins 1 and 5, associates with galectin-3 and supports cell migration.". Paret C., Bourouba M. ... "Induction of terminal differentiation in epithelial cells requires polymerization of hensin by galectin 3.". Hikita C., ...
  http://www.uniprot.org/uniprot/P08699
*  Galectin-3 Participates in Cardiovascular Remodeling Associated With Obesity | Hypertension
Galectin-3 Participates in Cardiovascular Remodeling Associated With Obesity. Ernesto Martínez-Martínez, Natalia López-Ándres, ... Galectin-3 Participates in Cardiovascular Remodeling Associated With Obesity. Ernesto Martínez-Martínez, Natalia López-Ándres, ... Galectin-3 Participates in Cardiovascular Remodeling Associated With Obesity. Ernesto Martínez-Martínez, Natalia López-Ándres, ... Galectin-3 (Gal-3) induces inflammation and fibrosis in the cardiovascular system. We have investigated the potential role of ...
  http://hyper.ahajournals.org/content/early/2015/09/08/HYPERTENSIONAHA.115.06032
*  Analysis Indicates BG Medicine's Galectin-3 Test is Predictive of Hospital Readmissions | GenomeWeb
... this week announced results from an analysis of three multicenter clinical research trials that indicate its BGM Galectin-3 ... Analysis Indicates BG Medicine's Galectin-3 Test is Predictive of Hospital Readmissions. Mar 28, 2014 ... Home » Analysis Indicates BG Medicine's Galectin-3 Test is Predictive of Hospital Readmissions ... this week announced results from an analysis of three multicenter clinical research trials that indicate its BGM Galectin-3 ...
  https://www.genomeweb.com/proteomics/analysis-indicates-bg-medicines-galectin-3-test-predictive-hospital-readmissions
*  Galectin-3, a Novel Binding Partner of β-Catenin | Cancer Research
Galectin-3, a Novel Binding Partner of β-Catenin. Tatsuo Shimura, Yukinori Takenaka, Souichi Tsutsumi, Victor Hogan, Akira ... Galectin-3, a Novel Binding Partner of β-Catenin. Tatsuo Shimura, Yukinori Takenaka, Souichi Tsutsumi, Victor Hogan, Akira ... Galectin-3, a Novel Binding Partner of β-Catenin. Tatsuo Shimura, Yukinori Takenaka, Souichi Tsutsumi, Victor Hogan, Akira ... Tcf-4 and Galectin-3 Interaction.. Based on the data presented above, we questioned (1) whether the β-catenin-gal-3 complex ...
  http://cancerres.aacrjournals.org/content/64/18/6363?ijkey=45e649ad11eda089f4064ccaef3418529f73b151&keytype2=tf_ipsecsha
*  Galectin-3 Blockade in Patients With High Blood Pressure - Full Text View - ClinicalTrials.gov
Galectin-3 Blockade in Patients With High Blood Pressure. This study is currently recruiting participants. See Contacts and ... Change in galectin-3 level [ Time Frame: Baseline and 6 months ]. Changes in galectin-3 level from baseline until 6 months will ... Elevated galectin-3 level (above sex-specific median based on Framingham Heart Study measures) ... Gal-3 appears to be a potential mediator of cardiac fibrosis, preceding the development of clinical heart failure. In this ...
  https://clinicaltrials.gov/ct2/show/NCT01960946?term=heart+block&recr=Open&fund=01&rank=17
*  Galectin-3-binding protein ELISA | Human LGALS3BP ELISA | Mac-2bp ELISA
Human Galectin-3-binding protein ELISA. Galectin-3-binding protein (also known as LGALS3BP, Mac-2bp, or 90K) is a N- ... It is thought that LGALS3BP may regulate cell adhesion through interaction with Galectin-3. LGALS3BP has been found to be ... Products , Cell_Biology_and_Epigenetics , Cell_Adhesion_and_Extracellular_Matrix , Galectin-3. ... Galectin proteins contain carbohydrate-recognition-binding domains (CRDs) that bind beta-galactoside sugars and are involved in ...
  http://www.clontech.com/US/Products/Cell_Biology_and_Epigenetics/Cell_Adhesion_and_Extracellular_Matrix/Galectin-3?sitex=10020:22372:US&PEBCL1=VLEPFh7Mdl7opBauxkgsoB8I96&PEBCL1_pses=ZGBA2BF6594C3443A4EF078C272CF6E69E776C772C42F00223804777CEFEA668F9BE415A1C01503FFC42B93B65C373766D48F61CA7A67670D2
*  Studies Shore up BG Medicine's Push for Galectin-3 Test in Hospital Readmission Risk Assessment | GenomeWeb
... earlier this year will help shore up the scientific foundation for the company's new strategy of marketing its galectin-3 test ... Studies Shore up BG Medicine's Push for Galectin-3 Test in Hospital Readmission Risk Assessment. Mar 08, 2013 ... Home » Studies Shore up BG Medicine's Push for Galectin-3 Test in Hospital Readmission Risk Assessment ... earlier this year will help shore up the scientific foundation for the company's new strategy of marketing its galectin-3 test ...
  https://www.genomeweb.com/proteomics/studies-shore-bg-medicines-push-use-galectin-3-test-hospital-readmission-risk-as
*  Galectin-3 - Wikipedia
Companies have developed galectin modulators that block the binding of galectins to carbohydrate structures. The galectin-3 ... Given galectin-3's broad biological functionality, it has been demonstrated to be involved in cancer, inflammation and fibrosis ... The roles of galectins and galectin-3, in particular, in cancer have been heavily investigated. Of note, galectin-3 has been ... Galectin Therapeutics in the United States is also using galectins for their research, finding recently that inhibition of ...
  https://en.wikipedia.org/wiki/Galectin-3
*  Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers | Cancer Discovery
Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers. Laetitia Seguin, Maria F. Camargo, Hiromi I. Wettersten, ... Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers. Laetitia Seguin, Maria F. Camargo, Hiromi I. Wettersten, ... Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers. Laetitia Seguin, Maria F. Camargo, Hiromi I. Wettersten, ... Galectin-3, a Druggable Vulnerability for KRAS-Addicted Cancers Message Subject (Your Name) has forwarded a page to you from ...
  http://cancerdiscovery.aacrjournals.org/content/7/12/1464.full
*  IJMS | Free Full-Text | Serum Galectin-9 and Galectin-3-Binding Protein in Acute Dengue Virus Infection
Lower serum levels of galectin-1, galectin-3, and E-, L-, and P-selectin in dengue patients were detected compared to bacteria- ... Our results showed the levels of galectin-9 and galectin-3BP were significantly higher in dengue patients than those in healthy ... The aim of this study was to investigate the serum concentration and potential interaction of soluble galectin-1, galectin-3, ... In addition, strong correlation between galectin-9 and galectin-3BP was observed in dengue patients. In summary, our study ...
  http://www.mdpi.com/1422-0067/17/6/832
*  Abstract 322: Functional significance of tyrosine phosphorylation of galectin-3 in prostate cancer progression | Cancer Research
Abstract 322: Functional significance of tyrosine phosphorylation of galectin-3 in prostate cancer progression. Vitaly Balan, ... Abstract 322: Functional significance of tyrosine phosphorylation of galectin-3 in prostate cancer progression ... Abstract 322: Functional significance of tyrosine phosphorylation of galectin-3 in prostate cancer progression ... Abstract 322: Functional significance of tyrosine phosphorylation of galectin-3 in prostate cancer progression ...
  http://cancerres.aacrjournals.org/content/72/8_Supplement/322
*  BG Medicine to Highlight Role of Galectin-3 Testing in Reducing Unplanned Hospital Readmissions at the 2012 American Heart...
The BGM Galectin-3® Test is cleared by the FDA as an aid in assessing the prognosis of patients with chronic heart failure. ... About Galectin-3 and Heart Failure. Galectin-3 is a unique carbohydrate-binding lectin, or protein, that binds to carbohydrates ... Galectin-3 is such a tool and should be considered for heart failure readmissions programs. Baseline galectin-3 is a powerful ... "Galectin-3 testing is a powerful tool for those seeking to make their intervention strategies on patients with clinical ...
  https://www.cnbc.com/id/100087330
*  IJMS | Free Full-Text | Galectin-3: The Impact on the Clinical Management of Patients with Thyroid Nodules and Future...
Furthermore, several galectin molecules also play a role in regulating the immune response. These functions are strongly ... Galectins bind β-galactose-containing glycoconjugates and are functionally active in converting glycan-related information into ... In this review, the biological role of galectin-3 expression in thyroid cancer, the validation and translation to a clinical ... The discovery of a restricted expression of galectin-3 in well-differentiated thyroid carcinomas (WDTC), compared to normal and ...
  http://www.mdpi.com/1422-0067/19/2/445
*  Poly N-acetyllactosamine substitutions on N- and not O-oligosaccharides or Thomsen-Friedenreich antigen facilitate lung...
Galectin-3 on vascular endothelium has been shown to facilitate lung specific metastasis. Metastatic variants of B16 melanoma ... Galectin-3 β1,6 branched N-oligosaccharides Poly N-acetyl lactosamine Adhesion Lung specific metastasis ... Stowell, S.R., Arthur, C.M., Mehta, P., Slanina, K.A., Blixt, O., Leffler, H., Smith, D.F., Cummings, R.D.: Galectin-1, -2, and ... Galectin-3 on vascular endothelium has been shown to facilitate lung specific metastasis. Metastatic variants of B16 melanoma ...
  https://rd.springer.com/article/10.1007/s10719-008-9194-9