*  Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration. - Radcliffe...
METHODS AND RESULTS: Endothelium-targeted overexpression of GTP cyclohydrolase (GCH) I increased levels of the endothelial NO ... METHODS AND RESULTS: Endothelium-targeted overexpression of GTP cyclohydrolase (GCH) I increased levels of the endothelial NO ...
  https://www.rdm.ox.ac.uk/publications/429649
*  GTP cyclohydrolase II - Wikipedia
In enzymology, a GTP cyclohydrolase II (EC 3.5.4.25) is an enzyme that catalyzes the chemical reaction ... Other names in common use include guanosine triphosphate cyclohydrolase II, and GTP-8-formylhydrolase. This enzyme participates ... GTP + 3 H2O ⇌. {\displaystyle \rightleftharpoons }. formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + ... Thus, the two substrates of this enzyme are GTP and H2O, whereas its 3 products are formate, 2,5-diamino-6-hydroxy-4-(5- ...
  https://en.wikipedia.org/wiki/GTP_cyclohydrolase_II
*  PND Association | Guanosine Triphosphate Cyclohydrolase I Deficiency
What is Guanosine Triphosphate Cyclohydrolase I Deficiency (GCH I, GTP Cyclohydrolase, GTPCH)?. Home , Diseases ... PDF/Printable Guide to Guanosine Triphosphate Cyclohydrolase I Deficiency(GCH I, GTP Cyclohydrolase, GTPCH) ... Guanosine Triphosphate Cyclohydrolase I Deficiency. Key Words: "GTP Cyclohydrolase". Access Listing: 600225. http://www.ncbi. ... Guanosine Triphosphate Cyclohydrolase I Deficiency (GTPCH) deficiency is a rare metabolic disorder which produces a lack of the ...
  http://www.pndassoc.org/diseases/gtpch.html
*  重组人GTP cyclohydrolase 1蛋白(ab114821)|Abcam中国
购买我们的重组人GTP cyclohydrolase 1蛋白。Ab114821为蛋白片段,在小麦胚芽中生产并经过ELISA, SDS ... Recombinant人GTP cyclohydrolase 1 protein. 参阅全部 GTP cyclohydrolase 1 蛋白酶. ... Defects in GCH1 are the cause of GTP cyclohydrolase 1 deficiency (GCH1D) [MIM:233910]; also known as atypical severe ... phenylketonuria due to GTP cyclohydrolase I deficiency;. GCH1D is one
  http://www.abcam.cn/recombinant-human-gtp-cyclohydrolase-1-protein-ab114821.html
*  Stoichiometric Relationships Between Endothelial Tetrahydrobiopterin, Endothelial NO Synthase (eNOS) Activity, and eNOS...
... mice with mice overexpressing endothelial GTP cyclohydrolase 1 (GCH-Tg), the rate-limiting enzyme in BH4 synthesis. eNOS ... Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces ... mice with mice overexpressing endothelial GTP cyclohydrolase 1 (GCH-Tg), the rate-limiting enzyme in BH4 synthesis. eNOS ... preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I ...
  https://www.semanticscholar.org/paper/Stoichiometric-Relationships-Between-Endothelial-T-Bendall-Alp/a6eac72b81983dc31ca94c642e83991cf61950cb
*  GTP Cyclohydrolase/BH4 Pathway Protects EPC Function via Suppressing Oxidative Stress and Thrombospondin-1 in Salt-Sensitive...
GTP Cyclohydrolase/BH4 Pathway Protects EPC Function via Suppressing Oxidative Stress and Thrombospondin-1 in Salt-Sensitive ... GTP Cyclohydrolase/BH4 Pathway Protects EPC Function via Suppressing Oxidative Stress and Thrombospondin-1 in Salt-Sensitive ... GTP Cyclohydrolase/BH4 Pathway Protects EPC Function via Suppressing Oxidative Stress and Thrombospondin-1 in Salt-Sensitive ...
  https://www.rdm.ox.ac.uk/publications/105938
*  Abstract 167: A Cell-Autonomous Role for Endothelial GTP Cyclohydrolase 1 and Tetrahydrobiopterin in Blood Pressure Regulation ...
We generated a novel mouse model with endothelial cell-specific deletion of GCH1, encoding GTP cyclohydrolase 1, an essential ... Abstract 167: A Cell-Autonomous Role for Endothelial GTP Cyclohydrolase 1 and Tetrahydrobiopterin in Blood Pressure Regulation ... Abstract 167: A Cell-Autonomous Role for Endothelial GTP Cyclohydrolase 1 and Tetrahydrobiopterin in Blood Pressure Regulation ... Abstract 167: A Cell-Autonomous Role for Endothelial GTP Cyclohydrolase 1 and Tetrahydrobiopterin in Blood Pressure Regulation ...
  http://atvb.ahajournals.org/content/34/Suppl_1/A167
*  Center for Structural Genomics of Infectious Diseases - Deposits
Crystal structure of GTP cyclohydrolase I from Yersinia pestis CO92 complexed with GTP (tree view) ... It catalyzes the conversion of GTP to 7,8-dihydroneopterin triphosphate. The 2.1A resolution structure of GTP cyclohydrolase I ... GTP cyclohydrolase I (encoded by gene folE) is the first Zn(2+)-dependent enzyme of the de novo tetrahydrofolate biosynthetic ... The structure contains, in the active site, five GTP molecules and Ca(2+) ions probably from crystallization in place of Zn(2+ ...
  https://csgid.org/deposits/view/1480
*  Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin. - Oxford Neuroscience
Synthesis of BH4 is regulated by GTP cyclohydrolase I (GTPCH), encoded by GCH1. Recent clinical studies report associations ... Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin. ... Synthesis of BH4 is regulated by GTP cyclohydrolase I (GTPCH), encoded by GCH1. Recent clinical studies report associations ... Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin. ...
  https://www.neuroscience.ox.ac.uk/publications/237264
*  GTP cyclohydrolase I - Wikipedia
GTP cyclohydrolase I (GTPCH) (EC 3.5.4.16) is a member of the GTP cyclohydrolase family of enzymes. GTPCH is part of the folate ... as well as GTP cyclohydrolase I deficiency. Deficiency of GTP cyclohydrolase I can occur in a recessive and in a dominant form ... Patients with the recessive form have mutations in both alleles for GTP cyclohydrolase I. Patients present with developmental ... ISBN 0-471-39223-5. GTP Cyclohydrolase I at the US National Library of Medicine Medical Subject Headings (MeSH) GeneReviews/ ...
  https://en.wikipedia.org/wiki/GTP_cyclohydrolase_I
*  GTP cyclohydrolase IIa - Wikipedia
In enzymology, a GTP cyclohydrolase IIa (EC 3.5.4.29) is an enzyme that catalyzes the chemical reaction GTP + 3 H2O ⇌ {\ ... The systematic name of this enzyme class is GTP 8,9-hydrolase (phosphate-forming). Graham DE, Xu H, White RH (2002). "A member ... the two substrates of this enzyme are GTP and H2O, whereas its two products are 2-amino-5-formylamino-6-(5-phosphoribosylamino) ... of a new class of GTP cyclohydrolases produces formylaminopyrimidine nucleotide monophosphates". Biochemistry. 41 (50): 15074- ...
  https://en.wikipedia.org/wiki/GTP_cyclohydrolase_IIa
*  folE - GTP cyclohydrolase 1 - Escherichia coli (strain K12) - folE gene & protein
GTP cyclohydrolase I activity, zinc ion binding, queuosine biosynthetic process, tetrahydrobiopterin biosynthetic process ... IPR001474 GTP_CycHdrlase_I. IPR018234 GTP_CycHdrlase_I_CS. IPR020602 GTP_CycHdrlase_I_dom. ... IPR001474 GTP_CycHdrlase_I. IPR018234 GTP_CycHdrlase_I_CS. IPR020602 GTP_CycHdrlase_I_dom. ... "Allosteric characteristics of GTP cyclohydrolase I from Escherichia coli.". Schoedon G., Redweik U., Frank G., Cotton R.G.H., ...
  https://www.uniprot.org/uniprot/P0A6T5
*  folE - GTP cyclohydrolase 1 - Xanthomonas axonopodis pv. citri (strain 306) - folE gene & protein
GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (folE). This subpathway is part of the pathway 7,8-dihydroneopterin ... IPR001474. GTP_CycHdrlase_I. IPR018234. GTP_CycHdrlase_I_CS. IPR020602. GTP_CycHdrlase_I_dom. ... IPR001474. GTP_CycHdrlase_I. IPR018234. GTP_CycHdrlase_I_CS. IPR020602. GTP_CycHdrlase_I_dom. ... GTP cyclohydrolase 1UniRule annotation. ,p>Manual validated information which has been generated by the UniProtKB automatic ...
  http://www.uniprot.org/uniprot/Q8PEP3
*  GTP cyclohydrolase deficiency; intrafamilial variation in clinical phenotype, including levodopa responsiveness | Journal of...
Increase of GTP cyclohydrolase 1 in mononuclear blood cells by stimulation: detection of heterozygotes of GTP cyclohydrolase 1 ... Identification of the GTP cyclohydrolase I (GTPCH 1) gene as the causative gene in most cases of levodopa responsive dystonia ... 1996) DOPA responsive dystonia in British patients: new mutations of the GTP cyclohydrolase 1 gene and evidence of genetic ... A family with a dominant form of partial GTP cyclohydrolase deficiency is described. Clinical severity varied from mild ...
  http://jnnp.bmj.com/content/66/1/86
*  folE - GTP cyclohydrolase 1 - Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) - folE gene & protein
IPR001474. GTP_CycHdrlase_I. IPR018234. GTP_CycHdrlase_I_CS. IPR020602. GTP_CycHdrlase_I_dom. ... IPR001474. GTP_CycHdrlase_I. IPR018234. GTP_CycHdrlase_I_CS. IPR020602. GTP_CycHdrlase_I_dom. ... GTP cyclohydrolase 1UniRule annotation. ,p>Manual validated information which has been generated by the UniProtKB automatic ... GTP cyclohydrolase IUniRule annotation. ,p>Manual validated information which has been generated by the UniProtKB automatic ...
  http://www.uniprot.org/uniprot/Q8KEA8
*  Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock. | Sigma...
Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.. [Anna ... GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme for BH4 biosynthesis. Under inflammatory conditions, GCH1 activity and ...
  https://www.sigmaaldrich.com/catalog/papers/25046538
*  Generation of an iPSC line from a patient with GTP cyclohydrolase 1 (GCH1) deficiency: HDMC0061i-GCH1 - Zurich Open Repository...
Generation of an iPSC line from a patient with GTP cyclohydrolase 1 (GCH1) deficiency: HDMC0061i-GCH1 ... Fibroblasts from a female patient carrying a heterozygous variation in GTP cyclohydrolase 1 (GCH1; OMIM: 600225; HGNC: 4193; c. ... Fibroblasts from a female patient carrying a heterozygous variation in GTP cyclohydrolase 1 (GCH1; OMIM: 600225; HGNC: 4193; c. ... Generation of an iPSC line from a patient with GTP cyclohydrolase 1 (GCH1) deficiency: HDMC0061i-GCH1. Stem Cell Research, 20: ...
  https://www.zora.uzh.ch/id/eprint/145474/
*  Corticotropin-releasing factor receptor antagonist attenuates LPS-induced increase of GTP cyclohydrolase I expression at murine...
Pretreatment with CP-154,526 attenuated the increase in expression levels of GTP cyclohydrolase I mRNA due to intraperitoneal ... Keywords: CORTICOTROPIN-RELEASING FACTOR; GTP CYCLOHYDROLASE I; LIPOPOLYSACCHARIDE; CP-154; LOCUS COERULEUS ... Pretreatment with CP-154,526 attenuated the increase in expression levels of GTP cyclohydrolase I mRNA due to intraperitoneal ... Corticotropin-releasing factor receptor antagonist attenuates LPS-induced increase of GTP cyclohydrolase I expression at murine ...
  http://booksandjournals.brillonline.com/content/journals/10.1163/156939105774647411
*  Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1. - Radcliffe...
GTP cyclohydrolase-1 transgenic (Tg) mice demonstrated a significant increase in baseline urine NO-to-creatinine ratio and a ... in mouse microvascular endothelial cells and in vivo in transgenic mice with overexpression of endothelial GTP cyclohydrolase, ... GTP cyclohydrolase-1 transgenic (Tg) mice demonstrated a significant increase in baseline urine NO-to-creatinine ratio and a ... Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1. ...
  https://www.rdm.ox.ac.uk/publications/105234
*  Expression of one isoform of GTP cyclohydrolase I coincides with the larval black markings of the swallowtail butterfly,...
Guanosine triphosphate cyclohydrolase I (GTPCHI) is essential for the synthesis of tetrahydrobiopterin (BH4) that is a cofactor ... Expression of one isoform of GTP cyclohydrolase I coincides with the larval black markings of the swallowtail butterfly, ... article{Futahashi2006ExpressionOO, title={Expression of one isoform of GTP cyclohydrolase I coincides with the larval black ...
  https://www.semanticscholar.org/paper/Expression-of-one-isoform-of-GTP-cyclohydrolase-I-Futahashi-Fujiwara/d2dadc5bd417ff921db834862ee1d31a357c3f9f
*  Explaining the Phenomenon of Nitrate Tolerance | Circulation Research
... decrease in GTP-cyclohydrolase I feedback regulatory protein mRNA.72 This protein controls the rate of BH4 synthesis by GTP ... induced oxidation of BH4 and reduced expression of GTP-cyclohydrolase (GTP-CH); (4) Vasoconstrictor supersensitivity caused by ... cyclohydrolase (Figure 2). Provided that mRNA and protein expression are directly correlated (which we do not know), the rate ...
  http://circres.ahajournals.org/content/97/7/618
*  Network Portal - Gene BC0072
GTP cyclohydrolase I (NCBI ptt file). 110, 152. BC2044. BC2044. Magnesium and cobalt efflux protein corC (NCBI ptt file). 110, ...
  http://networks.systemsbiology.net/bce/gene/BC0072
*  Metabolic and proteomic analyses of product selectivity and redox regulation in Clostridium pasteurianum grown on glycerol...
In addition, as described in the above redox balance analysis, a possible involvement of a ferredoxin-dependent butyryl-CoA dehydrogenase/electron transferring flavoprotein complex (BCdH-ETF) in H2 production was proposed. In the BCdH-ETF catalyzed reaction electron transfer flavoproteins (ETFs) are involved in the reduction of crotonyl-CoA to butyryl-CoA, coupled with ferredoxin(ox) reduction by bifurcating electrons from NADH (Fig. 5) [28, 37]. In this proteomic study, two ETFs, namely ETFs subunit alpha (F502_06282) and subunit alpha/beta-like protein (F502_06287), were identified among the most abundant proteins regardless of the iron availability; however, their abundances were slightly higher (1.5-1.7 folds) in the late phase of the Fe+ culture compared to the Fe− late condition. This might indicate a relative increase in the oxidized ferredoxin pool necessary to carry out the BCdH-ETF reaction and also contributed to the stronger H2 production in the late fermentation phase under Fe+ ...
  https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-017-0678-9