*  Transcription factor GATA-3 (IPR029521) | InterPro | EMBL-EBI
Transcription factor GATA-3 (IPR029521). Short name: GATA-3 Family relationships *Transcription factor, GATA-2/3 (IPR016374) * ... GATA-3 belongs to the GATA transcription factor family, which consists of a group of vertebrate GATA factors that have two ... GATA-3 is a trans-acting T-cell-specific transcription factor required for several developmental steps in T-cells [PMID: ... GATA-3 regulates the self-renewal of long-term hematopoietic stem cells.. Nat. Immunol. 14 1037-44 2013 ...
  http://www.ebi.ac.uk/interpro/entry/IPR029521
*  JCI - Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs
Previous studies showed that Gata3 is regulated by transcription factors HEB (37, 38), T cell factor 1 (TCF-1) (39), and RBP-J/ ... The transcription factor GATA3 is essential for the genesis and maturation of the T cell lineage, and GATA3 dysregulation has ... TCF-1, HEB, and RBP-J regulate Gata3 transcription by binding within Tce1. Several transcription factors have been proposed as ... Prediction of putative transcription factor-binding sites. A search for putative transcription factor-binding sites in Tce1 was ...
  https://www.jci.org/articles/view/83894
*  Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells...
Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells ... T-box transcription factor (T-bet), GATA3 (GATA Binding Protein 3), and CD152 (CTLA-4) expression in BTBR mice. Our results ... An imbalance in the production of pro- and anti-inflammatory cytokines and transcription factors plays a role in ... The augmented levels of IL-21/IL-22 and GATA3/T-bet could be due to altered A2AR signaling. Our results indicate that A2AR ...
  https://www.sigmaaldrich.com/catalog/papers/28807491
*  The Diagnostic Value of Transcription Factors T-bet-GATA3 Ratio in Predicting Antibody-Mediated Rejection - pdf descargar
The Diagnostic Value of Transcription Factors T-bet-GATA3 Ratio in Predicting Antibody-Mediated Rejection. . Biblioteca virtual ... The Diagnostic Value of Transcription Factors T-bet-GATA3 Ratio in Predicting Antibody-Mediated Rejection - Descarga este ... The Diagnostic Value of Transcription Factors T-bet-GATA3 Ratio in Predicting Antibody-Mediated Rejection. ... We compared the intraglomerular T-bet-GATA3 ratio in ABMR and TCMR. The intragraft expression of T-bet and GATA3 was studied ...
  http://libros.duhnnae.com/2017/jun9/149862664350-The-Diagnostic-Value-of-Transcription-Factors-T-bet-GATA3-Ratio-in-Predicting-Antibody-Mediated-Rejection.php
*  List of all Pillars of Immunology articles | The Journal of Immunology
Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role. Anne O'Garra and Leona Gabryšova. J Immunol ... Pillars Article: The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells. ... FOXP3, the Transcription Factor at the Heart of the Rebirth of Immune Tolerance. Jeffrey A. Bluestone. J Immunol 2017 198: 979- ... Pillars Article: Control of Regulatory T Cell Development by the Transcription Factor Foxp3. Science 2003. 299: 1057-1061. ...
  http://www.jimmunol.org/pillarsofimmunology
*  The transcription factor XBP-1 is essential for the development and survival of dendritic cells | JEM
Transcription factor GATA-3 is required for development of the T-cell lineage. Nature. 384:474-478. ... several intracellular signaling molecules and transcription factors-including Gfi1, Id2, Ikaros, IFN regulatory factor 2 (IRF-2 ... The transcription factor XBP-1 is essential for the development and survival of dendritic cells. Neal N. Iwakoshi, Marc Pypaert ... Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells. J. Immunol. ...
  http://jem.rupress.org/content/204/10/2267
*  JCI - Volume 126, Issue 3
The transcription factor GATA3 is essential for the genesis and maturation of the T cell lineage, and GATA3 dysregulation has ... Gata3. transcription in vivo. Here, we determined that the canonical Gata3. promoter is insufficient for Gata3. transcriptional ... Gata3. expression in T cells. Instead, we demonstrated that multiple lineage-affiliated transcription factors bind to Tce1. and ... Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs. ...
  https://jci.org/126/3
*  Safety, Tolerability, and Pharmacokinetics After a Single Dose of Orally Inhaled DNAzyme Solution for Nebulisation in Male...
The transcription factor GATA-3 plays a key role in mediating the asthmatic immune response and has been shown to be necessary ... By cleaving GATA-3 mRNA, hgd40 reduces specific cytokine production and thereby reduces key features of allergic airway ... a Human GATA-3-specific DNAzyme Solution for Nebulisation - A Randomised, Double-blind, Placebo-controlled, Parallel-group (Per ...
  https://clinicaltrials.gov/ct2/show/NCT01577953
*  Transcription Factor ets-2 Plays an Important Role in the Pathogenesis of Pulmonary Fibrosis
The roles of transcription factors, such as Smad3 (4), Nrf2 (5), CEBPβ (6), GATA-3 (7), PPARs (8, 9), Fra-2 (10), and p53 (11 ... Overexpression of the transcription factor GATA-3 enhances the development of pulmonary fibrosis. Am J Pathol 2006;169:96-104 [ ... Transcription Factor ets-2 Plays an Important Role in the Pathogenesis of Pulmonary Fibrosis. Christopher P. Baran,1 Sara N. ... The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J 2004;18:1258-1260 [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3262682/
*  Related Articles by Review for PubMed (Select 10935639) - PubMed - NCBI
Transcription factor GATA3 and the human HDR syndrome.. Van Esch H, Devriendt K. ... GATA3 haplo-insufficiency causes human HDR syndrome.. Van Esch H, Groenen P, Nesbit MA, Schuffenhauer S, Lichtner P, ... Role of the vascular endothelial growth factor isoforms in retinal angiogenesis and DiGeorge syndrome. ...
  https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed_reviews&from_uid=10935639
*  GATA3 - GATA-binding factor 3 - Gallus gallus (Chicken) - GATA3 gene & protein
Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites ... RNA polymerase II transcription factor binding Source: GO_Central. *transcriptional activator activity, RNA polymerase II ... sp,P23825,GATA3_CHICK GATA-binding factor 3 OS=Gallus gallus GN=GATA3 PE=2 SV=1 ... R-GGA-8939236. RUNX1 regulates transcription of genes involved in differentiation of HSCs. R-GGA-983231. Factors involved in ...
  http://www.uniprot.org/uniprot/P23825
*  Plus it
Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 2003;19:863-75. ... GATA-binding protein 3 (GATA3) is a transcription factor and a putative tumor suppressor that is highly expressed in normal ... GATA-binding protein 3 (GATA3) is a transcription factor that is highly expressed in normal breast luminal epithelium and the ... have shown by targeted disruption of GATA3 in mice that GATA3 is required for proper hair follicle stem cell function (28). In ...
  http://cebp.aacrjournals.org/content/16/11/2269
*  Recombinant Human GATA3 protein (ab114297) | Abcam
Buy our Recombinant Human GATA3 protein. Ab114297 is a protein fragment produced in Wheat germ and has been validated in WB, ... Trans acting T cell specific transcription factor GATA 3. *Trans-acting T-cell-specific transcription factor GATA-3 ... Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also ...
  http://www.abcam.com/recombinant-human-gata3-protein-ab114297.html
*  The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector...
T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-γ. Nat ... A recent study revealed that activating transcription factor 2 family transcription factors (ATF2) can promote transcription ... and the transcription factor c-myc. LEF1 also directly augments expression of the effector fate-specifying transcription factor ... 5 A). When compared with other transcription factors, LEF1 expression was proportional to GATA3 and PLZF and was largely ...
  http://jem.rupress.org/content/early/2015/04/14/jem.20141849
*  Protein (RefSeq) Links for PubMed (Select 19700764) - Protein - NCBI
PREDICTED: trans-acting T-cell-specific transcription factor GATA-3 isoform X2 [Mus musculus] ... PREDICTED: trans-acting T-cell-specific transcription factor GATA-3 isoform X1 [Mus musculus] ... trans-acting T-cell-specific transcription factor GATA-3 isoform 3 [Mus musculus] ... trans-acting T-cell-specific transcription factor GATA-3 isoform 4 [Mus musculus] ...
  https://www.ncbi.nlm.nih.gov/protein?LinkName=pubmed_protein_refseq&from_uid=19700764
*  Similar articles for PubMed (Select 22685315) - PubMed - NCBI
The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. ... The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. ... The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells. ... Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. ...
  https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=22685315
*  Catalog | Mendeley
Copyright © 2017 Mendeley Ltd. All rights reserved. Cookies are set by this site. To decline them or learn more, visit our cookies page.. ...
  https://www.mendeley.com/research-papers/updated-view-transcription-factor-gata3-mediated-regulation-th1-th2-cell-differentiation/
*  Dynamic Repositioning of CD4 and CD8 Genes during T Cell Development | JEM
Other transcription factors have been implicated in the development of CD4 or CD8 lineage T cells, including GATA3, Tox, and ... and Runx transcription factors (5-7). Other transcription factors including SAF and HES have also been implicated in CD4 ... Critical roles for transcription factor GATA-3 in thymocyte development. Immunity. 19:863-875. ... Other transcription factors have been implicated in CD4 and CD8 T cell development including GATA3, which is required for CD4 T ...
  http://jem.rupress.org/content/200/11/1427
*  Frontiers | Regulation of murine natural killer cell commitment | Immunology
While a few important transcription factors have identified for NK genesis the mechanisms of how this is achieved is far from ... While a few important transcription factors have identified for NK genesis the mechanisms of how this is achieved is far from ... in vivo and it remains to be addressed if a common NK cell precursor seeds diverse niches and how transcription factors may ... in vivo and it remains to be addressed if a common NK cell precursor seeds diverse niches and how transcription factors may ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2013.00014/full
*  Table of Contents - December 01, 2016, 197 (11) | The Journal of Immunology
Correction: Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role Anne O'Garra and Leona Gabryšová ...
  http://www.jimmunol.org/content/197/11
*  Immune Modulatory Treatment of Trinitrobenzene Sulfonic Acid Colitis with Calcitriol Is Associated with a Change of a T Helper ...
A representative immunoblot (IB) of the relevant Th1 or Th2 transcription factors T-bet (A) and GATA3 (C) are shown. T-bet: 1, ... GATA family of transcription factors 3, a Th2 master regulator (GATA3), Foxp3, cytotoxic T-lymphocyte-associated antigen 4 ( ... GATA3, GATA family of transcription factors 3, a Th2 master regulator; CTLA, cytotoxic T-lymphocyte-associated antigen. ... DC-derived factors, including augmentation of the transcription factor T-bet following activation by DC-derived IL-12. The ...
  http://jpet.aspetjournals.org/content/324/1/23.long
*  Plus it
A representative immunoblot (IB) of the relevant Th1 or Th2 transcription factors T-bet (A) and GATA3 (C) are shown. T-bet: 1, ... GATA family of transcription factors 3, a Th2 master regulator (GATA3), Foxp3, cytotoxic T-lymphocyte-associated antigen 4 ( ... GATA3, GATA family of transcription factors 3, a Th2 master regulator; CTLA, cytotoxic T-lymphocyte-associated antigen. ... DC-derived factors, including augmentation of the transcription factor T-bet following activation by DC-derived IL-12. The ...
  http://jpet.aspetjournals.org/content/324/1/23
*  Frontiers | Epigenomic Views of Innate Lymphoid Cells | Immunology
Although much is left to be learned, substantial progress has been made in understanding how transcription factors and ... Although much is left to be learned, substantial progress has been made in understanding how transcription factors and ... We review data on the role of lineage-defining- and signal dependent-transcription factors. ILC regulomes emerge ... We review data on the role of lineage-defining- and signal dependent-transcription factors. ILC regulomes emerge ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01579/full
*  Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber...
Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear. J Comp ... A-J: The expression of brain-derived neurotrophic factor (Bdnf) -LacZ in the ear and the effect of Bdnf null mutation on the ... A-C: The expression of brain-derived neurotrophic factor (Bdnf; A,B) and Atoh1 (C) is shown in embryonic day (E) 12.5 wild-type ... 7, 8). It is also conceivable that other as yet unknown factor(s) can be produced by these cells. Together, Bdnf and such ...
  http://onlinelibrary.wiley.com/doi/10.1002/dvdy.20370/full