GAP43) is a protein encoded by the GAP43 gene in humans. GAP43 is called a "growth" or "plasticity" protein because it is ... GAP43 is also referred to as: protein F1 neuromodulin neural phosphoprotein B-50 axonal membrane protein GAP-43 calmodulin- ... amyloid and tau protein, it may be useful to think of GAP43 as an adaptor protein situated within the terminal in a ... binding protein P-57 nerve growth-related peptide GAP43 neuron growth-associated protein 43 GAP43, is a nervous tissue-specific ...

Growth Associated Protein 43 kDa) or Neuromodulin Antibody. Useful for the study of neurogenesis including axon and neuron ... Rat GAP-43 is a 226 amino acid (aa) protein that contains an N-terminal lipid binding motif, an 11 aa IQ domain (IQ:Ile-Gln-X- ... MAP2 (Microtubule Associated Protein 2). RA22152. 100 ul. MARCKS (Myristoylated Alanine Rich C Kinase Substrate). CH22137. 100 ... GAP43 is a proven marker for developing and regenerating neurons, and to a lesser extent, reactive glial cells. It is used ...

... selectively stabilizes the GAP-43 mRNA in PC12 cells. To study the cellular mechanisms for this post-tra ... Downregulation of protein kinase C (PKC) by high doses of phorbol esters or selective PKC inhibitors prevented the induction of ... Thus, changes in GAP-43 mRNA turnover do not appear to require continuous protein synthesis. In conclusion, these data suggest ... In contrast, the rates of degradation and the levels of the GAP-43 mRNA in control and TPA-treated cells were not affected by ...

β-glycyrrhetinic acid alters expression and phosphorylation of the gap junction protein connexin-43 in enterocyte-like cells. ... Connexin protein monomers complex to form gap junction intercellular channels between various communicating cell types Connexin ... Blocking gap junctions in intestinal epithelial cells also blocks the epithelial healing process (R.B. & M.K., unpublished) ... β-glycyrrhetinic acid is a chemical inhibitor of gap junction communication in these and other cell types, with unknown mode of ...

... dc. ... On the origin of growth-associated protein-43 (GAP-43) immunoreactive processes present in the rat anterior pituitary. en. ...

Targeted overexpression of the neurite growth-associated protein B-50/GAP-43 in cerebellar Purkinje cells induces sprouting ... Targeted overexpression of the neurite growth-associated protein B-50/GAP-43 in cerebellar Purkinje cells induces sprouting ... B-50/GAP-43 is a nervous tissue-specific protein, the expression of which is associated with axon growth and regeneration. Its ... Thus, B-50/GAP-43 overexpression substantially modifies Purkinje cell response to axotomy, by inducing growth processes and ...

是扁形动物门的代表动物,也是发育生物学和再生生物学研究的模式生物之一[1].innexin(Inx)是间隙连接蛋白(gap junction protein)在无脊椎动物中的特殊存在方式[2],在染色体、神经系统和心脑血管疾病的发生[2-3]以及肿瘤抑制 ... 肌;连接蛋白 [gap=1953]Key words: Exercise training; Immunohistochemistry

Rat GAP43 (Growth Associated Protein 43) ELISA Kit , G-EC-05974 MSRP: ... QuicKey Pro Human CRP (C-Reactive Protein) ELISA Kit , G-EC-06100 QuicKey Pro Human CRP (C-Reactive Protein) ELISA Kit , G-EC- ... Rabbit hs-CRP (high-sensitivity C-Reactive Protein) ELISA Kit , G-EC-06068 Rabbit hs-CRP (high-sensitivity C-Reactive Protein) ... Rat IGFBP-3 (Insulin-Like Growth Factor Binding Protein 3) ELISA Kit , G-EC-06007 ...

Nitric oxide is known to prevent addition of the palmitate moiety to certain neuronal proteins such as GAP43 and SNAP-25 hence ... Subcellular distribution of cytokine-induced NOS2 compared with the palmitoylated proteins PSD-95 and GAP-43. PSD-95 and GAP-43 ... By analogy with the neuronal proteins SNAP25 and GAP-43 (Gonzalo and Linder, 1998; Bijlmakers and Marsh, 2003), palmitoylation ... The subcellular distribution of the palmitoylated proteins PSD-95, GAP-43 and NOS2 is different in COS7 cells, C2C12 myotubes ...

On the other hand, the protein GAP 43 seems to play an important role in the formation of the microtubules. Preusser: " ... therefore be to chemically inhibit the tumour cell network using calcium blockers or substances that affect connexin 43 or GAP ... connexin 43, that is able to form pores. ...

... the protein expression of GAP-43 in the model rats of the catalpol treatment group(1, 5 and 10 mg·kg-1) increased significantly ... Catalpol can up-regulate the protein expression of GAP-43 in the cerebral cortex surrounding the ischemic core, and enhance ... promote the expression of Bcl-2 protein and inhibit the expression of Bax protein, reduce oxidative stress damage via up- ... It is 88%-protein bound and is metabolized by the liver with primary excretion via the feces. Safety studies indicate that ...

2007) Expression of PKC substrate proteins, GAP-43 and neurogranin, is downregulated by cAMP signaling and alterations in ... TrkB-mediated protein synthesis is occluded in the Fmr1 KO. Results from our protein synthesis and signaling pathway ... Basal protein synthesis is elevated in the Fmr1 KO hippocampus. The molecular mechanisms underlying dysfunctional protein ... Thus, the cause of increased protein synthesis in the Fmr1 KO brain appears to be increased sensitivity of the protein ...

Disrupted cortical map and absence of cortical barrels in growth-associated protein (GAP)-43 knockout mice. Proceedings of the ... protein kinase A; and CaMKII alpha: calcium/calmodulin-dependent protein kinase II alpha) [101, 102, 103, 104]. These kinases ... such as the protein Lynx1, decrease the level of plasticity and provoke stability by locking the cortical network [87]. ... 43. (2):204-219. *3. Bharmauria V, Bachatene L, Cattan S, Chanauria N, Rouat J, Molotchnikoff S. Stimulus-dependent augmented ...

j-l) PD also inhibits gene expression (Q-PCR, N=3 per group) (j) as well as H3K9ac (k) and PCAF (l) at the promoters of GAP-43 ... The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration. EMBO J. 25, 4084-4096 (2006). ... b) Fold change increases observed in GAP-43, Galanin and BDNF gene expression at 1, 3 and 7 days post SNA but not DCA and at 3 ... In support of this, our data show that PCAF-dependent regulation of GAP-43, Galanin and BDNF is at the essential core of the ...

GAP GAP Links. * Gene neighbors Overlapping genes and two nearest non-overlapping genes on either side ... General protein information Go to the top of the page Help Preferred Names. transmembrane protein 43. NP_001394203.1. *EC 2.7. ... Protein interactions. Protein. Gene. Interaction. Pubs. Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to ... mRNA and Protein(s) * NM_001407274.1 → NP_001394203.1 transmembrane protein 43 isoform 2 ...

... and this resulted in a decrease in gap junction plaques. ... Protein kinase Cgamma regulation of gap junction activity ... Cell surface gap junction Cx43 plaques were detected by confocal microscopy. PKCgamma activity was measured with a PKC assay ... Overexpression of a loss-of-function PKCgamma mutant did not decrease gap junction Cx43 plaques or cause redistribution in ... Coimmunoprecipitation and Western blot analysis were used to detect protein expression and their interactions. Cav-1-containing ...

Click on the protein counts, or double click on taxonomic names to display all proteins containing IQ domain in the selected ... Neuromodulin (GAP-43). This protein is associated with nerve growth. It is a major component of the motile growth cones that ... A growing family of proteins is regulated by protein kinase C and calmodulin through IQ domains, a regulatory motif originally ... Several other RNA-binding proteins, including TLS/FUS and PSF, co-purify with EWS. PKC phosphorylation of these proteins also ...

The growth associated protein GAP-43, a molecule present in axons and growth cones, decreased in the dorsolateral striatum ... revealing marked regional differences in the response of axonal and glial proteins to afferent lesions. In addition, the ... despite an increased staining for glial fibrillary acidic protein (GFAP). The adhesion molecules tenascin, chondroitin sulfate ...

Co-induction of growth-associated protein GAP-43 and neuronal nitric oxide synthase in the cochlear nucleus following ... Thus, the NMDA-R protein level is regulated by the Reelin protein level in a Fyn-dependent manner in the mouse brain [36]. ... We found that Fyn phosphorylates the NMDA receptor and proteins associated with the receptor and proteins associated with the ... Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors. Vanhoose, A.M., Clements, J.M., Winder, D.G. J. ...

... acting as a scaffolding protein. Neuroligins are a family of cell adhesion proteins located on the post-synaptic membrane. ... GAP-43) [57], indicating that the exposure to several environmental chemicals can be a candidate factor associated with the ... Histone basic proteins (histones) form the core around which the DNA is wrapped. This formation constitutes the chromatin [20 ... Regions of DNA that do not code for proteins (i.e., intergenic regions) can be actively transcribed and participate in the ...

Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell. 2007; ... In scrape-loaded astrocytes, the dye traveled through functional gap junctions into adjacent gap junction-coupled astrocytes ... a gap junction protein richly expressed in spinal cord astrocytes, is a potential mediator of secondary damage. Here, we ... protein forms gap junctions that connect adjacent cells and hemichannels that open to the extracellular space; it is primarily ...

... considering the increase of the gap junction protein conexin 43 in diabetic animals. ... To fill this gap, we used the Manila clam Ruditapes philippinarum (the most farmed clam species worldwide) as model species to ... There are several gaps regarding the effects that parental exposure (F0) to environmental conditions exerts on indirectly ... Specifically, fish liver exhibited an altered protein metabolism with a drop in the level of amino acids, likely due to the ...

This is an important gap, especially given the recent publication of new research studies on this topic, such as the ... Importantly, these MRI-derived volume changes correlated with axonal growth-associated protein-43 (GAP-43) staining and not ... In this systematic review, we aimed at closing this gap and answering the following research question: Are there measurable ...

Arishima H, Sato K, Kubota T. Immunohistochemical and ultrastructural study of gap junction proteins connexin26 and 43 in human ... Immunohistochemistry would demonstrate positivity for glial fibrillary acidic protein (GFAP) and S100 protein in the glioma ... Protein 4.1B/differentially expressed in adenocarcinoma of the lung-1 functions as a growth suppressor in meningioma cells by ... Specific markers such as CD10 and Pax8 for renal cell carcinoma, as well as NKX3.1, prostatic acidic protein (PSA), prostate- ...

Differential expression of growth-associated protein (GAP-43) mRNA in rat primary sensory neurons after peripheral nerve lesion ... Intraspinal cellular responses after spinal cord transection in rats: Neuronal expression of growth-associated protein (GAP-43 ... Neurite outgrowth and GAP-43 mRNA expression in cultured adult rat dorsal root ganglion neurons: effects of NGF or prior ... GAP-43 N-terminal translocation signal targets beta-galactosidase to developing axons in a pan-neuronal transgenic mouse line. ...

... gap junction. The expression levels of proteins were normalized to the loading control GAPDH. Data are represented as mean ± ... D) Protein blot analyses and quantification of protein expression levels of cell-cell junction proteins and NEDD8 levels in ... Protein blot analyses (A) and quantification of protein expression levels (C) in total protein extracts from Csn6-iKO and ... D) Protein blot analysis and quantification of CSN6 protein levels in insoluble heart extracts from Dsp-cKO and control mice (n ...

Junctional Proteins in Plasma-Assisted Wound Healing. Interestingly, the gap junction protein connexin 43 (Cx43) might enhance ... Overexpression of the gap junction protein Cx43 as found in diabetic foot ulcers can retard fibroblast migration. Cell Biol. ... Roux, P.P.; Blenis, J. ERK and p38 MAPK-Activated Protein Kinases: A Family of Protein Kinases with Diverse Biological ... Upregulation of connexin proteins during diabetes leads to improper formation of gap junctions and attributes to the passage of ...

Bone marrow stromal cells upregulate expression of bone morphogenetic proteins 2 and 4, gap junction protein connexin-43 and ... Total RNA and proteins from cellular homogenates were extracted using Trizol (Roche Diagnostics). Protein concentration was ... Total RNA and protein isolation Once BMSC at passages 2, 7, and 12 had reached a confluence of approximately 90%, cell culture ... We observed less BDNF mRNA and protein as the number of passages in the culture increased (Figure 2A and 2B, upper panels). It ...

Phosphorylierung und Gap Junctions - Charakterisierung der Interaktion von Connexin 43 mit der Ubiquitin-Protein-Ligase Nedd4 ... In vivo-Untersuchungen von Konformations-Änderungen der Calcium-abhängigen Protein-Kinase NtCDPK2 aus Nicotiana tabacum by: ...

12). Gap junctions are intercellular channels composed of proteins called connexins.20,21 There are at least 13 members of the ... Gap junctions are intercellular channels composed of proteins called connexins.20,21 There are at least 13 members of the ... For example, the genes encoding the zona pellucida (ZP) proteins (i.e. ZP-1, ZP-2, and ZP-3) are transcribed and translated.17 ... Larger gap junctions (arrows) are evident between corona radiata cells.(Gilula NB, Epstein ML, Beers WH: Cell-to-cell ...