*  Effectiveness of GABA Agonists in Reducing the Reinforcing Effects of Cocaine - Full Text View - ClinicalTrials.gov
Cocaine likely creates its reinforcing and addictive effects by increasing levels of dopamine, a brain neurotransmitter. GABA agonists are chemicals that have the opposite effect by inhibiting the release of dopamine. Increasing GABA activity may result in greater inhibition of dopamine systems, which may lead to new treatments for cocaine abuse. The purpose of this study is to determine whether pretreatment with GABA agonists reduces the psychological and physiological reinforcing effects of cocaine. Specifically, the study will look at three different GABA agonists: tiagabine, baclofen, and trazolam.. This double-blind, placebo-controlled study will involve three separate experimental phases; each phase will last 4 weeks and will test one of three GABA agonists (tiagabine, baclofen, or trazolam). Daily testing sessions will last approximately 6 hours. One ...
  https://clinicaltrials.gov/ct2/show/NCT00218166
*  Altered pharmacology of synaptic and extrasynaptic GABAA receptors on CA1 hippocampal neurons is consistent with subunit...
Previously, we reported (Cagetti, Liang, Spigelman, and Olsen, 2003) that chronic intermittent ethanol (CIE) treatment leads to signs of alcohol dependence, including anxiety and hyperactivity, accompanied by reduced synaptic gamma-aminobutyric acid (A) receptor (GABAAR) function and altered sensitivity to its allosteric modulators consistent with a measured switch in subunit composition. In this study, we separated the synaptic and extrasynaptic components of GABAAR activation in recordings from pyramidal CA1 cells of hippocampal slices and demonstrated marked differences in the responsiveness of synaptic and extrasynaptic GABAARs to agonists and allosteric modulators in control rats, and in the way they are altered following CIE treatment. Notably, tonic inhibition mediated by extrasynaptic GABAARs was differentially sensitive to the partial agonist gaboxadol (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol; THIP) and the ...
  https://www.semanticscholar.org/paper/Altered-pharmacology-of-synaptic-and-extrasynaptic-Liang-Cagetti/67a0f4e60aefa092ed92038508521233414a3565
*  Temporary inactivation of the dorsal entorhinal cortex impairs acquisition and retrieval of spatial information.
We tested the effects of temporary inactivation of the dorsal entorhinal cortex on spatial discrimination using a conditioned cue preference (CCP) paradigm. The three phases of the procedure were: pre-exposure: unreinforced exploration of the center
  http://www.biomedsearch.com/nih/Temporary-inactivation-dorsal-entorhinal-cortex/19800978.html
*  Celebrities GABA Brain Food - Two Side Brain
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  http://www.twosidebrain.com/nootropics/online-gaba-brain-food/
*  Muscimol | GABAA receptor agonist | Hello Bio
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*  Frontiers | Metabotropic regulation of extrasynaptic GABAA receptors | Frontiers in Neural Circuits
A large body of work now shows the importance of GABAA receptor-mediated tonic inhibition in regulating CNS function. However, outside of pathological conditions, there is relatively little evidence that the magnitude of tonic inhibition is itself under regulation. Here we review the mechanisms by which tonic inhibition is known to be modulated, and outline the potential behavioural consequences of this modulation. Specifically, we address the ability of protein kinase A and C to phosphorylate the extrasynaptic receptors responsible for the tonic GABAA current, and how G-protein coupled receptors can regulate tonic inhibition through these effectors. We then speculate about the possible functional consequences of regulating the magnitude of the tonic GABAA current.
  https://www.frontiersin.org/articles/10.3389/fncir.2013.00171/full
*  GABA B Receptor 1 ELISA Kits | Biocompare.com
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  http://www.biocompare.com/pfu/110627/soids/2-29534/Assay_Kit/ELISA_GABA_B_Receptor_1
*  Frontiers | Functional role of ambient GABA in refining neuronal circuits early in postnatal development | Frontiers in Neural...
Early in development, gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the mature brain, depolarizes and excites targeted neurons by an outwardly directed flux of chloride, resulting from the peculiar balance between the cation-chloride importer NKCC1 and the extruder KCC2. The low expression of KCC2 at birth leads to accumulation of chloride inside the cell and to the equilibrium potential for chloride positive respect to the resting membrane potential. GABA exerts its action via synaptic and extrasynaptic GABAA receptors mediating phasic and tonic inhibition, respectively. Here, recent data on the contribution of 'ambient' GABA to the refinement of neuronal circuits in the immature brain have been reviewed. In particular, we focus on the hippocampus, where, prior to the formation of conventional synapses, GABA released from growth cones and astrocytes in a calcium- and SNARE-independent way, ...
  https://www.frontiersin.org/articles/10.3389/fncir.2013.00136/full
*  Profile | Exeter Medical School | University of Exeter
During slow-wave sleep, cortical neurons display synchronous fluctuations between periods of persistent activity ('UP states') and periods of relative quiescence ('DOWN states'). Such UP and DOWN states are also seen in isolated cortical slices. Recently, we reported that both spontaneous and evoked termination of UP states in slices from the rat medial entorhinal cortex (mEC) involves GABA B. receptors. Here, in order to dissociate the roles of GABA B1a - and GABA B1b -containing receptors in terminating UP states, we used mEC slices from mice in which either the GABA B1a. or the GABA B1b. subunit had been genetically ablated. Pharmacological blockade of GABA B. receptors using the antagonist CGP55845 prolonged the UP state duration in both wild-type mice and those lacking the GABA B1b. subunit, but not in those lacking the GABA B1a. subunit. Conversely, electrical ...
  http://medicine.exeter.ac.uk/people/profile/index.php?web_id=Michael_Craig
*  4-Chloro-1-methyl-1H-pyrrolo[3,2-c]pyridin-3-yl)methanol ,97% - Alfa Chemistry
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  http://www.alfa-chemistry.com/cas_97989-54-3.htm
*  ArQule moves forward with their cell cycle modulator...Wyeth develops selective GABA(A) alpha2/alpha3 subtype agonists as...
ArQule moves forward with their cell cycle modulator...Wyeth develops selective GABA(A) alpha2/alpha3 subtype agonists as candidate anxiolytics : Pharmaceutical feature | PharmiWeb.com
  https://www.pharmiweb.com/features/feature.asp?ROW_ID=834
*  JoVE Author Search: Atweh SF
Injection, Gaba, Glycine, Hyperalgesia, Injections, Lead, Lidocaine, Mononeuropathy, Pain, Rats, Gadolinium, Laboratory, Allodynia, Animals, Brainstem, Carrying, Documentation, Gaba Agonist, Injury, Neurons
  http://labindex.jove.com/author/Atweh-SF
*  GABA (gamma-aminobutyric acid) - amino acid studies
GABA is a non-essential amino acid. It plays an essential role in balancing brain chemicals. Learn all about the various health benefits of GABA
  http://aminoacidstudies.org/gaba-gamma-aminobutyric-acid/
*  Glutamat | GABA | Sinnsstemninger
Glutamat og GABA er de nevrotransmitterne det finnes mest av i nervesystemet, omtrent 50% av alle nevroner styres av glutamat, for GABA er tallet 45%. Glutamat er den sterkeste excitatory nevrotransmitteren vi har, som betyr den girer oss opp. GABA er den sterkeste inhibitory nevrotransmitteren, roer oss ned, og dannes av glutamat gjennom prosessen kalt…
  https://sinnsstemninger.wordpress.com/2014/06/22/glutamat-gaba/
*  GABA GABA GABA! | sympathomimetic
Why say it three times? Because if you really try, you can attribute almost ANYTHING your body does to GABA (it might take a little creativity, but work with me here). It is a neurotransmitter with a receptor by the same name (If you are feeling cheated because no one was creative enough to make…
  https://sympathomimetic.wordpress.com/2013/06/12/gaba-gaba-gaba/
*  Gentaur Molecular :FabGennix \ GABA Beta 1, FITC conjugates \ GABA100-FITC
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*  Kaufen Baclofen online. Sicher einkaufen Baclofen in der Internet-Apotheke. Qualitätsgarantie.
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*  Baclofen/samidorphan - AdisInsight
Alkermes was developing a fixed combination of extended-release baclofen and samidorphan for the oral treatment of alcohol dependence. Baclofen is an
  http://adisinsight.springer.com/drugs/800025253
*  Baclofen Polpharma - Drugs.com
Baclofen Polpharma is a medicine available in a number of countries worldwide. A list of US medications equivalent to Baclofen Polpharma is available on the Drugs.com website.
  https://www.drugs.com/international/baclofen-polpharma.html
*  GABA A receptor pi抗体|Abcam中国|Anti-GABA A receptor pi抗体
GABA A receptor pi兔多克隆抗体(ab116109)可与小鼠样本反应并经WB实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
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*  RA: Bjoern Scheurmann - Muscimol (Joachim Spieth remix) on Affin
Jamie xx turns his band's lovelorn hit into a trance and filter house-influenced rave-up. Check out the Alasdair McLellan-directed video.. ...
  https://www.residentadvisor.net/tracks/16058
*  Switch to Europe/Worldwide website
The Ligand: GABAGamma-aminobutyric acid (GABA) is the most abundant and most important neurotransmitter of mammalian brain. GABA controls the degree…
  https://www.acris-antibodies.com/reviews/gaba-receptor-regulator-excitability-drug-ta.htm
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