*  G Protein-Coupled Receptor Kinase-Interacting Protein 1 - CAGS
Animal studies have helped further elucidate the role of this protein. Git1 knockout mice have been shown to exhibit ADHD-like ... The GIT1 gene encodes an enzyme that functions as a GTPase activating protein for the ADP ribosylation factor (Arf) family. By ... Its coding sequence is contained within 21 exons and the gene encodes an 84 kDa protein product comprised of 761 amino acids. ... The protein has also been speculated to play a role in the increased speed of cell migration, the size and frequency of ...
  http://www.cags.org.ae/ctga/details.aspx?id=2375&pg=5&se=Latest
*  G-Protein-Coupled Receptor Kinase Interacting Protein-1 Mediates Intima Formation by Regulating Vascular Smooth Muscle...
G-protein-coupled receptor kinase interacting protein-1 (GIT1) was important for cell survival in vivo and in vitro. A and B, ... G-protein-coupled receptor kinase interacting protein-1 (GIT1) protein expression was highly regulated in vivo and in vitro. A ... Effects of G-protein-coupled receptor kinase interacting protein-1 (GIT1) on cell cycle progression. A, Mouse aortic smooth ... G-protein-coupled receptor kinase interacting protein-1 (GIT1) was important for vascular smooth muscle cell (VSMC) migration. ...
  http://atvb.ahajournals.org/content/33/5/999
*  Sequence Detail
... protein_coding transcript_biotype:protein_coding gene_symbol:Grk1 description:G protein-coupled receptor kinase 1 [Source:MGI ... G protein-coupled receptor kinase 1. 27. 1. 8. 5. Sequence references in MGI J:91388 Mouse Genome Informatics Scientific ... cdna chromosome:GRCm38:8:13405081:13421945:1 gene:ENSMUSG00000031450 gene_biotype: ...
  http://www.informatics.jax.org/sequence/ENSMUST00000033827
*  G Protein-Coupled Receptor Kinases | Springer for Research & Development
... both associated with G protein-coupled receptor (GPCR) functions and the recepto ... This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, ... Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily ... Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK ...
  https://rd.springer.com/book/10.1007/978-1-4939-3798-1
*  Anti-GRK1 antibody [D11] (ab2776) | Abcam
Retina-specific kinase involved in the signal turnoff via phosphorylation of rhodopsin (RHO), the G protein- coupled receptor ... Rhodopsin kinase is a G-protein-coupled Ser/Thr kinase, also known as GRK1, which is a key element in the regulation of this ... Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.. Contains 1 AGC-kinase C-terminal ... This antibody does not cross-react with other G protein-coupled kinases. ...
  http://www.abcam.com/grk1-antibody-d11-ab2776.html
*  G protein-coupled receptor kinase - Wikipedia
G protein-coupled receptor kinases (GRKs, GPCRKs) are a family of protein kinases that regulate the activity of G protein- ... Ma L, Gao J, Chen X (2005). "G Protein-Coupled Receptor Kinases". In Devi LA. The G Protein-Coupled Receptors Handbook ( ... "G Protein-Coupled Kinases and Desensitization of Receptors". In Bernstein G, Tatsuya H. G protein-coupled receptors. Boca Raton ... GRKs regulate also cellular responses independent of their kinase activity. In particular, G protein-coupled receptor kinase 2 ...
  https://en.wikipedia.org/wiki/G_protein-coupled_receptor_kinase
*  OriGene - GRK1 (NM 002929) Human ORF cDNA Clone
Human G protein-coupled receptor kinase 1 (GRK1) available for purchase from OriGene - Your Gene Company. ... G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and ... Lenti ORF clone of Grk1 (Myc-DDK-tagged ORF) - Rat G protein-coupled receptor kinase 1 (Grk1), (10 ug). $878. 7 weeks. ... Lenti ORF clone of Grk1 (Myc-DDK-tagged ORF) - Rat G protein-coupled receptor kinase 1 (Grk1), (10 ug). $878. 7 weeks. ...
  http://www.origene.com/Human_ORF_Clone/RG214569.aspx
*  GIT1 - Wikipedia
... a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein". Proc Natl Acad Sci U S A. 95 ... "Entrez Gene: GIT1 G protein-coupled receptor kinase interactor 1". Zhang H, Webb DJ, Asmussen H, Horwitz AF (2003). "Synapse ... phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins ... GIT1 has been shown to interact with: ARHGEF7, Beta adrenergic receptor kinase, GIT2, PCLO, PLCG1, PPFIA4 PTK2, and liprin- ...
  https://en.wikipedia.org/wiki/GIT1
*  Dopamine-Mediated Inhibition of Renal Na,K-ATPase Is Reduced by Insulin | Hypertension
G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc Natl Acad Sci U S A. 2002; 99: 3872- ... In addition to the stimulation of GTP proteins, the abundance of Gsα and Gq/11α proteins, known to be coupled to D1 receptors, ... hyperphosphorylation of the D1 receptor caused by an increase in the constitutive activity of G-protein-coupled receptor kinase ... The other possible explanation for decreased D1 receptor protein in whole cells could be the mitogen-activated protein kinase ...
  http://hyper.ahajournals.org/content/41/6/1353
*  Rhodopsin kinase - Wikipedia
Rhodopsin kinase (EC 2.7.11.14, cone opsin kinase, G-protein-coupled receptor kinase 1, GPCR kinase 1, GRK1, GRK7, opsin kinase ... Rhodopsin Beta adrenergic receptor kinase G-protein coupled receptor kinases Lorenz W, Inglese J, Palczewski K, Onorato JJ, ... Kutuzov MA, Andreeva AV, Bennett N (December 2012). "Regulation of the methylation status of G protein-coupled receptor kinase ... "The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase ...
  https://en.wikipedia.org/wiki/Rhodopsin_kinase
*  Beta-1 adrenergic receptor - Wikipedia
Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ (Jan 2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic ... It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein and is expressed predominantly in cardiac ... "A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor". The Journal of ... "GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation". The Journal ...
  https://en.wikipedia.org/wiki/Beta-1_adrenergic_receptor
*  OriGene - GRK6 (NM 002082) cDNA Clone
... of Human G protein-coupled receptor kinase 6 (GRK6), transcript variant 2 available for purchase from OriGene - Your Gene ... G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated ... GRK6 (untagged)-Kinase deficient mutant (K215M) of Human G protein-coupled receptor kinase 6 (GRK6), transcript variant 2, NM_ ... Lenti ORF clone of Grk6 (mGFP-tagged) - Mouse G protein-coupled receptor kinase 6 (Grk6), transcript variant 3. $980. 3 weeks. ...
  http://www.origene.com/cdna/trueclone/accession/NM_002082/SC323679.aspx
*  DLGAP2 - Wikipedia
2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". J. Biol. Chem. 277 ( ... 1997). "Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that ... Disks large-associated protein 2 is a protein that in humans is encoded by the DLGAP2 gene. The product of this gene is one of ... a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95". Genes Cells. 2 (6): 415-24. doi: ...
  https://en.wikipedia.org/wiki/DLGAP2
*  Plus it
Lowry OH, Rosebrough NJ, Farr AL, and Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265 ... 2002) Involvement of nuclear factor-kappaB and apoptosis signal-regulating kinase 1 in G-protein-coupled receptor agonist- ... Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. Drug Metab Dispos 35: 1126-1134 ... Heart microsomal protein from control or isoproterenol treated rats was incubated with 50 μM arachidonic acid, and arachidonic ...
  http://dmd.aspetjournals.org/content/36/11/2277
*  Table of Contents - April 01, 2004, 35 (4) | Stroke
Hypoxia/Ischemia Modulates G Protein-Coupled Receptor Kinase 2 and β-Arrestin-1 Levels in the Neonatal Rat Brain Maria Stella ... Dual Role of Fcγ Receptor in Transient Focal Cerebral Ischemia in Mice Miki Komine-Kobayashi, Nei Chou, Hideki Mochizuki, ... Decrease in Cortical Benzodiazepine Receptors in Symptomatic Patients With LeukoaraiosisA Positron Emission Tomography Study M ... Cerebral Ischemia Enhances Vascular Angiotensin AT1 Receptor-Mediated Contraction in Rats Emelie Stenman, Lars Edvinsson ...
  http://stroke.ahajournals.org/content/35/4
*  Bradford C. Berk, M.D., Ph.D. - University of Rochester Medical Center
Title: Method of Inhibiting Angiogenesis Using Inhibitors of G-Protein -Coupled Receptor Kinase Interacting Protein-1 (GIT1). U ... Mechanisms by which blood vessels sense changes in blood flow using protein kinases as targets for signal events. Using ... growth by angiotensin II is focused on the activation of intracellular kinases and phosphatases by the angiotensin II receptor ... The first project investigates the mechanisms by which flow activates the Big MAP kinase (or ERK5) and inhibits inflammation ...
  https://www.urmc.rochester.edu/people/22436740-bradford-c-berk/articles
*  Plus it
G protein-coupled receptor kinase 5 mediates Tazarotene-induced gene 1-induced growth suppression of human colon cancer cells. ... A, Protein expression of the indicated proteins involved in the cell death pathway. B, Proliferation of tumor cells (from five ... We used our collection of three HPV-negative and two HPV16-positive HNSCC cell lines to analyze the expression of proteins ... Notably, HPV-associated OPSCCs express viral proteins, and we have shown that they may function as tumor-specific antigens for ...
  http://clincancerres.aacrjournals.org/content/24/3/634
*  DNASU Plasmid | Plasmid Collections
G protein-coupled receptor kinase 5. NA. NM_005308. No/Yes. FUSION. pDNR-Dual. bacterial: ampicillin ... G protein-coupled receptor kinase 5. NA. NM_005308. No/Yes. CLOSED. pDNR-Dual. bacterial: ampicillin ... G protein-coupled receptor kinase 1. NA. NM_002929. No/No. FUSION. pDNR-Dual. bacterial: ampicillin ... G protein-coupled receptor kinase 1. NA. NM_002929. No/No. CLOSED. pLDNT7_nFLAG. bacterial: chloramphenicol ...
  https://dnasu.org/DNASU/GetCollection.do?collectionName=RGS
*  GRK5 - Wikipedia
G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated ... "Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C". The Journal ... "Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase ... "beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase- ...
  https://en.wikipedia.org/wiki/GRK5
*  Full text] CXCR4 in breast cancer: oncogenic role and therapeutic targeting | DDDT
Chemokines bind to specific G-protein-coupled seven-span transmembrane receptors. Chemokines play a fundamental role in the ... CXCR4 belongs to the superfamily of the seven transmembrane domain heterotrimeric G protein-coupled receptors and is ... C-X-C chemokine receptor type 4 (CXCR4), also known as fusin or CD184, is an alpha-chemokine receptor specific for stromal- ... 1,* Hong Zhao,1,* Haitao Chen,1 Qinghua Yao2,3 1First Clinical College of Zhejiang Chinese Medical University, 2Department of ...
  https://www.dovepress.com/cxcr4-in-breast-cancer-oncogenic-role-and-therapeutic-targeting-peer-reviewed-fulltext-article-DDDT
*  Rhodopsin kinase, catalytic domain (IPR037716) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... Rhodopsin kinase (also known as G-protein-coupled Receptor Kinase 1, GRK1) is a retina-specific kinase involved in the signal ... Rhodopsin kinase, catalytic domain (IPR037716). Short name: GRK1_dom Overlapping homologous superfamilies *Protein kinase-like ...
  http://www.ebi.ac.uk/interpro/entry/IPR037716
*  IMP: Integrative Multi-species Prediction
G protein-coupled receptor kinase interacting ArfGAP 1. 0.034. RASSF5. Ras association (RalGDS/AF-6) domain family member 5. ... protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1. 0.013. ... protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1). 0.034. ... hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit. 0.025. ...
  http://imp.princeton.edu/predictions/process/human-context-global/10951/?gene=15060
*  G Protein-Coupled Receptor Kinase 2, With β-Arrestin 2, Impairs Insulin-Induced Akt/Endothelial Nitric Oxide Synthase Signaling...
G protein-coupled receptor kinases (GRKs) were initially identified as serine/threonine kinases that participate, together with ... Vascular-targeted overexpression of G protein-coupled receptor kinase-2 in transgenic mice attenuates beta-adrenergic receptor ... in the regulation of multiple G protein-coupled receptors (GPCRs). The GRKs constitute a group of protein kinases that ... G-protein-coupled receptor kinase activity is increased in hypertension. J Clin Invest 1997;99:2087-2093pmid:9151780. ...
  http://diabetes.diabetesjournals.org/content/61/8/1978?with-ds=yes
*  G protein-coupled receptor kinase Protein Superfamily Detail
Term: G protein-coupled receptor kinase. ID: PIRSF000584 Mouse Protein Superfamily Annotations. Select one or more mouse PIRSF ... MGI protein superfamily detail pages represent the protein classification set for a homeomorphic superfamily from the Protein ... The number of protein sequences returned does not always match the numbers of homologs shown, because the same protein sequence ... You can also "Select all" mouse superfamily members to obtain their protein sequences and the protein sequences for all mouse, ...
  http://www.informatics.jax.org/vocab/pirsf/PIRSF000584