*  Viruses | Free Full-Text | Foamy Virus Assembly with Emphasis on Pol Encapsidation
In contrast to orthoretroviral Pol, which is synthesized as a Gag-Pol fusion protein and packaged through Gag-Gag interactions ... In addition, a mutant in which Pol is expressed as an orthoretroviral-like Gag-Pol fusion protein is discussed. We also discuss ... Thus, encapsidation of FV Pol requires a different mechanism. We detail how WT Pol lacking Gag sequences is incorporated into ... The regions of Gag, Pol and genomic RNA required for viral assembly are described. ...
  http://www.mdpi.com/1999-4915/5/3/886
*  SGDB | Browse SGDB
gag-pol fusion protein. Fuller 2001. human Immunodeficiency Virus (HIV-1). Homo sapiens. Unknown. UE. HTML , XML. ... gag-pol. Wagner 2000. human Immunodeficiency Virus (HIV-1). Homo sapiens, Simian. Yes. SIE. HTML , XML. ... CO gag-pol. Singh 2004. human immunodeficiency virus (HIV1). Mus musculus. Unknown. IE. HTML , XML. ... gag-pol. Fuller 2001. human Immunodeficiency Virus (HIV-1). Homo sapiens. Unknown. IE. HTML , XML. ...
  http://www.umbc.edu/codon/sgdb/browse.php?submitter=&149=149&sort=Author
*  YDR261W-B Protein | SGD
Protein Product. gag-pol fusion protein Feature Type. transposable_element_gene Description. Retrotransposon TYA Gag and TYB ... Protein Help YDR261W-B Protein Protein abundance data, domains, shared domains with other proteins, protein sequence retrieval ... Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse ... This diagram displays domains (colored squares) shared between the given protein (yellow circle) and other proteins (gray ...
  https://www.yeastgenome.org/locus/S000007397/protein
*  YCL019W Result Summary | BioGRID
Polyprotein Is Processed To Make A Nucleocapsid-like Protein (Gag), Reverse Transcriptase (RT), Protease (PR), And Integrase ( ... Retrotransposon TYA Gag And TYB Pol Genes; Transcribed/translated As One Unit; ... gag-pol fusion protein. Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed ... to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral ...
  https://thebiogrid.org/30964/summary/saccharomyces-cerevisiae/ycl019w.html
*  Killer yeast - Wikipedia
Ribas, J. C.; Wickner, RB (1998). "The Gag Domain of the Gag-Pol Fusion Protein Directs Incorporation into the L-A Double- ... The genomic segment encodes for the viral coat protein and a protein which replicates the viral genomes. The M dsRNAs encode ... The initial protein product from translation of the M dsRNA is called the preprotoxin, which is targeted to the yeast secretory ... A killer yeast is a yeast, such as Saccharomyces cerevisiae, which is able to secrete one of a number of toxic proteins which ...
  https://en.wikipedia.org/wiki/Killer_yeast
*  Gag/pol translational readthrough site - Wikipedia
... the mechanism of translation readthrough of the stop codon at the gag-pol junction producing the gag and pol fusion protein in ... Retroviruses whose gag and pol genes are in the same reading frame often depend upon approximately 5% read-through of the gag ... Gag/pol translational readthrough site (or Retroviral readthrough element) is a cis-regulatory element found in retroviruses. ... UAG termination codon to form the gag-pol polyprotein. This readthrough is usually dependent on a pseudoknot located eight ...
  https://en.wikipedia.org/wiki/Gag/pol_translational_readthrough_site
*  Double-stranded RNA viruses - Wikipedia
Gag (76 kDa) and a Gag-Pol fusion protein (180 kDa) formed by a -1 ribosomal frameshift. L-A can support the replication and ... which codes for two proteins. Among the twelve proteins, six are structural and six are non-structural proteins. It is a double ... The IBDV capsid protein exhibits structural domains that show homology to those of the capsid proteins of some positive-sense ... While the structural proteins of RDV share no sequence similarity to other proteins, their folds and the overall capsid ...
  https://en.wikipedia.org/wiki/Double-stranded_RNA_viruses
*  List of MeSH codes (D12.776) - Wikipedia
... gag-pol MeSH D12.776.964.775.350.400 - hiv core protein p24 MeSH D12.776.964.775.375.325 - fusion proteins, gag-pol MeSH ... gag MeSH D12.776.964.970.600.850.350.325 - fusion proteins, gag-pol MeSH D12.776.964.970.600.850.350.400 - hiv core protein p24 ... groel protein MeSH D12.776.602.500.500.100 - fusion proteins, bcr-abl MeSH D12.776.602.500.500.320 - fusion proteins, gag-onc ... fusion proteins, gag-onc MeSH D12.776.964.775.350.320.700 - oncogene protein p65(gag-jun) MeSH D12.776.964.775.350.325 - fusion ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
*  Env (gene) - Wikipedia
... allowing for binding of the fusion protein. The fusion peptide inserts itself in the host cell membrane and brings the host ... the gene is always located downstream of gag, pro, and pol. The env mRNA must be spliced for expression. The mature product of ... the surface protein (SU) and the transmembrane protein (TM). The tropism of the virus is determined by the SU protein domain ... where it can assist in fusion with the host cell. Fusion inhibitor drugs such as enfuvirtide block the fusion process by ...
  https://en.wikipedia.org/wiki/Env_(gene)
*  Gammaretrovirus - Wikipedia
The typical gammretrovirus genome contains a gag protein, a pol protein, and an env protein. The gammaretrovirus will act as a ... Virion attach the host cell receptors via the SU glycoprotein, then the TM glycoprotein assists with fusion with the cell ... The unspliced viral RNA translation produces env, gag, and gag-pol polyproteins. The Env becomes a polypeptide precursor and ... This gene was discovered using a non virulent protein of murine leukemia virus. This protein will block replication of some ...
  https://en.wikipedia.org/wiki/Gammaretrovirus
*  Simian foamy virus - Wikipedia
Proteins: consisting of gag proteins, protease (PR), pol proteins, and env proteins. Group-specific antigen (gag) proteins are ... If enough proteins are at the surface with other CD4+ T cells nearby, the glycoproteins will attach and result in the fusion of ... Protease performs proteolytic cleavages during virion maturation to make mature gag and pol proteins. Pol proteins are ... Whereas gag, pol, and env are conserved throughout retroviruses, the tas gene is unique and found only in Spumaviridae. It ...
  https://en.wikipedia.org/wiki/Simian_foamy_virus
*  Syncytin-1 - Wikipedia
... and is preceded by ERVW1 gag (Group AntiGen) and pol (POLmerase) within the provirus, both of which contain nonsense mutations ... Syncytin-1 is a cell-cell fusion protein whose function is most well characterized in placental development. The placenta in ... ERVW-1 is a single locus within the HERV-W family encoding a fully functional env protein. mRNA and protein expression of the ... Syncytin-1 also known as enverin is a protein found in humans and other primates that is encoded by the ERVW-1 gene (endogenous ...
  https://en.wikipedia.org/wiki/Syncytin-1
*  LTR retrotransposon - Wikipedia
Gag proteins form virus-like particles in the cytoplasm inside which reverse-transcription occurs. The Pol gene produces three ... Depending on the host species, two different strategies can be used to express the two polyproteins: a fusion into a single ... All functional LTR-retrotransposons encode a minimum of two genes, gag and pol, that are sufficient for their replication. Gag ... Occasional ribosomal frameshifting allows the production of both proteins, while ensuring that much more Gag protein is ...
  https://en.wikipedia.org/wiki/LTR_retrotransposon
*  Bovine immunodeficiency virus - Wikipedia
The core of the virus contains Gag and Gag-Pol polyproteins. These polyproteins are cleaved in the mature virus to their ... The attached virus enters the cell by one of two ways, receptor mediated endocytosis or viral envelope-cell membrane fusion. ... After translation, the viral structural proteins assemble the virus particle at the plasma membrane and form a complex with the ... The genome contains the usual retroviral structural genes including gag, pol, and env. These genes are surrounded by and 5' and ...
  https://en.wikipedia.org/wiki/Bovine_immunodeficiency_virus
*  Jaagsiekte sheep retrovirus - Wikipedia
There are 4 genes that encode the viral structural proteins. They are "gag" encoding the structural internal virion proteins ... The genome of the exogenous virus is 7462 bases and has the classical "gag", "pol", "env" genome arrangement and is flanked by ... Côté M, Zheng YM, Liu SL (2009). "Receptor binding and low pH coactivate oncogenic retrovirus envelope-mediated fusion". J. ... Following release from the cell, the "Gag"-"Pro"-"Pol" polyproteins are cleaved into their mature forms by protease. This step ...
  https://en.wikipedia.org/wiki/Jaagsiekte_sheep_retrovirus
*  Discovery and development of HIV-protease inhibitors - Wikipedia
These drugs prevent proteolytic cleavage of HIV Gag and Pol polyproteins that include essential structural and enzymatic ... is required to cleave a viral polyprotein precursor into individual mature proteins. The viral RNA and viral proteins assemble ... This fusion creates a pore through which the viral capsid enters the cell. Following entry into the cell the RNA of the virus ... including those at protease cleavage sites in the Gag-Pol polyprotein precursors. The cleavage sites have highly diverse ...
  https://en.wikipedia.org/wiki/Discovery_and_development_of_HIV-protease_inhibitors
*  Retrovirus - Wikipedia
Proteins: consisting of gag proteins, protease (PR), pol proteins, and env proteins. Group-specific antigen (gag) proteins are ... of the Env protein, while the ability of the retrovirus to enter the cell via membrane fusion is imparted by the membrane- ... It functions in proteolytic cleavages during virion maturation to make mature gag and pol proteins. Pol proteins are ... For example, the gag gene is translated into molecules of the capsid protein, the pol gene is translated into molecules of ...
  https://en.wikipedia.org/wiki/Retrovirus
*  Management of HIV/AIDS - Wikipedia
Particularly, these drugs prevent the cleavage of gag and gag/pol precursor proteins. Virus particles produced in the presence ... or fusion inhibitors) interfere with binding, fusion and entry of HIV-1 to the host cell by blocking one of several targets. ... To prevent fusion of the virus with the host membrane, enfuvirtide can be used. Enfuvirtide is a peptide drug that must be ... Since the conversion of RNA to DNA is not done in the mammalian cell it is performed by a viral protein which makes it a ...
  https://en.wikipedia.org/wiki/Management_of_HIV/AIDS
*  Avian sarcoma leukosis virus - Wikipedia
Both RSV and ASLV contain the gag gene, which is common to most retroviruses and encodes for the capsid proteins, and the pol ... The TM glycoproteins are directly involved in the fusion of the virus and host membranes for entry. The surface glycoproteins ... Hence, it is an enveloped virus with a condensed, central core, and has barely visible envelope spikes, or proteins. ASLV is ... Viral glycoprotein-receptor interactions are required to initiate membrane fusion of the virus and cell. The surface ...
  https://en.wikipedia.org/wiki/Avian_sarcoma_leukosis_virus
*  HIV-1 protease - Wikipedia
Gag and Gag-Pol) at the appropriate places to create the mature protein components of an infectious HIV virion. Without ... Other drug therapy targets include reverse transcriptase, virus attachment, membrane fusion, cDNA integration and virion ... HIV protease's protein structure has been investigated using X-ray crystallography. It exists as a homodimer, with each subunit ... According to the mechanism for HIV protease protein cleavage proposed by Mariusz Jaskolski and colleagues, water acts as a ...
  https://en.wikipedia.org/wiki/HIV-1_protease
*  Human Endogenous Retrovirus-W - Wikipedia
A complete HERV contains U3RU5- gag- pro- pol- env -U3RU5, where U3RU5 are long terminal repeats (LTRs) and gag, pro, pol and ... However, in patients with MS lesions there is a large accumulation of Gag proteins in demyelinated white matter. This data ... fusion of cells as opposed to a 48% fusion with the HERV-W vector, thus revealing the gene encoded by HERV-W env is a highly ... gag- pol- env- U3R sequences; a polypurine tract; and a primer-binding site (PBS). The pol and gag ORFs are not replication ...
  https://en.wikipedia.org/wiki/Human_Endogenous_Retrovirus-W
*  Structure and genome of HIV - Wikipedia
... capsid protein, p24); SP1 (spacer peptide 1, p2); NC (nucleocapsid protein, p7); SP2 (spacer peptide 2, p1) and P6 protein. pol ... It is a fusion of parts of the tat, env, and rev genes, and codes for a protein with some of the properties of tat, but little ... The gag gene provides the basic physical infrastructure of the virus, and pol provides the basic mechanism by which ... HIV has a 9.2kb unspliced genomic transcript which encodes for gag and pol precursors; a singly spliced, 4.5 kb encoding for ...
  https://en.wikipedia.org/wiki/Structure_and_genome_of_HIV
*  Murine leukemia virus - Wikipedia
From 5' to 3' (typically displayed as "left" to "right"), the genome contains gag, pol, and env regions, coding for structural ... The research discovered protective epitopes that were localized to F-MuLV gag and env proteins. This was achieved using ... and membrane fusion". Virology. 405 (1): 214-224. doi:10.1016/j.virol.2010.06.004. D'Souza V, Dey A, Habib D, Summers MF (2004 ... The lipid bilayer contains integrated host and viral proteins studded with carbohydrate molecules. The viral particle is ...
  https://en.wikipedia.org/wiki/Murine_leukemia_virus
*  Oncovirus - Wikipedia
... pol and env. In the gag region of the virus, the synthesis of the internal virion proteins are maintained which make up the ... a virus that infects and kills cancer cells Gag-onc fusion protein List of infectious diseases Valladares Y. (1960). "Studies ... HPV instead degrades p53: the HPV protein E6 binds to a cellular protein called the E6-associated protein (E6-AP, also known as ... DNA oncoviruses typically impair two families of tumor suppressor proteins: tumor proteins p53 and the retinoblastoma proteins ...
  https://en.wikipedia.org/wiki/Oncovirus
*  Rous sarcoma virus - Wikipedia
RSV has four genes: gag - encodes capsid proteins pol - encodes reverse transcriptase env - encodes the envelope gene src - ... Fusion occurs when the virus fuses together with the target cell membrane and releases its genome into the cell. RSV enters the ... Gag proteins are necessary for virion assembly and mature virus infection of the host cell. The gag protein (Pr76) for RSV ... "An assembly domain of the Rous sarcoma virus Gag protein required late in budding". J. Virol. 68 (10): 6605-18. PMC 237081 . ...
  https://en.wikipedia.org/wiki/Rous_sarcoma_virus