Thermodynamics of the fragile X mental retardation protein RGG box interactions with G quartet forming RNA
... the loss of the fragile X mental retardation protein (FMRP). FMRP is an RNA binding protein that binds to G quartet forming RNA ... Thermodynamics of the fragile X mental retardation protein RGG box interactions with G quartet forming RNA. Zanotti, KJ ; ... Thermodynamics of the fragile X mental retardation protein RGG box interactions with G quartet forming RNA. Login ... Fragile X syndrome, the most common form of inherited mental retardation, is the result of an unstable expansion of a CGG ...
Fragile X Mental Retardation Protein (medical concept explorer)
On BC1 RNA and the fragile X mental retardation protein. | Cervo Brain Research Centre
p,The fragile X mental retardation protein (FMRP), the functional absence of which causes fragile X syndrome, is an RNA-binding ... On BC1 RNA and the fragile X mental retardation protein.. Publication Type:. Journal Article ... Animals, Biotinylation, Brain, Fragile X Mental Retardation Protein, Gene Expression Regulation, Immunoprecipitation, Mice, ... Mice, Knockout, Nucleic Acid Hybridization, Protein Biosynthesis, RNA, Messenger, RNA, Small Cytoplasmic, RNA-Binding Proteins ...
The Drosophila fragile X mental retardation protein participates in the piRNA pathway - Archive ouverte HAL
The RNA-binding fragile X mental retardation protein (FMRP, also known as FMR1) controls translation and its loss triggers the ... most frequent syndromic form of mental retardation as well as gonadal defects in humans. Here, we demonstrate for the first ... Our data provide novel perspectives for understanding the phenotypes observed in Fragile X patients and support the view that ... Moreover, dFmr1 interacts genetically and biochemically with Aubergine, an Argonaute protein and a key player in this pathway. ...
Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons - Archive ouverte HAL
... is caused by the absence of the Fragile X Mental Retardation Protein (FMRP) in neurons. In the mouse, the lack of FMRP is ... Overexpression of Dgkκ in neurons is able to rescue the dendritic spine defects of the Fragile X Mental Retardation 1 gene KO ... notably including postsynaptic proteins. This local protein synthesis deregulation is proposed to underlie the observed defects ... How FMRP impacts synaptic protein translation and which mRNAs are most important for the pathology remain unclear. Here we show ...
G-quadruplex - Wikipedia
Fragile X mental retardation protein (FMRP) is a widely expressed protein coded by the FMR1 gene that binds to G-quadruplex ... as seen in the fragile X mental retardation gene 1 (FMR1) gene and Fragile X Syndrome. The C9orf72 gene codes for the protein ... Darnell JC, Jensen KB, Jin P, Brown V, Warren ST, Darnell RB (November 2001). "Fragile X mental retardation protein targets G ... February 2009). "Translational regulation of the human achaete-scute homologue-1 by fragile X mental retardation protein". The ...
IL-17a promotes sociability in mouse models of neurodevelopmental disorders
Fragile X Mental Retardation Protein Grants and funding * R01 MH115037/MH/NIMH NIH HHS/United States ... fragile X mental retardation-1 (Fmr1)6 or Sh3 and multiple ankyrin repeat domains 3 (Shank3)7. We establish that the social ... 4 with mouse models that are genetically deficient for contactin-associated protein-like 2 (Cntnap2)5, ...
Molecular functions of the mammalian fragile X mental retardation protein: insights into mental retardation and synaptic...
T1 - Molecular functions of the mammalian fragile X mental retardation protein. T2 - insights into mental retardation and ... Molecular functions of the mammalian fragile X mental retardation protein: insights into mental retardation and synaptic ... Molecular functions of the mammalian fragile X mental retardation protein: insights into mental retardation and synaptic ... Molecular functions of the mammalian fragile X mental retardation protein: insights into mental retardation and synaptic ...
82-FIP, a novel FMRP (Fragile X Mental Retardation Protein) interacting protein, shows a cell cycle-dependent intracellular...
82-FIP, a novel FMRP (Fragile X Mental Retardation Protein) interacting protein, shows a cell cycle-dependent intracellular ... FMRP is an RNA binding protein whose absence produces pathological manifestations of the fragile-X syndrome. FMRP is a ... FMRP is an RNA binding protein whose absence produces pathological manifestations of the fragile-X syndrome. FMRP is a ... We named this protein 82-FIP (82-kD FMRP Interacting Protein). FMRP interacts with 82-FIP through a novel interaction motif ...
AFF2 gene: MedlinePlus Genetics
The AFF2 gene provides instructions for making a protein that is found in the nucleus of cells but whose function is not well ... Hillman MA, Gecz J. Fragile XE-associated familial mental retardation protein 2 (FMR2) acts as a potent transcription activator ... FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming ... fragile X E mental retardation syndrome protein. *fragile X mental retardation 2 protein ...
A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response - Fingerprint -...
3H8Z: The Crystal Structure of the Tudor Domains from FXR2
Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X...
Fragile X syndrome (FXS) is caused by the loss of the FMR1 gene product FMRP (fragile X mental retardation protein) (Verkerk et ... Fragile X syndrome (FXS) is caused by loss of the FMR1 gene product FMRP (fragile X mental retardation protein), a repressor of ... 2004) Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses. Proc ... 2001) The fragile X mental retardation protein inhibits translation via interacting with mRNA. Nucleic Acids Res 29:2276-2283. ...
A novel KCNT1 mutation in a Japanese patient with epilepsy of infancy with migrating focal seizures | Human Genome Variation
Plus it
2009) Fragile X mental retardation protein in learning-related synaptic plasticity. Mol Cells 28:501-507, doi:10.1007/s10059- ... 2000) Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein. Mol Cell Biol ... 2008) Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning. Development ... the fragile-X mental retardation protein, increases sleep intensity during the day. Our results show that sleep is not ...
Frontiers | Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex Are Associated with...
Here we report a class of mRNA granules in human neuronal processes that are enriched in the nuclear cap-binding protein ... Here we report a class of mRNA granules in human neuronal processes that are enriched in the nuclear cap-binding protein ... The existence of mRNAs retaining both nuclear cap binding protein and EJC in the distal sites of neuronal processes suggests ... The existence of mRNAs retaining both nuclear cap binding protein and EJC in the distal sites of neuronal processes suggests ...
Effects of early life exposure to traffic-related air pollution on brain development in juvenile Sprague-Dawley rats |...
Depletion of the fragile X mental retardation protein in embryonic stem cells alters the kinetics of neurogenesis. Stem Cells ( ... Table 1 Protein levels of cytokine, chemokine, and growth factors in the hippocampus at PND 51-55.. Full size table. ... Glial fibrillary acidic protein-expressing neural progenitors give rise to immature neurons via early intermediate progenitors ... and growth factors in hippocampal tissue from PND 51-55 subjects using a Bio-Plex ProTM assay that quantifies protein levels of ...
Publications scientifiques | IGBMC
Inherited Retardation And Autism Corrected In Mice | ScienceDaily
Fragile X syndrome, affecting 100,000 Americans, is the most common inherited cause of mental retardation and autism. New ... They have significantly alleviated a wide range of abnormalities due to fragile X syndrome by altering only a single gene, ... countering the effects of the fragile X mutation. ... Scientists have corrected key symptoms of mental retardation ... Individuals with FXS have mutations in the X chromosomes FMR1 gene, which encodes the fragile X mental retardation protein, ...
Sears JC[au] - Search Results - PubMed
Monther Abu-Remaileh | Stanford Medicine
Upon mTORC1 inhibition, NUFIP1 (nuclear fragile X mental retardation-interacting protein 1) redistributes from the nucleus to ... Upon mTORC1 inhibition, NUFIP1 (nuclear fragile X mental retardation-interacting protein 1) redistributes from the nucleus to ... Upon mTORC1 inhibition, NUFIP1 (nuclear fragile X mental retardation-interacting protein 1) redistributes from the nucleus to ... Multiple protein complexes regulate the Rag GTPases in response to amino acids, including GATOR1, a GTPase activating protein ...
Xinyu Zhao, PhD - Slide of the Week
Fragile X syndrome results from a loss of the RNA-binding protein fragile X mental retardation protein (FMRP). How FMRP ... We identify the regulator of G protein signaling 6 (RGS6) as a key factor that mediates running impact on adult-born neurons. ... correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of Fragile X ... correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of Fragile X ...
Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders | bioRxiv
Major defects in neocortical GABAergic inhibitory circuits in mice lacking the fragile X mental retardation protein. Neurosci. ... The Dutch-Belgian Fragile X Consortium, 1994. Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch- ... a well-studied animal model for fragile-X syndrome (The Dutch-Belgian Fragile X Consortium, 1994). We compared the data from ... Sensory hypo-excitability in a rat model of fetal development in Fragile X Syndrome. Sci Rep 6, 30769. doi:10.1038/srep30769. ...
Prevalence of fragile X syndrome in males and females in Indonesia
FMR1 is a gene in humans which encodes a protein called fragile X mental retardation protein. This protein is important for ... Key Words: Fragile X syndrome, Intellectual disability, Fragile X mental retardation 1, CGG repeat, Indonesia ... Table 1 Fragile X mental retardation 1 gene analysis of index fragile X syndrome subjects. ... Oostra BA, Willemsen R. The X chromosome and fragile X mental retardation. Cytogenet Genome Res. 2002;99:257-264. [PubMed] [DOI ...
FMR1 gene: MedlinePlus Genetics
The FMR1 gene provides instructions for making a protein called FMRP. Learn about this gene and related health conditions. ... Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X ... Fragile X syndrome. Almost all cases of fragile X syndrome are caused by an expansion of the CGG trinucleotide repeat in the ... The abnormal or missing protein disrupts nervous system functions, leading to the signs and symptoms of fragile X syndrome. ...
Psychiatric Features in High-Functioning Adult Brothers With Fragile X Spectrum Disorders | Psychiatrist.com
Decreased fragile X mental retardation protein expression underlies amygdala dysfunction in carriers of the fragile X ... 7 Some individuals with the premutation have a mild-to-moderate deficit of fragile X-related mental retardation protein (FMRP). ... Fragile X-associated tremor/ataxia syndrome-an older face of the fragile X gene. Nat Clin Pract Neurol. 2007;3(2):107-112. ... The emerging fragile X premutation phenotype: evidence from the domain of social cognition. Brain Cogn. 2005;57(1):53-60. ...
What does the existence of long genes tell us? | Spectrum | Autism Research News
Transcriptome profiling in engrailed-2 mutant mice reveals common molecular pathways associated with autism spectrum disorders ...
... fragile X mental retardation, autosomal homolog 2 (Fxr2) P = 0.0004; protein kinase C, beta (Prkcb) P = 0.001; gamma- ... Bear MF, Huber KM, Warren ST: The mGluR theory of fragile X mental retardation. Trends Neurosci. 2004, 27: 370-377. 10.1016/j. ... Nrxn3 encodes neuronal adhesion proteins of the Neurexin (NRXN) family. NRXNs are presynaptic cell adhesion proteins that form ... Mouse mitochondrial ribosomal protein L41 (Mrpl41) was used as a standard for quantification as previously shown [30]. Primers ...
Agenda - IMIM Institut Hospital del Mar d'Investigacions Mèdiques
We have discovered that fragile X mental retardation protein (FMRP) is an essential regulator of neurogenesis. We showed that ... Post-transcriptional Regulation of Neural Stem Cells and Learning by Fragile X Proteins. *Importar al calendari de lOutlook ... Post-transcriptional Regulation of Neural Stem Cells and Learning by Fragile X Proteins impartida per la Prof. Xinyu Zhao, ... In addition, although many studies are focusing on FMRP, the functions of two related proteins, FXR1 and FXR2, are unclear. Our ...
NIH Director's Transformative Research Award Program - 2009 Award Recipients | NIH Common Fund
This defect is thought to be responsible for Fragile-X syndrome, the most common inherited form of mental retardation. This ... The detection of proteins is fundamental to essentially all biomedical research. Current strategies to detect proteins include ... To accelerate research in this field, new protein capture tools for the detection and identification of specific proteins are ... for detecting and quantifying proteins. The sensors will be used to monitor protein expression in cells in real time. The ...