Substrates of Factor XIII-A: roles in thrombosis and wound healing Victoria R. Richardson; Victoria R. Richardson ... Victoria R. Richardson, Paul Cordell, Kristina F. Standeven, Angela M. Carter; Substrates of Factor XIII-A: roles in thrombosis ... FXIII (Factor XIII) is a Ca2+-dependent enzyme which forms covalent ϵ-(γ-glutamyl)lysine cross-links between the γ-carboxy- ... Myeloid cell-specific deletion of epidermal growth factor receptor aggravates acute cardiac injury ...

Factor XIIIa: novel target for anticoagulation? 5. November 2015. Factor XIIIa: novel target for anticoagulation?. by Alisa ... Factor XIIIa-dependent retention of red blood cells in clots is mediated by fibrin alpha-chain crosslinking. Blood. 2015;126: ... Hanna M. Congenital deficiency of factor 13: report of a family from Newfoundland with associated mild deficiency of factor XII ... Targeted inactivation of the mouse locus encoding coagulation factor XIII-A: hemostatic abnormalities in mutant mice and ...

Factor XIII-A: An Indispensable "Factor" in Haemostasis and Wound Healing. 2021 - Published. ... Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability. 2023 - Published. ... Monocytes Expose Factor XIII-A and Stabilize Thrombi against Fibrinolytic Degradation. 2021 - Published. ... Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery. 2020 - Published. ...

3-Substituted Imidazo[1,2-d][1,2,4]-thiadiazoles: A Novel Class of Factor XIIIa Inhibitors. ... Classtissue plasminogen activatorFibrinolysis ratesconcentrationthiadiazoleresponsepolymerizationSubstitutedImidazoFactor XIIIa ... A Novel Class of Factor XIIIa Inhibitors ...

Factor XIIIa-positive dendritic cells also are present, but the presence of CD68-positive histiocytes was inconsistent, ... 18] A coagulation factor XIIIA subunit missense mutation may play a role in autosomal dominant multiple dermatofibromas. [19] ... Coagulation Factor XIII-A Subunit Missense Mutation in the Pathobiology of Autosomal Dominant Multiple Dermatofibromas. J ... CD34 and factor-XIIIa immunoreactivity in dermatofibrosarcoma protuberans and dermatofibroma. Am J Dermatopathol. 1997 Apr. 19( ...

It is activated by thrombin to factor XIIIa. Factor XIIIa is an enzyme of the blood coagulation system that crosslinks fibrin. ... Factor XIIIa (dimer of two active A units) crosslinks fibrins within the clot by forming isopeptide bonds between various ... Factor XIII is a transglutaminase that circulates in human blood as a heterotetramer of two A and two B subunits. Factor XIII ... Factor XIII Deficiency is also known as Laki-Lorand factor, after Kalman Laki and Laszlo Lorand, the scientists who first ...

... human factor XIIIa) (Bishop et al., 1990) and Streptomyces spp. (Streptoverticillium TGase) (Washizu et al., 1994). In 1980s, ... Factor XIII, a type of TGase extracted from blood of cattle and swine at slaughter, was found to be unsuitable for food ...

Differential expression of factor XIIIa and CD34 in cutaneous mesenchymal tumors. J Cutan Pathol. 1993 Apr. 20(2):154-8. [QxMD ... Risk factors for complicated Mohs surgery in the South Sweden Mohs Cohort. J Eur Acad Dermatol Venereol. 2022 Apr 2. [QxMD ... Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. ...

Alagaratnam, S. et al. Serum protein profiling in mice: identification of Factor XIIIa as a potential biomarker for muscular ... Blood serum is the portion of blood which does not contain cells or clotting factors, and has been widely studied in the past ... and lack of interfering factors, such as comorbidities or influence of prescribed medications, makes it ideal for evaluating ...

It was characterized by expression of CD34 and negative for factor XIIIa. The sensitivity of CD34 immunohistochemistry in DFSP ... Thus, the width of the tumor-free margins is an essential factor to be considered for complete excision for both WLE and MMS ... To achieve negative resection margins, the width of the tumor-free margins and infiltrating depth are two essential factors to ... and platelet-derived growth factor-β (PDGFB at 22q13) genes.[3] Surgery options are resection with wide margins or Mohs ...

Enhanced thrombolysis by a factor XIIIa inhibitor in a rabbit model of femoral artery thrombosis. Thromb Res. 1990;59(1):15-26. ... Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice. ... Inhibition of factor XIIIa in a canine model of coronary thrombosis: effect on reperfusion and acute reocclusion after ... Nikolajsen CL, Dyrlund TF, Toftgaard Poulsen E, Enghild JJ, Scavenius C. Coagulation Factor XIIIa substrates in human plasma. ...

Indeed, there was no co-expression of Factor XIIIa and L1-protein, thus showing the absence of recruitment from monocytes. The ... Factor XIIIa), and Langerhans cells (CD1a). The proliferation marker (Ki67) and the antibody to Fas receptor (CD95R) were also ... No cells co-expressed factor XIIIa and Mac 387 immunoreactivities. CD45RO+ T lymphocytes, CD68+ and Mac 387+ macrophages were ... Numerous Factor XIIIa+ DD were present in the papillary dermis with only sparce perivascular CD45RO+ T lymphocytes and ...

... release of angiogenic growth factors, and blood clot formation. By way of this review, a deeper understanding of the basic ... Alshehri, F. S. M., Whyte, C. S., and Mutch, N. J. (2021). Factor XIII-A: An Indispensable "Factor" in Haemostasis and Wound ... Following trauma, factor Ⅲ (FIII; tissue factor) stimulates factor VII (FVII) to form an activated complex (TF-FVIIa) wherein ... driven by growth factors such as BMPs, transforming growth factor beta (TGF-β) and platelet derived growth factor (PDGF). These ...

... reproducible results in immunohistochemistry and western blotting experiments with Factor XIII A Ab-1, Mouse Monoclonal ... Factor XIII is a Β-globulin found in plasma and is composed of two subunits. Factor XIII-A is the catalytic subunit and is a ... Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for ... Detect factor XIII in both reduced and non-reduced forms. This abtibody does not react with human Factor XIII B-chain or human ...

The skin contained large numbers of CD68+/factor XIIIa+ dendritic cells and increased expression of transforming growth factor- ... Immunohistochemical staining for CD34, factor XIIIa, CD31, smooth muscle actin, CD68, and colloidal iron were similar for both ... 21] performed immunohistochemical studies using antibodies to transglutaminase-2, factor XIIIa, transglutaminase isopeptide, ... factor XIIIa, and transglutaminase isopeptide. They posited that this represented increased expression, activation, or ...

Platelet factor XIIIa release during platelet aggregation and plasma clot strength measured by thrombelastography in patients ... Prediction of Ischemic Events after Percutaneous Coronary Intervention: Thrombelastography Profiles and Factor XIIIa Activity. ... A comprehensive review and meta-analysis of risk factors for statin-induced myopathy. Nguyen KA; Li L; Lu D; Yazdanparast A; ... Factor XIII Val34Leu polymorphism and recurrent myocardial infarction in patients with coronary artery disease. Kreutz RP; ...

... adding FAR to the model of established risk factors, the C-statistic increased from 0.706 to 0.720, 0.650 to 0.668, and 0.611 ... Multivariate Cox regression analysis indicated that FAR was an independent prognostic factor for MACE at 30 days, 6 months, and ... regarded as a novel inflammatory and thrombotic biomarker was the risk factor for coronary artery disease (CAD). In this study ... with the help of thrombin and factor XIIIa [16]. The study by Peng et al. showed that admission of was an independent predictor ...

Reid M, Gray C, Fea J, Bird C: Immunohistological demonstration of factors XIIIa and XIIIs in reactive neoplastic fibroblastic ... Factors associated with reduced quality of life in Hidradenitis Suppurativa ...

The tumour cells were diffusely positive for vimentin and factor XIIIa, and weakly positive for CD34. The patient did not ...

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and factor XIIIa. These methods are useful in treatment of conditions, including tumors and diabetes. ...

... recessive disorder caused by deficiency of functional plasma clotting factor VIII (FVIII). In a significant number of cases, ... the resultant clot is stabilized by factor XIIIa and the cross-linking of adjacent fibrin strands. ... TF also adsorbs factor X to enhance the reaction between factor VIIa, factor X, and calcium ions. Factor IXa and factor XII ... In the extrinsic system, the conversion of factor X to factor Xa involves tissue factor (TF), or thromboplastin; factor VII; ...

Administration, IntranasalAnimalsFactor XIIIaFibrinolysisHemostasisMaleOligopeptidesPlatelet AggregationProlineRats ... while platelet aggregation and activity of factor XIIIa in rat blood plasma decreased over 3 h after single intranasal ... while platelet aggregation and activity of factor XIIIa in rat blood plasma decreased over 3 h after single intranasal ...

Alterations in the epidermal-dermal melanin axis and factor XIIIa melanophages in senile lentigo and ageing skin ... Skin aging has been shown to result from a combination of the effects of chronological factors (intrinsic aging) and of ... The paracrine role of stem cell factor/c-kit signaling in the activation of human melanocytes in ultraviolet-B-induced ... Stem cell factor-KIT signalling plays a pivotal role in regulating pigmentation in mammalian hair ...

These immune cells then release a clotting factor, Factor XIIIA, which Pecot says creates a fibrin scaffold that tumor cells ... They produce a large amount of a factor that leads to clot in the tumor, which the tumor cells can latch onto and climb across ...

Factor XIIIa. Produtos. PA0449: 7ml Factor XIIIa Bond RTU Prim. Contact Us for a quote. ... Epidermal Growth Factor Receptor. Produtos. EGFR-L-CE: 1ml NCL-L-EGFR. ...

Influence of factor XIIIa activity on human whole blood clot lysis in vitro . Thromb Haemost. 1987. 7: 171-5 ... Among the various coagulation factors (CFs), low activity of CFXIII is thought to be one of the important factors in the ... Our univariate analyses indicated that among the potential risk factors, low CFXIII activity is a risk factor for CSH ... Clinical assessment for coagulation factor XIII activity and other factors. We assessed the CFXIII activity (normal range, 70- ...

On immunohistochemistry, positive staining with macrophage markers - CD68, HAM56 and lysozyme - and factor XIIIa, a ... positive for factor XIIIa and macrophage markers HAM56 and KiM1p, was consistent with the clinical impression of generalized ... Risk factors for diabetes insipidus in langerhans cell histiocytosis.. Grois N, Potschger U, Prosch H, Minkov M, Arico M, ... Lung involvement did not appear to be an unfavourable prognostic factor. However, the toxic effects of treatment on the lungs ...

Factor XIII-A: An Indispensable "Factor" in Haemostasis and Wound Healing. Alshehri, F. S. M., Whyte, C. & Mutch, N., 17 Mar ... Functional factor XIII-A is exposed on the stimulated platelet surface. Mitchell, J. L., Lionikiene, A. S., Fraser, S. R., ... Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability. Mitchell, J. L., Little, G., Bye ... Location, location, location: Fibrin, cells, and fibrinolytic factors in thrombi. Narwal, A., Whyte, C. S. & Mutch, N. J., 18 ...