Excitatory amino acid receptor agonist - Wikipedia
... acid Kainic acid N-Methyl-D-aspartic acid Quisqualic acid Excitatory amino acid receptor antagonist Excitatory amino acid ... An excitatory amino acid receptor agonist, or glutamate receptor agonist, is a chemical substance which agonizes one or more of ... Excitatory amino acid agonists at the US National Library of Medicine Medical Subject Headings (MeSH) MeSH list of agents ...https://en.wikipedia.org/wiki/Excitatory_amino_acid_receptor_agonist
Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy.
Systemic injection of kainic acid (KA) in the rat produces an animal model of human temporal lobe epilepsy. We examined the ... 0/Amino Acid Transport System X-AG; 0/Excitatory Amino Acid Agonists; 0/Excitatory Amino Acid Transporter 3; 0/Glutamate Plasma ... Excitatory Amino Acid Agonists / toxicity*. Excitatory Amino Acid Transporter 3. Glutamate Plasma Membrane Transport Proteins. ... We examined the temporal expression of the sodium-dependent neuronal glutamate transporter, excitatory amino acid carrier 1 ( ...http://www.biomedsearch.com/nih/Translocation-glutamate-transporter-subtype-excitatory/12875997.html
Treatment of N-methyl-D-aspartate (NMDA) Enhancers for Schizophrenia - Full Text View - ClinicalTrials.gov
Excitatory Amino Acid Agonists. Excitatory Amino Acid Agents. Neurotransmitter Agents. Molecular Mechanisms of Pharmacological ...https://clinicaltrials.gov/ct2/show/NCT01047592
Gossypium herbaceam extracts attenuate ibotenic acid-induced excitotoxicity in rat hippocampus.
Excitatory Amino Acid Agonists / toxicity. Gossypium / chemistry*. Hippocampus / drug effects, pathology, physiopathology*. ... 0/Calcium-Binding Protein, Vitamin D-Dependent; 0/Excitatory Amino Acid Agonists; 0/Plant Preparations; 0/Proto-Oncogene ... on learning and memory impairment induced by excitatory neurotoxin ibotenic acid were examined in vivo using Morris water maze ... Ibotenic Acid / toxicity. Injections, Intraventricular / methods. Male. Maze Learning / drug effects. Neurotoxicity Syndromes ...http://www.biomedsearch.com/nih/Gossypium-herbaceam-extracts-attenuate-ibotenic/19221423.html
NMDA receptor agonist An excitatory amino acid agonist which binds to NMDA receptors and triggers a response. ... NMDA receptor agonist An excitatory amino acid agonist which binds to NMDA receptors and triggers a response. ... glycine (CHEBI:15428) is a α-amino acid (CHEBI:33704) glycine (CHEBI:15428) is a proteinogenic amino acid (CHEBI:83813) glycine ... serine family amino acid (CHEBI:26650) glycine (CHEBI:15428) is conjugate acid of glycinate (CHEBI:32508) glycine (CHEBI:15428 ...http://www.ebi.ac.uk/chebi/es/searchId.do?chebiId=CHEBI:15428
NMDA receptor agonist An excitatory amino acid agonist which binds to NMDA receptors and triggers a response. ... NMDA receptor agonist An excitatory amino acid agonist which binds to NMDA receptors and triggers a response. ... D-serine (CHEBI:16523) has role NMDA receptor agonist (CHEBI:64571) D-serine (CHEBI:16523) is a D-α-amino acid (CHEBI:16733) D- ... D-serine (CHEBI:16523) is conjugate acid of D-serinate (CHEBI:32840) D-serine (CHEBI:16523) is conjugate base of D-serinium ( ...http://www.ebi.ac.uk/chebi/searchId.do?chebiId=16523
Glutamate: its role in learning, memory, and the aging brain | SpringerLink
l-Glutamate is the most abundant of a group of endogenous amino acids in the mammalian central nervous system which presumably ... function as excitatory neurotransmitters and under abnormal conditions... ... Garthwaite G, Garthwaite J (1986) Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices. Dependence ... Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. ...https://link.springer.com/article/10.1007%2FBF02253527
They are conditional because they were evoked by excitatory amino acid agonists (MacLean et al., 1997; Schmidt et al., 1998; ... acid kynurenic (1.5 mm), N-methyl-dl-aspartic acid (NMA) (15 μm), 5-hydroxytryptamine creatinine sulfate (5-HT) (5 μm), TTX ( ... Ipsilaterally projecting excitatory interneurons have been hypothesized to be the source of rhythm generation in the locomotor ... 2007) Intrinsic bursters increase the robustness of rhythm generation in an excitatory network. J Neurophysiol 97:1515-1526. ...http://www.jneurosci.org/content/28/34/8577
Excitatory amino acid receptor ligand - Wikipedia
They include excitatory amino acid receptor agonists and excitatory amino acid receptor antagonists.. ... Excitatory amino acid receptor ligands are ligands of excitatory amino acid receptors (EAARs), also known as glutamate ...https://en.wikipedia.org/wiki/Excitatory_amino_acid_receptor_ligand
Is Topical Ketamine Ready For Prime Time?
Trist D. Excitatory amino acid agonists and antagonists: pharmacology and therapeutic applications. Pharm Acta Helv. 2000;74: ...https://www.practicalpainmanagement.com/treatments/pharmacological/non-opioids/topical-ketamine-ready-prime-time
Excitatory Amino Acid Neurotoxicity | Springer for Research & Development
The excitatory potency of the acidic amino acids glutamate and aspartate in various regions of the central nervous system (CNS ... Garthwaite G, Garthwaite J. Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: dependence on ... Neurotoxicity of excitatory amino acids. In: McGeer EG, Olney JW, McGeer PL, eds. Kainic acid as a Tool in Neurobiology. New ... Structure-function studies on N-oxalyldiamino-dicarboxylic acids and excitatory amino acid receptors: evidence that beta-L-ODAP ...https://rd.springer.com/chapter/10.1007/978-1-4615-0123-7_1
1989) Effects of excitatory amino acid receptor antagonists and agonists on suprachiasmatic nucleus responses to ... Antagonists. Animals received 200 nl microinjections of 10 mm NMDA, 10 mm NMDA plus 10 mm 2-amino-5-phosphopentanoic acid (AP-5 ... phase delays and advances induced by NMDA were blocked by coinjection of the NMDA antagonist 2-amino-5-phosphopentanoic acid ... 1997) GABAA and GABAB agonists and antagonists alter the phase shifting effects of light when microinjected into the ...http://www.jneurosci.org/content/19/12/5124
Computational Analysis of AMPK-Mediated Neuroprotection Suggests Acute Excitotoxic Bioenergetics and Glucose Dynamics Are...
Garthwaite G, Garthwaite J. Neurotoxicity of excitatory amino acid receptor agonists in rat cerebellar slices: dependence on ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148326
quinolinic acid (CHEBI:16675)
NMDA receptor agonist An excitatory amino acid agonist which binds to NMDA receptors and triggers a response. ... NMDA receptor agonist An excitatory amino acid agonist which binds to NMDA receptors and triggers a response. ... quinolinic acid (CHEBI:16675) is a pyridinedicarboxylic acid (CHEBI:36112) quinolinic acid (CHEBI:16675) is conjugate acid of ... quinolinic acid (CHEBI:16675) has role Escherichia coli metabolite (CHEBI:76971) quinolinic acid (CHEBI:16675) has role human ...http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16675
Frontiers | Monoamine Release in the Cat Lumbar Spinal Cord during Fictive Locomotion Evoked by the Mesencephalic Locomotor...
The effects of intrathecal administration of excitatory amino acid agonists and antagonists on the initiation of locomotion in ... Brodin, L., Ohta, Y., Hökfelt, T., and Grillner, S. (1989). Further evidence for excitatory amino acid transmission in lamprey ... Buchanan, J. T., Brodin, L., Dale, N., and Grillner, S. (1987). Reticulospinal neurones activate excitatory amino acid ... Ohta, Y., and Grillner, S. (1989). Monosynaptic excitatory amino acid transmission from the posterior rhombencephalic reticular ...https://www.frontiersin.org/articles/10.3389/fncir.2017.00059/full
... electrophysiological characteristics and the effects of selective excitatory amino acid receptor agonists. Brain Res 525: 181- ... Inhibitory and indirect excitatory effects of dopamine on sympathetic preganglionic neurones in the neonatal rat spinal cord in ... Excitatory and indirect inhibitory actions of 5-hydroxytryptamine on sympathetic preganglionic neurones in the neonate rat ... Enhancement of bistability in spinal motoneurons in vivo by the noradrenergic alpha 1 agonist methoxamine. J Neurophysiol 81: ...http://jn.physiology.org/content/103/1/490
Pharmacological Properties of Metabotropic Glutamate Receptors | SpringerLink
Excitatory amino acid agonist-antagonist interactions at 2-amino-4-phosphonobutyric acid-sensitive quisqualate receptors ... Boss, V. and Conn, P. J. (1993) L-Cysteine sulfinic acid (L-CSA): an endogenous agonist of a metabotropic excitatory amino acid ... a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor. Eur. J. Pharmacol. 166, 585-587.PubMed ... and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3-phosphonopropionic acid. ...https://link.springer.com/chapter/10.1007/978-1-4757-2298-7_2
Excitatory amino acid reuptake inhibitor - Wikipedia
Glutamatergic GABA reuptake inhibitor Glycine reuptake inhibitor Excitatory amino acid receptor agonist Excitatory amino acid ... An excitatory amino acid reuptake inhibitor (EAARI) is a type of drug which inhibits the reuptake of the excitatory ... neurotransmitters glutamate and aspartate by blocking one or more of the excitatory amino acid transporters (EAATs). Examples ... October 2005). "Characterization of novel aryl-ether, biaryl, and fluorene aspartic acid and diaminopropionic acid analogs as ...https://en.wikipedia.org/wiki/Excitatory_amino_acid_reuptake_inhibitor
Pharmacological Characterization of Sigma Binding Sites in Guinea Pig Brain Membranes | SpringerLink
Radioligand binding to central phencyclidine recognition sites is dependent on excitatory amino acid receptor agonists, Eur. J ... Bowen, W.D., Kirschner, B.N., Newman, A.H. and Rice, K.C., 1988, Sigma receptors negatively modulate agonist-stimulated ...https://link.springer.com/chapter/10.1007/978-1-4684-5907-4_5
Felbamate Oral Suspension - FDA prescribing information, side effects and uses
... is not effective in protecting chick embryo retina tissue against the neurotoxic effects of the excitatory amino acid agonists ... Patients were converted to monotherapy with felbamate or low-dose valproic acid during the first 28 days of the 112-day ... The most commonly used antiepileptic drug during the baseline period was valproic acid. The frequency of all types of seizures ... Inactive Ingredients: carboxymethylcellulose sodium, citric acid monohydrate, FD&C Yellow No. 6, FD&C Red No.40, flavor (cherry ...https://www.drugs.com/pro/felbamate-oral-suspension.html
1993) Attenuation of excitatory amino acid toxicity by metabotropic glutamate receptor agonists and aniracetam in primary ... 1990) Stereoselectivity and mode of inhibition of phosphoinositide-coupled excitatory amino acid receptors by 2-amino-3- ... 1993) Purkinje cell survival is differentially regulated by metabotropic and ionotropic excitatory amino acid receptors. J ... 1992) Activation of hippocampal metabotropic excitatory amino acid receptors leads to seizures and neuronal damage. Neurosci ...http://www.jneurosci.org/content/18/17/6662
Modulation of Glutamate Responses by Noradrenaline and GABA in Neo- and Archicortical Structures | SpringerLink
... the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), and the neuromodulator noradrenaline (NA) have been found to be ... Excitatory Amino Acid Membrane Potential Change Inositol Phospholipid GABAB Receptor Agonist NMDA Response These keywords were ... The excitatory neurotransmitter glutamate, the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), and the ... aim of the study reported here was to analyze the influence of NA and GABA on the action of the glutamate subreceptor agonist N ...https://link.springer.com/chapter/10.1007/978-1-4757-1379-4_12
Downstream activation of caspases and enhanced phosphat | Open-i
Excitatory Amino Acid Agonists/pharmacology. *Excitatory Amino Acid Antagonists/pharmacology. *Female. *Flow Cytometry ... C in the presence of 500 μM MK-801 or memantine or were supplemented with NMDA in addition to the medium-borne agonists (510 μM ... C in the presence of 500 μM MK-801 or memantine or were supplemented with NMDA in addition to the medium-borne agonists (510 μM ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4469746_zh00111577390008&req=4
Stimulation of noradrenaline release in the cerebral cortex via presynaptic N-methyl-D-aspartate (NMDA) receptors and their...
Structure-activity relationship in the development of excitatory amino acid receptor agonists and competitive antagonists. ... Lodge D, Johnson KM (1990) Noncompetitive excitatory amino acid receptor antagonists. Trends Pharmacol Sci 11: 81-86PubMed ... NMDA Receptor Noradrenaline Release Kainate Receptor Excitatory Amino Acid Receptor Cortical Synaptosome These keywords were ...https://rd.springer.com/chapter/10.1007/978-3-7091-9175-0_16
... to excitatory amino acid agonists and antagonists. Glutamate and aspartate--as well as the synthetic agonists N-methyl-D- ... Kynurenic acid, piperidine dicarboxylic acid, and gamma-D- glutamylglycine antagonized responses to all 5 of the agonists. ... The antagonist 2- amino-5-phosphonovaleric acid had no effect on responses to quisqualate and kainate but completely blocked ... evidence that corticocollicular neurons in culture express both NMDA-type and non-NMDA receptors for excitatory amino acids. ...http://www.jneurosci.org/content/6/10/3044