Identification of the epitopes on HCV core protein recognized by HLA-A. 2. restricted cytotoxic T lymphocytes. World J ... Identification of the epitopes on HCV core protein recognized by HLA-A. 2. restricted cytotoxic T lymphocytes. World J ...

Suboptimal Stimulation by Weak Agonist Epitope Variants Does Not Drive Dysfunction of HIV-1-Specific Cytotoxic T Lymphocyte ...

... influenza A virus-specific memory cytotoxic T lymphocyte (CTL) clones tested in limiting dilution did not react with ... U Kees, P H Krammer; Most influenza A virus-specific memory cytotoxic T lymphocytes react with antigenic epitopes associated ... Most influenza A virus-specific memory cytotoxic T lymphocytes react with antigenic epitopes associated with internal virus ... This paper shows that most murine (C57BL/6) influenza A virus-specific memory cytotoxic T lymphocyte (CTL) clones tested in ...

In the RANK measure, we compare two methods at a time and count how often each of the methods rank the epitope highest. In ... NetCTL is a web-based tool designed for predicting human CTL epitopes in any given protein. It does so by integrating ... The source proteins are split into all possible 9 mers and except for annotated epitopes; all other 9 mers are considered non- ... Lastly, for each method, we calculate the percentage of known epitopes that rank within the 5% peptides with the highest ...

B-Lymphocyte" by people in this website by year, and whether "Epitopes, B-Lymphocyte" was a major or minor topic of these ... "Epitopes, B-Lymphocyte" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Epitopes, B-Lymphocyte" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Epitopes, B-Lymphocyte". ...

The amino acid sequence of the peptide epitope was compared to six other known virus peptides known to be restricted by HLA B8 ... The dominant epitope was mapped using recombinant vaccinia viruses that expressed fragments of the NP and then synthetic ... One of the predicted epitope peptides was made and shown to be recognized by specific CTL. These and the two others were shown ... HLA B8-restricted cytotoxic T lymphocytes (CTL) specific for influenza A virus were generated and shown to recognize the ...

Keywords: Allergy; Art v 1; IgE epitope; allergen; allergen-specific immunotherapy; epitope mapping; mugwort pollen allergy. ... Art v 1 IgE epitopes of patients and humanized mice are conformational J Allergy Clin Immunol. 2022 Oct;150(4):920-930. doi: ... Humanized mice transgenic for a human T-cell receptor specific for the major Art v 1 T-cell epitope and the corresponding HLA ... Objective: We sought to characterize IgE epitopes of Art v 1-sensitized patients and humanized mice for molecular immunotherapy ...

Combined structural and immunological refinement of HIV-1 HLA-B8-restricted cytotoxic T lymphocyte epitopes ... Combined structural and immunological refinement of HIV-1 HLA-B8-restricted cytotoxic T lymphocyte epitopes ...

CD8+ CTL lines were derived from lymphocytes of two HLA B37-positive donors and used to show that the peptide was represented ... Influenza-specific CTL from 10 donors of other HLA types failed to recognize this epitope. ... on virus-infected cells and to determine the probable boundaries of the epitope. ... HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes. ...

Indeed, we previously showed that CyaA toxins carrying a single cytotoxic T lymphocyte (CTL) epitope can induce efficient ... Finally, human DC treated with the recombinant CyaA were shown to process and present efficiently the melanoma epitopes to ... Altogether, our results demonstrate that tumoral epitopes inserted into CyaA are efficiently processed and presented in ... we constructed two recombinant CyaA carrying HLA*0201-restricted melanoma epitopes. Here we show that these recombinant CyaA ...

Cytotoxic T-Lymphocyte Epitopes for HLA-B53 and Other HLA Types in the Malaria Vaccine Candidate Liver-Stage Antigen 3 ... Cytotoxic T-Lymphocyte Epitopes for HLA-B53 and Other HLA Types in the Malaria Vaccine Candidate Liver-Stage Antigen 3 ...

The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells ... The proteasome-specific inhibitor lactacystin blocks presentation of cytotoxic T lymphocyte epitopes in human and murine cells ...

Cytotoxic T Lymphocyte Epitopes of HIV-1 Nef: Generation of Multiple Definitive Major Histocompatibility Complex Class I ... Unexpectedly, the five ligands correspond to only three cytotoxic T lymphocyte (CTL) epitopes, two of which occur in two COOH- ... Parallel analyses of proteasomal digests of a Nef fragment encompassing the epitopes revealed that all five ligands are direct ... Although a pivotal role of proteasomes in the proteolytic generation of epitopes for major histocompatibility complex (MHC) ...

"Mapping and characterization of visna/maedi virus cytotoxic T-lymphocyte epitopes". J. Gen. Virol. 89 (Pt 10): 2586-96. doi: ... This causal lentivirus can be found in monocytes, lymphocytes and macrophages of infected sheep in the presence of humoral and ... Infected differentiated monocytes, also known as macrophages, will continuously present VMV antigens inducing T-lymphocytes to ... visna virus does not infect T-lymphocytes. The relationship of visna and HIV as lentiviruses was first published in 1985 by ...

... its absence does not block the presentation of HLA-A2-restricted TAP-dependent epitopes to cytotoxic T lymphocytes indicating ... HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin. ... HLA-A*0201 presents TAP-dependent peptide epitopes to cytotoxic T lymphocytes in the absence of tapasin. ... its absence does not block the presentation of HLA-A2-restricted TAP-dependent epitopes to cytotoxic T lymphocytes indicating ...

Definition of an epitope on NS3 recognized by human CD4+ cytotoxic T lymphocyte clones cross-reactive for dengue virus types 2 ... This is the first epitope to be defined that is recognized by human CD4+ CTL cross-reactive for dengue virus types 2, 3, and 4. ... These T cell clones were established from the peripheral blood T lymphocytes of a dengue-3-immune donor, using a limiting ... In the present paper, we have defined a dengue serotype-cross-reactive epitope recognized by two CD4+ CD8- cytotoxic T ...

T-Lymphocytes / virology* * gag Gene Products, Human Immunodeficiency Virus / genetics * gag Gene Products, Human ... Human T cells expressing two additional receptors (TETARs) specific for HIV-1 recognize both epitopes Blood. 2011 Nov 10;118(19 ... Cell sorting revealed that one individual cell indeed recognized both epitopes. The T cells diminished their reactivity to each ... epitope after stimulation but sequentially killed targets that presented the gag epitope and then targets that presented the ...

... epitope (Pol residues 476-484). Within HIV-1 RT is a dominant HLA A*0201-restricted epitope. ... IFN-γ Exposes a Cryptic Cytotoxic T Lymphocyte Epitope in HIV-1 Reverse Transcriptase. J Immunol . 1999 Jun 15 ; 162(12) 7075 ... Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses. J Immunol . 2003 Nov 15 ; 171( ... This is a reverse transcriptase (RT) epitope (Pol residues 476-484). Within HIV-1 RT the peptide appears to be the dominant HLA ...

... the hypothesis that tissue damage during an immune response can lead to the priming of self-reactive T and/or B lymphocytes, ... This review will focus primarily on epitope spreading at the T-cell level. Understanding the cellular and molecular basis of ... epitope spreading in various chronic immune-mediated human diseases and their animal models is crucial to understanding the ... CRYPTIC EPITOPE. A cryptic epitope is defined as a hidden or sequestered epitope that is processed and presented more ...

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature. 1998;394:482-5. ... Original antigenic sin: a bone marrow-derived lymphocyte memory phenomenon modulated by thymus-derived lymphocytes. J Exp Med. ... with ongoing selection and expansion of lymphocyte clones that have increasing antibody avidity at key cross-reactive epitopes ... 7-10) and possibly with epitope competition between naïve and antigen-specific B cells (8). A phenomenon analogous to original ...

Epitopes, B-Lymphocyte--therapeutic use. Immunotoxins--therapeutic use. Lymphoma, B-Cell--drug therapy. Mesothelioma--drug ...

2.T-lymphocytes are the key responding cellular elements of the immune response to M. tuberculosis. These cells should be ... This should permit amino acid analysis and synthesis of epitopes which may be useful for serologic or skin-test diagnosis. ... A related area to be explored is the study of the T-lymphocyte antigen receptor. Conclusion There is an urgent need for ... High priority should be placed on the search for genus- and species-specific epitopes. 2.DNA probes specific for M. ...

Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in ... Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and ... Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells ... Identification of type-specific cytotoxic T lymphocyte responses to homologous viral proteins in laboratory workers ...

The peptide epitopes of EBOV GP and VP40 proteins that are specific for CD8+ T lymphocytes in BALB/c mouse (GP-T1: LYDRLASTV; ... Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins. Virol. J. 9:111. doi: ... Generation of Ebola-Specific CD8+ T Lymphocyte Responses. The IFN-γ ELISPOT assay was performed to examine the Ebola antigen- ... Splenocytes were isolated from plasmid-immunized mice and were stimulated in vitro with GP- or VP40-specific epitopes. A ...

Open the PDF for Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic ... Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD mice. ... View article titled, Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 ... t-lymphocyte epitopes (1) Date. Filter by date. Date range Single date ...

T-cell lymphocytes are believed to react against thyroid follicular cells with shared antigenic epitopes in the retroorbital ... 45] anti-CD20 (rituximab) therapy to deplete B-cell lymphocytes, [46] and antitumor necrosis factor (anti-TNF) drugs (eg, ... 12] with orbital fibroblast modulation of T-cell lymphocytes. ... believed to damage orbital fibroblasts or perhaps lymphocytes. ...

MECA-79 antibody inhibits L-selectin-dependent lymphocyte and platelet homing to lymph nodes ,/span>,span style=font-style: ... MECA-79 antibody inhibits L-selectin-dependent lymphocyte and platelet homing to lymph nodes ,/span>,span style=font-style: ... span style=font-family:Times,serif;font-size:9pt;>The MECA-79 antibody reacts with sulfate-dependent carbohydrate epitopes of ... span style=font-family:Times,serif;font-size:9pt;>The MECA-79 antibody reacts with sulfate-dependent carbohydrate epitopes of ...

Assessment of the extent of variation in influenza A virus cytotoxic T-lymphocyte epitopes by using virus-specific CD8+ T-cell ... 6. Universal Coverage: Epitopes, HLA, and Ethnicity. The major antigenic targets of influenza-specific T cells are epitopes ... In addition, little is known about CD4+ epitope variation during influenza infection due to a paucity of defined epitopes. ... Despite this, T cell responses usually focus only on a few peptide + HLA epitopes, with responses to the same epitopes ...

... conventional CD4+ tumor-infiltrating lymphocytes (TIL) in most patients and higher clonality by TCRβ sequencing. Analyses of ... The secondary objective was to assess the effect of anti-OX40 on lymphocyte subsets in the tumor and blood. Neoadjuvant anti- ... CD8-Positive T-Lymphocytes, *Cell Proliferation, *Clone Cells, *Disease-Free Survival, *Epitopes, ... The secondary objective was to assess the effect of anti-OX40 on lymphocyte subsets in the tumor and blood. Neoadjuvant anti- ...

Neutrophil-lymphocyte ratio (NLR) was defined as the absolute neutrophil count divided by the absolute lymphocyte count (13). ... Identification of universal HLA-DR-restricted CD4 T-cell epitopes from TERT. To predict the existence of CD4 epitopes within ... For this purpose, lymphocytes isolated from peripheral blood of healthy volunteers were in vitro stimulated using a pool of UCP ... Blood lymphocytes from 22 healthy volunteers were used as control. Responses were considered positive when the number of IFN-γ ...