Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and...
... and the constitutive transcription factors (CTFs) CREB, CREM, ATF-2 and SRF as they pertain to gene … ... This article reviews findings up to the end of 1997 about the inducible transcription factors (ITFs) c-Jun, JunB, JunD, c-Fos, ... Early Growth Response Protein 1 * Gene Expression Regulation / genetics * Gene Expression Regulation / physiology* ... Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and ...
The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the...
... signaling in naive T cells induces expression of the transcription factor Foxp3, a master regulator of regulatory T cells (T( ... Early Growth Response Transcription Factors / physiology* * Forkhead Transcription Factors / metabolism* * Gene Expression ... Transforming growth factor-beta (TGF-beta) signaling in naive T cells induces expression of the transcription factor Foxp3, a ... regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor ...
Pathways of Egr-1-mediated gene transcription in vascular biology
Early growth response proteins - Wikipedia
"Early growth response transcription factors and the modulation of immune response: implications towards autoimmunity". ... Early growth response transcription factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e ( ... Early growth response proteins are a family of zinc finger transcription factors. Members of the family include: EGR1, EGR2, ... Transcription factors, Zinc proteins, Protein families, All stub articles, Protein stubs). ...
Publications - Vitiligo Clinic & Research Center UMass Chan Medical School
Early growth response gene-2, a zinc-finger transcription factor, is required for full induction of clonal anergy in CD4+ T ... We report the identification of the early growth response gene (Egr-2; Krox-20), a zinc-finger transcription factor, as a key ... CONCLUSION: Measuring CXCL9 directly in the skin might be effective in clinical trials as an early marker of treatment response ... A network of high-mobility group box transcription factors programs innate interleukin-17 production Tuesday, April 09, 2013 ...
Early Growth Response Protein 1 | Harvard Catalyst Profiles | Harvard Catalyst
An early growth response transcription factor that has been implicated in regulation of CELL PROLIFERATION and APOPTOSIS. ... "Early Growth Response Protein 1" by people in Harvard Catalyst Profiles by year, and whether "Early Growth Response Protein 1" ... Transcription Factors [D12.776.930]. *Early Growth Response Transcription Factors [D12.776.930.313]. *Early Growth Response ... "Early Growth Response Protein 1" by people in Profiles.. * BRCA1-BARD1 regulates transcription through modulating topoisomerase ...
EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor |...
... early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. The SS18- ... In this study, we report a central role of the transcription factor, ... In this study, we report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC ... Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog Nucleic Acid Res Mol ...
A Taiwanese Propolis Derivative Induces Apoptosis through Inducing Endoplasmic Reticular Stress and Activating Transcription...
... growth arrest- and DNA damage-inducible gene 153 (GADD153), phosphorylated eukaryotic initiation factor 2,i,α,/i, (eIF2,i ... a stress-inducible transcription factor, is rapidly upregulated under various stress conditions and plays an important role in ... "Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3- ... "Resveratrol-induced apoptosis is mediated by early growth response-1, Krüppel-like factor 4, and activating transcription ...
Frontiers | Decidualization of human endometrial stromal cells requires steroid receptor coactivator-3
... particularly in patients presenting non-aneuploid early pregnancy loss. ... Early growth response 1 transcription factor is essential for the pathogenic properties of human endometriotic epithelial cells ... Importantly, the normal induction of the majority molecular signals tested-hormones, growth factors, transcription factors, and ... Early growth response 1 transcriptionally primes the human endometrial stromal cell for decidualization. J Steroid Biochem Mol ...
EGR1 - Wikipedia
"Early growth response transcription factors: key mediators of fibrosis and novel targets for anti-fibrotic therapy". Matrix ... EGR-1 (Early growth response protein 1) also known as ZNF268 (zinc finger protein 268) or NGFI-A (nerve growth factor-induced ... and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1)". The Biochemical Journal. 336 ( Pt 1) (1 ... "Entrez Gene: EGR1 early growth response 1".. *^ Knapska E, Kaczmarek L (November 2004). "A gene for neuronal plasticity in the ...
Fatty Liver: Overview, Etiology, Epidemiology
The role of the early growth response-1 (EGr-1) transcription factor is thought to be essential for ethanol-induced fatty liver ... Which factors increase the risk for fatty liver disease?. Which factors increase the risk for advanced alcoholic liver disease ... Patients with growth hormone deficiency who receive growth hormone can experience reversal of NASH. [44] ... Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency. Gastroenterology. 2007 ...
Idiopathic pulmonary fibrosis pathophysiology - wikidoc
"Early growth response transcription factors: key mediators of fibrosis and novel targets for anti-fibrotic therapy". Matrix ... Reduced expression of angiogenic factors,. vascular endothelial growth factor (VEGF)[7]. Elevation of angiostatic factors,. ... There are multiple initiating factors that cause pulmonary injury. However, immunopathogenic responses of lung tissue are quite ... "Syndecan-2 is a novel target of insulin-like growth factor binding protein-3 and is over-expressed in fibrosis". PLoS One. 7 (8 ...
Identification of new risk loci shared across systemic vasculitides points towards potential target genes for drug repurposing ...
Early growth response gene-2 is essential for M1 and M2 macrophage activation and plasticity by modulation of the transcription ... IRF1 encodes a transcription factor that promotes transcription of genes involved in both innate and acquired immune responses. ... Early growth response gene 2-expressing CD4+LAG3+ regulatory T cells: the therapeutic potential for treating autoimmune ... It has been described that this transcription factor has anti-inflammatory functions, however, ETS2 is also involved in the ...
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Tech Science Press - Publisher of Open Access Journals
Other transcription factors, such as Mohawk (Mkx) or early growth response (Egr), maintain Scx expression and extracellular ... Once the commitment of tenogenic lineage occurs, transforming growth factor-beta (TGFβ) induces the Scx gene expression, ... Scx knockout mice develop some but not all tendons, suggesting that additional factors are necessary for tendon commitment, ... Frontiers in Heat and Mass Transfer Achieves First Impact Factor of 1.8 ...
Differential Gene Expression of SARS-CoV-2 Positive Bronchoalveolar Lavages: A Case Series | Pathobiology | Karger Publishers
Early growth response gene-2 (EGR2), an essential factor for the expression of the transcription factors CEBPβ and PPARγ in M2- ... Early Growth response gene-2 is essential for M1 and M2 macrophage activation and plasticity by modulation of the transcription ... JUN and FOS regulate the activity of the AP-1 transcription factor, which, in turn, impacts the glucocorticoid receptor in a ... von Willebrand factor [VWF]), interferon response (IFRD1, IL12RB2), and a zinc metalloprotease that is elevated in human asthma ...
WikiGenes - Lhb - luteinizing hormone beta polypeptide
Gonadotropin-releasing hormone activation of c-jun, but not early growth response factor-1, stimulates transcription of a ... Gonadotropin-releasing hormone activation of c-jun, but not early growth response factor-1, stimulates transcription of a ... Differential activation by xenoestrogens of ER alpha and ER beta when linked to different response elements. Pennie, W.D., ... To localize the LH beta estrogen response element (ERE) by biological function, portions of the 5-flanking region of the LH ...
The Promise of Predictive Biomarkers for Antipsychotic Efficacy: A Review of Peripheral microRNAs to Evaluate Schizophrenia...
Liu et al17 witnessed significant downregulation of transcription factor (early growth response protein 1 [EGR1]) and miR-30a- ... The early growth response protein 1-miR-30a-5p-neurogenic differentiation factor 1 axis as a novel biomarker for schizophrenia ... After introduction in the early 1990s, miRNAs became a special focus due to their unique functions and mechanism of action. ... treatment with antipsychotics had increased expression of EGR1 and miR-30a-5p and decreased expression of transcription factor ...
Cellular interactions in the pathogenesis of interstitial lung diseases | European Respiratory Society
Early growth response transcription factors: key mediators of fibrosis and novel targets for anti-fibrotic therapy. Matrix Biol ... The early growth response gene Egr2 (alias Krox20) is a novel transcriptional target of transforming growth factor-β that is up ... transforming growth factor; IL: interleukin; MCP: monocyte chemotactic protein; PDGF: platelet-derived growth factor; ET: ... Egr-1 (early growth response protein 1) expression is also increased in lesional skin and lung biopsies from patients with ...
PE/Cyanine7 anti-STAT5 Phospho (Tyr694) Antibody, STAT5 Phospho Tyr694, A17016B.Rec
... mediating growth and cytokine signaling. STAT5 consists of two closely related family members, STAT5A and STAT5B, which exhibit ... STAT5 is a member of the signal transducer and activator of transcription factors (STAT) family, ... STAT5 is a member of the signal transducer and activator of transcription factors (STAT) family, mediating growth and cytokine ... STAT5 is a transcription regulator and is involved in cell differentiation, proliferation, and survival, in response to several ...
The FOXO1 transcription factor is very important to multiple aspects of | immune-source.com
These MAPKs increase the expression or activity of several transcription factors such as early growth response protein 1 (EGR1 ... The FOXO1 transcription factor is very important to multiple aspects of. immune Uncategorized Bay 65-1942, Rabbit Polyclonal to ... The FOXO1 transcription factor is very important to multiple aspects of reproductive function. administration induced ... cJUN cFOS and activating Bay 65-1942 transcription factor 2 (ATF2) mediating and synthesis (28). FOXO1 was recently reported to ...
JCI - CCN1 induces hepatic ductular reaction through integrin αvβ5-mediated activation of NF-κB
Expression of cyr61, a growth factor-inducible immediate-early gene. Mol Cell Biol. 1990;10(7):3569-3577.. View this article ... Pobbati AV, Hong W. Emerging roles of TEAD transcription factors and its coactivators in cancers. Cancer Biol Ther. 2013;14(5): ... These phenotypes are specific to Ccn1D125A/D125A mice, indicating that CCN1 plays crucial roles in response to BDL through its ... Ccn1 is a growth factor-inducible immediate-early gene that is transcriptionally activated by a variety of stimuli (62). As a ...
The bZIP transcription factor UvbZIP6 mediates fungal growth, stress response, and false smut formation in Ustilaginoidea...
Our study indicates that UvbZIP6 is required for fungal growth, conidiation, stress response, and false smut ball formation of ... Basic leucine zipper (bZIP) proteins, which belong to an evolutionarily conserved transcription factor family and play critical ... Deletion of UvbZIP6 in U. virens resulted in an increase in fungal growth and sensitivity to Congo red and calcofluor white, ... Hu Z, Dang Y, Liu C, Zhou L, Liu H. Acute exposure to ustiloxin A affects growth and development of early life zebrafish, Danio ...
The Nobel Prize in Physiology or Medicine 2019 - Advanced information - NobelPrize.org
... a transcription factor that regulates these oxygen-dependent responses. He named this factor HIF, for Hypoxia Inducible Factor ... In the early 1770s, the Swedish scientist Carl Scheele determined that, from his calculations, approximately one fourth of the ... The paper from Kaelin established that VHL is a tumor suppressor gene, whose activity can act to inhibit tumor growth of cells ... hypoxia inducible factor) transcription factor. The discovery of this factor had its roots in the work done by a number of ...
Circuits of cancer drivers revealed by convergent misregulation of transcription factor targets across tumor types | Genome...
This is key not only to understand how carcinogenesis appears and develops in these malignancies to be able to early diagnose ... Then, I collect a list of downstream targets of the all driver transcription factors (TFs), and identify which of them exhibit ... Here, I focus on driver transcription factors and their connection to tumorigensis in several tumor types through the ... a differential expression upon alterations of driver transcription factors. I identify the subset of targets of each TF most ...
Global identification of long non-coding RNAs involved in the induction of spinach flowering | BMC Genomics | Full Text
Indeed, bolting is an event induced by the coordinated effects of various environmental factors and endogenous genetic ... Spinach is a beneficial annual vegetable species and sensitive to the bolting or early flowering, which causes a large ... It is proven that numerous higher plants increase their growth rate and accelerate the floral transition in response to warmer ... putative transcription factor PHYTOCHROME INTERACTING FACTOR 4 (PIF4:Spo08670) was found as a flowering-time-related gene among ...
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism |...
... is considered not only as a cytoprotective factor regulating the expression ... The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) ... proteins that regulate the expression of other transcription factors and growth factors and many more. ... Leung L, Kwong M, Hou S, Lee C, Chan JY (2003) Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic ...
Charcot-Marie-Tooth Disease Neuropathies: An Introduction: Overview, Clinical Presentation, Diagnostic Considerations
Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. Nat Genet. 1998 Apr. 18(4): ... EGR2 is a transcription factor linked to Charcot-Marie-Tooth disease type 1D (CMT1D). ... early growth response gene 2 (EGR2), periaxin (PRX), and others. ... which are determined at least in part by transcription factors ... Mutations in structural myelin genes or the transcription factors responsible for their expression lead to demyelination (ie, ...
New therapeutic target could reduce diabetic retinopathy | AOA
... fibrovascular membrane tissue and identified the presence of the transcription factor RUNX1 expressed in response to high ... Catching diabetic retinopathy early enough is critical to preserving vision, but this study hints at going beyond early ... and how RUNX1 and vascular endothelial growth factor (VEGF) interplay in angiogenesis. ... Study finds common transcription factor that may be key to reduced retinopathy. ...