Drug synergism: its detection and applications. J Pharmacol Exp Ther 2001;298:865-72 [review].. ... each drug should show a dose-effect relationship, at least three data points are required for each single drug effect, and the ... we chose only to analyze concurrent exposures because in patients treated with these drugs, continuous therapeutic drug levels ... Schedule-dependent synergism between raltitrexed and irinotecan in human colon cancer cells in vitro. Clin Cancer Res 1998;4: ...http://clincancerres.aacrjournals.org/content/11/9/3597
where the ratio Dy,1/Dy,2 is called the relative potency of drug 2 versus drug 1. Thus, the growth inhibition produced by drug ... Schedule-dependent cytotoxic synergism of pemetrexed and erlotinib in human non-small cell lung cancer cells. Clin Cancer Res ... C) for three drugs can be described as. d. 1. D. y. ,. 1. +. d. 2. D. y. ,. 2. +. d. 3. D. y. ,. 3. =. 1. (C)where (d1, d2, d3 ... Results of drug interaction analyses in the Emax model and semiparametric model supported the conclusion that drug combinations ...http://cancerpreventionresearch.aacrjournals.org/content/3/8/917
Adjuvants, Pharmaceutic | CTD
Agents that aid or increase the action of the principle drug (DRUG SYNERGISM) or that affect the absorption, mechanism of ... action, metabolism, or excretion of the primary drug (PHARMACOKINETICS) in such a way as to enhance its effects.. ...http://ctdbase.org/detail.go?type=chem&acc=D000277
Institute of Cancer Research Repository - Acquired resistance to combination treatment through loss of synergy with MEK and...
ICR divisions , Clinical Studies , Medicine (Kaye Drug Development Unit). Clinical Units , Drug Development Unit. ... Supplementation of endothelin in parental cells converted synergism to antagonism. Silencing of TGFB2 or EDN1 in cells with AQR ... To test whether an altered drug interaction could be an additional factor in AQR to combination treatment, models of AQR to ... Differences were also observed between the models in cellular phenotypes, pathway signaling and drug cross-resistance. Genomics ...http://publications.icr.ac.uk/15188/
Systematic exploration of synergistic drug pairs | Molecular Systems Biology
Jawetz E, Gunnison JB (1953) Antibiotic synergism and antagonism; an assessment of the problem. Pharmacol Rev 5: 175-192. ... Another model of drug synergy proposes that drugs may exhibit synergy if a drug's action helps a second drug's availability in ... Drug synergy allows a therapeutic effect to be achieved with lower doses of component drugs. Drug synergy can result when drugs ... all observed drug synergies. When two drugs acted synergistically, we attributed the drug synergy to the drug with the highest ...http://msb.embopress.org/content/7/1/544
Pentoxifylline (Trental) as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS - Full Text View ...
Drug Evaluation. Acquired Immunodeficiency Syndrome. Cachexia. Drug Synergism. Additional relevant MeSH terms: ...https://clinicaltrials.gov/show/NCT00000646?order=69
Interleukin-2 and a T cell hybridoma (MP6) derived B cell-stimulatory factor act synergistically to induce proliferation and...
Cell Division / drug effects. DNA / biosynthesis*. Dose-Response Relationship, Drug. Drug Synergism. Humans. Interleukin-2 / ... Cell Cycle / drug effects. Cell Differentiation / drug effects. ... and act in strong synergism with induction of simultaneous high ...http://www.biomedsearch.com/nih/Interleukin-2-T-cell-hybridoma/2787454.html
Indole-3-carbinol enhances anti-proliferative, but not anti-invasive effects of oxaliplatin in colorectal cancer cell lines.
Cell Membrane / drug effects, metabolism. Cell Movement / drug effects. Cell Proliferation / drug effects*. Drug Synergism. ... Apoptosis / drug effects. Cadherins / biosynthesis. Cell Cycle / drug effects. Cell Line, Tumor. ...http://www.biomedsearch.com/nih/Indole-3-carbinol-enhances-anti/18358454.html
Topical nitrates potentiate the effect of botulinum toxin in the treatment of patients with refractory anal fissure.
Drug Synergism. Drug Therapy, Combination. Female. Fissure in Ano / drug therapy*. Humans. Isosorbide Dinitrate / therapeutic ...http://www.biomedsearch.com/nih/Topical-nitrates-potentiate-effect-botulinum/11156644.html
Green tea extract increases cyclophosphamide-induced teratogenesis by modulating the expression of cytochrome P-450 mRNA.
Drug Synergism. Female. Fetal Development / drug effects, physiology. Gene Expression Regulation, Developmental / drug effects ... Microsomes, Liver / drug effects, enzymology. Plant Extracts / pharmacology*. Pregnancy. RNA, Messenger / drug effects*, ... Abnormalities, Drug-Induced*. Animals. Aryl Hydrocarbon Hydroxylases / biosynthesis*, genetics. Camellia sinensis / chemistry* ...http://www.biomedsearch.com/nih/Green-tea-extract-increases-cyclophosphamide/19103281.html
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Monoclonal antibody to the ICAM-1 adhesion site reduces neurological damage in a rabbit cerebral embolism stroke model. |...
Drug Synergism. *Intercellular Adhesion Molecule-1. *Intracranial Embolism and Thrombosis (complications, pathology, ... Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find ...http://www.curehunter.com/public/pubmed8094342.do
Experimental study of new cerebral protective substances--functional recovery of severe, incomplete ischemic brain pretreated...
Brain Ischemia (drug therapy, physiopathology) *Cerebrovascular Circulation. *Dogs. *Drug Synergism. *Drug Therapy, Combination ... After pretreatment with the drugs, blood flow was reduced via the pump to 1/10 of the normal flow volume and 1 hr later, return ... Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find ... Subsequent changes in electrical activity were observed and the effects of the drugs evaluated. In the control group, no ...http://www.curehunter.com/public/pubmed6792553.do
2001) Drug synergism: its detection and applications. J Pharmacol Exp Ther 298:865-872. ... 2012) Emerging drugs for chronic obstructive pulmonary disease. Expert Opin Emerg Drugs 17:61-82. ... Analysis of Synergism Studies.. Analysis of the potential synergism between RPL554 plus salbutamol, RPL554 plus atropine, or ... Preparation of Drugs. The following drugs were used: acetylcholine (ACh), histamine, salbutamol, atropine, glycopyrrolate, ...http://jpet.aspetjournals.org/content/346/3/414
Drug synergism: its detection and applications. J Pharmacol Exp Ther 2001;298:865-72. ... Only 40% of mice treated with the combination of both drugs did not develop any peritoneal disease, and in the ones who did, ... Huynh H, Soo KC, Chow PK, Panasci L, Tran E. Xenografts of human hepatocellular carcinoma: a useful model for testing drugs. ... It would be attractive to consider therapy with this combination of drugs in a palliative setting, where absence of ascites and ...http://mct.aacrjournals.org/content/6/11/2959
Superbugs & Superdrugs USA : Pharmaceuticals : All
11:40 The novel strategy to fight multidrug resistance by multiple drugs synergism, based on docking in drug design and TRIZ. ... Drug Discovery Today is one of the most cited review journals in the field of drug discovery, with an impact factor of 6.422.. ... DRUG DISCOVERY: Enable antibiotic drug development through novel approaches in treating gram-negative infections. TARGETING ... Drug Discovery Today is one of the most cited review journals in the field of drug discovery, with an impact factor of 6.422.. ...http://www.smi-online.co.uk/pharmaceuticals/archive/11-2016/conference/superbugs-superdrugs-usa?o=login&dl=cc&p1=5152&p2=619
Inhibitors of Metabolite Synthesis: How Sulfa Drugs Work - Video & Lesson Transcript | Study.com
... it is called synergism. Sulfa drugs and trimethoprim are a great example of drug synergism. ... Sulfa Drugs. Sulfa drugs are a class of synthetic drugs that all have a sulfonamide chemical group. These drugs have many ... Synergism With Trimethoprim. That's why sulfa drugs are often administered in combination with trimethoprim, which is another ... Sulfa drugs like Sulfamethoxazole inhibit the enzyme that catalyzes the first step of this pathway. Sulfa drugs are competitive ...https://study.com/academy/lesson/inhibitors-of-metabolite-synthesis-how-sulfa-drugs-work.html
A and B Pralatrexate is effective against H2052 xenogra | Open-i
Cell Survival/drug effects. *Dose-Response Relationship, Drug. *Drug Synergism. *Female. *Folic Acid Antagonists/administration ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4209237_280_2014_2580_Fig3_HTML&req=4
Dietary CQ with excess zinc in the drinking water (CQ/Z | Open-i
Drug Synergism. *Humans. *Intestines/metabolism/pathology. *Liver/metabolism/pathology. *Mice. *Mice, Knockout ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3755987_pone.0072543.g002&req=4
Synergistic anti-proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines.
However, recent investigations on gambogic acid have focused mainly on mono-drug therapy, and its potential role in cancer ... Cell Proliferation / drug effects. Colorectal Neoplasms / drug therapy*, genetics, metabolism. Drug Synergism. Herb-Drug ... Determination of synergism and antagonism Synergism or antagonism after drug treatments was quantitated with the median-effect ... drug resistance or side effects derived from the various drugs. Accumulating evidence suggests that certain natural ...http://www.biomedsearch.com/nih/Synergistic-anti-proliferative-effects-gambogic/22546220.html
Venditti J, Goldin A. Drug synergism in antineoplstic chemotherapy. Adv Chemother 1964;13:397-498. ... The distribution of drug-efflux pumps, P-gp, BCRP, MRP1 and MRP2, in the normal blood-testis barrier and in primary testicular ... Study drugs and reagents. Ixabepilone and paclitaxel were synthesized in the Oncology Chemistry Department of Bristol-Myers ... Matrigel plug assays. The in vivo effects of each drug on angiogenesis were analyzed in mice using a VEGF/basic fibroblast ...http://clincancerres.aacrjournals.org/content/14/24/8123
Effects of nalfurafine on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone: modeling...
Revisiting the isobole and related quantitative methods for assessing drug synergism. Tallarida, RJ ... Possible pharmacotherapy of the opioid kappa receptor agonist for drug dependence. Hasabe, K; Kawai, K; Suzuki, T; Kawamura, K ... Kappa-opioid receptor agonist U50,488H modulates cocaine and morphine self-administration in drug naïve rats and mice ... Assessment of the kappa opioid agonist, salvinorin a, as a punisher of drug self-administration in monkeys ...https://www.deepdyve.com/lp/springer_journal/effects-of-nalfurafine-on-the-reinforcing-thermal-antinociceptive-and-F1d6PeGeko
Comparison of PK profiles of uridine following Nucleoma | Open-i
Drug Synergism. *Female. *Humans. *Male. *Middle Aged. *Models, Biological. *Osmolar Concentration. *Up-Regulation/drug effects ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3040752_pone.0014709.g003&req=4
Morphine in Combination with Metabotropic Glutamate Receptor Antagonists on Schedule-Controlled Responding and Thermal...
Loewe S (1953) The problem of synergism and antagonism of combined drugs. Arzneimittelforschung 3: 285-290. ... Tallarida RJ (2000) Drug Synergism and Dose-Effect Data Analysis, Chapman & Hall/CRC Press, Boca Raton, FL. ... Drug Interactions across Behavioral Endpoints. Previous research suggests that interactions between two drugs may depend on the ... For time course determinations, a single injection of a drug or drug mixture was administered i.p., and antinociceptive ...http://jpet.aspetjournals.org/content/324/2/732.long
Frontiers | The Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock...
Note, that although ivabradine is a specific drug it has unspecific effects on both clocks (Yaniv et al., 2013b). A better ... Maltsev, V. A., and Lakatta, E. G. (2009). Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks ... the net effect of both drugs was a 6% increase in the AP firing rate (i.e., not additive). Finally, we tested how and whether ... The concentrations of drugs used for the experiments were: isoproterenol (ISO, 1 μM), calyculin A (1 μM), blebbistatin (10 μM ...https://www.frontiersin.org/articles/10.3389/fphys.2016.00419/full