Low-protein diet found to slow Alzheimer's disease in mice, USC study finds | 89.3 KPCC
Researchers at USC have announced that a protein-restricted diet appears to improve memory and slow the advance of Alzheimer's disease in laboratory mice.. For their research, the scientists placed mice with advanced stages of the dementia on a low-protein diet with amino acid supplements every other week for four months. The researchers then ran the mice through mazes and found that those on the low protein diet had improved cognitive ability compared to a control group of mice that ate a higher-protein diet. The mice on the low-protein diets also showed lower levels of the growth hormone IGF-1 - which has been associated with aging and disease in mice and several diseases in older humans.. What's more, the mice on the protein-restricted diet also showed lower levels of the ...https://www.scpr.org/news/2013/02/19/36012/low-protein-diet-found-slow-alzheimers-disease-mic/
The effects of ad libitum feeding of synthetic, low-protein diets on the incidence and number of gastric cancers induced by N-methyl-N′-nitro-N-nitrosoguanidine were investigated in Wistar rats. Rats were fed synthetic diets of equal calorie content containing 25% casein (normal protein diet), 10% casein (low-protein diet), or 5% casein (very-low-protein diet) after treatment with N-methyl-N′-nitro-N-nitrosoguanidine p.o. for 25 weeks. Administration p.o. of a very-low-protein diet containing 5% casein resulted in a significant increase in the incidence and number of gastric cancers in experimental Week 52. However, it did not affect the histology of the cancers. The very-low-protein diet also caused a significant increase in tissue norepinephrine concentration of the antral portion of the ...http://cancerres.aacrjournals.org/content/51/13/3493
Prenatal programming of renal sodium handling in the rat | Clinical Science
Prenatally programmed hypertension induced by maternal protein restriction is associated with increased expression of the renal tubular Na+/K+/2Cl− co-transporter (NKCC2) and the Na+/Cl− co-transporter (NCC). This has led to the suggestion that renal Na+ retention contributes to the development of hypertension in the LP rat (offspring exposed to a maternal low-protein diet in utero). However, this hypothesis has not been tested in vivo. Renal clearance measurements in hypertensive 4-week-old male and female LP rats showed that, although the glomerular filtration rate remained unaltered, urine flow (P,0.01) and urinary Na+ excretion rates (1.6±0.3 and 3.0±0.4 μmol·min−1·100 g−1 of body weight in control male and LP male respectively; P,0.001) were increased. Na+ excretion was positively correlated with mean arterial pressure in both males (P,0.01) and females (P,0.05), but neither the slope nor the intercept differed between control and LP rats. Fractional ...http://www.clinsci.org/content/117/2/75
Programming of hepatic insulin-sensitive enzymes in offspring of rat dams fed a protein-restricted diet. - Semantic Scholar
Hepatic enzymes associated with glucose hemostasis were studied in offspring of dams fed either a 20% protein (control) or an isocaloric 8% protein (low-protein) diet during pregnancy and lactation. Additionally, offspring were exposed to maternal 8% protein diet only during gestation (recuperated) or lactation (postnatal low-protein). Glucokinase activity decreased (approximately 50%), whereas phosphoenolpyruvate carboxykinase (PEPCK) activity increased (approximately 100%), in the low-protein and recuperated offspring compared with controls (P | 0.001) at 21 days of age. However, the postnatal low-protein offspring had enzyme activities comparable with those of controls. These changes were still evident in 11-mo-old offspring weaned onto a normal laboratory chow. Parallel changes were apparent in mRNA levels of glucokinase and PEPCK in the ...https://www.semanticscholar.org/paper/Programming-of-hepatic-insulin-sensitive-enzymes-i-Desai-Byrne/71115d633756728dd8679417f02d53ca688d0984
Quantitative Requirements of Docosahexaenoic Acid for Neural Function in Children With Phenylketonuria - Full Text View -...
Patients with phenylketonuria (PKU) have an inborn error in the metabolism of the amino acid phenylalanine (Phe) and thus must follow a strictly controlled protein-restricted diet from early infancy. This protein-restricted diet is devoid of natural dietary sources of n-3 long chain polyunsaturated fatty acids (LC-PUFA), such as eggs, meat, milk or fish. Therefore, blood concentrations of n-3 LC-PUFA, especially of docosahexaenoic acid (DHA) are reduced in PKU children compared to healthy controls. DHA availability is considered important for optimal neurological function. Previous studies have shown that neural function of PKU children is improved by high dose supplementation of fish oil providing DHA, as shown by significant improvements of both visual evoked potential latencies and of fine motor skills and coordination, but no dose response relationship has been established so far.. This ...https://clinicaltrials.gov/ct2/show/NCT00909012?term=Phenylketonuria&rank=7
Investigation of the role of epigenetic modification of the rat glucokinase gene in fetal programming - University of...
Fetal malnutrition is associated with development of impaired glucose tolerance, diabetes and hypertension in later life in humans and several mammalian species. The mechanisms that underlie this phenomenon of fetal programming are unknown. We hypothesize that adverse effects in utero and early life may influence the basal expression levels of certain genes such that they are re-set with long-term consequences for the organism. An excellent candidate mechanism for this re-setting process is DNA methylation, since post-natal methylation patterns are largely established in utero. We have sought to test this hypothesis by investigating the glucokinase gene (Gck) in rat offspring programmed using a maternal low protein diet model (MLP). Northern blot reveals that fasting levels of Gck expression are reduced after programming, although this distinction disappears after feeding. Bisulphite sequencing of the hepatic Gck promoter indicates a complete absence of methylation at the 12 ...http://eprints.hud.ac.uk/id/eprint/204/
Project : USDA ARS
Objective 1: Differentiate the effects of fetal versus postnatal maternal dietary protein restriction on satellite cell accretion and skeletal muscle mass. Sub-objective 1.A. Determine in vivo the number of skeletal muscle satellite cells undergoing division, apoptosis, and differentiation in term fetuses of mouse dams that are fed a protein-restricted (PR) or a control (C) diet ad libitum during gestation. Sub-objective 1.B. Determine in vivo the number of skeletal muscle satellite cells undergoing division, differentiation, and apoptosis in 21-d-old mouse pups that are suckled by dams fed either a PR or a C diet ad libitum from birth. Sub-objective 1.C. Determine satellite cell and myonuclear numbers, myofiber cross-sectional area, and muscle mass in the 15-wk-old and 18-mo-old offspring of dams fed a PR diet either during gestation or during the suckling period, and then refed from birth ...https://www.ars.usda.gov/research/project/?accnNo=416974
Authors at Oakland 2011 - Kresge Library - Oakland University
Augustyniak, R. A., Singh, K., Zeldes, D., Singh, M. & Rossi, N. F. (2010). Maternal protein restriction leads to hyperresponsiveness to stress and salt-sensitive hypertension in male offspring. American journal of physiology. Regulatory, integrative, and comparative physiology 298(5), 1377-1382. ...https://library.oakland.edu/events/library_events/authors/moreInformation2011.htm
Most recent papers with the keyword Propionyl carnitine | Read by QxMD
Liver transplant is a treatment option for patients with MMA-emia. While this therapy does not bring about a complete cure, it is expected to prolong survival and improve the QOL of patients. The aim of this study was to evaluate the significance of LDLT for patients with MMA-emia in Japan. Clinical information on 13 patients with MMA-emia who underwent LDLT was acquired using a self-developed questionnaire sent to the doctors who provided medical care to patients with MMA-emia after LDLT. Almost all of the patients continued on a protein-restricted diet, and the number of acidosis attacks had significantly decreased ...https://www.readbyqxmd.com/keyword/118134
High Versus Normal Protein Diet in Polycystic Ovary Syndrome (PCOS)
The objective of this study is to assess the effects of a high protein (HP) and a normal protein diet (NP) on patients with polycystic ovary syndrome (Phttp://www.knowcancer.com/cancer-trials/NCT01184963/
Commercially available amino acid supplementation of low-protein diets for broiler chickens with different ratios of digestible...
This work studied the effect of supplementing commercially available amino acids in low-protein diets using different ratios of digestible (dig) glycine+serine:lysine (Gly+Ser:Lys) on performance, serum parameters, feathering, and litter characteristhttp://www.biomedsearch.com/nih/Commercially-available-amino-acid-supplementation/23155025.html
Bonnie's Blog With Bonnie & Steve Minsky: May 2013
A study published in the May issue The Journal of Nutrition aimed to gather a consensus of the different outcomes of energy-restricted high-protein diets depending on the dietary protein content. The objective was to determine the effects of dietary protein content on body weight loss-related variables during a 6-month energy restriction with the use of diets containing protein. In overweight and obese participants, protein intake was consistent in the normal protein diet and high protein diet groups throughout the study. Body fat mass similarly decreased in the normal protein diet and high protein diet groups. Fat free mass, resting energy expenditure, and diastolic blood pressure changed favorably with the ...http://nutritionalconcepts.blogspot.com/2013/05/
Effect of nutritional restriction in early pregnancy on isolated femoral artery function in mid-gestation fetal sheep -...
Unbalanced maternal nutrition affects fetal endocrine and cardiovascular systems, sometimes accompanied by changes in growth, although this is usually in late gestation. We determined the effect of moderate restriction for the first half of gestation of maternal dietary protein, or of total calorific intake on isolated resistance artery function of mid-gestation fetal sheep. Welsh Mountain ewes were nutritionally restricted by 30 % of the recommended nutrient intake (globally restricted) or 30 % of the recommended protein intake (protein-restricted), compared to control ewes fed 100 % of recommended nutrient intake, for ~12 days prior to conception and for the subsequent 70 days of gestation. At mid-gestation, fetal and placental weights were similar in all dietary groups. In isolated femoral arteries, the response curve to noradrenaline was reduced in ...https://eprints.soton.ac.uk/25848/
Whole Health Source: June 2016
In 2012, David Ludwig's group published an interesting RCT that suggested a substantial 'metabolic advantage' resulting from a high-protein, very-low-carbohydrate diet (VLC) (1). In other words, this diet led to a higher energy expenditure relative to a normal-protein, low-fat diet (LF) over a one month period (a low-glycemic-load, normal-protein diet was in the middle and not significantly different from the other two). Resting energy expenditure (REE) was slightly but significantly higher on the VLC diet, and total energy expenditure (TEE) was elevated by a whopping 300+ kcal/day! I covered the study at the time, describing it as 'fascinating' and 'groundbreaking', and calling for the study to be replicated so we can be more confident in its unexpected result (2 ...http://wholehealthsource.blogspot.no/2016/06/
It's nearly as bad as smoking, says Dr Valter Longo, co-author of a study in the journal Cell Metabolism.. The most healthy mix is a high-carbohydrate, low protein diet, say Australian scientists who have published a study in the same journal.. This leads to increased body fat, but a longer lifespan, say the scientists from the University of Sydney's Charles Perkins Centre. They tested 25 different diet combinations on 900 mice to see what happened to their appetite, metabolic health, ageing and lifespan.. Calories aren't all the same, says Professor Steve Simpson, academic director at the centre.. "We need to look at where the calories come from and how they interact." Although the mice on a high-protein diet ate less and were slimmer, they also had a reduced lifespan and poor heart and overall health.. Those on a high-carbohydrate, low-protein diet ate more and got fat, but lived longest.. ...http://www.low-histamine.com/tag/histamine/
The protein-metabolism link: How to maintain lean muscle and avoid body fat | New Hope Network
Healthy weight management: It's the perennial New Year topic. When our editorial staff tackled the topic for 2012, we were excited to choose 'The hormone balance plan,' an in-depth look at how to "reset" your metabolism by eating (and avoiding) the right foods. After interviewing several experts, what was writer Lisa Marshall's biggest takeaway? Eat more protein.. And this week, this approach was firmly backed up by new study published in the Journal of the American Medical Association. Over a 3-month period, study subjects overate and were deliberately inactive. Those who ate a low-protein (5 percent) diet did lose more weight-but they also stored more body fat and lost lean muscle mass. In fact, the low-protein group stored an astounding 90 percent of their calories as body fat, versus just 50 percent for the high-protein (25 percent) group. (Your body uses more energy building muscle than storing fat; we all know that, ...http://www.newhope.com/blog/protein-metabolism-link-how-maintain-lean-muscle-and-avoid-body-fat
Intrauterine programming of bone. Part 2: alteration of skeletal structure. - Nuffield Department of Orthopaedics, Rheumatology...
Osteoporosis is believed to be partly programmed in utero. Rat dams were given a low protein diet during pregnancy, and offspring were studied at different ages. Old aged rats showed site-specific strength differences. In utero nutrition has consequences in later life.Epidemiological studies suggest skeletal growth is programmed during intrauterine and early postnatal life. We hypothesize that age-related decrease in bone mass has, in part, a fetal origin and investigated this using a rat model of maternal protein insufficiency.Dams received either 18% w/w (control) or w/w 9% (low protein) diet during pregnancy, and the offspring were studied at selected time points (4, 8, 12, 16, 20, 47, 75 weeks).Using micro-CT, we found that at 75 weeks of age female offspring from mothers fed a restricted protein diet during pregnancy had femoral heads with thinner, less dense ...https://www.ndorms.ox.ac.uk/publications/126608
Low-Protein Diet May Extend Lifespan - Slashdot
sciencehabit writes 'A new theory about the foods that can extend life is taking shape, and it's sure to be a controversial one. Two studies out this week, one in mice (PDF) and another primarily in people (PDF), suggest that eating relatively little protein and lots of carbohydrates - the opp...https://science.slashdot.org/story/14/03/04/2227234/low-protein-diet-may-extend-lifespan
Baby boy or girl - are what you eat?
Yvonne Bishop-Weston fertility expert from Foods for Life, Nutritionist London says "There are a number of things you can do to increase the odds in your favour of a baby boy or a baby girl including carefully choosing nutrients. However it's dangerous to start enccouraging women to consume more calories or restrict calories before conception. Low fat diets can lead to insufficient essental fats for the baby's brain and eye development or in extreme cases of calorie restriction lead to misscarriage. Many high calorie foods can hinder your ability to concieve. This research was carefully supervised but once the information is diluted into another urban myth it could equally lead to more infertility rather than more aspirational sons and daughters ...http://nutrition-news.blogspot.com/2008/04/baby-boy-or-girl-are-what-you-eat.html
Study finds higher-protein diets lead to more weight gain, muscle
'Those who were randomly assigned to eat a low-protein diet -- with just 5 percent of their calories from protein -- gained seven pounds, about half as much weight as the two other groups, which were given 15 percent or 25 percent of their calories from protein.'http://www.americanrunning.org/w/article/study-finds-higher-protein-diets-lead-to-more-weight-gain-muscle
enzyme-replacement-therapy-for-HCU-MAJTAN-KRAUS - HCU
My name is Hayley and I am 17 years old. I have B6 non-responsive homocystinuria, which means I am constantly taking medication and must maintain a low-protein diet. Although this can be difficult at times, I am alive and well. Having HCU has not stopped me from doing many of the things that other 17…. ...https://www.hcunetworkaustralia.org.au/enzyme-replacement-therapy-for-hcu-majtan-kraus/
Cobalamin-related-MTHFR-deficiency-webinar - HCU
My name is Hayley and I am 17 years old. I have B6 non-responsive homocystinuria, which means I am constantly taking medication and must maintain a low-protein diet. Although this can be difficult at times, I am alive and well. Having HCU has not stopped me from doing many of the things that other 17…. ...https://www.hcunetworkaustralia.org.au/event/cblc-deficiency-guidelines-webinar/cobalamin-related-mthfr-deficiency-webinar/
HCU-fact9 - HCU
My name is Hayley and I am 17 years old. I have B6 non-responsive homocystinuria, which means I am constantly taking medication and must maintain a low-protein diet. Although this can be difficult at times, I am alive and well. Having HCU has not stopped me from doing many of the things that other 17…. ...https://www.hcunetworkaustralia.org.au/hcu-fact9/
accugo-apple - HCU
Loprofin low protein pasta gnoccetti sardi | LloydsPharmacy
Great price on Loprofin low protein pasta gnoccetti sardi. FREE delivery options available. Trusted service, convenient and safe shopping onlinehttp://www.lloydspharmacy.com/en/loprofin-low-protein-pasta-gnoccetti-sardi