*  Analysis of Overlapped and Noisy Hydrogen/Deuterium Exchange Mass Spectra | SpringerLink
Noisy and overlapped mass spectrometry data hinder the sequence coverage that can be obtained from hydrogen deuterium exchange ... the precision of deuterium uptake measurements was improved for nearly every peptide examined. The improved processing ... H/D exchange Overlap Bimodal Deconvolution Deuterium Conformational dynamics Binomial Electronic supplementary material. The ... Guttman, M., Scian, M., Lee, K.K.: Tracking hydrogen/deuterium exchange at glycan sites in glycoproteins by mass spectrometry. ...
  https://link.springer.com/article/10.1007%2Fs13361-013-0727-5
*  Nalle Jonsson's group
Measurement of hydrogen/deuterium exchange at amide groups by NMR is frequently used for characterization of the dynamics in ...
  http://www.ifm.liu.se/chemistry/molbiotech/nalle_jonssons_group/
*  Most recent papers with the keyword Hydrogen exchange mass spectrometry | Read by QxMD
Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of ... empirical-correction-for-differences-in-chemical-exchange-rates-in-hydrogen-exchange-mass-spectrometry-measurements ... www.readbyqxmd.com/read/29182876/solid-state-hydrogen-deuterium-exchange-mass-spectrometry-correlation-of-deuterium-uptake-and- ... Hydrogen/deuterium exchange (HDX) mass spectrometry (MS) reports on backbone H-bond fluctuations. HDX/MS therefore represents a ...
  https://www.readbyqxmd.com/keyword/61452
*  Influence of Viscosity in Fluid Atomization with Surface Acoustic Waves
Digital Microfluidics Combined with Surface Acoustic Wave Nebulization for Hydrogen-Deuterium Exchange Measurements. Journal of ... Our measurements show a linear decrease of the static contact angle on the sputter- deposited SiO2 surface with increasing ... An extraction unit was used to collect the aerosol above the measurement spot in order to prohibit fluid condensation on the ... The measurement point density used here was 2.1 points/wavelength in y-direction and 500 µm in x-direction. Fluid contact ...
  http://www.scirp.org/Journal/PaperInformation.aspx?paperID=71077
*  Super Spy variants implicate flexibility in chaperone action | eLife
Crosslinking and hydrogen-deuterium exchange measurements suggest that this hydrophobic region is involved in client protein ... Hydrogen-deuterium exchange. Hydrogen-deuterium exchange of Spy and Spy-Im7 complex was performed using top-down ECD-FTICR-MS, ... Hydrogen-deuterium exchange identifies Spy residues involved in client binding. Hydrogen-deuterium exchange at individual ... To ascertain the effects of client protein binding on deuterium exchange, we compared the level of hydrogen-deuterium exchange ...
  https://elifesciences.org/articles/01584
*  Faculty Collaboration Database - Brian Smith PhD
Deuterium Exchange Measurement. *Enzyme Activators. *Enzyme Inhibitors. *Enzymes and Coenzymes. *Histone Code ...
  https://fcd.mcw.edu/?module=faculty&func=view&name=Brian_Smith_PhD&id=5575
*  MS Wil GmbH - Deurion SAWN interface
... digital microfluidics combined with surface acoustic wave nebulization for hydrogen-deuterium exchange measurements. J ...
  https://www.mswil.com/sawn
*  Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New...
... amide deuterium exchange measurements and collisional cross sectional areas of molecules from ion mobility mass spectrometry ... Amide H/D exchange mass spectrometry shows that apo RA is highly dynamic and highlights clear differences in deuterium exchange ... All reported deuterium exchange values were corrected for a 32.7% back exchange by multiplying the raw centroid values by a ... This is completely consistent from both amide exchange and x-ray crystallography, whereby increased deuterium exchange together ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3047156/
*  Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis. - PubMed - NCBI
Deuterium Exchange Measurement. *Humans. *Mass Spectrometry. *Metals/metabolism. *Mutation/genetics. *Superoxide Dismutase/ ... Global H/D exchange kinetics of WT and A4V apo-SOD1S-S under native and nonnative conditions. (A) H/D exchange kinetics for A4V ... The H/D exchange properties of the mutants were also wide-ranging: the MBR mutant apoproteins exhibited H/D exchange kinetics ... The results of H/D exchange compared with those of DSC for 12 ALS mutant SOD1S-S apoproteins. TMs as determined by DSC are ...
  https://www.ncbi.nlm.nih.gov/pubmed/16020530
*  Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but...
The antigenic regions targeted by the two mAbs were accurately mapped by hydrogen-deuterium exchange mass spectrometry (HDX-MS ... Deuterium Exchange Measurement, Epitope Mapping, Epitopes, Genetic Variation, Humans, Mass Spectrometry, Meningococcal ... The antigenic regions targeted by the two mAbs were accurately mapped by hydrogen-deuterium exchange mass spectrometry (HDX-MS ... MenB vaccine, hydrogen/deuterium exchange mass spectrometry, mAb synergy, meningococcal antigen, Antibodies, Monoclonal, ...
  https://www.neuroscience.ox.ac.uk/publications/445779
*  NMR paper NMR-detected hydrogen exchange and molecular dynamics simulations provide structural - BioNMR
NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion ... NMR-detected hydrogen-deuterium exchange measurements, and molecular dynamics simulations. The fibrils contain approximately 50 ... NMR-detected hydrogen exchange and molecular dynamics simulations provide structural NMR-detected hydrogen exchange and ... Related Articles NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril ...
  http://www.bionmr.com/forum/journal-club-9/nmr-detected-hydrogen-exchange-molecular-dynamics-simulations-provide-structural-10056/
*  ABI Elite ESI-QqTOF Mass Spectrometry System - Natalie Ahn
It is also used extensively for proteomics applications, including hydrogen-deuterium exchange measurements to map protein- ... mass spectrometer capable of rapid scanning and high accuracy mass measurements, and a Waters ultra-high pressure liquid ...
  http://grantome.com/grant/NIH/S10-RR026641-01
*  Publikationen | Max-Planck-Institut für biophysikalische Chemie
Chevelkov, V.; Giller, K.; Becker, S.; Lange, A.: Measurement of backbone hydrogen-deuterium exchange in the type III secretion ...
  http://www.mpibpc.mpg.de/publikationen?seite=3
*  Protein & RNA Folding and Methods development - IBS - Institut de Biologie Structurale - Grenoble / France
... or the measurement of fast hydrogen-deuterium exchange rates in partially unstructured native states or molten globular states ... However, multidimensional NMR requires long measurement times that are exponentially increasing with the dimensionality of the ...
  http://www.ibs.fr/research/research-groups/biomolecular-nmr-spectroscopy-group-paul-schanda/team-protein-folding-and-methods/article/protein-rna-folding-and-methods?lang=en
*  Department of Chemistry : News Archive - Durham University
... which involved pKa measurements of around 20 triazolium ions from the kinetics of deuterium exchange. Triazolium ions are used ... to establish a PhD student exchange program with a consortium of South African universities, coordinated by the University of ... electrostatic potential in order to allow the user to evaluate local as well as global changes caused by the residues exchange ... determination of the collision properties of ground-state molecules in a fully state-selective way with precision measurements ...
  https://www.dur.ac.uk/chemistry/news/news_archive/
*  Localizing Carbohydrate Binding Sites in Proteins Using Hydrogen/Deuterium Exchange Mass Spectrometry | SpringerLink
The application of hydrogen/deuterium exchange mass spectrometry (HDX-MS) to localize ligand binding sites in carbohydrate- ... Time-resolved HDX-MS measurements were performed on the free and ligand-bound forms of CTB5, Stx1B5, and TcdA-A2. A summary of ... Peptide-column interactions and their influence on back exchange rates in hydrogen/deuterium exchange-MS. J. Am. Soc. Mass ... Hamuro, Y., Coales, S.J., Morrow, J.A., Molnar, K.S., Tuske, S.J., Southern, M.R., Griffin, P.R.: Hydrogen/deuterium-exchange ( ...
  https://link.springer.com/article/10.1007%2Fs13361-015-1263-2
*  Hydrogen-deuterium exchange - Wikipedia
"Electron transfer dissociation facilitates the measurement of deuterium incorporation into selectively labeled peptides with ... deuterium exchange mass spectrometry can determine the overall deuterium content of molecules which have undergone H/D exchange ... Hydrogen-deuterium exchange (also called H-D or H/D exchange) is a chemical reaction in which a covalently bonded hydrogen atom ... Undesired deuterium-hydrogen exchange is referred to as back-exchange and various methods have been devised to correct for this ...
  https://en.wikipedia.org/wiki/Hydrogen%E2%80%93deuterium_exchange
*  Proteins and Peptides: Higher-Order Structures - Fundamentals of Contemporary Mass Spectrometry - Dass - Wiley Online Library
ion mobility measurements and protein conformational changes;. *CSD in ESI mass spectrum and hydrogen-deuterium isotopic ... Hydrogen-Deuterium Exchange to Study Conformational States of Proteins. * Chemical Cross-Linking as a Probe for the Three- ...
  http://onlinelibrary.wiley.com/doi/10.1002/9780470118498.ch10/summary
*  Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry...
The propeptide interactions with the base of the hexons concur with recent hydrogen-deuterium exchange mass spectrometry ... studies (18) as well as with affinity measurements between VI and the hexon (32). Moreover, although it was not reported by Liu ... in agreement with recent interpretations from hydrogen-deuterium exchange mass spectrometry studies (18). ...
  http://www.pnas.org/content/111/32/11715
*  Dietary Cholesterol Feeding Suppresses Human Cholesterol Synthesis Measured by Deuterium Incorporation and Urinary Mevalonic...
4) The flux of sterol from the free-exchange pool is small during the measurement period.29 In contrast, determination of the ... Deuterium incorporation relies on several assumptions: (1) Newly synthesized cholesterol enters the larger, free-exchange ... Deuterium Incorporation Methodology. Incorporation of deuterium into erythrocyte free cholesterol was determined by sequential ... During the final week of each diet, 0.7 g D2O was given per kilogram of body water and deuterium incorporation into the ...
  http://atvb.ahajournals.org/content/16/10/1222.long
*  ORBi: Browsing ORBi
With this aim, we will use pulse-labelling hydrogen/deuterium exchange experiments, in combination with 2D-NMR measurements, to ... Here we report the backbone resonance assignments as the requirement for further hydrogen/deuterium exchange studies. [less ▲] ... Circular dichroism measurements indicated that all five ficins were highly structured, both in term of secondary and tertiary ... D1 and D2 according to their sequence of elution from a cation-exchange chromatographic support. Following rapid fractionation ...
  http://orbi.ulg.ac.be/browse?type=author&value=Vandenameele,%20Julie%20p010795
*  Gas-phase hydrogen/deuterium exchange in a travelling wave ion guide for the examination of protein conformations
... the measurement of the kinetics of gas-phase chemistry such as proton transfer reactions 12-14 or hydrogen/deuterium exchange ( ... up to 10-20 deuteriums) isotopic exchange. As shown for the [M+10H]10+ and [M+11H]11+ charge states, however, the deuterium ... Gas-phase hydrogen/deuterium exchange in a travelling wave ion guide for the examination of protein conformations. Kasper D. ... S3 for the deuterium labeling of GFP in the source TWIG). A likely explanation is the interference to the exchange process of ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2794942/
*  Hydrogen isotope biogeochemistry - Wikipedia
Their ratios represent an exchange factor that can calibrate measurements to correct for hydrogen and deuterium swapping. For ... This rapid exchange is particularly problematic for measurements of bulk organic material with these functional groups because ... This enables the measurements of quadrupolar doublets for each nonequivalent deuterium atom. Thus reduces peak overlaps and ... Analyzing deuterium content at the compound level avoids problems from differences in exchange rates, simplifies sources and ...
  https://en.wikipedia.org/wiki/Hydrogen_isotope_biogeochemistry
*  In the Beginning: Compelling Evidence for Creation and the Flood - References and Notes
Only after the measurements are announced are the technicians making the measurements told the history of any specimen. Subtle ... One out of every 6,400 hydrogen atoms in our oceans is heavy hydrogen (2H, called deuterium). Each fast neutron thermalized by ... No one should think that all scientists are unbiased and freely exchange data and information. Some even suppress information ... "Optical measurements of the beryllium and boron abundances in halo stars have been achieved by the 10 meter KECK telescope and ...
  https://creationscience.com/onlinebook/Radioactivity7.html
*  Publikationen | Max-Planck-Institut für biophysikalische Chemie
... and tertiary structural changes of cytochrome c in complexes with anionic lipids using amide hydrogen exchange measurements: an ... studied by deuterium and phosphorus-31 NMR spectroscopy. Biochemistry 32 (37), S. 9709 - 9713 (1993) ... Marsh, D.: Progressive saturation and saturation transfer ESR for measuring exchange processes of spin labeled lipids and ... Walter, N.; Steiner, C.: Fast chemiluminescent measurement of RNA polymerase activity based on photon counting technology. ...
  https://www.mpibpc.mpg.de/publikationen?year=1993