Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes | Journal of Cell Biology | Rockefeller University...
Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes Desmosomal cadherins utilize distinct kinesins for ... Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes Oxana E. Nekrasova, Oxana E. Nekrasova ... Desmosomal cadherins utilize distinct kinesins for assembly into desmosomes. J Cell Biol 24 June 2013; 201 (7): 1085. doi: ...
DSC1 - Wikipedia
2000). "Clustered cadherin genes: a sequence-ready contig for the desmosomal cadherin locus on human chromosome 18". Genomics. ... 2001). "Assembly of desmosomal cadherins into desmosomes is isoform dependent". J. Invest. Dermatol. 117 (1): 26-35. doi: ... Garrod DR, Merritt AJ, Nie Z (2003). "Desmosomal cadherins". Curr. Opin. Cell Biol. 14 (5): 537-45. doi:10.1016/S0955-0674(02) ... Jun 1993). "Nomenclature of the desmosomal cadherins". J Cell Biol. 121 (3): 481-3. doi:10.1083/jcb.121.3.481. PMC 2119574. ...
Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to...
Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of ... To our knowledge, we are the first to report that misexpression of a desmosomal cadherin in the epidermis affects ... Desmosomal cadherin misexpression alters beta-catenin stability and epidermal differentiation. Mol. Cell. Biol. ... Direct Ca2+ dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell ...
Hidradenitis Suppurativa: Practice Essentials, Background, Pathophysiology
Immunochemistry for various cytokeratins and 6 desmosomal cadherins (ie, desmogleins [Dsgs] 1-3, desmocollins [Dscs] 1-3) ...
Striate palmoplantar keratoderma
Characterization of the desmosomal cadherin gene family: genomic organization of two desmoglein genes on human chromosome 18q12 ... Localization of a locus for the striated form of palmoplantar keratoderma to chromosome 18q near the desmosomal cadherin gene ... They belong to the desmosomal cadherin superfamily. Several mutations in the desmoglein 1 gene have been identified as the ... Amino-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma. ...
The Lifestory Of A Cadherin - 1234 Words | Ostatic
Affected individuals make antibodiesagainst one of their own desmosomal cadherin proteins. These antibodies bindto and disrupt ... More like The Lifestory Of A Cadherin Assignment. Essay On A History Of The Beatles. 2530 words - 11 pages ... Probably the ... The Lifestory Of A Cadherin. 1234 words - 5 pages Anchoring junctions occur in two functionally different forms:Adherens ... Anti-cadherin antibodies that block theformation of adherens junctions, for example, also block the formation of tightjunctions ...
SMART: ARM domain annotation
Interction of plakoglobin and beta-catenin with desmosomal cadherins. 3knd. TPX2:importin-alpha complex. ... Crystal structure of p120 catenin in complex with E-cadherin. 3l6y. Crystal structure of p120 catenin in complex with E- ... In plakoglobin arm repeats bind alpha-catenin and N-cadherin.. Interpro abstract (IPR000225):. The armadillo (Arm) repeat is an ... Cadherins are calcium-dependent, cell surface glycoproteins involved in cell-cell adhesion. To function in cell-cell adhesion, ...
SMART: ARM domain annotation
Interction of plakoglobin and beta-catenin with desmosomal cadherins. 3knd. TPX2:importin-alpha complex. ... Crystal structure of p120 catenin in complex with E-cadherin. 3l6y. Crystal structure of p120 catenin in complex with E- ... In plakoglobin arm repeats bind alpha-catenin and N-cadherin.. Interpro abstract (IPR000225):. The armadillo (Arm) repeat is an ... Cadherins are calcium-dependent, cell surface glycoproteins involved in cell-cell adhesion. To function in cell-cell adhesion, ...
Pemphigus foliaceus
These autoantibodies are directed against the desmosomal cadherin desmoglein 1, a 160-kd glycoprotein. ... The 85 kD protein is the adherence junction molecule plakoglobin while the 160 kD protein is desmoglein I, a desmosomal core ... In the cases of EPF, even though the desmosomal changes occurred in all epithelial layers, blisters did not occur in the ...
JCI - Desmosomal COP9 regulates proteome degradation in arrhythmogenic right ventricular dysplasia/cardiomyopathy
Human desmosomal mutations associated with ARVD/C affect CSN6 localization. (A-G) Immunofluorescence staining of N-cadherin ( ... Loss of desmosomal proteome degradation control due to CSN6 loss is sufficient to trigger the desmosomal-targeted disease ARVD/ ... CSN6 loss accelerated desmosomal protein complex destruction, as Csn6 knockout hearts displayed selective loss of desmosomal ... Human desmosomal mutations destabilizing CSN6 are sufficient to trigger the desmosomal targeted disease ARVD/C. To precisely ...
Protocadherin 20 maintains intestinal barrier function to protect against Crohn's disease by targeting ATF6 | Genome Biology |...
We identify the cadherin superfamily member protocadherin 20 (PCDH20) as a crucial factor in Crohns disease. Here we describe ... Cadherin superfamilies include classical cadherins, protocadherins (PCDHs), and desmosomal cadherins [9]. Moreover, cadherins ... To identify key cadherins involved in CD pathogenesis, colonic mucosa from 10 pairs of CD patients and healthy donors were ... We identify the cadherin superfamily member protocadherin 20 (PCDH20) as a crucial factor in Crohns disease. Here we describe ...
Systems biology approaches to cervical pre-cancer and cancer | SYSTEMCERV | Project | News & Multimedia | FP7 | CORDIS |...
DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon | Nature Communications
... characterized by low expression of desmosomal β-catenin and E-cadherin42,43 as well as to a more penetrable mucus layer44. ... Expression of catenins and E-cadherin during epithelial restitution in inflammatory bowel disease. J. Pathol. 185, 413-418 ( ... Mehta, S., Nijhuis, A., Kumagai, T., Lindsay, J. & Silver, A. Defects in the adherens junction complex (E-cadherin/ β-catenin) ... We found that during chronic inflammation, the levels of transcripts encoding the adherens junctional proteins E-cadherin (Cdh1 ...
Description: Characterization of cellular and humoral immune responses in pemphigus patients and an HLA-transgenic mouse model ...
... mainly target the desmosomal cadherins Desmoglein 3 (Dsg3) and Dsg1 within the epidermis. This process, referred to as ... mainly target the desmosomal cadherins Desmoglein 3 (Dsg3) and Dsg1 within the epidermis. This process, refe... ...
Sara Stahley - Fingerprint - Penn State
Naegeli-Franceschetti-Jadassohn Syndrome: Background, Pathophysiology, Etiology
Purchase Cialis , Online Drugstore. - Irish Kidney Association
PKP2 Polyclonal Antibody (PA5-66048)
Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function ... Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate ... Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. ... cadherin binding involved in cell-cell adhesion ...
Nirk Quispe Calla, MD's Profile | Stanford Profiles
DeCS
Acrokeratosis verruciformis - Altmeyers Encyclopedia - Department Dermatology
A case of pemphigus vulgaris showing reactivity with pemphigus antigens (Dsg1 and Dsg3) and desmocolliins<...
... are members of the desmoglein subfamily of the cadherin supergene family. Another desmosomal cadherin, desmocollin, is ... are members of the desmoglein subfamily of the cadherin supergene family. Another desmosomal cadherin, desmocollin, is ... are members of the desmoglein subfamily of the cadherin supergene family. Another desmosomal cadherin, desmocollin, is ... are members of the desmoglein subfamily of the cadherin supergene family. Another desmosomal cadherin, desmocollin, is ...
Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis | Oncotarget
While the authors did not examine the protein levels and distribution of E-cadherin, α/β-catenin or desmosomal cadherins, they ... while E-cadherin expression downregulated N-cadherin and, plakoglobin expression increased N-cadherin levels and stability [29 ... Classical and desmosomal cadherins at a glance. J Cell Sci. 2012; 125:2547-52. doi: 10.1242/jcs.066654. ... Mathur M, Goodwin L, Cowin P. Interactions of the cytoplasmic domain of the desmosomal cadherin Dsg1 with plakoglobin. J Biol ...
Búsqueda | BVS Bolivia
Desmosomal cadherins are essential cell adhesion molecules expressed in the epidermis. We identified a mutation of a cadherin ...
Re-evaluation of the myoepithelial cells roles in the breast cancer progression | Cancer Cell International | Full Text
Using specific peptides targeting the desmosomal cadherins yielded in ablation of alveologenesis, ductal tree formation, and ... and cadherins (P-cadherin) with other various cellular junction proteins [2, 4]. Cadherins are adherents junctional proteins ... suppression of specific desmosomal cadherins produced exclusively by MECs such as desmocollin 3 (Dsc 3) and desmoglein 3 (Dsg 3 ... P-cadherin in the mammary gland is exclusively expressed by the MECs that line both ductal and alveolar compartments. Lack of P ...
anti-Homo sapiens (Human) DSG2 Antibody, FITC conjugated raised in Rabbit - Cusabio
Specific desmosomal cadherins contribute differently to keratinocyte cohesion and that Dsg2 compared to Dsg3 is less important ... DSG2: a Vital Member of Desmosomal Cadherin Family, an Exciting New Target for Cardiomyopathy, Adenovirus, and Tumors! The ... Gal3 has a role in stabilizing desmoglein-2, a desmosomal cadherin, and intercellular adhesion in intestinal epithelial cells ... Modulation of the palmitoylation status of desmosomal cadherins can affect desmosome dynamics. PMID: 27703000 ...
Mouse VE-Cadherin Alexa Fluor® 405-conjugated Antibody (FAB1002V) | Bio-Techne
View Mouse VE-Cadherin Alexa Fluor® 405-conjugated Antibody (FAB1002V) validated in Mouse & Flow Cytometry from R&D Systems. ... and desmosomal-related cadherins (1-3). VE-Cadherin (vascular endothelial cadherin; also cadherin-5 and CD144) is a 125 kDa ... Mouse VE-Cadherin ECR is 92%, 77%, and 73% aa identical to rat, human and porcine VE-Cadherin ECR, respectively. VE-Cadherin is ... rhN-Cadherin, recombinant mouse (rm) E-Cadherin, or rmP-Cadherin is observed. ...
Mutagenetix > Incidental...
Plakophilin 3 Monoclonal Antibody [7F6] - ImmuQuest
Pemphigus as a paradigm of autoimmunity and cell adhesion<...
Identification of the target antigens has redefined pemphigus as an autoimmune disease against desmosomal cadherin or ... Identification of the target antigens has redefined pemphigus as an autoimmune disease against desmosomal cadherin or ... Identification of the target antigens has redefined pemphigus as an autoimmune disease against desmosomal cadherin or ... Identification of the target antigens has redefined pemphigus as an autoimmune disease against desmosomal cadherin or ...