*  Desmosine | definition of desmosine by Medical dictionary
... desmosine explanation free. What is desmosine? Meaning of desmosine medical term. What does desmosine mean? ... Looking for online definition of desmosine in the Medical Dictionary? ... Non-denatured collagen, elastin and hyaluronic acid (HA), along with the elastin building blocks desmosine and iso-desmosine, ... Desmosine , definition of desmosine by Medical dictionary https://medical-dictionary.thefreedictionary.com/desmosine ...
  http://medical-dictionary.thefreedictionary.com/desmosine
*  Desmosine - Wikipedia
Desmosine causes a yellow color. Millipore product catalogue, purified desmosine "Archived copy". Archived from the original on ... A desmosine cross-link is formed from three allysyl side chains plus one unaltered lysyl side chain from the same or ... Detection of desmosine in urine, plasma or sputum samples can be a marker for elastin breakdown due to high elastase activity ... Ma, S; Turino, G. M.; Lin, Y. Y. (2011). "Quantitation of desmosine and isodesmosine in urine, plasma, and sputum by LC-MS/MS ...
  https://en.wikipedia.org/wiki/Desmosine
*  Steroid modulation of cytokine release and desmosine levels in bilateral total knee replacement: a prospective, double-blind,...
Urinary desmosine levels were obtained at baseline and at one and three days postoperatively. The level of IL-6 was measured at ... Desmosine / analysis, metabolism*. Dose-Response Relationship, Drug. Drug Administration Schedule. Female. Follow-Up Studies. ... The significantly lower values of desmosine in the study group suggest that this treatment may be protective against lung ... 23097096 - Steroid modulation of cytokine release and desmosine levels in bilateral total knee rep.... 19194836 - Effect of ...
  http://www.biomedsearch.com/nih/Steroid-Modulation-Cytokine-Release-Desmosine/23097096.html
*  Impaired Fibrillin-1 Function Promotes Features of Plaque Instability in Apolipoprotein E-Deficient Mice | Circulation
Determination of Desmosine and Isodesmosine. The desmosine and isodesmosine content of aortic segments of ApoE−/− and ApoE−/− ... as shown by the decrease in the content of desmosine and isodesmosine (Table I in the online-only Data Supplement). The ...
  http://circ.ahajournals.org/content/120/24/2478
*  A Pathophysiologic Approach to Biomarkers in Acute Respiratory Distress Syndrome
Elastin/Desmosine. Elastin is another critical protein of the ECM that gives the lung its elastic recoil ability. In adults, ... D. E. McClintock, B. Starcher, M. D. Eisner et al., "Higher urine desmosine levels are associated with mortality in patients ... Elastin breakdown results in smaller fragments containing desmosine and isodesmosine [155]. In a large study of 579 patients ... with ARDS, those ventilated with lower tidal volumes had lower urine desmosine levels, a finding that may reflect reduced ...
  https://www.hindawi.com/journals/dm/2016/3501373/
*  Application # 2012/0035268. SPHINGO-GUANIDINES AND THEIR USE AS INHIBITORS OF SPHINGOSINE KINASE - Patents.com
... desmosine; 2,2'-diaminopimelic acid; 2,3-diaminopropionic acid; N-ethylglycine; N-ethylasparagine; hydroxylysine; allo- ...
  http://patents.com/us-20120035268.html
*  MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized,...
However, in a subset of treated patients with a short disease duration, the level of urinary desmosine dropped significantly ... Nevertheless, a subset of treated patients with fairly short disease duration showed a post-treatment reduction of desmosine ... was checked by a pretreatment/postreatment evaluation of levels of plasma elastin-derived peptides and urinary desmosine. There ... Desmosine as a biomarker of elastin degradation in COPD: current status and future directions.. *M Luisetti, S Ma, +6 authors G ...
  https://www.semanticscholar.org/paper/MR889%2C-a-neutrophil-elastase-inhibitor%2C-in-patients-Luisetti-Sturani/2747a6c2b89a828eec4c68c3d1de16f276db364b
*  Search of: 'alpha-1 antitrypsin deficiency' - List Results - ClinicalTrials.gov
Measurement of sputum, plasma and urine concentrations of desmosine and isodesmosine. *Assessment of pulmonary function tests ...
  https://clinicaltrials.gov/ct2/results?cond=%22alpha-1+antitrypsin+deficiency%22&show_rss=Y
*  Richard Bland | Stanford Medicine Profiles
Postmortem lung desmosine content was increased significantly in the 20 breaths/min group. Tropoelastin mRNA expression was ... urine desmosine doubled), TGF-β activation (pSmad-2 tripled), and apoptosis (cleaved-caspase-3 increased 10-fold). Quantitative ...
  https://med.stanford.edu/profiles/richard-bland
*  Exacerbations of chronic obstructive pulmonary disease | European Respiratory Society
Fiorenza D, Viglio S, Lupi A, et al. Urinary desmosine excretion in acute exacerbations of COPD: a preliminary report. Respir ... This is consistent with an increase in urinary desmosine, which is an indicator of elastolysis 43. This may provide a causal ...
  http://erj.ersjournals.com/content/29/6/1224.long
*  Physical Exercise, Aortic Blood Pressure, and Aortic Wall Elasticity and Composition in Rats | Hypertension
Giummelly P, Botton B, Friot R, Prima-Putra D, Atkinson J. Measurement of desmosine and isodesmosine by capillary zone ... and the aortic wall content of the elastin-specific cross-linking amino acids desmosine and isodesmosine (μg/g aortic wet wt) ... Physical training had no effect on aortic calcium or desmosine-plus-isodesmosine content. Neither cardiac nor left ventricular ...
  http://hyper.ahajournals.org/content/35/4/919
*  Protocols and Video Articles Authored by Gabriele Grunig (Translated to Korean)
... desmosine 및 isodesmosine) P ,.05. 이전 연구에서 aerosolized 하는 탄성 섬유를 우대 바인딩 그것은 부상에서 그들을 보호할 수 있습니다 제안 보였다. 이러한 연구 결과 폐 기종에 대 한 치료로 ...
  https://www.jove.com/author/Gabriele_Grunig?language=Korean
*  Mechanisms, Pathophysiology, and Therapy of Arterial Stiffness | Arteriosclerosis, Thrombosis, and Vascular Biology
Elastin molecules are also stabilized by cross-linking (by LOX) to form desmosine and isodesmosine. Disruption of these cross- ...
  http://atvb.ahajournals.org/content/25/5/932.long
*  Connective Tissue Flashcards by Mary Miller | Brainscape
They're held together by four Lys molecules of diff elastin chains form covalent bonds with each other and form desmosine ...
  https://www.brainscape.com/flashcards/connective-tissue-4198078/packs/6207546
*  WikiGenes - Artifacts
Desmosine and isodesmosine as cross-links in the hinge-ligament protein of bivalves. 3,3'-Methylenebistyrosine as an artefact. ...
  https://www.wikigenes.org/e/mesh/e/11377.html
*  Protein primary structure - Wikipedia
Other crosslinks include desmosine. The chiral centers of a polypeptide chain can undergo racemization. Although it does not ...
  https://en.wikipedia.org/wiki/Protein_primary_structure
*  Collagen Cross-Linking | SpringerLink
Heathcote, J. G., Eyre, D. R., and Gross, J., 1982, Mature bovine Descemet's membrane contains desmosine and isodesmosine, ...
  https://link.springer.com/chapter/10.1007/978-1-4684-7636-1_5
*  Hepatic Fibrosis and Cirrhosis | SpringerLink
Velebny V, Kasafirek E, Kanta J. Desmosine and isodesmosine contents and elastase activity in normal and cirrhotic rat liver. ...
  https://link.springer.com/chapter/10.1007/978-1-4419-7107-4_30
*  Vitamin K deficiency: the linking pin between COPD and cardiovascular diseases? (pdf) | Paperity
Circulating desmosine levels do not predict emphysema progression but are associated with cardiovascular risk and mortality in ... COPD; Cardiovascular diseases; Desmosine; Elastin; Matrix Gla protein; Vascular calcification; Vitamin K; Vitamin K antagonists ... Desmosine and isodesmosine (DES) are two amino acids that are only present in crosslinked elastin fibers, and plasma DES levels ... Desmosine and isodesmosine; dp-uc: Desphospho-uncarboxylated (i.e. inactive); KH2: Vitamin K hydroquinone; KO: Vitamin K ...
  http://paperity.org/p/85331771/vitamin-k-deficiency-the-linking-pin-between-copd-and-cardiovascular-diseases
*  Systemic elastin degradation in chronic obstructive pulmonary disease | Thorax
Indeed, desmosine levels in the lung parenchyma are similar in patients with severe COPD and healthy donor lungs.49 Future ... but our protein extraction methods were suitable to extract MMPs and not the relatively insoluble desmosine/isodesmosine from ... studies could specifically assess desmosine levels, its relationship with elastin degradation and its prospective use as a ...
  http://thorax.bmj.com/content/67/7/606
*  FLS Flashcards - Cram.com
Study Flashcards On FLS at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
  http://www.cram.com/flashcards/fls-512298
*  Protocols and Video Articles Authored by Gabriele Grunig (Translated to Danish)
... desmosine and isodesmosine) in bronchoalveolar lavage fluid (0.3 versus 7.0 ng/mL; P < .05). As in previous studies, the ...
  https://www.jove.com/author/Gabriele_Grunig?language=Danish
*  Diagnostics | Free Full-Text | TD-GC-MS Investigation of the VOCs Released from Blood Plasma of Dogs with Cancer | HTML
Ma, S.; Turino, G.M.; Lin, Y.Y. Quantitation of desmosine and isodesmosine in urine, plasma, and sputum by LC-MS/MS as ...
  http://www.mdpi.com/2075-4418/3/1/68/htm
*  Safety and Efficacy of Oral BAY85-8501 in Patients With Non-CF (Cystic Fibrosis) Bronchiectasis - Full Text View -...
Change From Baseline of Biomarkers in Urine at Days 14, 28, 56: Desmosine [ Time Frame: Baseline (Day 1), Day 14, 28 and 56 ]. ... Change From Baseline of Biomarkers in Urine at Days 14, 28, 56: Normalized Desmosine Value to Creatinine [ Time Frame: Baseline ...
  https://clinicaltrials.gov/ct2/show/NCT01818544?recr=Open&cond=%22Bronchiectasis%22&rank=20