Initiation of polyoma virus DNA synthesis : a mutational analysis
Initiation of polyoma virus DNA synthesis: a mutational analysis. Österlund, Mårten Uppsala University, Disciplinary Domain of ...http://uu.diva-portal.org/smash/record.jsf?pid=diva2:294505
Biology | Free Full-Text | A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G
... but none reveal how this enzyme binds to substrate single-stranded DNA. Here, we constructed a panel of APOBEC3G amino acid ... APOBEC3G is the best known of several DNA cytosine deaminases that function to inhibit the replication of parasitic genetic ... A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G. Keisuke Shindo †. ... "A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G." Biology 1, no. 2: 260-276. ...http://mdpi.com/2079-7737/1/2/260/xml
Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis - Zurich Open...
Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis ... Download PDF 'Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis'. ... Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis. Journal of ... Separating substrate recognition from base hydrolysis in human thymine DNA glycosylase by mutational analysis. Journal of ...https://www.zora.uzh.ch/id/eprint/34314/
Purdue e-Pubs - The Summer Undergraduate Research Fellowship (SURF) Symposium: Mutational Analysis of the Putative Dimer...
DNA methyltransferase 3a and 3b (Dnmt3a andDnmt3b) are two enzymes that establish this epigenetic modification during early ... We hypothesize that unlike Dnmt3a, Dnmt3b does not oligomerize and to test this hypothesis, we performed mutational analysis of ... DNA methylation is an epigenetic process involved in gene regulation that is key for cell differentiation and viability. ... crystal structure of Dnmt3a catalytic domain shows that it forms a tetramer and it was shown to methylate multiple sites on DNA ...https://docs.lib.purdue.edu/surf/2018/Presentations/128/
RNA Therapeutics - & related info | Mendeley
DNA Mutational Analysis. *DNA Replication Timing. *Drug Resistance. *Drug metabolism. *Drug resistance ...https://www.mendeley.com/research-papers/rna-therapeutics-1/
A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers.
DNA repair, cell-cycle checkpoints, and transcriptional regulation. BRCA1 germline mutations confer a high risk of early-onset ... DNA Mutational Analysis. DNA Repair-Deficiency Disorders. DNA, Neoplasm / analysis. Death-Associated Protein Kinases. Female. ... BRCA1 breast cancers displayed a mutational signature consistent with that caused by lack of HR DNA repair in both ER-positive ... Sequencing analysis of independent cohorts of hereditary BRCA1 and sporadic non-BRCA1 breast cancers for the presence of ...http://www.biomedsearch.com/nih/whole-genome-massively-parallel-sequencing/22362584.html
Mutational spectrum induced in Saccharomyces cerevisiae by the carcinogen N-2-acetylaminofluorene.
DNA Adducts. DNA Mutational Analysis. DNA, Fungal. Molecular Sequence Data. Mutagenicity Tests. Mutagens / toxicity*. Orotidine ... 0/DNA Adducts; 0/DNA, Fungal; 0/Mutagens; 53-96-3/2-Acetylaminofluorene; EC 220.127.116.11/Orotidine-5'-Phosphate Decarboxylase ... Sequence analysis of the URA3 mutants revealed approximately 48% frameshifts, approximately 44% base substitutions and ...http://www.biomedsearch.com/nih/Mutational-spectrum-induced-in-Saccharomyces/7845359.html
A general role of the DNA glycosylase Nth1 in the abasic sites cleavage step of base excision repair in Schizosaccharomyces...
One of the most frequent lesions formed in cellular DNA are abasic (apurinic/apyrimidinic, AP) sites that are both cytotoxic ... DNA Glycosylases / genetics, metabolism, physiology*. DNA Mutational Analysis. DNA Repair*. DNA-(Apurinic or Apyrimidinic Site ... phoshodiesterase or dRPase leaving a gap in DNA. The gap is filled by a DNA polymerase and the strand sealed by a DNA ligase. ... DNA glycosylase activities in cell extracts from S.pombe. (A) Cleavage of A/8oxoG-containing duplex DNA. An aliquot of 0.5 and ...http://www.biomedsearch.com/nih/general-role-DNA-glycosylase-Nth1/15452279.html
MYD88 | Cancer Genetics Web
To investigate the mutational profile of PCNSL, we analyzed nine paired tumor and germline DNA samples from PCNSL patients by ... Mutational analysis of primary central nervous system lymphoma.. Oncotarget. 2014; 5(13):5065-75 [PubMed] Article available ... Literature Analysis. Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about ... Analysis of BRAF and NRAS showed mutation frequencies of 4.8 and 9.5%, respectively. No MYD88 mutations could be detected in ...http://www.cancerindex.org/geneweb/MYD88.htm
EXTL1 | Cancer Genetics Web
... we performed 1p deletion analysis and mutation screening of the EXTL1-coding region on DNA from 22 primary neuroblastomas and ... Literature Analysis. Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about ... Mutation analysis of hereditary multiple exostoses in the Chinese.. Hum Genet. 1999 Jul-Aug; 105(1-2):45-50 [PubMed] Related ... Genetic analyses have revealed HME to be a multigenic disorder linked to three loci on chromosomes 8q24 (EXT1), 11p11-13 (EXT2 ...http://www.cancerindex.org/geneweb/EXTL1.htm
An overview of familial Mediterranean fever with emphasis on pyrin and colchicine.
DNA Mutational Analysis. Exons / genetics. Familial Mediterranean Fever / diagnosis, drug therapy*, genetics*. Genetics, ... 23051629 - Predictors of braf mutation in melanocytic nevi: analysis across regions with different.... 24440239 - Spectrum and ... 24148579 - Inherited common variants in mitochondrial dna and invasive serous epithelial ovarian c.... 23317199 - Association ... 1456289 - Familial mediterranean fever: analysis of inheritance and current linkage data.. 9713229 - Linear epidermolytic ...http://www.biomedsearch.com/nih/overview-familial-Mediterranean-fever-with/19534089.html
FGFR3, HRAS, KRAS, NRAS and PIK3CA mutations in bladder cancer and their potential as biomarkers for surveillance and therapy.
DNA Mutational Analysis. Disease-Free Survival. Female. Gene Frequency. Genetic Predisposition to Disease / genetics. Genotype ...http://www.biomedsearch.com/nih/Fgfr3-hras-kras-nras-pik3ca/21072204.html
VHL | Cancer Genetics Web
DNA Mutational Analysis. *Basic Helix-Loop-Helix Transcription Factors. *Single Nucleotide Polymorphism ... Literature Analysis. Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about ... Mutational status of VHL gene and its clinical importance in renal clear cell carcinoma.. Virchows Arch. 2014; 465(3):321-30 [ ... Genomic DNA was isolated from normal and tumor tissues of 19 renal cell carcinoma patients. The samples were screened for ...http://www.cancerindex.org/geneweb/VHL.htm
Laryngeal involvement in the Dowling-Meara variant of epidermolysis bullosa simplex with keratin mutations of severely...
DNA Mutational Analysis. Epidermolysis Bullosa Simplex / genetics*, pathology. Female. Humans. Infant, Newborn. Keratins / ... Molecular analysis confirmed the diagnosis by identification of mis-sense point mutations in basal cell keratin genes in both ...http://www.biomedsearch.com/nih/Laryngeal-involvement-in-Dowling-Meara/10730767.html
A genome-wide screen and linkage mapping for a large pedigree with episodic ataxia.
DNA Mutational Analysis. Diagnosis, Differential. Female. Genetic Markers / genetics*. Genetic Predisposition to Disease / ... Haplotype analysis and fine mapping yielded a peak 2-point lod score of 4.14 and indicated a 4-cM region on 1q42 that is likely ...http://www.biomedsearch.com/nih/genome-wide-screen-linkage-mapping/16009908.html
PRSS1 | Cancer Genetics Web
DNA Mutational Analysis. *VEGFA. *alpha-Fetoproteins. *Cystic Fibrosis Transmembrane Conductance Regulator. Tag cloud generated ... Multiple single SNP analyses showed associations, which will require replication. Exploratory pathway analyses by recursive ... Association studies were done at the gene level by principal components analysis, whereas recursive partitioning analysis was ... A case-control analysis revealed a 0.118-fold (95% CI: 0.037-0.653), 0.842-fold (95% CI: 0.177-4.010), and 0.750-fold (95% CI: ...http://www.cancerindex.org/geneweb/PRSS1.htm
Molecular analysis of the PROP1 and HESX1 genes in patients with septo-optic dysplasia and/or pituitary hormone deficiency
Keywords: DNA mutational analysis; septo-optic dysplasia; pituitary hormonal deficiency. RESUMO. OBJETIVO: O presente estudo ... Analysis of the HESX1 gene was performed using genomic DNA isolated from peripheral blood leukocytes. Exons 1, 2, 3 and 4 were ... Analysis of the PROP1 gene was performed using genomic DNA isolated from peripheral blood leukocytes. Exons 1, 2 and 3 were ... Sequence analysis. All the exons of the HESX1 gene were amplified at the expected sizes. In the SOD patient group, sequence ...http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000500009&lng=en&tlng=en
Mutations in the UBIAD1 gene, encoding a potential prenyltransferase, are causal for Schnyder crystalline corneal dystrophy.
DNA Mutational Analysis. Dimethylallyltranstransferase / chemistry, genetics*, metabolism. Female. Genetic Linkage. Genotype. ... To facilitate phase determination during subsequent haplotype analysis, we collected DNA specimens from as many family members ... We used the Oragene kits from DNA Genotek (Ottawa, Canada) for self-collection of salivary DNA (particularly in situations ... nor 59 Caucasian HapMap DNA samples (118 chromosomes), nor 89 Asian HapMap DNA samples (178 chromosomes), nor are any of these ...http://www.biomedsearch.com/nih/Mutations-in-UBIAD1-gene-encoding/17668063.html
FLT3 | Cancer Genetics Web
Mutational analysis of certain genes, such as SF3B1, is also becoming an important tool to distinguish subsets of MDS that have ... DNA for every AML patient was extracted and underwent PCR with FLT3-ITD primers.. RESULTS: The mean age at diagnosis was 28.5 ... with data confirmed by state-of-the-art analyses of internalization, cell biology, gene analysis for FLT3-IDT gene, and Western ... Molecular genetic analysis of CEBPA, NPM1, and FLT3 is already standard of care in patients with AML, and mutations in several ...http://www.cancerindex.org/geneweb/FLT3.htm
NPM1 | Cancer Genetics Web
Mutational analysis of certain genes, such as SF3B1, is also becoming an important tool to distinguish subsets of MDS that have ... We analyzed DNA samples from 20 childhood (cAML) and 20 adult AML (aAML) patients, using NGS targeted sequencing. The average ... Mutational analysis of JAK2, CBL, RUNX1, and NPM1 genes in familial aggregation of hematological malignancies.. Ann Hematol. ... Molecular genetic analysis of CEBPA, NPM1, and FLT3 is already standard of care in patients with AML, and mutations in several ...http://www.cancerindex.org/geneweb/NPM1.htm
R25C mutation in the NKX2.5 gene in Italian patients affected with non-syndromic and syndromic congenital heart disease.
DNA Mutational Analysis / methods. Dogs. Gene Frequency. Genetic Predisposition to Disease. Heart Defects, Congenital / ... and mutational analysis was performed using denaturing high performance liquid chromatography and DNA sequencing.. RESULTS: One ... The coding region and flanking regions involved in gene splicing of the CSX/NKX2.5 gene were amplified from genomic DNA by PCR ...http://www.biomedsearch.com/nih/R25C-mutation-in-NKX25-gene/22964646.html
The proportion of the carriers of less commonIL1B-511*T | Open-i
DNA Mutational Analysis. *Female. *Genetic Association Studies. *Humans. *Joint Prosthesis/adverse effects ... The results from a single locus analysis in IL1B gene were reflected also in a haplotype level: The IL1B −511/ +3962 TC ... The results from a single locus analysis in IL1B gene were reflected also in a haplotype level: The IL1B −511/ +3962 TC ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC3475038_1471-2172-13-25-2&req=4
A conserved tract of amino acids in transmembrane domai | Open-i
DNA Mutational Analysis. *Fluorescent Antibody Technique. *Humans. *Mice. *Models, Molecular. *Molecular Sequence Data ... Utilizing this model for structure-function analysis, we identified and characterized a gain-of-function mutant of FIT2 (FLL( ... Utilizing this model for structure-function analysis, we identified and characterized a gain-of-function mutant of FIT2 (FLL( ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2875400_pone.0010796.g003&req=4
BRCA1 | Cancer Genetics Web
All the coding exons and intron/exon boundaries of PALB2 were subjected to mutational analysis by heteroduplex analysis (HDA) ... damaged DNA binding - DNA binding - DNA damage response, signal transduction by p53 class mediator resulting in transcription ... Western blot protein analysis was used to assess response to treatment by using γH2AX to measure DNA damage and PAR to measure ... Western blot protein analysis showed that the addition of a PARP inhibitor adjuvant to radiation increases DNA damage in both ...http://www.cancerindex.org/geneweb/BRCA1.htm
The required memory (in Mb) to store all IBD matrices i | Open-i
DNA Mutational Analysis/methods*. *Quantitative Trait Loci/genetics*. *Sequence Analysis, DNA/methods* ... Our approaches provide immediately useful techniques for use in single QTL analyses in the variance component QTL mapping ... Our approaches provide immediately useful techniques for use in single QTL analyses in the variance component QTL mapping ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2194736_1471-2105-8-440-3&req=4