RCSB PDB - P0T Ligand Summary Page
Cytochrome P450 2C8. MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDI.... unknown. substrate,inhibitor. Cytochrome P450 2D6. ... Cytochrome P450 3A5. MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV.... unknown. substrate,inhibitor. Cytochrome P450 2A6. ... Cytochrome P450 3A5. MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV.... unknown. inhibitor. Cytochrome P450 2D6. ... Cytochrome P450 1A2. MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPL.... unknown. inhibitor. Cytochrome P450 3A7. ...
Effect of conjugated equine estrogens on oxidative metabolism in middle-aged and elderly postmenopausal women
CYP phenotype was characterized by caffeine (CYP1A2), chlorzoxazone (CYP2E1), dapsone (CYP, N-acetyltransfera … ... 0.625 mg daily on cytochrome P450 (CYP) were quantified in 12 middle-aged and 13 elderly postmenopausal women at baseline and 6 ... The effects of conjugated equine estrogens (CEE) 0.625 mg daily on cytochrome P450 (CYP) were quantified in 12 middle-aged and ... CEE significantly influenced CYP1A2, CYP2D6, and CYP-mediated dapsone oxidative metabolism but not CYP2C19, CYP2E1, or N- ...
WTS database | WHO FCTC
Cytochrome P-450-1A (CYP1A) is a major pathway activating carcinogens from tobacco smoke. Our primary aim was to compare CYP1A2 ... CYP1A2 activity was assessed as the caffeine metabolic ratio in plasma. One-day urine collection was used for determining ... CYP1A2 activity was greater (p,0.0001) in cigarette smokers (median: 0.61; interquartile range: 0.52-0.76) than in pipe or ... In multivariate analysis, cigarette smoking was the only independent predictor of CYP1A2 activity (p,0.0001) and of 1- ...
Trp-P-2
Summary Report | CureHunter
Cytochrome P-450 CYP1A2 (CYP1A2) 6. Aflatoxin B1 (Aflatoxin B) 7. Zoxazolamine ...
Cytochrome P-450 CYP1A1
- CYP1A1
Summary Report | CureHunter
A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and ... CYP1A2) 6. Tetrachlorodibenzodioxin (TCDD) 7. Estrogens (Estrogen) 8. DNA (Deoxyribonucleic Acid) ... Cytochromes: 1553*Cytochrome P-450 Enzyme System: 3623*Aryl Hydrocarbon Hydroxylases: 16*Cytochrome P-450 CYP1A1: 1575*estrogen ... Cytochromes: 1553*Cytochrome P-450 Enzyme System: 3623*Aryl Hydrocarbon Hydroxylases: 16*Cytochrome P-450 CYP1A1: 1575*estrogen ...
DailyMed - DOTTI- estradiol patch, extended release
In vitro and in vivo studies have shown that estrogens are metabolized partially by cytochrome P450 3A4 (CYP3A4). Therefore, ... These transformations take place mainly in the liver by Cytochrome 450 isoforms CYP1A2 and CYP3A4. Estradiol undergoes further ...
Flavin-containing monooxygenase 3 - Wikipedia
Only FMO3 formed 6-OH-MXAA at a similar rate to that in cDNA-expressed cytochromes P-450 (CYP)1A2. The results of this study ... indicate that human FMO3 has the capacity to form 6-OH-MXAA, but plays a lesser important role for this reaction than CYP1A2 ... cytochrome P450 and flavin monooxygenase. Cashman JR, Xiong YN, Xu L, Janowsky A (March 1999). "N-oxygenation of amphetamine ...
DailyMed - LANSOPRAZOLE tablet, orally disintegrating, delayed release
Lansoprazole is metabolized through the cytochrome P450 system, specifically through the CYP3A and CYP2C19 isozymes. Studies ... Theophylline: When lansoprazole was administered concomitantly with theophylline (CYP1A2, CYP3A), a minor increase (10%) in the ... These compounds are metabolized through various cytochrome P450 isozymes including CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A. ... have shown that lansoprazole does not have clinically significant interactions with other drugs metabolized by the cytochrome P ...
Frontiers | Gynura procumbens: An Overview of the Biological Activities
Ghofur, A., Hamid, I. S., and Listyorini, D. (2015). Anti-carcinogenic activity of Gynura procumbens extract through cytochrome ... CYP1A2, and CYP1A1 (Afandi et al., 2014; Ghofur et al., 2015). This inhibition may lead to a lower risk of cancer as it will ... The treatment with ethanolic extract caused a significant reduction in expression and activity of cytochrome P-450 enzymes such ... Antioxidant properties of Gynura procumbens extracts and their inhibitory effects on two major human recombinant cytochrome ...
RX List database - use generic or medication brand name - GlobalRPH
Drugs Affecting Cytochrome P-450 Enzymes. Ondansetron does not appear to induce or inhibit the cytochrome P-450 drug- ... CYP1A2), inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron [see ... In vitro metabolism studies have shown that ondansetron is a substrate for multiple human hepatic cytochrome P-450 enzymes, ... Because ondansetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes (CYP3A4, CYP2D6, ...
TOOLS | دانلود مقالات ISI TOOLS | 87 مقاله انگلیسی + ترجمه فارسی
Perinatal dioxin exposure, cytochrome P-450 activity, liver functions and thyroid hormones at follow-up after 7-12 years ... Cytochrome P450; DL-PCBs; Dioxin-like PCBs; PCB-I; Indicator PCBs; NDL-PCBs; Non-Dioxin-lik ...
Dong-Young Ryu - Citation Index - NCSU Libraries
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption - Fingerprint
- Research...
Zhiling YU - Research Output - Hong Kong Baptist University
Stereoselectivity in the oxidation of bufuralol, a chiral substrate, by human cytochrome P450s - Fingerprint - Okayama...
Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1A2(-/-)mouse - Fingerprint ...
Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1A2(-/-)mouse. ... cytochrome P-450 CYP2G1 26% * 3-(glutathion-S-yl)acetaminophen 22% * allyl sulfide 18% ... Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1A2(-/-)mouse. Together they ...
The Mechanism Underlying the Extreme Sensitivity of Duck to Aflatoxin B1
This review highlights significant advances in our understanding of the AFB,sub,1,/sub, metabolic activation, like cytochrome ... CYP1A2 metabolizes human hepatocytes at lower concentrations (0.133 μM AFB1), and at higher concentrations (256 μM AFB1), they ... S. X. Hu, "Effect of age on hepatic cytochrome P450 of Ross 708 broiler chickens," Poultry Science, vol. 92, no. 5, pp. 1283- ... As the livers dominant enzyme to metabolize AFB1, CYP1A2 can metabolize AFB1 into AFM1 and aflatoxin Q1 (AFQ1). CYP3A4 can ...
Effect of smoking and CYP2D6 polymorphisms on the extent of fluvoxamine-alprazolam interaction in patients with psychosomatic...
Purpose: Fluvoxamine (FVX) is metabolized by cytochrome P450 (CYP) 2D6 and CYP1A2 and inhibits CYP3A4. The aim of this study ... N2 - Purpose: Fluvoxamine (FVX) is metabolized by cytochrome P450 (CYP) 2D6 and CYP1A2 and inhibits CYP3A4. The aim of this ... AB - Purpose: Fluvoxamine (FVX) is metabolized by cytochrome P450 (CYP) 2D6 and CYP1A2 and inhibits CYP3A4. The aim of this ... abstract = "Purpose: Fluvoxamine (FVX) is metabolized by cytochrome P450 (CYP) 2D6 and CYP1A2 and inhibits CYP3A4. The aim of ...
Genome-wide association study identifies eight loci associated with blood pressure<...
CYP1A2 (P = 1 × 10 23), FGF5 (P = 1 × 10 21), SH2B3 (P = 3 × 10 18), MTHFR (P = 2 × 10 13), c10orf107 (P = 1 × 10 9), ZNF652 (P ... Cytochrome P-450 CYP1A2 Medicine & Life Sciences 13% * Computer Simulation Medicine & Life Sciences 10% ... CYP1A2 (P = 1 × 10 23), FGF5 (P = 1 × 10 21), SH2B3 (P = 3 × 10 18), MTHFR (P = 2 × 10 13), c10orf107 (P = 1 × 10 9), ZNF652 (P ... CYP1A2 (P = 1 × 10 23), FGF5 (P = 1 × 10 21), SH2B3 (P = 3 × 10 18), MTHFR (P = 2 × 10 13), c10orf107 (P = 1 × 10 9), ZNF652 (P ...
BESPONSA™ (inotuzumab ozogamicin) Warnings and Precautions | Pfizer Medical Information - US
Inter-individual variation in imatinib disposition: any role for prevalent variants of CYP1A2, CYP2C8, CYP2C9, and CYP3A5 in...
This study, hence, evaluated some other unstudied functionally significant polymorphisms in CYP1A2, CYP2C8, CYP2C9, and CYP3A5 ... Humans, Leukemia, Myeloid, Chronic-Phase, Cytochrome P-450 CYP1A2, Antineoplastic Agents, Prospective Studies, ... Inter-individual variation in imatinib disposition: any role for prevalent variants of CYP1A2, CYP2C8, CYP2C9, and CYP3A5 in ... Inter-individual variation in imatinib disposition: any role for prevalent variants of CYP1A2, CYP2C8, CYP2C9, and CYP3A5 in ...
Black Tea: MedlinePlus Supplements
Medications that decrease break down of other medications by the liver (Cytochrome P450 CYP1A2 (CYP1A2) inhibitors). Black tea ... has no impact on the pharmacokinetic profile of probe drugs for cytochrome P450 isoenzymes CYP3A4, CYP1A2, CYP2C9 and CYP2C19 ... an indication of melatonin metabolism by cytochrome P450(CYP)1A2. J.Endocrinol.Invest 2003;26:403-406. View abstract. ... Zheng, J., Chen, B., Jiang, B., Zeng, L., Tang, Z. R., Fan, L., and Zhou, H. H. The effects of puerarin on CYP2D6 and CYP1A2 ...
Amit Joshi, M.B.,B.S., Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
Forum - Nolvadex 10 mg Antiestrogens Nolvadex - Az SEASONS MAGAZINES ONLINE
Pharmacogenetics
Pharmacokinetic drug interactions of new antidepressants: A review of the effects on the metabolism of other drugs<...
The isoforms of the CYPs most relevant to the use of antidepressants are CYP1A2. CYP2C9, CYP2C19, CYP2D6, and CYP3A4. CYP ... Many of these drugs are potent inhibitors of the cytochrome P- 450 enzymes (CYPs) of the liver. The isoforms of the CYPs most ... The isoforms of the CYPs most relevant to the use of antidepressants are CYP1A2. CYP2C9, CYP2C19, CYP2D6, and CYP3A4. CYP ... The isoforms of the CYPs most relevant to the use of antidepressants are CYP1A2. CYP2C9, CYP2C19, CYP2D6, and CYP3A4. CYP ...
Recombinant Human CYP1A2, N-His - Order at ProteoGenix
Order Recombinant Human CYP1A2, N-His at ProteoGenix. ... Buy Recombinant Human CYP1A2, N-His in Escherichia coli (E.coli ... Hydroperoxy icosatetraenoate dehydratase, Cytochrome P450-P3, Cytochrome P450 4, CYP1A2, Cholesterol 25-hydroxylase, CYPIA2, ... Be the first to review "Recombinant Human CYP1A2, N-His" Cancel reply. Your email address will not be published. Required ...
Cytochrome P-450 CYP1B1 | Profiles RNS
"Cytochrome P-450 CYP1B1" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... A cytochrome P450 aryl hydrocarbon hydroxylase that has specificity for ESTROGENS which it converts into 4-hydroxy estrogens. ... This graph shows the total number of publications written about "Cytochrome P-450 CYP1B1" by people in this website by year, ... Below are the most recent publications written about "Cytochrome P-450 CYP1B1" by people in Profiles. ...
Ондантор : Uses, Side Effects, Interactions, Dosage / Pillintrip
In vitro metabolism studies have shown that ondansetron is a substrate for human hepatic cytochrome P- 450 enzymes, including ... CYP1A2), inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron. On the ... Ondansetron elimination may be affected by cytochrome P-450 inducers. In a pharmacokinetic study of 16 epileptic patients ... Because ondansetron is metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes (CYP3A4, CYP2D6, ...