*  Cadp-ribose - Alfa Chemistry
Cadp-ribose/ACM119340535 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and ... cyclic adenosine 5-diphosphoribose; Cyclic Adenosine Diphosphate Ribose; cADP-Ribose; Cyclic ADPR; cyclic ADP-D-ribose; E-NAD; ... Enzyme-activated NAD; cyclic adenosine 5-diphosphate ribose; cADPR; adenosine 5-cyclic-diphosphoribose; ...
  http://www.alfa-chemistry.com/cas_119340-53-5.htm
*  Quantification of intracellular levels of cyclic ADP-ribose by high-performance liquid chromatography. - Department of...
... method was developed for the analysis of endogenous levels of cyclic adenosine diphosphoribose (cADPR) in cell extracts. The ... Adenosine Diphosphate Ribose, Cell Line, Chromatography, High Pressure Liquid, Chromatography, Ion Exchange, Cyclic ADP-Ribose ... Quantification of intracellular levels of cyclic ADP-ribose by high-performance liquid chromatography. ... Quantification of intracellular levels of cyclic ADP-ribose by high-performance liquid chromatography. ...
  https://pharm.ox.ac.uk/publications/678637
*  Modulation of endoplasmic reticulum Ca2+ store filling by cyclic ADP-ribose promotes inositol trisphosphate (IP3)-evoked Ca2+...
... the second messenger cyclic ADP-ribose (cADPR) also accelerates the activity of SERCA pumps, which sequester Ca(2+) into the ER ... Modulation of endoplasmic reticulum Ca2+ store filling by cyclic ADP-ribose promotes inositol trisphosphate (IP3)-evoked Ca2+ ... Modulation of endoplasmic reticulum Ca2+ store filling by cyclic ADP-ribose promotes inositol trisphosphate (IP3)-evoked Ca2+ ... Animals, Calcium, Calcium Signaling, Cyclic ADP-Ribose, Cytosol, Electrochemistry, Endoplasmic Reticulum, Inositol 1,4,5- ...
  https://pharm.ox.ac.uk/publications/258442
*  Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives. - Department of Pharmacology
ADP-ribosyl cyclase weakly catabolised cADPR whereas NAD-glycohydrolase showed no such activity. In contrast, N1-cyclic inosine ... various alterations in the molecule ranging from substitutions at C8 of the base up to full replacement of the ribose moieties ... EXPERIMENTAL APPROACH: cADPR and the inosine-based analogues were incubated with CD38, ADP-ribosyl cyclase and NAD- ... hypoxanthine-cyclic pyrophosphate (N1-cIDP-DE) and N1-ethoxymethyl-cIDPR (N1-cIDPRE). In contrast, in primary T cells neither ...
  https://pharm.ox.ac.uk/publications/678625
*  Multiple Calcium Stores: Separate but Interacting | Science Signaling
... operated and cyclic ADP-ribose (cADPR)-operated calcium stores is discussed. Lee also addresses the role of NAADP in regulating ...
  http://stke.sciencemag.org/content/2000/40/pe1
*  Characterization of cyclic adenosine diphosphate-ribose-induced Ca2+ release in T lymphocyte cell lines. - Department of...
Recently, a metabolite of nicotinamide adenine dinucleotide+ (NAD+), termed 'cyclic adenosine diphosphate-ribose' (cADPr), has ... Cyclic GMP (cGMP)-induced Ca2+ release was also partly antagonized by ruthenium red, indicating involvement of a cGMP-dependent ... Adenosine Diphosphate Ribose, Calcium, Cell Line, Chromatography, High Pressure Liquid, Cyclic ADP-Ribose, Humans, Signal ... Characterization of cyclic adenosine diphosphate-ribose-induced Ca2+ release in T lymphocyte cell lines. ...
  https://pharm.ox.ac.uk/publications/678622
*  Ryanodine receptor subtype 2 encodes Ca2+ oscillations activated by acetylcholine via the M2 muscarinic receptor/cADP-ribose...
Prakash, Y. S., Kannan, M. S., Walseth, T. F. and Sieck, G. C. (1998). Role of cyclic ADP-ribose in the regulation of [Ca2+]i ... Ge, Z. D., Zhang, D. X., Chen, Y. F., Yi, F. X., Zou, A. P., Campbell, W. B. and Li, P. L. (2003). Cyclic ADP-ribose ... Lee, H. C. (2004). Multiplicity of Ca2+ messengers and Ca2+ stores: a perspective from cyclic ADP-ribose and NAADP. Curr. Mol. ... Bradley, K. N., Currie, S., MacMillan, D., Muir, T. C. and McCarron, J. G. (2003). Cyclic ADP-ribose increases Ca2+ removal in ...
  http://jcs.biologists.org/content/118/10/2261
*  7-Deaza-8-bromo-cyclic ADP-ribose, the first membrane-permeant, hydrolysis-resistant cyclic ADP-ribose antagonist. - Department...
Cyclic ADP-ribose (cADPR) is a putative second messenger that has been demonstrated to mobilize Ca2+ in many cell types. Its ... 7-Deaza-8-bromo-cyclic ADP-ribose, the first membrane-permeant, hydrolysis-resistant cyclic ADP-ribose antagonist. ... 7-Deaza-8-bromo-cyclic ADP-ribose, the first membrane-permeant, hydrolysis-resistant cyclic ADP-ribose antagonist. ... Adenosine Diphosphate Ribose, Animals, Calcium, Cyclic ADP-Ribose, Hydrolysis, Sea Urchins, Structure-Activity Relationship ...
  https://pharm.ox.ac.uk/publications/677863
*  A specific cyclic ADP-ribose antagonist inhibits cardiac excitation-contraction coupling. - Department of Pharmacology
Cyclic ADP-ribose (cADPR) has been shown to act as a potent cytosolic mediator in a variety of tissues, regulating the release ... Adenosine Diphosphate Ribose, Animals, Calcium, Calcium Channels, Cyclic ADP-Ribose, Guinea Pigs, Humans, In Vitro Techniques, ... A specific cyclic ADP-ribose antagonist inhibits cardiac excitation-contraction coupling. Rakovic S., Galione A., Ashamu GA., ... BACKGROUND: Cyclic ADP-ribose (cADPR) has been shown to act as a potent cytosolic mediator in a variety of tissues, regulating ...
  https://pharm.ox.ac.uk/publications/677868
*  Cyclic ADP-ribose - Wikipedia
Hon Cheung Lee, the discoverer of cyclic ADP-ribose. Cyclic ADP-ribose and NAADP. The first book on these two second messengers ... "Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase". ... Cyclic ADP Ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups ... NAADP IP3 ADP-ribose Lee HC, Walseth TF, Bratt GT, Hayes RN, Clapper DL (1989). "Structural determination of a cyclic ...
  https://en.wikipedia.org/wiki/Cyclic_ADP-ribose
*  Calcium signaling: Nuclear Reaction Makes Cyclic ADP Ribose | Science Signaling
Calcium signaling: Nuclear Reaction Makes Cyclic ADP Ribose Message Subject. (Your Name) has forwarded a page to you from ... Ryanodine receptors, which function as calcium channels activated by binding of cyclic ADP ribose (cADPr), are present in ... now report that ADP-ribose cyclase or CD38, the membrane-associated enzyme that generates cADPr from nicotinamide adenine ... A new function for CD38/ADP-ribosyl cyclase in nuclear calcium homeostasis. Nature Cell Biol. 1: 409-414. [Online Journal] ...
  http://stke.sciencemag.org/content/1999/4/tw3
*  Cyclic ADP-ribose (cADPR) and Nicotinic Acid Adenine Dinucleotide...: Ingenta Connect
Cyclic ADP-ribose (cADPR) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP): Novel Regulators of Ca 2+-Signaling and ... Keywords: Adenine Dinucleotide Phosphate; Cyclic ADP-ribose; D-myo-inositol 1,4,5-trisphosphate; Guanosine triphosphate; ... cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP). This review concentrates on (i) receptor- ... mediated formation of cADPR by ADP-ribosyl cyclases, (ii) intracellular and extracellular effects of cADPR in a variety of cell ...
  https://www.ingentaconnect.com/content/ben/cmm/2002/00000002/00000003/art00004
*  Sympathetic Potentiation of Cyclic ADP-Ribose Formation in Rat Cardiac Myocytes | Springer for Research & Development
In CICR in the heart, both cyclic ADP-ribose (cADP-ribose) and Ca2+ cooperatively activate type-II ryanodine receptors to ... Hashii, M., Minabe, Y. and Higashida, H., 2000, Cyclic ADP-ribose potentiates Ca2+ elevation and Ca2+ entry via L-type voltage- ... Higashida, H., Hashii, M., Yokoyama, S., Hoshi, N., Asai, K. and Kato, T., 2001, Cyclic ADP-ribose as a potential second ... 2002) Sympathetic Potentiation of Cyclic ADP-Ribose Formation in Rat Cardiac Myocytes. In: Nagatsu T., Nabeshima T., McCarty R ...
  https://rd.springer.com/chapter/10.1007/978-1-4757-3538-3_14
*  Frontiers | Cyclic ADP-Ribose and Heat Regulate Oxytocin Release via CD38 and TRPM2 in the Hypothalamus during Social or...
... and ADP in mouse oxytocinergic neurons. As these -NAD+ metabolites activate warm-sensitive TRPM2 cation channels, when the ... and ADP in mouse oxytocinergic neurons. As these -NAD+ metabolites activate warm-sensitive TRPM2 cation channels, when the ... is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. Previously, we showed that ... is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. Previously, we showed that ...
  https://www.frontiersin.org/articles/10.3389/fnins.2016.00304/full
*  KAKEN - Research Projects | Role of cyclic ADP-ribose in signal transduction in airway cells. (KAKENHI-PROJECT-05670513)
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15.' Cytogenetics and Cell Genetics. 69. 38-39 (1995). *. ... Cloning and characterization of cDNA encoding rat ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (homologue to human CD38) ... Publications] S.Takasawa: 'Cyclic ADP-ribose in β cells.' Science. 262. 585-585 (1993). *. Related Report. 1993 Annual Research ... Publications] S.TAKASAWA: 'Cyclic ADP-ribose in insulin secretion from pancreatic β cells.' Science. 259. 370-373 (1993). *. ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05670513/
*  A single residue in a novel ADP-ribosyl cyclase controls production of the calcium-mobilizing messengers cyclic ADP-ribose and...
However, unlike most other members, SpARC4 shows a remarkable preference for producing cyclic ADP-ribose over nicotinic acid ... the ADP-ribosyl cyclases. Not all ADP-ribosyl cyclases have been identified, and how production of different messengers is ... Here, we report the cloning and characterization of a novel ADP-ribosyl cyclase (SpARC4) from the sea urchin, a key model ... Like several other members of the ADP-ribosyl cyclase superfamily, SpARC4 is a glycoprotein targeted to the plasma membrane via ...
  https://www.semanticscholar.org/paper/A-single-residue-in-a-novel-ADP-ribosyl-cyclase-of-Ramakrishnan-Muller-Steffner/42af6685efa83e286820b56546ebfbe7705ebcb1
*  Medicinal chemistry and pharmacology of cyclic ADP-ribose. - Department of Pharmacology
These approaches allow the synthesis of analogs with stable linkages between N1 of adenine and the northern ribose (or ... Hydrolysis resistant analogs were generated by replacing the southern ribose with a carbocyclic structure or by replacing the ... hydroxyl group of the southern ribose for activity. ... Cyclic ADP-ribose (cADPR) is a signaling molecule that has been ... analogs was synthesized by a chemo-enzymatic approach that took advantage of the broad substrate specificity of Aplysia ADP- ...
  https://pharm.ox.ac.uk/publications/677839
*  Ca2+ entry induced by cyclic ADP-ribose in intact T-lymphocytes. - Department of Pharmacology
Cyclic ADP-ribose (cADPr) is a potent Ca2+-mobilizing natural compound (Lee, H. C., Walseth, T. F., Bratt, G. T., Hayes, R. N ... Adenosine Diphosphate Ribose, Calcium, Cyclic ADP-Ribose, Fluorescent Dyes, Fura-2, Humans, Jurkat Cells, Microinjections, ... Cyclic ADP-ribose (cADPr) is a potent Ca2+-mobilizing natural compound (Lee, H. C., Walseth, T. F., Bratt, G. T., Hayes, R. N ...
  https://pharm.ox.ac.uk/publications/678548
*  Concentrative influx of functionally active cyclic ADP-ribose in dimethylsulfoxide-differentiated HL-60 cells | IRIS Università...
Native human HL-60 cells do not express CD38, a multifunctional ectoenzyme, which generates cyclic ADP-ribose (cADPR), a potent ... Native human HL-60 cells do not express CD38, a multifunctional ectoenzyme, which generates cyclic ADP-ribose (cADPR), a potent ... Concentrative influx of functionally active cyclic ADP-ribose in dimethylsulfoxide-differentiated HL-60 cells. ... Concentrative influx of functionally active cyclic ADP-ribose in dimethylsulfoxide-differentiated HL-60 cells ...
  https://iris.unige.it/handle/11567/250709
*  KAKEN - Research Projects | Physiological functions of a novel family of nucleotide-metabolizing enzymes (KAKENHI-PROJECT...
Oscillation of ADP-ribosyl cyclase activity during the cell cycle and function of cyclic ADP-ribose in a unicellular organism, ... CD38 catalyzes not only the hydrolysis of NAD^+, but also the formation and hydrolysis of cyclic ADP-ribose (cADPR), that is a ... Publications] O.Scruel,et al.: 'Effects of D-glucose and starvation upon the cyclic ADP-ribose content of rat pancreatic islets ... Publications] O.Scruel,et al.: 'Effects of D-glucose and starvation upon the cyclic ADP-ribose content of rat pancreatic islets ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09480160/
*  JCI - Volume 127, Issue 5
Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers. ... NRP-1-mediated transport can be triggered by the cyclic tumor-penetrating peptide iRGD. In a KRAS-induced orthotopic PDAC model ... Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers. ... Further, we observed that the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib synergizes with GLS1 inhibitors to suppress ...
  https://hzyouma.com.www.mobile.jci.org/127/5
*  Medical Advisor Journals, Kyle J. Norton Site, Health Tips for Better Living and Living Health: Endometrial Cancer In Herbs'...
ADP-ribose) polymerase(14) A multi-centre case-control study of 454 endometrial cancer cases and 908 controls, allium ... The sweet and warm herb has been used in TCM to treat improves cAMP(cyclic adenosine mono phosphate... ...
  https://kylejnorton.blogspot.com/2014/02/endometrial-cancer-in-herbs-points-of.html
*  CD38抗体(FITC)[FS02]|Abcam中国|Anti-CD38抗体(FITC)[FS02]
Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. ... Cyclic ADP ribose hydrolase antibody. *Cyclic ADP ribose hydrolase 1 antibody. *Cyclic ADP-ribose hydrolase 1 antibody ... ADP ribosyl cyclase antibody. *ADP ribosyl cyclase/cyclic ADP-ribose hydrolase antibody ...
  http://www.abcam.cn/cd38-antibody-fs02-fitc-ab1173.html