Complementarity-determining regions (CDRs) are part of the variable chains in immunoglobulins (antibodies) and T cell receptors ... Complementarity+determining+regions at the U.S. National Library of Medicine Medical Subject Headings (MeSH) PyIgClassify -- ... Framework region Hypervariable region Abbas AK and Lichtman AH (2003). Cellular and Molecular Immunology (5th ed.). Saunders, ... these regions are sometimes referred to as hypervariable regions. Within the variable domain, CDR1 and CDR2 are found in the ...

Grafting of "abbreviated" complementarity-determining regions containing specificity-determining residues essential for ligand ... Grafting of "abbreviated" complementarity-determining regions containing specificity-determining residues essential for ligand ... "Superhumanized" antibodies: reduction of immunogenic potential by complementarity-determining region grafting with human ... was generated by grafting the complementarity-determining regions (CDRs) of COL-1 onto the frameworks of the variable light and ...

We localized the regions in a VH3-encoded Ab required for S … ... and JH-encoded regions and light chain sequences. The SPA- ... complementarity-determining region 2, and framework region 3 on human VH3-encoded Igs K N Potter 1 , Y Li, J D Capra ... complementarity-determining region 2, and framework region 3 on human VH3-encoded Igs K N Potter et al. J Immunol. 1996. . ... When any one of the three regions was replaced with the corresponding region from the nonbinding Ab, SPA binding was severely ...

Domain swapping of complementarity-determining region in nanobodies produced by Pichia pastoris *Natsuko Miura ...

Complementarity Determining Regions / genetics* * DNA Primers / genetics * DNA, Mitochondrial / genetics* * Genetic ...

CDR = complementarity determining region; NAWM = normal-appearing white matter; TCR = T-cell receptor ... Silent Mutations in the CDR3 Regions. Interestingly, the CDR3 regions of several TCR ß-chains contained silentmutations, i.e ... Table 2. HLA Alleles Expressed by the Four Ms Patients as Determined by Genomic HLA-typing Patient. HLA-. ... Table 2. HLA Alleles Expressed by the Four Ms Patients as Determined by Genomic HLA-typing Patient. HLA-. ...

CDR (complementarity-determining regions) These are regions of the variable (V) regions of light and heavy antibody chains that ... adjacent regions of the genome to produce a continuous nucleotide sequence across a chromosomal region. See mapping. ... crown The region at the base of the stem of cereals and forage species from which tillers or branches arise. In woody plants, ... comparative positional candidate gene A gene that is likely to be located in the same region as a DNA marker that has been ...

COMPLEMENTARITY DETERMINING REGIONS. REGIONES DETERMINANTES DE COMPLEMENTARIEDAD. RELAÇÃO QUANTITATIVA ESTRUTURA-ATIVIDADE. ...

Sequence analysis indicated that the mAbs shared 100% amino acid identity in their complementarity determining regions (CDR). A ... We sought to determine how fast PSA concentrations decline during the first 10 h after exposure to semen. STUDY DESIGN: Women ... METHODS: First, we determined the technical abilities and needs of middle-aged and older adults with serious mental illnesses ... At the climate region level, consistently elevated but not statistically significant estimates were observed for at least 2 ...

Jones, P.T.; Dear, P.H.; Foote, J.; Neuberger, M.S.; Winter, G. Replacing the complementarity-determining regions in a human ... This can be done by grafting the complementarity determining regions (CDRs) of the murine variable domain into the best fitting ... It was reported that the replacement of the constant (C) regions of the heavy and the light chains by human C regions can ... However, in some cases this exchange is not sufficient, since the variable regions can also be immunogenic [160,161,162]. ...

Variable regions consist of framework regions and complementarity determining regions (CDRs). The CDRs are unique among ... CH and CL and framework regions in VH and VL) (Figure 1, gray parts) or idiotopes in the complementarity determining regions ( ... All other regions are conserved regions (gray) between different antibodies, and make up the framework regions of the VH and VL ... 4140 the mice developed antibodies that either recognized conserved regions (e.g. constant regions: ...

Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions.. Sidhu SS; Li B; Chen Y; ... Isolation of picomolar affinity anti-c-erbB-2 single-chain Fv by molecular evolution of the complementarity determining regions ... mutagenesis reveals a high level of mutational plasticity both inside and outside the complementarity-determining regions. ... In vitro affinity maturation of a specificity-determining region-grafted humanized anticarcinoma antibody: isolation and ...

... humanized monoclonal IgG1 antibody that contains human framework regions and murine complementarity-determining regions. ... these reports are insufficient to determine drug associated risks. In animal reproduction studies, intravenous administration ... of efficacy of bevacizumab as an adjunct to standard chemotherapy for the adjuvant treatment of colon cancer was determined in ...

Evaluation of a complementarity-determining region-grafted (humanized) anti-carcinoembryonic antigen monoclonal antibody in ... From the extrapolation of the straight region of the curve, the average number of MORF groups per MN14 was estimated to be 0.27 ... Immediately after imaging at 24 h, the mice were killed and the biodistribution of the radiolabel was determined. ...

... joined by three hypervariable regions, also called complementarity determining regions or CDRs. The CDRs from the two chains of ... Antigen-binding portions include, inter alia, Fab, Fab′, F(ab′).sub.2, Fv, dAb, and complementarity determining region (CDR) ... Chimeric 2A2 antibody will be humanized by using complementarity determining region (CDR) grafting. The human framework ... The noncoding regions ("5′ and 3′ untranslated regions") are the 5′ and 3′ sequences which flank the coding region and are not ...

... engineered from a human source except that the Fab portions complementarity-determining regions are of murine origin [7]. ... The antigen-binding fragment (Fab) is the region that binds to Fc, the fragment crystallizable region or the tail region of an ... the region that has a constant structure for different antigens, and a variable region, the region that changes to different ... Chimeric CmAbs typically comprise variable regions gleaned from a murine source, and constant regions (65%) from a human source ...

... whereby the respective complementarity determining regions (CDR) determine to which pathogenic bacterial antigens or strains ... Antibody complementarity-determining regions (CDRs) can display differential antimicrobial, antiviral and antitumor activities ... Antibody complementarity-determining regions (CDRs) can display differential antimicrobial, antiviral and antitumor activities ... For their discoveries concerning genetically determined structures on the cell surface that regulate immunological reactions ...

Selective detection of complementarity-determining regions of monoclonal antibody by limiting protease access to the substrate ... Selective detection of complementarity-determining regions of monoclonal antibody by limiting protease access to the substrate ...

VHHs or Nbs have long complementarity-determining region 3 (CDR3) loops and are capable of binding to unique epitopes not ... and their antigen recognition region is solely formed by the variable heavy chains (VHHs) (also called nanobodies, Nbs). ...

Grafting of "abbreviated" complementarity-determining regions containing specificity-determining residues essential for ligand ... In vitro affinity maturation of a specificity-determining region-grafted humanized anticarcinoma antibody: isolation and ... Determining the Stoichiometry of a Protein-Polymer Conjugate Using Multisignal Sedimentation Velocity Analytical ... Multi-signal sedimentation velocity analysis with mass conservation for determining the stoichiometry of protein complexes. ...

B precursor acute lymphoblastic leukemia third complementarity-determining regions predominantly represent an unbiased ... 1953) concluded that the ovary may be the critical organ in determining the lowest injurious dose for 210Po because of its ... Analyses for the presence of 210Po in drinking water are rarely made, and 210Po is not measured directly to determine ... Because of its radiosensitivity and tendency to concentrate 210Po, the ovary may be the critical organ in determining the ...

B precursor acute lymphoblastic leukemia third complementarity-determining regions predominantly represent an unbiased ...

Variable regions VL and VH form the antigen-binding sites that consist of complementarity determining regions (CDRs) of about ... Each chain has domains called the V (variable) region and C (constant) region. Variable region constitutes the antibody binding ... The constant (C) regions of IgG, IgA, and IgD consist of only 3 CH domains. In IgM and IgE, the C regions consist of 4 CH ... The constant region at the carboxyl-terminal end of the heavy chain, called the Fc region, binds to the Fc receptors of ...

It includes hypervariable regions (COMPLEMENTARITY DETERMINING REGIONS) and framework regions. DF: IG VARIABLE REGION ... Variable Regions, Ig; Ig Variable Regions; Ig Framework Regions; Framework Regions, Immunoglobulin; Framework Regions, Ig; ... Other names Variable Region, Immunoglobulin; Variable Region, Ig; Variable Regions, Immunoglobulin; Regions, Immunoglobulin ... Framework Region, Ig; Immunoglobulin V; Immunoglobulin Framework Region; Ig Variable Region; Ig Framework Region; Framework ...

Å in individual complementarity determining region (CDR) loops that are similar to those that have previously been attributed ... Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop ...

... complementarity determining regions (CDR) that provide the majority of the binding contacts. The idiotype represents the ... Figure 1. Antibody idiotope- the unique set of antigenic determinants of the variable region of an antibody. ... to avoid enrichment of specificities that bind to other regions of the antibody drug and to ensure idiotope specificity. ...