*  RCSB PDB - 2QOS: Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site...
Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: ... Crystal structure of complement protein C8 in complex with a peptide containing the C8 binding site on C8. *DOI: 10.2210/ ... Complement component C8 alpha chain A 11 Homo sapiens Mutation: C164A Gene Name(s): C8A Gene View ... Complement component 8, gamma polypeptide C 173 Homo sapiens Mutation: C40A Gene Name(s): C8G Gene View ...
  http://www.rcsb.org/pdb/explore/explore.do?structureId=2qos
*  "Human Complement Protein C8: Crystal Structure and Analysis of Binding" by Christopher Langston Cooper
The MAC is comprised of complement proteins C5b, C6, C7, C8 and C9. The 150-kDa C8 protein consists of three non-identical ... The role of C8 within the MAC is to initiate formation of a transmembrane pore consisting of 12-18 molecules of C9. ... Human C8 is part of the membrane attack complex (MAC) that assembles on bacterial cell membranes to form a lethal pore-like ... The MAC is comprised of complement proteins C5b, C6, C7, C8 and C9. The 150-kDa C8 protein consists of three non-identical ...
  https://scholarcommons.sc.edu/etd/668/
*  KAKEN - Research Projects | Planning-Coordination Committe on Special Cancer Research (KAKENHI-PROJECT-09042003)
Publications] Kojima,T.: 'Genetic basis of human complement c8 α-γ deficiency.' J.Immunology. 161. 3762-3766 (1998). *. Related ... Publications] Kojima, T.: 'Genetic basis of human complement c8 α-γ deficiency.' J.Immunology. 161. 3762-3766 (1998). *. ... Publications] Kojima, T.: 'Genetic basis of human complement c8 alpha-gamma deficiency.' J.Immunology. 161. 3762-3766 (1998). * ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09042003/
*  34. Infections in immunodeficiency Flashcards by Eva Gonzales | Brainscape
A boy with C8 complement deficiency requires a vaccine. Which vaccine does he need? Which bacterium is he most susceptible to ... Meningococcal vaccine; Neisseria, as there is no formation of membrane attack complex (late complement deficiency). ... bacteria --> encapsuled species with early complement deficiencies, Neisseria with late compoment deficiencies ...
  https://www.brainscape.com/flashcards/34-infections-in-immunodeficiency-5336270/packs/7987181
*  Enzyme Explorer Key Resource: Plasma Proteins Table | Sigma-Aldrich
Includes, Albumin, Complement Products, Lipoprotein Products, Plasma Proteins, RBC Proteins and Sera and Plasma. ... Complement C8 deficient serum human. C1538. Complement C8 from human serum, 1 mg/mL in 15 mM sodium phosphate, 150 mM NaCl, pH ... Complement C9 deficient serum human C1663. Complement C9 from human serum, 1 mg/mL in 15 mM sodium phosphate, 135 mM NaCl, pH ... Complement C3 from human serum, ~95% (SDS-PAGE) lyophilized powder. C0651. Complement C3 from human serum, ,50 C3H50 units/mg ( ...
  https://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/learning-center/plasma-blood-protein/plasma-proteins-table.html
*  Recombinant Human C8G protein (ab113121) | Abcam
Complement component 8 gamma polypeptide. *Complement component C8 gamma chain. *MGC142186. see all ... C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 ...
  https://www.abcam.com/recombinant-human-c8g-protein-ab113121.html
*  IUCr) Acta Crystallographica Section D Volume 63, Part 6, June 2007
Crystal structure of CD59: implications for molecular recognition of the complement proteins C8 and C9 in the membrane-attack ... The crystal structure of the human complement protein CD59 is presented at 2.1 Å resolution. This structure is compared with a ... previous NMR model and the binding region for C8 and C9 is mapped. ...
  http://journals.iucr.org/d/issues/2007/06/00/index.html
*  Table], What is the prevalence of primary immunodeficiency in children and young people with meningococcal disease? - Bacterial...
Hereditary complement deficiency in survivors of meningococcal disease: high prevalence of C7/C8 deficiency in Sephardic ( ... Genetic aspects of complement component C8 in Norwegian meningococcal disease patients. Scandinavian Journal of Infectious ... Complement deficiencies in patients over ten years old with meningococcal disease due to uncommon serogroups: Comment. ... Low prevalence of complement deficiencies among patients with meningococcal disease in Norway. Scandinavian Journal of ...
  https://www.ncbi.nlm.nih.gov/books/NBK83066/table/appendixes.app6.tu31/?report=objectonly
*  MACPF - Wikipedia
... proteins of the complement system (C6, C7, C8α, C8β and C9) and perforin (PF). Members of this protein family are pore-forming ... "Identity of the segment of human complement C8 recognized by complement regulatory protein CD59". J. Biol. Chem. 270 (34): ... Complement proteins C6-C9 all contain a MACPF domain and assemble into the membrane attack complex. C6, C7 and C8β appear to be ... The binding site on C8α is known, however, the precise role of C8γ in the MAC remains to be understood. Deficiency of C9, or ...
  https://en.wikipedia.org/wiki/MACPF
*  Lipocalin - Wikipedia
Peitsch MC, Tschopp J, Jenne DE, Haefliger JA (1991). "Structural and functional characterization of complement C8 gamma, a ... complement component C8 gamma chain; crustacyanin; epididymal-retinoic acid binding protein (E-RABP); insectacyanin; odorant ...
  https://en.wikipedia.org/wiki/Lipocalin
*  Molecular characterization of invasive capsule null Neisseria meningitidis in South Africa | BMC Microbiology | Full Text
... in a male child with deficiency of the sixth complement component, and with the exception of two single nucleotide ... Complement C8 deficiency with recurrent meningococcemia: examination of meningococcal opsonization. Aust Paediatr J. 1985;21: ... A complement C5 gene mutation, c.754G , A:p.A252T, is common in the Western Cape, South Africa and found to be homozygous in ... The third patient was a male child with deficiency of the sixth complement component (C6). In 2011, he was diagnosed with ...
  https://0-bmcmicrobiol-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s12866-017-0942-5
*  PROSITE: PDOC00021 (documentation file)
Complement-activating component of Ra-reactive factor (RARF) (1 copy).. - Complement components C6, C7, C8 alpha and beta ...
  http://bioinfo.mbb.yale.edu/course/classes/c10/egf-prosite.html
*  anti-CD59 antibody [MEM-43] (Azide free) | GeneTex
This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during ... This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte ... complement regulatory protein Antibody , G344 Antibody , MIC11 Antibody , MIN1 Antibody , MEM43 Antibody , MAC-IP Antibody , ...
  http://www.genetex.com/CD59-antibody-MEM-43-GTX74620.html
*  Cellufine Sulphate | amsbio
Complement C5, C6, C8 *Complement C3 Activator *Tryspin *Tryspin Inhibitor *Chymotrypsinogen *Lysozyme ...
  http://www.amsbio.com/affinity-chromatography.aspx
*  CD59 Antibody for IHC, WB/Western LS-C331645
This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during ... CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal ...
  https://www.lsbio.com/antibodies/cd59-antibody-ihc-wb-western-ls-c331645/342004
*  Recombinant Human C9 protein (ab114199) | Abcam
Belongs to the complement C6/C7/C8/C9 family.. Contains 1 EGF-like domain.. Contains 1 LDL-receptor class A domain.. Contains 1 ... Defects in C9 are a cause of complement component 9 deficiency (C9D) [MIM:613825]. A rare defect of the complement classical ...
  http://www.abcam.com/recombinant-human-c9-protein-ab114199.html
*  CD59 / Complement Regulatory Protein / Protectin Antibody - Without BSA and Azide - Mouse Monoclonal Antibody [Clone SPM616 ]...
CD59 / Complement Regulatory Protein / Protectin Antibody - Without BSA and Azide, Mouse Monoclonal Antibody [Clone SPM616 ] ... Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the ... This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during ... AH12768: CD59 / Complement Regulatory Protein / Protectin Antibody. AH12773: CD59 / Complement Regulatory Protein / Protectin ...
  http://www.abgent.com/products/AH12772-CD59--Complement-Regulatory-Protein--Protectin-Antibody-Without-BSA-and-Azide
*  C8 complex - Wikipedia
Figure created in Pymol Complement C8 at the US National Library of Medicine Medical Subject Headings (MeSH) The crystal ... C8 is a heterotrimer; it consists of three different subunits. These are called C8 alpha, beta and gamma chains, encoded by the ... Complement component 8 is a protein involved in the complement system. It is part of the membrane attack complex (MAC). A ... hereditary deficiency of C8 can result in increased susceptibility to Neisseria infections, such as meningitis and gonorrhea. ...
  https://en.wikipedia.org/wiki/C8_complex
*  Lipocalin-2 - Wikipedia
... the four genes for complement C8 gamma chain, prostaglandin-D-synthase, oncogene-24p3, and progestagen-associated endometrial ...
  https://en.wikipedia.org/wiki/Lipocalin-2
*  Table of Contents - August 01, 1986, 14 (4) | Biochemical Society Transactions
The function of C8 in the complement membrane attack complex investigated using monoclonal antibodies AREFAINE ABRAHA, ELAINE M ...
  http://www.biochemsoctrans.org/content/14/4
*  Human Complement C7 ELISA Kit (ab125964) | Abcam
Abcam's Complement C7 ELISA Kit suitable for Cell culture supernatant, Saliva, Milk, Urine, Serum, Plasma, Cerebral Spinal ... Belongs to the complement C6/C7/C8/C9 family.. Contains 1 EGF-like domain.. Contains 1 LDL-receptor class A domain.. Contains 1 ... Defects in C7 are a cause of complement component 7 deficiency (C7D) [MIM:610102]. A rare defect of the complement classical ... A Complement C7 specific antibody has been precoated onto 96-well plates and blocked. Standards or test samples are added to ...
  http://www.abcam.com/human-complement-c7-elisa-kit-ab125964.html
*  Evolving Immunity
C5b attracts the complement proteins C6, C7, C8 and C9. This group of proteins, C5b through C9, forms a membrane attack complex ... The complement proteins C6, C7, C8, and C9 all share key structural motifs, which may indicate a common origin. Phylogenetic ... The origin and evolution of the complement system. *The evolution of complement begins with an ancestor to protease inhibitor a ... Model for the evolution of the complement system Any model for the origin of the complement system must begin with the ...
  http://www.talkdesign.org/faqs/Evolving_Immunity1.2.html
*  Evolving Immunity
C5b attracts the complement proteins C6, C7, C8 and C9. This group of proteins, C5b through C9, forms a membrane attack complex ... The complement proteins C6, C7, C8, and C9 all share key structural motifs, which may indicate a common origin. Phylogenetic ... complement protein homologous to complement C3 of the mammalian complement system." Journal of Immunology 133(6): 3242-3249. ... The origin and evolution of the complement system. *The evolution of complement begins with an ancestor to protease inhibitor a ...
  http://www.talkdesign.org/faqs/Evolving_Immunity.html
*  Complement C8A Antibody for IHC, ELISA LS-C675439
Complement C8A antibody LS-C675439 is an unconjugated rabbit polyclonal antibody to human Complement C8A. Validated for ELISA ... Complement C8A antibody was raised against recombinant human Complement component C8 alpha chain protein (310-460AA) ... Complement C8A antibody LS-C675439 is an unconjugated rabbit polyclonal antibody to human Complement C8A. Validated for ELISA ... Complement C8A antibody LS-C675439 is an unconjugated rabbit polyclonal antibody to human Complement C8A. Validated for ELISA ...
  https://www.lsbio.com/antibodies/complement-c8a-antibody-elisa-ihc-ls-c675439/690109