Complement factor I - Wikipedia
Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. Complement ... either C3b or C4b) and a cofactor protein (Factor H, C4b-binding protein, complement receptor 1, and membrane cofactor protein ... Whaley K (March 1980). "Biosynthesis of the complement components and the regulatory proteins of the alternative complement ... is a protein of the complement system, first isolated in 1966 in guinea pig serum, that regulates complement activation by ...
High Complement Factor I Activity in the Plasma of Children with Autism Spectrum Disorders
Complement factor I is a serine protease present in human plasma that is involved in the degradation of complement protein C3b ... Immune system abnormalities may be caused partly by complement system factor I deficiency. ... which is a major opsonin of the complement system. Deficiency in factor I activity is associated with an increased incidence of ... suggesting that high activity of complement factor I might have an impact on the development of ASD. ...
Cfi gene cDNA ORF clone, Rattus norvegicus(Norway rat) - GenScript
Next-day shipping cDNA ORF clones derived from Cfi complement factor I available at GenScript, starting from $99.00. ... General protein information. Preferred Names. complement factor I. Names. complement factor I. C3B/C4B inactivator ... mouse homolog is a regulatory serine proteinase of the complement cascade that cleaves C3b and C4b and inactivates them [RGD, ... Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay ...
Frontiers | The Immunogenetic Conundrum of Preeclampsia
... is a serine protease that inactivates C3b and C4b in the presence of a co-factor protein, such as complement factor H (FH) and ... and classical pathways of complement activation by binding to C3b or C4b and acting as a co-factor to the inactivator enzyme ... Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. PLoS Med. ( ... Complement system is an ancient part of innate immunity, which consists of cell surface-bound and freely circulating proteins ...
Complement cascade and its inhibitors | Abcam
Learn about the three pathways lead to complement activation and some of their key inhibitors. ... Complement inhibitors include the plasma serine proteinase inhibitor serpin (C1 inactivator). The plasma proteins, Factor I and ... Note, C3b generated in the classical pathway feeds into the alternative pathway to amplify the activation of complement. ... Most of the C3b generated by the convertase is hydrolysed. However, if C3b comes into contact with an invading micro-organism ...
Department of Orthopedics - Research output - Taipei Medical University
Complement C3b Inactivator Proteins 47% * Therapeutic Uses 27% * Complement C4b 20% 3 Citations (Scopus) ... Effects of Protein Supplementation Combined with Resistance Exercise Training on Walking Speed Recovery in Older Adults with ... Targeting therapeutic agent against C3b/C4b, SB002, on the inflammation-induced bone loss in experimental periodontitis. Huang ... Correlation between C-reactive protein and postoperative mortality in patients undergoing hip fracture surgery: a meta-analysis ...
骨科學科 - 研究成果 - 臺北醫學大學
Complement C3b Inactivator Proteins 47% * Therapeutic Uses 27% * Complement C4b 20% 3 引文 斯高帕斯（Scopus） ... Effects of Protein Supplementation Combined with Resistance Exercise Training on Walking Speed Recovery in Older Adults with ... Targeting therapeutic agent against C3b/C4b, SB002, on the inflammation-induced bone loss in experimental periodontitis. Huang ... Correlation between C-reactive protein and postoperative mortality in patients undergoing hip fracture surgery: a meta-analysis ...
CFI gene: MedlinePlus Genetics
The CFI gene provides instructions for making a protein called complement factor I. Learn about this gene and related health ... C3B/C4B inactivator. *C3BINA. *CFAI_HUMAN. *complement component I. *complement control protein factor I ... The CFI gene provides instructions for making a protein called complement factor I. This protein helps regulate a part of the ... Complement factor I and several related proteins protect healthy cells by preventing activation of the complement system when ...
Fact file for C4 binding protein α deficiency
Protein function: C4BP controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator ( ... It also accelerates the degradation of the C4bc2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha ... It interacts also with anticoagulant protein S and with serum amyloid P component. ... C3bina), which then hydrolyzes the complement fragment C4b. ... C4b-binding protein alpha chain precursor. *Proline-rich ...
Complement-Related Disorders: Background, Pathophysiology, Activation
Complement receptor 1 (CR1) has factor H-like activity, permitting factor I to cleave C3b. Membrane cofactor protein also has ... Table 3. Proteins of the Human Complement (C) System, Lectin Pathway *Table 4. Proteins of the Human Complement (C) System, C3 ... Table 1. Proteins of the Human Complement (C) System, Classical Pathway* *Table 2. Proteins of the Human Complement (C) System ... Table 6. Proteins of the Human Complement (C) System, Membrane Receptor and Control Proteins (Open Table in a new window) ...
Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferi. -...
This binding is dependent on the expression of proteins termed complement-regulator acquiring surface proteins (CRASPs). The ... Serum-resistant B. burgdorferi strains bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochaete surface. ... Our analysis indicates that its protein topology apparently evolved to provide a high affinity interaction site for FH/FHL-1 ... This work demonstrates that pathogens interact with complement regulators in ways that are distinct from the mechanisms used by ...
Mutational analyses of the BbCRASP-1 protein of Borrelia burgdorferi identify residues relevant for the architecture and...
... attack by acquisition host complement regulators FHL-1 and factor H via complement regulator-acquiring surface proteins ( ... BbCRASPs). The BbCRASP-1 protein is the first bacterial factor H/FHL-1-binding protein for which the atomic structure has been ... Previously, 3 regions including the C terminus were identified as putative contact sites for the two complement regulators by ... of both complement regulators. Mapping the mutations onto the atomic structure of BbCRASP-1 reveals that, in contrast to ...
21 CFR §866 Immunology And Microbiology Devices - Code of Federal Regulations
... inactivator) immunological test system.. 21:8.0.1.1.20.6.1.20. SECTION 866.5260. 866.5260 Complement C3b inactivator ... 866.5270 C-reactive protein immunological test system.. 21:8.0.1.1.20.6.1.22. SECTION 866.5320. 866.5320 Properdin factor B ... 866.5240 Complement components immunological test system.. 21:8.0.1.1.20.6.1.19. SECTION 866.5250. 866.5250 Complement C1 ... 866.5150 Bence-Jones proteins immunological test system.. 21:8.0.1.1.20.6.1.11. SECTION 866.5160. 866.5160 Beta-globulin ...
The OspE-related proteins inhibit complement deposition and enhance serum resistance of Borrelia burgdorferi, the lyme disease...
Complement C3b Inactivator Proteins. * Complement C3b Inactivator Proteins. * Complement Factor H. * Complement Factor H ... The OspE-related proteins inhibit complement deposition and enhance serum resistance of Borrelia burgdorferi, the lyme disease ... The OspE-related proteins inhibit complement deposition and enhance serum resistance of Borrelia burgdorferi, the lyme disease ... The OspE-related proteins inhibit complement deposition and enhance serum resistance of Borrelia burgdorferi, the lyme disease ...
Complement Inactivator Proteins | Profiles RNS
Complement C1 Inactivator Proteins. *Complement C3 Nephritic Factor. *Complement C3b Inactivator Proteins ... "Complement Inactivator Proteins" by people in UAMS Profiles by year, and whether "Complement Inactivator Proteins" was a major ... Complement Inactivator Proteins*Complement Inactivator Proteins. *Inactivator Proteins, Complement. *Proteins, Complement ... "Complement Inactivator Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ...
DeCS 2017 - December 21, 2017 version
Factors, Conglutinogen Activating use Complement C3b Inactivator Proteins Factors, Cord use Cord Factors ... FADD Protein, Fas Associating use Fas-Associated Death Domain Protein FADD Protein, Fas-Associating use Fas-Associated Death ... FADD, Fas-Associating Protein use Fas-Associated Death Domain Protein Fade, Neuromuscular use Refractory Period, ... F Box and WD 40 Domain Containing Protein 7 use F-Box-WD Repeat-Containing Protein 7 ...
DeCS 2017 - December 21, 2017 version
Factors, Conglutinogen Activating use Complement C3b Inactivator Proteins Factors, Cord use Cord Factors ... FADD Protein, Fas Associating use Fas-Associated Death Domain Protein FADD Protein, Fas-Associating use Fas-Associated Death ... FADD, Fas-Associating Protein use Fas-Associated Death Domain Protein Fade, Neuromuscular use Refractory Period, ... F Box and WD 40 Domain Containing Protein 7 use F-Box-WD Repeat-Containing Protein 7 ...
DeCS 2018 - July 31, 2018 version
Factors, Conglutinogen Activating use Complement C3b Inactivator Proteins Factors, Cord use Cord Factors ... FADD Protein, Fas Associating use Fas-Associated Death Domain Protein FADD Protein, Fas-Associating use Fas-Associated Death ... FADD, Fas-Associating Protein use Fas-Associated Death Domain Protein Fade, Neuromuscular use Refractory Period, ... F Box and WD 40 Domain Containing Protein 7 use F-Box-WD Repeat-Containing Protein 7 ...
DeCS 2017 - July 04, 2017 version
Factors, Conglutinogen Activating use Complement C3b Inactivator Proteins Factors, Cord use Cord Factors ... FADD Protein, Fas Associating use Fas-Associated Death Domain Protein FADD Protein, Fas-Associating use Fas-Associated Death ... FADD, Fas-Associating Protein use Fas-Associated Death Domain Protein Fade, Neuromuscular use Refractory Period, ... Factor-1, Myeloid Cell use Myeloid Cell Leukemia Sequence 1 Protein Factor-4A1, Eukaryotic Initiation use Eukaryotic Initiation ...
DeCS 2020 - June 23, 2020 version
Factors, Conglutinogen Activating use Complement C3b Inactivator Proteins Factors, Cord use Cord Factors ... FADD Protein, Fas Associating use Fas-Associated Death Domain Protein FADD Protein, Fas-Associating use Fas-Associated Death ... FADD, Fas-Associating Protein use Fas-Associated Death Domain Protein Fade, Neuromuscular use Refractory Period, ... F Box and WD 40 Domain Containing Protein 7 use F-Box-WD Repeat-Containing Protein 7 ...
Plus it
For example, CFI is a serine protease which acts as a C3b/C4b inactivator, while C3b is part of the C5 convertases that cleave ... Most of the proteins identified as being differentially expressed are linked to immune regulation, complement activation, ... PLG is a complement inhibitor that binds C3, the C3 cleavage products C3b and C3d, and C5, and enhances CFI-mediated C3b ... Complement activation after oxidative stress: role of the lectin complement pathway. Am J Pathol 2000; 156: 1549-1556. doi: ...
DeCS 2006 - Changed terms
Complement 3a. Complement C3a. Complement 3b. Complement C3b. Complement 3b Inactivators. Complement C3b Inactivator Proteins. ... Complement Inactivators. Complement Inactivator Proteins. DNA-Binding Protein, Cyclic AMP-Responsive. Cyclic AMP Response ... Proto-Oncogene Protein c-met. Proto-Oncogene Proteins c-met. Proto-Oncogene Protein p21(ras). Proto-Oncogene Proteins p21(ras) ... Complement. Complement System Proteins. Complement 1. Complement C1. Complement 1 Inactivators. Complement C1 Inactivator ...
DeCS 2006 - Changed terms
Complement 3a. Complement C3a. Complement 3b. Complement C3b. Complement 3b Inactivators. Complement C3b Inactivator Proteins. ... Complement Inactivators. Complement Inactivator Proteins. DNA-Binding Protein, Cyclic AMP-Responsive. Cyclic AMP Response ... Proto-Oncogene Protein c-met. Proto-Oncogene Proteins c-met. Proto-Oncogene Protein p21(ras). Proto-Oncogene Proteins p21(ras) ... Complement. Complement System Proteins. Complement 1. Complement C1. Complement 1 Inactivators. Complement C1 Inactivator ...
DeCS 2006 - Changed terms
Complement 3a. Complement C3a. Complement 3b. Complement C3b. Complement 3b Inactivators. Complement C3b Inactivator Proteins. ... Complement Inactivators. Complement Inactivator Proteins. DNA-Binding Protein, Cyclic AMP-Responsive. Cyclic AMP Response ... Proto-Oncogene Protein c-met. Proto-Oncogene Proteins c-met. Proto-Oncogene Protein p21(ras). Proto-Oncogene Proteins p21(ras) ... Complement. Complement System Proteins. Complement 1. Complement C1. Complement 1 Inactivators. Complement C1 Inactivator ...
DeCS 2006 - Changed terms
Complement 3a. Complement C3a. Complement 3b. Complement C3b. Complement 3b Inactivators. Complement C3b Inactivator Proteins. ... Complement Inactivators. Complement Inactivator Proteins. DNA-Binding Protein, Cyclic AMP-Responsive. Cyclic AMP Response ... Proto-Oncogene Protein c-met. Proto-Oncogene Proteins c-met. Proto-Oncogene Protein p21(ras). Proto-Oncogene Proteins p21(ras) ... Complement. Complement System Proteins. Complement 1. Complement C1. Complement 1 Inactivators. Complement C1 Inactivator ...
DeCS 2006 - Changed terms
Complement 3a. Complement C3a. Complement 3b. Complement C3b. Complement 3b Inactivators. Complement C3b Inactivator Proteins. ... Complement Inactivators. Complement Inactivator Proteins. DNA-Binding Protein, Cyclic AMP-Responsive. Cyclic AMP Response ... Proto-Oncogene Protein c-met. Proto-Oncogene Proteins c-met. Proto-Oncogene Protein p21(ras). Proto-Oncogene Proteins p21(ras) ... Complement. Complement System Proteins. Complement 1. Complement C1. Complement 1 Inactivators. Complement C1 Inactivator ...
DeCS 2006 - Changed terms
Complement 3a. Complement C3a. Complement 3b. Complement C3b. Complement 3b Inactivators. Complement C3b Inactivator Proteins. ... Complement Inactivators. Complement Inactivator Proteins. DNA-Binding Protein, Cyclic AMP-Responsive. Cyclic AMP Response ... Proto-Oncogene Protein c-met. Proto-Oncogene Proteins c-met. Proto-Oncogene Protein p21(ras). Proto-Oncogene Proteins p21(ras) ... Complement. Complement System Proteins. Complement 1. Complement C1. Complement 1 Inactivators. Complement C1 Inactivator ...
DeCS 2006 - Changed terms
Complement 3a. Complement C3a. Complement 3b. Complement C3b. Complement 3b Inactivators. Complement C3b Inactivator Proteins. ... Complement Inactivators. Complement Inactivator Proteins. DNA-Binding Protein, Cyclic AMP-Responsive. Cyclic AMP Response ... Proto-Oncogene Protein c-met. Proto-Oncogene Proteins c-met. Proto-Oncogene Protein p21(ras). Proto-Oncogene Proteins p21(ras) ... Complement. Complement System Proteins. Complement 1. Complement C1. Complement 1 Inactivators. Complement C1 Inactivator ...
Membranoproliferative Glomerulonephritis: Practice Essentials, Pathophysiology, Etiology
The binding of NFa to C3b,Bb stabilizes the complex, preventing degradation by its normal inactivators, resulting in complement ... arising as a result of alternate complement activation or mutations in the complement-regulating proteins. C3NeF is commonly ... Adipocytes produce adipsin, which is identical to complement factor D and is responsible for activating the preconvertase C3b, ... The classic and alternate pathway convertases cause C3 activation, forming C3a and C3b. C3b is an opsonin itself, and C3 ...
US Patent for Structure of compstatin-C3 complex and use for rational drug design Patent (Patent # 8,442,776 issued May 14,...
... and use of this information for rational design or identification of complement-inhibiting drugs are disclosed. ... The structure of C3c in complex with the complement inhibitor, compstatin, ... Notably, in the crystal of C3b, a C3b-C3b binding site is formed by the same face of the MG-ring (see FIG. 4A. ) (Janssen et al ... Physicochemical and residue conservation calculations to improve the ranking of protein-protein docking solutions. Protein Sci ...