*  JoVE Search Results: Complement C1 Inhibitor Protein
Complement, Immunity, Disease, Morbidity, Risk, Mortality, and Treatment ... Human complement regulators C4b-binding protein and C1 esterase inhibitor interact with a novel outer surface protein of ... Human pasteurized C1-inhibitor concentrate for the treatment of hereditary angioedema due to C1-inhibitor deficiency. Abstract ... Treatment with C1-inhibitor concentrate does not induce IgM type anti-C1 inhibitor antibodies in patients with hereditary ...
  http://labindex.jove.com/group/Complement-C1-Inhibitor-Protein
*  Safety of Ruconest in 2-13 Year Old Hereditary Angioedema (HAE) Patients - Full Text View - ClinicalTrials.gov
Complement C1 Inhibitor Protein. Complement Inactivating Agents. Immunosuppressive Agents. Immunologic Factors. Physiological ... Experimental: Recombinant Human C1 Inhibitor Drug: rhC1INH Patients up to 84 kg will receive one i.v. injection of Ruconest at ... Pharmacokinetics and Efficacy of Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Pediatric Patients With ...
  https://clinicaltrials.gov/ct2/show/NCT01359969
*  Clinical review of hereditary angioedema: diagnosis and management.
... is caused by a deficiency in C1 esterase inhibitor and is characterized by sudden attacks of edema associated with discomfort ... 0/Complement C1 Inactivator Proteins; 0/Complement C1 Inhibitor Protein; 0/Estrogen Antagonists; 0/SERPING1 protein, human; ... Complement C1 Inactivator Proteins / adverse effects, therapeutic use. Complement C1 Inhibitor Protein / metabolism. Danazol / ... Hereditary angioedema (HAE) is caused by a deficiency in C1 esterase inhibitor and is characterized by sudden attacks of edema ...
  http://www.biomedsearch.com/nih/Clinical-review-hereditary-angioedema-diagnosis/19940422.html
*  Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks - Full Text View -...
Complement C1s. Complement C1 Inhibitor Protein. Complement C1 Inactivator Proteins. Immunologic Factors. Physiological Effects ... Nanofiltered C1-esterase inhibitor for the acute management and prevention of hereditary angioedema attacks due to C1-inhibitor ... Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks (CHANGE 2). The ... Antigenic C1 Inhibitor (C1INH) Serum Levels [ Time Frame: Pre-infusion to 1 hour post-infusion ]. Change in antigenic C1INH ...
  https://clinicaltrials.gov/ct2/show/NCT00438815?cond=%22hereditary+angioedema%22&rank=5
*  Berinert P Study of Subcutaneous Versus Intravenous Administration - Full Text View - ClinicalTrials.gov
Complement C1s. Complement C1 Inhibitor Protein. Complement C1 Inactivator Proteins. Immunologic Factors. Physiological Effects ... C1-Inhibitor activity , 50% and C1-Inhibitor antigen , 15.4 mg/dl) or HAE type II (C1-Inhibitor activity , 50% and C1-Inhibitor ... The pathophysiological correlate of this disease is a deficiency in functionally active C1-Esterase Inhibitor (C1-INH). Today, ... Individual courses of C1-inhibitor levels, from these will be derived pharmacokinetic parameters [ Time Frame: i.v. and s.c. ...
  https://clinicaltrials.gov/ct2/show/NCT00748202
*  Acute Transverse Myelitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
Complement C1 Inactivator Proteins. Phase 1. 41. Complement C1 Inhibitor Protein. Phase 1. ... C1-esterase Inhibitor (Cinryze) for Acute Treatment of Neuromyelitis Optica Exacerbation. Completed. NCT01759602 Phase 1. C1- ... esterase inhibitor (Cinryze). 7. Ublituximab for Acute Neuromyelitis Optica (NMO) Relapses. Active, not recruiting. NCT02276963 ...
  http://www.malacards.org/card/acute_transverse_myelitis
*  LEVP2006-4 CHANGE 3 Trial (C1-Inhibitor in Hereditary Angioedema Nanofiltration Generation Evaluating Efficacy): Open-Label Use...
This study investigated the tolerability and efficacy of complement C1 inhibitor protein [C1INH-nf] for the prevention of ... Drugs Complement C1 inhibitor protein (Primary) * Indications Hereditary angioedema * Focus Registrational; Therapeutic Use ... LEVP2006-4 CHANGE 3 Trial (C1-Inhibitor in Hereditary Angioedema Nanofiltration Generation Evaluating Efficacy): Open-Label Use ... LEVP2006-4 CHANGE 3 Trial (C1-Inhibitor in Hereditary Angioedema Nanofiltration Generation Evaluating Efficacy): Open-Label Use ...
  https://adisinsight.springer.com/trials/700242737?error=cookies_not_supported&code=102edb3e-9bc1-4464-8173-21cbc92ecdfa
*  Find Research Outputs - the University of Bath's research portal
Complement C1 Inhibitor Protein Bordetella pertussis Complement C3b Complement Membrane Attack Complex ... Bordetella pertussis isolates vary in their interactions with human complement components article. Brookes, C., Freire-Martin, ...
  https://researchportal.bath.ac.uk/en/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&originalSearch=&nexusOrganisationUuid=&format=&page=6
*  A Double-blind, Randomized-withdrawal, Placebo-controlled Study to Evaluate the Efficacy and Safety of Human Plasma-derived C1...
Drugs Complement C1 inhibitor protein (Primary) ; Complement C1 inhibitor protein (Primary) * Indications Transplant rejection ... Placebo-controlled Study to Evaluate the Efficacy and Safety of Human Plasma-derived C1-esterase Inhibitor as add-on to ... Placebo-controlled Study to Evaluate the Efficacy and Safety of Human Plasma-derived C1-esterase Inhibitor as add-on to ...
  http://adisinsight.springer.com/trials/700286332?error=cookies_not_supported&code=5dc5051a-c760-4fcb-b88c-b0fc61677537
*  Clinical Trials sub-cluster 83
... tested for deficiency of functional complement C1 esterase inhibitor protein (functional C1 INH). The general population sample ... BACKGROUND: Proton pump inhibitors (PPIs) are potent inhibitors of gastric acid secretion and give hypergastrinemia secondary ... Background: Matrix metalloproteinase-9 (MMP-9) and its inhibitor tissue inhibitor of metalloproteinase-1 (TIMP-1) are involved ... effects on the resistance to protease inhibitors and reverse transcriptase inhibitors were evaluated in protease inhibitor- ...
  http://www.biomedsearch.com/cluster/19/Clinical-Trials/sub-83-p2.html
*  List of proteins - Wikipedia
Complement proteins C1-inhibitor C3-convertase Factor VIII Factor XIII Protein C Protein S Protein Z Protein Z-related protease ... A list of proteins (and protein complexes). This list aims to organize information on the protein universe. All proteins can be ... G-protein-coupled receptor Rhodopsin Estrogen receptor Histones Protamines CI protein % Transcription regulatory proteins that ... For more information about categorizing protein types, see List of types of proteins. Arp2/3 Coronin Dystrophin FtsZ Keratin ...
  https://en.wikipedia.org/wiki/List_of_proteins
*  Patente US8102176 - NMR device for detection of analytes - Google Patentes
... analytes include C3 complement, C4 complement, C1 inhibitor, C-reactive protein, and/or rheumatoid fator); polyclonal/ ... serum proteins, cell surface proteins, protein fragments, modified proteins), any infectious disease (e.g., bacterial based on ... a viral protein (e.g., hemagglutinin), an extracellular matrix protein, a lectin, or an ectodomain of a cell surface protein. ... The binding moiety can also be an antibody directed toward an antigen or any protein-protein interaction. Also, the binding ...
  http://www.google.es/patents/US8102176
*  Complement c1 inactivator proteins facts | Factolex
C1-inhibitor) -- a serine protease inhibitor (serpin) protein, the main function of which is the inhibition of the complement ... Complement c1 inactivator proteins (C1-inhibitor) C1-inhibitor. also called Complement c1 inactivator proteins and has 6 more ... Click this checkbox if your fact describes another meaning of C1-inhibitor.Add this fact to a new term C1-inhibitor that will ... This way, C1-inh prevents the proteolytic cleavage of later complement components C4 and C2 by C1 and MBL. created by factobot ...
  http://en.factolex.com/Complement_c1_inactivator_proteins:complement_system
*  Urticarial vasculitis - Wikipedia
... named C1-inhibitor. The inhibition of C1-inhibitor leads to over-activation of the complement pathway and one protein that ... Also, there has been some speculation as to an additional autoantibody against an inhibitor protein (in the complement pathway ... Consequently, levels of all complement proteins become low. The complement pathway is composed of several subset pathways: the ... C1q is an integral component within the complement pathway - a complicated cascade of protein interactions, culminating in an ...
  https://en.wikipedia.org/wiki/Urticarial_vasculitis
*  Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway | JEM
Complement 1 inhibitor (C1-INH)* is a critically important protein that controls activation of multiple plasma mediator ... We studied complement 1 inhibitor (C1-INH) as an inhibitor of the alternative complement pathway. C1-INH prevented lysis, ... C1-INH and alternative-complement activities in C1-INH depleted serum. C1-INH functional activity (white bars) and alternative- ... All the above attempts failed to detect interaction between labeled proteins and C1-INH or control proteins. However, C1-INH ...
  http://jem.rupress.org/content/194/11/1609
*  Current Topics in Complement II | SpringerLink
Complement has long been regarded as a pivotal effector arm of the innate immune response, eliciting important immunoregulatory ... Human Astrovirus Coat Protein: A Novel C1 Inhibitor Neel K. Krishna, Kenji M. Cunnion ... protein structures, design of complement inhibitors, and complement assays discussed during the conference. ... Role of Complement in Motor Neuron Disease: Animal Models and Therapeutic Potential of Complement Inhibitors ...
  https://link.springer.com/book/10.1007%2F978-0-387-78952-1
*  Angioedema - Immune Disorders - Merck Manuals Consumer Version
C1 inhibitor is one of the proteins in the complement system, which is part of the immune system. Symptoms usually start during ... acquired C1 inhibitor deficiency) are caused by a deficiency or malfunction of C1 inhibitor, which is part of the immune system ... Acquired C1 Inhibitor Deficiency). By Peter J. Delves, PhD, Professor of Immunology, Division of Infection & Immunity, Faculty ... These drugs, taken by mouth, can stimulate the body to produce more C1 inhibitor, but they may be less effective for acquired ...
  http://www.merckmanuals.com/home/immune-disorders/allergic-reactions-and-other-hypersensitivity-disorders/hereditary-and-acquired-angioedema?Ref=s&ItemId=v6575594&RefId=/immune_disorders/allergic_reactions_and_other_hypersensitivity_disorders/hereditary_and_acquired_angioedema&Speed=256&Plugin=WMP&Error=
*  Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney ... ( SAN FRANCISCO July 30...
C1-INH,May,Aid,in,Prevention,of,Antibody-Mediated,Rejection,Following,Kidney,Transplant,biological,advanced biology technology, ... SAN FRANCISCO July 30 2014 /-...The study shows that post-transplant treatment with C1-INH results in ... Antibody-mediated ... C1-INH is a human protein and an important inhibitor of the complement system. ... C1-INH function and antigen levels in blood increased with C1-INH treatment [C1 function (p=0.0007) and C1-INH antigen percent ...
  http://bio-medicine.org/biology-technology-1/Study-Suggests-C1-INH-May-Aid-in-Prevention-of-Antibody-Mediated-Rejection-Following-Kidney-Transplant-29756-1/
*  Hereditary C1 esterase deficiency in a Zulu kindred
... of C1 inhibitor (C1-INH) - a protein that prevents complement activation by both the classic route and the mannan-binding ... Fresh-frozen plasma contains several complement proteins and is considered first-line therapy where C1 esterase inhibitor ... C1 esterase inhibitor protein can be used for long-term prophylaxis in selected patients.3 ... The most effective medical treatment for acute episodes of HA is intravenous C1 esterase inhibitor protein,3 which is ...
  http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742009000100015&lng=en&nrm=iso&tlng=en
*  C4bp complement protein - Semantic Scholar
It binds as a cofactor to COMPLEMENT FACTOR I which then hydrolyzes the COMPLEMENT C4B in the CLASSICAL PATHWAY C3 CONVERTASE ( ... A serum protein that regulates the CLASSICAL COMPLEMENT ACTIVATION PATHWAY. ... Human Complement Regulators C4b-Binding Protein and C1 Esterase Inhibitor Interact with a Novel Outer Surface Protein of ... C4bp complement protein. Known as: C4bC3bINA Cofactor, Complement C3b C4b Inactivator Cofactor, Protein, Complement C4b-Binding ...
  https://www.semanticscholar.org/topic/C4bp-complement-protein/1286503
*  Classical Pathway Evaluation - Current Protocols
Deficiencies in regulator proteins. 1. C1 Inhibitor. In Hereditary and Acquired Complement Deficiencies in Animals and Man (K. ... Basic Protocol 3: Measurement of C1 Esterase Inhibitor (C1‐INH) Function by Indirect RID. ... Basic Protocol 3: Measurement of C1 Esterase Inhibitor (C1‐INH) Function by Indirect RID ... Assay of complement components C1, C4, C2, C3 and C9 in whole rat serum. Int. Arch. Allergy Appl. Immunol. 43:887‐897. ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-im1301.html?quicktabs_cp=abstract
*  C1 inhibitor - definition of C1 inhibitor by The Free Dictionary
C1 inhibitor synonyms, C1 inhibitor pronunciation, C1 inhibitor translation, English dictionary definition of C1 inhibitor. ... Angioedema can occur in patients with decrease serum levels or abnormal function of regulatory complement protein, C1 inhibitor ... C1 inhibitor - definition of C1 inhibitor by The Free Dictionary https://www.thefreedictionary.com/C1+inhibitor ... C1 esterase inhibitor deficiency is a hereditary condition where reduced activity of C1 inhibitor leads to episodic angioedema ...
  http://www.thefreedictionary.com/C1+inhibitor
*  List of MeSH codes (D12.776.124) - Wikipedia
... complement c1 inactivator proteins MeSH D12.776.124.486.274.920.250.500 -- complement c1 inhibitor protein MeSH D12.776.124.486 ... complement c5a, des-arginine MeSH D12.776.124.486.274.050 -- complement c1 MeSH D12.776.124.486.274.050.270 -- complement c1q ... complement c3b inactivator proteins MeSH D12.776.124.486.274.920.325.200 -- complement factor h MeSH D12.776.124.486.274.920. ... 325.210 -- complement factor i MeSH D12.776.124.486.274.920.662 -- complement c4b-binding protein MeSH D12.776.124.486.274.930 ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776.124)
*  Pancreatitis-associated Protein Protects the Lung from Leukocyte-induced Injury | Anesthesiology | ASA Publications
Heller A, Kirschfink M: Effects of C1-inhibitor and sCR-1 on complement induced lung injury (abstract). Acta Anaesthesiol Scand ... Protein concentration was measured according to Bradford. 25 Part of the protein solution was submitted to sodium dodecyl ... the protein was called pancreatitis-associated protein (PAP). PAP may be of clinical relevance as a prognostic marker because a ... Pancreatitis-associated Protein Protects the Lung from Leukocyte-induced Injury Axel Heller, M.D.; Fritz Fiedler, M.D.; Joachim ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1946609
*  anti-C1 inhibitor antibody [C1C3] | GeneTex
... serpin peptidase inhibitor, clade G (C1 inhibitor), member 1) for IHC-P, WB. Anti-C1 inhibitor pAb (GTX119690) is tested in ... Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. ... C1 esterase inhibitor antibody, complement component 1 inhibitor antibody, plasma protease C1 inhibitor antibody, C1-inhibiting ... Recombinant protein encompassing a sequence within the center region of human C1 inhibitor. The exact sequence is proprietary. ...
  http://www.genetex.com/C1-inhibitor-antibody-C1C3-GTX119690.html