*  Radiotherapy may cause long-term cognitive impairment
Washington D.C. [USA], June 10 (ANI): U.S. researchers have found that radiation therapy (RT) used for treating patients with brain tumors can alter neural networks and cause long-term cognitive impairment.
  https://www.aninews.in/news/health/radiotherapy-may-cause-long-term-cognitive-impairment/
*  Nephrology Now » Blog Archive » Chronic kidney disease is associated with incident cognitive impairment in the elderly: the...
This study aimed to assess the relationship between renal impairment and cognitive decline. Of the 3769 patients, 396 (10%) had cognitive impairment at the outset. After the 2-year follow-up, 194 participants (6.2%) developed new cognitive impairment. Multiple logistic regression analysis showed that moderate-to-severe impaired renal function was associated with incident cognitive impairment after 2 years in a large cohort of elderly subjects ...
  http://www.nephrologynow.com/publications/chronic-kidney-disease-is-associated-with-incident-cognitive-impairment-in-the-elderly-the-invade-study
*  Postoperative cognitive dysfunction - Wikipedia
Postoperative cognitive dysfunction (POCD) is a decline in cognitive function (especially in memory and executive functions) that may last from a few days to a few weeks after surgery. In rare cases, this disorder may persist for several months after major surgery. POCD is distinct from emergence delirium. It occurs most commonly in older patients and those with pre-existing cognitive impairment. The causes of POCD are not understood. It does not appear to be caused by lack of oxygen or impaired blood flow to the brain and is equally likely under regional and general anesthesia. It may be mediated by the body's inflammatory response to surgery. POCD is common after cardiac surgery, and recent studies have now verified that POCD also exists after major non-cardiac surgery, although at a lower incidence. The risk of POCD increases with age, and the type of surgery is also important because there is a very low incidence associated with minor surgery. POCD is common in adult patients of all ages at ...
  https://en.wikipedia.org/wiki/Postoperative_cognitive_dysfunction
*  British Library EThOS: Inflammatory signalling in postoperative cognitive dysfunctions
Major surgeries, such as cardiac or orthopaedic procedures in particular, expose the patient to extensive trauma, blood loss, and tissue injury; all of these factors effectively modulate the immune system to ultimately trigger an inflammatory response. Postoperative cognitive dysfunction (POCD), the condition being characterized by impairment of short and long-term memory, is one of common complicates following surgery. Recently, our data have demonstrated that neuroinflammation and microglia activation in the hippocampus following surgery are associated with cognitive decline. The aim of this thesis is to investigate the inflammatory signaling pathways specifically involved with POCD, with a particular interest between systemic inflammation and local inflammation in the brain following surgery. The data presented in this thesis introduce the general concepts and the involvement of inflammation in the etiology of cognitive dysfunctions using a mouse model of POCD. Upon the identification of ...
  http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540660
*  Postoperative Cognitive Decline, Inflammation, and Plasma Levels of Beta-amyloids - Full Text View - ClinicalTrials.gov
Postoperative cognitive dysfunction (POCD) can be a serious complication. The development of therapeutic strategies for the prevention and treatment of this condition requires the identification of subgroup of patients with the greatest incidence of POCD. Several retrospective analyses have raised the possibility that surgery is a risk factor for the accelerated progression of Alzheimer's disease (AD). Moreover, there is increasing evidence that inflammatory mechanisms are involved in the pathogenesis of AD. Major surgery can be associated with a profound systemic inflammatory response. Consequently, it is reasonable to suggest that there is a link between major surgery and the postoperative development of AD in patients who are already at high risk for this complication, e.g. the elderly with mild cognitive impairment. In addition, there are several laboratory investigations that suggest that anesthetic agents increase amyloid peptide levels as well as enhance oligomerization of these proteins. ...
  https://clinicaltrials.gov/ct2/show/NCT00850928
*  The Mini-Mental State Exam (MMSE) 1.0 free download for iPhone & iPad | FreeNew
Free download the The Mini-Mental State Exam (MMSE) 1.0 iPhone & iPad app (★★½,522 downloads),The Mini-Mental State Exam (MMSE) is the most widely used cognitive test for dementia in US clinical pract
  http://www.freenew.net/iphone/the-mini-mental-state-exam-mmse-10/259449.htm
*  Mood and Cognition in Old Age | Frontiers Research Topic
Improving psychological well-being and cognitive health is now listed as the priority on the healthy aging agenda. Depression and cognitive impairment are great challenges for the elderly population. There have been numerous studies on depression and cognitive impairment and dementia. However, the neural correlates of depression and cognitive impairment have not yet been elucidated. With the development of neuroscience and relevant technologies, studies on anatomical and functional neural networks, neurobiological mechanisms of mood and cognition in old age will provide more insight into the potential diagnosis, prevention and intervention in depression and cognitive impairment. For example, longitudinal neuroimaging studies depicting the trajectories of patterns of structural and functional brain networks of mild cognitive impairment may provide potential imaging markers for the onset of dementia.Population-based studies have addressed the potential interaction between mood and cognitive ...
  https://www.frontiersin.org/research-topics/4691/mood-and-cognition-in-old-age
*  A biomarker for postoperative cognitive dysfunction - aspartic acid in the hippocampus
Postoperative cognitive dysfunction is the deterioration of cognitive performance after anesthesia and surgery, and manifests as impairments in short-term memory, concentration, language comprehension, and social integration skills ...
  https://www.painweek.org/news_posts/a-biomarker-for-postoperative-cognitive-dysfunction-aspartic-acid-in-the-hippocampus.html
*  Response to Letter by Blackburn et al Regarding Article, "Is the Montreal Cognitive Assessment Superior to the Mini-Mental...
Response:. We thank Blackburn et al for their interesting comments on screening tests for poststroke cognitive impairment. Given the frequency and impact of poststroke cognitive impairment, choosing the best possible screening test is important. In view of the MMSE score's poor sensitivity to vascular cognitive impairment and our recent results,1 Blackburn et al suggest that the Montreal Cognitive Assessment (MoCA) should be used instead of the MMSE, with a cutoff ≤23. Although we agree with some of Blackburn et al's points, the currently available evidence (including our own study) does not fully support their position. First, our study supported the moderate sensitivity (0.66) of MMSE when recommended cutoffs are used.1 However, sensitivity improved using cut-off after adjustment of the score for education level (Table 21). Second, Blackburn et al indicate that use of a cutoff ≤23 for the MoCA yielded a sensitivity of 0.84 and a specificity of 0.81 as indicated in Table 3.1 We wish to ...
  http://stroke.ahajournals.org/content/42/11/e583
*  Aspartic acid in the hippocampus: A biomarker for postoperative cognitive d... ( Postoperative cognitive dysfunction ...)
...Postoperative cognitive dysfunction is the deterioration of cognitive ......,Aspartic,acid,in,the,hippocampus:,A,biomarker,for,postoperative,cognitive,dysfunction,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
  http://www.bio-medicine.org/biology-news-1/Aspartic-acid-in-the-hippocampus-3A-A-biomarker-for-postoperative-cognitive-dysfunction-34863-1/
*  Severity of cognitive impairment at initial diagnosis of Alzheimer's disease was the strongest predictor of survival | Evidence...
Given the aging population and the corresponding increase in the incidence of AD, information on the prognosis of AD will help practitioners and unpaid caregivers to better meet the needs of patients with AD.. This well designed, prospective study by Larson et al provides estimates of survival after initial diagnosis of AD. Estimated survival rates were longer than those reported by the Canadian Study of Health and Aging (3.2 y for men and 3.4 y for women).1 This difference may be attributed to the older sample in the Canadian Study of Health and Aging.. Length of survival after onset of AD may be quite different from length of survival after initial diagnosis. Identifying the precise onset of AD may be difficult because of the insidious nature of the disease, unpaid caregiver's lack of awareness of changes in cognition and functional abilities, and the patient's ability to compensate for impairments. Although diagnosis at the onset of disease may not alter the natural course of AD, it could ...
  http://ebn.bmj.com/content/7/4/120.full?cited-by=yes&legid=ebnurs
*  Mini-Mental State Exam
This page includes the following topics and synonyms: Mini-Mental State Exam, Mini-Mental Status Exam, Folstein Mini Mental Status Exam, Folstein MMSE, MMSE.
  http://fpnotebook.com/Neuro/Exam/MnMntlStExm.htm
*  1 in 4 people with mild cognitive impairment may get better - Health - CBC News
Older people with mild cognitive problems may revert to normal brain function if they keep physically and mentally active and open to new experiences, say Australian researchers.
  http://www.cbc.ca/news/health/1-in-4-people-with-mild-cognitive-impairment-may-get-better-1.1364373
*  Depressive Symptoms and 3-Year Mortality in Older Hospitalized Medical Patients | Annals of Internal Medicine | American...
Results:. The mean age of the patients was 80 years; 68% of patients were women. Patients with six or more depressive symptoms had greater comorbid illness, functional impairment, and cognitive impairment at admission than patients with fewer depressive symptoms. Three-year mortality was higher in patients with six or more depressive symptoms (56% compared with 40%; hazard ratio, 1.56 [95% CI, 1.22 to 2.00]; P , 0.001). After adjustment for age, acute illness severity, comorbid illness, functional impairment, and cognitive impairment at the time of admission, patients with six or more depressive symptoms continued to have a higher mortality rate during the 3 years after admission (hazard ratio, 1.34 [CI, 1.03 to 1.73]). Although depressive symptoms contributed less to the mortality rate than did the total burden of comorbid medical illnesses, the excess mortality rate associated with depressive symptoms was greater than that conferred by one additional comorbid medical condition. ...
  http://annals.org/aim/article-abstract/712644/depressive-symptoms-3-year-mortality-older-hospitalized-medical-patients
*  Altered proteins in the aging brain
The classification of neurodegenerative disorders is based on the major component of the protein aggregates in the brain. The most common altered proteins associated with neurodegeneration are Hyperphosphorylated tau (HPt), beta amyloid (Aβ), alpha-synclein (αS) and transactive response DNA binding protein 43 (TDP43). In this study we assessed the incidence and the neuroanatomical distribution of proteins associated with neurodegeneration in the brain tissue of cognitively unimpaired subjects.. We demonstrated the early involvement of the Locus Coeruleus (LC) with HPt pathology in cognitively unimpaired mid aged subjects, a finding which supports the notion that LC is an initiation site of HPt pathology. This may suggest that development of clinical assessment techniques and radiological investigations reflecting early LC alterations may help in identifying subjects with early stages of neurodegeneration.. Furthermore, we studied a large cohort of cognitively unimpaired subjects with age at ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:904441
*  Who coped with Studies (MBA in my case), Short Term Memory Loss and Cognitive Disability? - Fibromyalgia - HealingWell.com Forum
welcome to the forum! i agree that one of the most frustrating parts of this dd is the problem with cognitive functions. i am currently working towards my bachelor's in accounting and have definitely seen a decline in my ability to remember information. i have had to fall back on notes, notes, notes! i have notes in a couple of different places regarding when everything is due-in my planner, on my dry erase board, sticky notes on my computer-and that seems to really have helped me get things done on time. with regards to remembering important information, i've started relating information i need to know to other things..little tips or jingles or small poems or whatever that contains the information i need to remember and that has really helped, too. also, i take all of my classes online (which is very helpful!) and NEVER do homework or take a test if i'm in a lot of pain or overly tired or hungry. if you're taking 'in person' classes then you obviously don't have the freedom of flexibility that ...
  https://www.healingwell.com/community/default.aspx?f=24&m=1372365
*  Metabolite Retention May Cause Cognitive Impairment in Kidney Failure Patients
Retention of certain metabolites in the blood may contribute to cognitive impairment in patients with kidney failure, revealed a new study.
  http://www.medindia.net/news/metabolite-retention-may-cause-cognitive-impairment-in-kidney-failure-patients-162037-1.htm
*  1:59 pm
Currently, 5 million Americans age 65 and up are actively suffering from dementia, a syndrome characterized by significant cognitive impairment - at a cost of $203 billion per year, which doesn't include the 17.5 billion hours of unpaid care from caregivers. Dementia (the original Latin word for madness) encompasses both short and long-term memory loss but also includes dramatic changes in personality as well as behaviors that are difficult to handle. This often surprises people given that they don't expect their well-mannered elderly relatives to act petulantly or unreasonably. Furthermore, caregivers bear a large burden because basic life-sustaining skills, such as eating and going to the bathroom, are no longer routine for the affected people. In addition to the living-assistance these patients require, the cost of taking care of a demented patient can reach exorbitant sums which are unaffordable for many families. Dementia is not a curable disease so its exigent conditions demand that we ...
  http://www.askdrmarisela.com/dementia-the-fear-of-old-age/
*  Lidocaine For Neuroprotection During Cardiac Surgery - Full Text View - ClinicalTrials.gov
To characterize cognitive function over time, while minimizing potential redundancy in the cognitive measures, a factor analysis was performed on the 14 cognitive test scores from baseline. We chose a five-factor solution, which represents 5 cognitive domains: structured verbal memory, unstructured verbal memory, executive function, visual memory and attention/concentration. To quantify overall cognitive function, a baseline cognitive index was first calculated as the mean of the 5 preoperative domain scores. The cognitive index score has a mean of zero, thus any positive score is above the mean, any negative score is below the mean. A continuous change score was then calculated by subtracting the baseline from the 6-week cognitive index. The resulting outcome measure is unbounded with standard deviation of 0.35. A negative change score indicating decline and a positive score indicating improvement ...
  https://clinicaltrials.gov/ct2/show/NCT00938964?term=Heart+Block&recr=Open&fund=01&rank=19
*  Nonconventional Treatments of Cognitive Impairment: Page 3 of 3 | Psychiatric Times
The numbers of patients with Alzheimer disease (AD), as well as those with severe cognitive impairment caused by traumatic brain injury and stroke, are continuing to increase. This article includes some nonconventional treatment approaches for which the evidence is limited.
  http://www.psychiatrictimes.com/articles/nonconventional-treatments-cognitive-impairment/page/0/3?pageNumber=2
*  Brain circuitry loss may be a very early sign of cognitive decline in healthy elderly people
The degeneration of a small, wishbone-shaped structure deep inside the brain may provide the earliest clues to future cognitive decline, long before healthy older people exhibit clinical symptoms of memory loss or dementia, a study by researchers at the UC Davis Alzheimer's Disease Center has found.
  http://www.ucdmc.ucdavis.edu/publish/news/cvc/8172
*  Study: Omega-3 supplements have no effect on cognitive decline - UPI.com
A five-year study by the National Institutes of Health found omega-3 supplements had no effect on cognitive decline, contrary to long-held beliefs.
  https://www.upi.com/Health_News/2015/08/25/Study-Omega-3-supplements-have-no-effect-on-cognitive-decline/1861440541095/?st_rec=1841440596919
*  Meetings : Health and Medicine Division
This public workshop will bring together key stakeholders to provide input to the Committee on Decreasing the Risk of Developing Alzheimer's-Type Dementia, Mild Cognitive Impairment, and Age-Related Cognitive Impairment on the draft AHRQ systematic review of the evidence on interventions associated with decreasing the risk of developing clinical Alzheimer's-type dementia and MCI, and delaying or slowing ARCD ...
  http://nationalacademies.org/hmd/Global/Meetings.aspx?topic1=%7BC7C4B78C-62B6-438F-97A6-114348CC1C29%7D&topic2=%7B8CE3B06F-AC82-444E-B27F-AE059D56402F%7D
*  Efficacy and Safety of Actovegin in Post-stroke Cognitive Impairment (PSCI) - Full Text View - ClinicalTrials.gov
The ADAS-cog measures cognitive performance by combining the ratings of 11 items. The cognitive domains mainly addressed by ADAS-cog are: memory (short term), language, ability to orientate (reflects memory), construction/planning of simple designs and performance. The extended version of the ADAS-cog (ADAS-cog+) includes 3 additional items: a 2-number cancellation task to test for attention, a delayed recall task to test for memory consolidation and a maze test for executive performance. Each item is scored and then the item scores are totaled. Total scores range from 0 (best) to 90 (worst). Higher scores indicate greater cognitive impairment. A negative change from Baseline indicates improvement.. Analysis of Covariance (ANCOVA) model was used for analyses that included treatment, pooled centre, and their interaction as factors and Baseline ADAS-cog+ score as a covariate. ...
  https://clinicaltrials.gov/ct2/show/NCT01582854
*  REVISED: Attention Talk News June 10, 2013
Companies are good at accommodating physical disabilities, but what about cognitive disabilities? Now, that is a different story. In this edition of Attention Talk Radio, ADHD coach and host Jeff Copper interviews part-time ADHD coach Jay Carter, whose day job has included being the chair of a disability advisory committee for a Fortune 100 company. At present, he is on the corporate advisory board of U.S. Business Leadership Network which is an employer-led group who exists to help companies hire, train, and retain employees with disabilities. The interview will focus on the key things you need to attend to before addressing workplace accommodation, including disclosure, costs of accommodation, chain of influence, and why you need to understand your specific needs. If you have ADHD and struggle at work, this is the show for you ...
  http://archive.constantcontact.com/fs152/1110806865747/archive/1113747862102.html