Clusterin - Wikipedia
"Entrez Gene: clusterin". Koltai T (2014). "Clusterin: a key player in cancer chemoresistance and its inhibition". OncoTargets ... In humans, clusterin is encoded by the CLU gene on chromosome 8. CLU is a molecular chaperone responsible for aiding protein ... Clusterin was first identified in ram rete testis fluid where it showed signs of clustering with rat sertoli cells and ... Wei L, Xue T, Wang J, Chen B, Lei Y, Huang Y, Wang H, Xin X (Aug 2009). "Roles of clusterin in progression, chemoresistance and ...
αM and clusterin mediated lyso [IMAGE] | EurekAlert! Science News Releases
α2M and clusterin are molecular chaperones involved in extracellular proteostasis, but α2M has a greater affinity for ... αM and clusterin mediated lysosomal degradation of misfolded extracellular proteins (IMAGE) Chiba University ...
Dynamics of clusterin protein expression in the brain and plasma following experimental traumatic brain injury | Scientific...
Our previous mRNA-seq data revealed a 1.8-2.5 fold increase in clusterin mRNA expression in lesioned brain areas in rats with ... We validated our mRNA-seq findings with RT-qPCR, confirming increased clusterin mRNA levels in the perilesional cortex (FC 3.3 ... On this basis, we hypothesized that TBI leads to increases in the brain levels of clusterin protein, and consequently, ... Enzyme-linked immunoassays indicated that an acute 15% reduction, rather than an increase in plasma clusterin levels ...
Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling. | ALZFORUM
Study links protein, clusterin, to cardiac and metabolic diseases
Houston Methodist Research Institute and Houston Methodist Cancer Center have linked the protein clusterin-for the first time- ... "Fat cells increase clusterin production as they enlarge in obesity. Clusterin may be a biomarker of disease, as well as a ... More information: David Bradley et al, Clusterin Impairs Hepatic Insulin Sensitivity and Adipocyte Clusterin Associates With ... The clusterin protein is a key component of the extracellular matrix, so this work opens up a new vista to understand the role ...
Clusterin Human ELISA | BioVendor R&D
Measure human Clusterin/Apolipoprotein J in serum, plasma, CSF and urine. Quantification in less than 3 hours, Quality Controls ... Human - Clusterin - Immunoassays. Clusterin - for Serum - Immunoassays. Clusterin - for Plasma-EDTA - Immunoassays. Clusterin ... Clusterin. By Technical Data. Clusterin - Immunoassays. Clusterin - Sandwich ELISA, Biotin-labelled antibody - Immunoassays. ... Clusterin - for Urine - Immunoassays. Clusterin - for Cerebrospinal fluid - Immunoassays. Clusterin - RUO - Immunoassays. ...
The heat shock response in FAP: The role of the extracellular chaperone clusterin | www.ibmc.up.pt
Clusterin protects neurons against intracellular proteotoxicity | Acta Neuropathologica Communications | Full Text
We have examined in this study whether or not increased expression of clusterin is able to protect neuronal cells against ... We used the amyotrophic lateral sclerosis-associated protein TDP-43 as a primary model to investigate the effects of clusterin ... We have shown that clusterin directly interacts with TDP-43 in vitro and potently inhibits its aggregation, and observed that ... We also showed that in Drosophila photoreceptor cells, clusterin co-expression gave ER stress-dependent protection against ...
Human Clusterin - Ampersand Biosciences
Alzheimer Disease: Practice Essentials, Background, Anatomy
Clusterin. Clusterin, a plasma protein, plays an important role in the pathogenesis of AD. In one study, clusterin was ... Plasma clusterin and the risk of Alzheimer disease. JAMA. 2011 Apr 6. 305(13):1322-6. [QxMD MEDLINE Link]. ... Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen ... 24] A study by Schrijvers et al notes that although plasma clusterin levels are significantly associated with baseline ...
Alzheimer Disease: Practice Essentials, Background, Anatomy
Clusterin. Clusterin, a plasma protein, plays an important role in the pathogenesis of AD. In one study, clusterin was ... Plasma clusterin and the risk of Alzheimer disease. JAMA. 2011 Apr 6. 305(13):1322-6. [QxMD MEDLINE Link]. ... Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen ... 24] A study by Schrijvers et al notes that although plasma clusterin levels are significantly associated with baseline ...
Human Clusterin (CLU) ELISA Kit, Cat#EKU03249 - Biomatik
CLU / Clusterin. Target Synonyms. CLU; TRPM2; KUB1; CLI; APOJ; SGP2; AAG4; APO-J; SP-40; Apolipoprotein J; Complement Lysis ... Human Clusterin (CLU) ELISA Kit, Cat#EKU03249. Rating Required Select Rating. 1 star (worst). 2 stars. 3 stars (average). 4 ... Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Clusterin (CLU) were tested 20 ... Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Clusterin (CLU) were tested on 3 ...
Custom Human Clusterin-like protein 1 IQELISA™ Kit | RayBiotech
Clusterin-like protein 1 Microplate (Item A)**: 96 well PCR plate coated with anti-Human Clusterin-like protein 1 ... Detection Affinity Reagent for Clusterin-like protein 1 (Item F): 2 vials of a 4x concentrated solution of anti-Human Clusterin ... Custom Human Clusterin-like protein 1 IQELISA™ Kit Be the first to review this product ... Standards and samples are pipetted into the wells and Clusterin-like protein 1 present in a sample is bound to the wells by the ...
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. - Munich Cluster for Systems...
Upon interaction with Tau aggregates, Clusterin stabilizes highly potent, soluble seed species. Tau/Clusterin complexes enter ... The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model.. Nat Commun. 2021 Aug 11;12(1):4863. ... Thus, upregulation of Clusterin, as observed in AD patients, may enhance Tau seeding and possibly accelerate the spreading of ... Here we show in a cellular model system and in neurons that Clusterin, an abundant extracellular chaperone, strongly enhances ...
Clusterin attenuates the development of renal fibrosis - Fingerprint - Korea University
Who Will the Teachers Be? | Security Magazine
Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene
Glycosylation of Human Plasma Clusterin Yields a Novel Candidate Biomarker of Alzheimer's Disease. - Oxford Neuroscience
The glycosylation of clusterin from human plasma was comprehensively analyzed and characterized using mass spectrometry (MS)- ... These results provide a novel and robust workflow suitable for rapid verification of specific clusterin glycoforms with utility ... which demonstrates the utility of clusterin isoforms as diagnostic and prognostic Alzheimers disease (AD) markers. ... More detailed structural characterization of clusterin glycopeptides was also performed, demonstrating the presence of ...
Deregulated Clusterin as a Marker of Bone Fragility: New Insights into the Pathophysiology of Osteoporosis
... Visconti, Virginia ... Clusterin (CLU) is a secreted heterodimeric glycoprotein expressed in all organism fluids as well as in the intracellular ... Clusterin (CLU) is a secreted heterodimeric glycoprotein expressed in all organism fluids as well as in the intracellular ... 2022). Deregulated Clusterin as a Marker of Bone Fragility: New Insights into the Pathophysiology of Osteoporosis. GENES, 13(4 ...
Podoplanin and clusterin are reliable markers of nonneoplastic synovium at various sites<...
Podoplanin and clusterin are reliable markers of nonneoplastic synovium at various sites. / Talmon, Geoffrey; Wake, Laura; ... Clusterin (CLU) has been noted to mark synovium adjacent to tenosynovial tumors, and studies suggest that podoplanin (PP) is ... Talmon G, Wake L, Muirhead D. Podoplanin and clusterin are reliable markers of nonneoplastic synovium at various sites. ... Podoplanin and clusterin are reliable markers of nonneoplastic synovium at various sites. In: International journal of surgical ...
Overexpression of Clusterin in Ovarian Cancer is Correlated With Impaired Survival | International Journal of Gynecologic Cancer
Leber Congenital Amaurosis - American Academy of Ophthalmology
JCI - Volume 93, Issue 5
Clusterin, a marker for cell injury, was expressed primarily in the S3 segment and in the distal tubule with distinct staining ... Likewise, none of the PCNA or vimentin-positive cells expressed clusterin at detectable levels. Thus, in the S3 segment, where ... Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a ... Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a ...
Antisense oligonucleotide of clusterin mRNA induces apoptotic cell death and prevents adhesion of rat ASC-17D sertoli cells<...
Treatment of antisense oligonucleotide induced a marked reduction of synthesis for clusterin protein, but not for clusterin ... Treatment of antisense oligonucleotide induced a marked reduction of synthesis for clusterin protein, but not for clusterin ... Treatment of antisense oligonucleotide induced a marked reduction of synthesis for clusterin protein, but not for clusterin ... Treatment of antisense oligonucleotide induced a marked reduction of synthesis for clusterin protein, but not for clusterin ...
Background Clusterin (Clu) is a stress-responding proteins with multiple biological features. - Inhibition of autophagy with...
Background Clusterin (Clu) is a stress-responding proteins with multiple biological features.. Background Clusterin (Clu) is a ... Moreover cytoprotection mediated by clusterin was partially abrogated by Akt inhibitor LY294002. Conclusions Clusterin/Akt ... The microarray data also indicated that clusterin (Clu) was up-regulated in MSCGATA-4. Clusterin can be a multifunctional ... Outcomes (1) Clusterin manifestation was up-regulated in MSCGATA-4 in comparison to control MSCs transfected with empty-vector ...
Clusterin silencing inhibits proliferation and reduces invasion in human laryngeal squamous carcinoma cells | World Journal of...
Clusterin is, in its major form, a secreted heterodimeric disulfide-linked glycoprotein (sCLU), which plays important roles in ... Lau SH, Sham JS, Xie D, Tzang CH, Tang D, Ma N, Hu L, Wang Y, Wen JM, Xiao G, Zhang WM, Lau GK, Yang M, Guan XY: Clusterin ... Clusterin silencing inhibits proliferation and reduces invasion in human laryngeal squamous carcinoma cells. *Qianjin Wang1, ... Clusterin is, in its major form, a secreted heterodimeric disulfide-linked glycoprotein (sCLU). It was first linked to cell ...
Clusterin/apolipoprotein J is independently associated with survival in patients with chronic heart failure<...
Clusterin/apolipoprotein J is independently associated with survival in patients with chronic heart failure. In: Journal of ... Clusterin/apolipoprotein J is independently associated with survival in patients with chronic heart failure. Journal of ... Clusterin/apolipoprotein J is independently associated with survival in patients with chronic heart failure. / Koller, Lorenz; ... BACKGROUND: Clusterin/apolipoprotein J (CLU) is a ubiquitous expressed glycoprotein with cytoprotective properties capable to ...