*  Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae - UCL Discovery
Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae. Doctoral thesis , UCL ( ... Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae ... Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae. ... Next, the mechanism underlying chromosome fragility at RSZs was investigated by examining the contribution of various ...
  http://discovery.ucl.ac.uk/16125/
*  New light shed on chromosome fragility
... as this fragility is involved in the development of tumors. A team from the Institut de Génétique et de Biologie Moleculaire et ... Why are certain chromosome regions prone to breakages? The answer is crucial, ... New light shed on chromosome fragility. December 26, 2011 Why are certain chromosome regions prone to breakages? The answer is ... crucial, as this fragility is involved in the development of tumors. A team from the Institut de Génétique et de Biologie ...
  https://phys.org/news/2011-12-chromosome-fragility.html
*  Telomere abnormalities and chromosome fragility in patients affected by familial papillary thyroid cancer. | IRIS Univ. Cagliari
Telomere abnormalities and chromosome fragility in patients affected by familial papillary thyroid cancer. ... Aim: We aimed to verify whether familial fPTC patients show an increased spontaneous chromosome fragility. Methods: To this ... Telomere abnormalities and chromosome fragility in patients affected by familial papillary thyroid cancer. ... Aim: We aimed to verify whether familial fPTC patients show an increased spontaneous chromosome fragility. Methods: To this ...
  https://iris.unica.it/handle/11584/109399
*  Replication-Dependent Mechanism of Chromosome Fragility at the Site of Inverted Repeats in Saccharomyces cerevisiae - pdf...
Replication-Dependent Mechanism of Chromosome Fragility at the Site of Inverted Repeats in Saccharomyces cerevisiae. . ... Replication-Dependent Mechanism of Chromosome Fragility at the Site of Inverted Repeats in Saccharomyces cerevisiae - Descarga ... Replication-Dependent Mechanism of Chromosome Fragility at the Site of Inverted Repeats in Saccharomyces cerevisiae. ... From this data, we propose a model for a replication-dependent mechanism of chromosomal fragility at the site of inverted ...
  http://libros.duhnnae.com/2017/jun7/149815427652-Replication-Dependent-Mechanism-of-Chromosome-Fragility-at-the-Site-of-Inverted-Repeats-in-Saccharomyces-cerevisiae.php
*  Visiting Lecture Series | College of Graduate Studies |SUNY Upstate Medical University
Chromosome fragility: When Replication Goes Awry. We are interested in the mechanisms of how replication defects lead to DNA ... We also develop novel methods using NextGen sequencing to identify chromosome fragile sites in the human genome. ...
  http://upstate.edu/grad/faculty/lecture-series.php
*  Evolutionary stability of topologically associating domains is associated with conserved gene regulation | BMC Biology | Full...
Chromosomes fold locally into topologically associating domains (TADs) defined by increased intra-domain chromatin contacts. ... Genome organization drives chromosome fragility. Cell. 2017;170(3):1-15.Google Scholar. ... Comparative analysis of chicken chromosome 28 provides new clues to the evolutionary fragility of gene-rich vertebrate regions ... For each chromosome, we placed the same number of actual breakpoints at a random position of the chromosome. For each ...
  https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0556-x
*  Mutation Rates, Spectra, and Genome-Wide Distribution of Spontaneous Mutations in Mismatch Repair Deficient Yeast | G3: Genes |...
2007 Chromosome fragility: molecular mechanisms and cellular consequences. Front. Biosci. 12: 4911-4924. ... microsatellites are often sites of chromosome fragility, a phenomenon typically attributed to secondary structure formation and ... are shown at their chromosomal position for each of the 16 yeast chromosomes. Mutation number was plotted against chromosome ... per chromosome correlated with chromosome size (R2 = 0.91 and 0.87, respectively). ...
  http://www.g3journal.org/content/3/9/1453.full
*  First-line treatment for severe aplastic anemia in children: bone marrow transplantation from a matched family donor versus...
13 Underlying inherited marrow failure disorders were excluded clinically and by chromosome fragility testing. Marrow ...
  http://www.haematologica.org/content/99/12/1784
*  Chromosomal fragile site - Wikipedia
"Human chromosome fragility", Biochimica et Biophysica Acta, 1779 (1): 3-16, doi:10.1016/j.bbagrm.2007.10.005, PMID 18078840 ... A chromosomal fragile site is a specific heritable point on a chromosome that tends to form a gap or constriction and may tend ... Common fragile sites are considered part of normal chromosome structure and are present in all (or nearly all) individuals in a ... Sutherland, GR; Baker, E; Seshadri, RS (Jul 1980). "Heritable fragile sites on human chromosomes. V. A new class of fragile ...
  https://en.wikipedia.org/wiki/Chromosomal_fragile_site
*  Fanconi anemia - Wikipedia
Many FA patients (about 30%) do not have any of the classic physical findings, but Diepoxybutane chromosome fragility assay ... FANCB is the one exception to FA being autosomal recessive, as this gene is on the X chromosome. These genes are involved in ... Furthermore, cells will show chromosomal aberrations, the most frequent being monosomy 7 and partial trisomies of chromosome 3q ... which means that if the mother carries one mutated Fanconi anemia allele on one X chromosome, a 50% chance exists that male ...
  https://en.wikipedia.org/wiki/Fanconi_anemia
*  Genetic Evidence for Roles of Yeast Mitotic Cyclins at Single-Stranded Gaps Created by DNA Replication | G3: Genes | Genomes |...
2015 Break-seq reveals hydroxyurea-induced chromosome fragility as a result of unscheduled conflict between DNA replication and ... indicating correct chromosomes segregation, in line with the previous observation that chromosomes segregate correctly in the ... 1995 DNA2 encodes a DNA helicase essential for replication of eukaryotic chromosomes. J. Biol. Chem. 270: 26766-26769. ... The role of Clb2 in chromosome segregation is unlikely, by itself, to explain this strong synergistic effect. First, as shown ...
  http://www.g3journal.org/content/8/2/737
*  Aplastic anemias - ONA
The diagnosis includes chromosome fragility, i.e. damage to chromosomes with exposure to the deoxyribonucleic acid (DNA) cross- ... Chromosome fragility test and detailed family history in patients less than 40 years old to investigate for Fanconi's anemia. ... Demonstration of specific clonal cytogenetic abnormalities, such as trisomies of chromosome 8 or 21 and deletions of 5, 7 and ...
  https://www.oncologynurseadvisor.com/hospital-medicine/aplastic-anemias/article/601258/
*  Hyun-Min Kim -BIO-PROTOCOL
Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair. EMBO J 27(21): 2896- ...
  https://bio-protocol.org/UserHome.aspx?id=1007160
*  Major Research Areas | College of Graduate Studies |SUNY Upstate Medical University
... genomic instability and chromosome fragility in both the yeast and human genome. ... genomic instability and chromosome fragility in both the yeast and human genome. ... genomic instability and chromosome fragility in both the yeast and human genome. ... genomic instability and chromosome fragility in both the yeast and human genome. ...
  http://www.upstate.edu/grad/faculty/major-areas.php
*  Quarterly statistics: Life Sciences, Q2 2012 - UCL Discovery
Hashash, N. (2009) Molecular bases underlying chromosome fragility at Replication Slow Zones in Saccharomyces cerevisiae. ...
  http://discovery.ucl.ac.uk/past_stats/faculty/life-sci-2012-2.html
*  List of MeSH codes (C23) - Wikipedia
... chromosome fragility MeSH C23.550.210.170 --- chromosome breakage MeSH C23.550.210.175 --- chromosome deletion MeSH C23.550. ... chromosome fragility MeSH C23.550.382.250 --- eosinophilic granuloma MeSH C23.550.382.375 --- granuloma annulare MeSH C23.550. ... ring chromosomes MeSH C23.550.210.815 --- sex chromosome aberrations MeSH C23.550.210.815.970 --- xyy karyotype MeSH C23.550. ... 210.420 --- inversion, chromosome MeSH C23.550.210.430 --- isochromosomes MeSH C23.550.210.570 --- micronuclei, chromosome- ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C23)
*  List of MeSH codes (G13) - Wikipedia
... chromosome fragility MeSH G13.920.590.175.175 --- chromosome breakage MeSH G13.920.590.175.177 --- chromosome deletion MeSH ... chromosome fragility MeSH G13.380.350 --- gene dosage MeSH G13.380.355 --- genetic predisposition to disease MeSH G13.380.360 ... ring chromosomes MeSH G13.920.590.175.815 --- sex chromosome aberrations MeSH G13.920.590.175.815.970 --- xyy karyotype MeSH ... File "2006 MeSH Trees".) MeSH G13.330.159 --- gene flow MeSH G13.330.320 --- genetic drift MeSH G13.370.180 --- chromosome ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(G13)
*  Division of Clinical Genetics
... chemotherapy toxicity and may display chromosome fragility Catucci, Irene; Osorio, Ana; Arver, Brita; Neidhardt, Guido; ... In Genes Chromosomes and Cancer 57(3). p.123-139 Mark ...
  https://lup.lub.lu.se/search/search/organization/V1000554?limit=20&start=&sort=year.desc
*  Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells | BMC Biology ...
Lukusa T, Fryns JP: Human chromosome fragility. Biochim Biophys Acta. 2008, 1779: 3-16.View ArticlePubMedGoogle Scholar. ... Lowercase letters in bold indicate the name of the marker chromosome used to describe the patterns of marker chromosomes in ... Whilst it has long been known that low folate levels can induce fragile sites in both human and mouse chromosomes [29-31], ... Figure 3D shows the frequency distribution of the various patterns (A-J) of these five marker chromosomes in both cell lines. ...
  https://preview-bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-8-6
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Chromosome fragility induced by DNA interstrand crosslink (ICL)-inducing agents such as diepoxybutane (DEB) or mitomycin C (MMC ... Chromosome fragility in patients with Fanconi anaemia: diagnostic implications and clinical impact. ...
  https://www.jove.com/visualize?author=Jos%C3%A9+Sanchez+de+Toledo
*  Welcome to LibAge, the ageing reference resource
Chromosome Fragility *Cyclin-Dependent Kinase Inhibitor p21/metabolism *DNA Damage/genetics *E2F1 Transcription Factor/ ... 2009) "Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased ...
  http://libage.ageing-map.org/entries/tags/495/
*  astigmatic LASIK proscar po jakim czasie efekty
J. Only one of the chromosome 18 pair is affected. C. 49-7202-613346 Fax 49-7243-13944 e-mail kd. N Engl J Med 3378, 1997 ... disease characterized by low bone mass and michroarchitectural deterioration of bone tissue leading to enhanced bone fragility ... In an elegant experiment on the effect of cortisol on memory, with the human gene mapping to a region on chromosome 5p. ...
  http://anigroup.ru/buy-ed-pills/proscar-po-jakim-czasie-efekty.html
*  mua-3, a gene required for mechanical tissue integrity in Caenorhabditis elegans, encodes a novel transmembrane protein of...
1997), are ced-7(n1892) III, unc-32 (e189) III, unc-69(e587) III, and rol-6(su1006sd). The balancer chromosome qC1 is described ... The C. elegans homologue has been subsequently shown to encode the tissue fragility gene mup-4 (Gatewood and Bucher, 1997; Hong ... mutations that showed abnormal tissue fragility in response to mechanical stress were isolated (Plenefisch et al., 2000). Here ... elegans gene 2 megabases distant from mua-3 on chromosome III. ... were identified by their involvement in tissue fragility ...
  http://www.biomedsearch.com/nih/mua-3-gene-required-mechanical/11470828.html