This causes the cell lineage and cell fate to be highly correlated. Other organisms, such as humans, have variable lineages and ... Giurumescu, Claudiu A.; Chisholm, Andrew D. (2011). "Cell Identification and Cell Lineage Analysis". Methods in Cell Biology. ... is activated and permanently labels the cell of interest and its offspring cells, thus the name cell lineage tracing. With the ... "Building a lineage from single cells: genetic techniques for cell lineage tracking". Nature Reviews. Genetics. 18 (4): 230-244 ...
... was a significant step forward in the specific analysis of platelet and megakaryocyte cell biology. However, in the present ... The development of a megakaryocyte lineage specific Cre deleter, using the Pf4 (CXCL4) promoter (Pf4-Cre), ... Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny PLoS One. 2012;7(12):e51361. doi: 10.1371/journal. ... we demonstrate that Pf4-Cre activity is not megakaryocyte lineage-specific but extends to other myeloid and lymphoid lineages ...
Cell surface fluctuations regulate early embryonic lineage sorting. Add to your list(s) Download to your calendar using vCal ... Cell surface fluctuations regulate early embryonic lineage sorting ...
Directed differentiation of human pluripotent stem cells along the pancreatic endocrine lineage.. Return to Grants ... experience by which one can differentiate hPSCs along the pancreatic lineage to generate insulin-producing beta-cell-like cells ... experience by which one can differentiate hPSCs along the pancreatic lineage to generate insulin-producing beta-cell-like cells ... Many research groups are engaged in using human pluripotent stem cells (hPSCs) to generate surrogate pancreatic beta-cells for ...
Gene-specific transcriptional memory in mammalian cell lineages. View ORCID ProfileNicholas E. Phillips, Aleksandra Mandic, ... Gene-specific transcriptional memory in mammalian cell lineages Message Subject (Your Name) has forwarded a page to you from ...
Single-cell multi-omics and lineage tracing to dissect cell fate decision-making View in MDC Repository ... The concept of cell fate relates to the future identity of a cell, and its daughters, which is obtained via cell ... Recent insights obtained from single-cell genomic and integrative lineage-tracing approaches have further aided to identify ... Understanding, predicting, and manipulating cell fate has been a long-sought goal of developmental and regenerative biology. ...
The combination of the two offers the opportunity to map gene functions and gene networks in vivo at single-cell resolution ... using cell tracking and quantification of cellular phenotype … ... 1400 perturbed cell lineages and 600,000 digitized single cells ... Digital development: a database of cell lineage differentiation in C. elegans with lineage phenotypes, cell-specific gene ... cell-specific gene functions and a multiscale model. The database stores data from recent systematic studies of cell lineage ...
Overall, the results presented in this study show a common mechanism of endocytosis for MSC EVs across different cell types and ... Overall, the results presented in this study show a common mechanism of endocytosis for MSC EVs across different cell types and ... Our first important observation is that, MSC EVs possess a common mechanism of endocytosis across multiple cell types. Second, ... Our first important observation is that, MSC EVs possess a common mechanism of endocytosis across multiple cell types. Second, ...
Mesenchymal Stem Cells, Adipose-Lineage, Microgravity, Bed Rest, Muscle Weakness, MSC Regulation, Adipose Tissue ... Such cells from different sources can proliferate and differentiate into different lineages (e.g. osteogenic, chondrogenic and ... Clonal Analysis of Synovial Fluid Stem Cells to Characterize and Identify Mesenchymal Stromal Cell/Mesenchymal Progenitor Cell ... Is Adipocyte Differentiation the Default Lineage for Mesenchymal Stem/Progenitor Cells after Loss of Mechanical Loading? A ...
B12 Exploring the Genome-wide DNA Methylation Patterns in HD-IPS Cells during Striatal Lineage Commitment ... B12 Exploring the Genome-wide DNA Methylation Patterns in HD-IPS Cells during Striatal Lineage Commitment ... 2Department of BioSciences and Center for Stem Cell Research, Università Degli Studi Di Milano, via Viotti 3/5, 20133 Milan, ... Human induced pluripotent stem cells (hiPS) constitute an appropriate cellular model that can be exploited to mimic and ...
Raj B, Wagner DE, McKenna A, Pandey S, Klein AM, Shendure J, et al. Simultaneous single-cell profiling of lineages and cell ... Single-Cell Transcriptomics Meets Lineage Tracing. Cell Stem Cell. 2018;23(2):166-179. Available from: https://www. ... Large-scale reconstruction of cell lineages using single-cell readout of transcriptomes and CRISPR-Cas9 barcodes by scGESTALT. ... Quinn JJ, Jones MG, Okimoto RA, Nanjo S, Chan MM, Yosef N, et al. Single-cell lineages reveal the rates, routes, and drivers of ...
A computational model for understanding stem cell, trophectoderm and endoderm lineage determination PLoS ONE 3, e3478 (2008) ... It provides a framework to explore strategies of reprogramming a cell from a differentiated state to a stem cell state through ... In particular, an excess of Cdx2 over Oct4 determines the trophectoderm lineage whereas an excess of Gata-6 over Nanog ... Conclusions. The computational model provides a mechanistic understanding of how different lineages arise from the dynamics of ...
Recent saturation lineage-tracing, single-cell lineage-tracing and promoter-driven lineage-tracing studies have provided ... cells of a single lineage (full) versus those populated by both single- or multicoloured FP+ cells and/or unlabelled cells of a ... cells of a single lineage (full) versus those populated by both single- or multicoloured FP+ cells and/or unlabelled cells of a ... H) Cell neighbour analysis showing that the majority of FP+ cells had a same-colour FP+ neighbour of the same lineage [data are ...
In this thesis, Chapter 1 introduces the importance of cell lineage and spatial organization to cell fate determination, and ... In multicellular organisms, the lineage history and spatial organization of cells both play pivotal roles in cell fate ... cells and disentangled the relative contribution of lineage and space to cell fate determination in Drosophila brain ... we developed a new synthetic lineage tracking system that allows us to image single-cell lineage history. This system, termed ...
bNAbs are derived from B cells that express B cell receptors formed by specific VH/VL alleles. We report that the variable ... and that removing the variable domains from the immunogen reduces the number of activated B cell lineages and leads to the ... Our findings shed new light into how HIV-1 evades detection from B cells that can produce bNAbs and also provides information ... domains of recombinant HIV-1 Env immunogens activate a large number of B cell clones that give rise to many non-neutralizing ...
T cells. Na{i}ve-like T-bet-experienced cells are polarized to the T H1 lineage, predisposed to produce IFN-γ upon cell ... T cells. Naïve-like T-bet-experienced cells are polarized to the T H1 lineage, predisposed to produce IFN-γ upon cell ... T cells. Naïve-like T-bet-experienced cells are polarized to the T H1 lineage, predisposed to produce IFN-γ upon cell ... T cells. Naïve-like T-bet-experienced cells are polarized to the T H1 lineage, predisposed to produce IFN-γ upon cell ...
Stem cell weekly reads include pushback the FDA, He Jiankui, and pushback related LifeWave X39 patches. ... Weekly reads: bat stem cells & viruses, Lineage Cell, He Jiankui visa. By Professor Paul Knoepfler, Ph.D. / Leave a Comment / ... Recommended stem cell reads. Bat pluripotent stem cells reveal unusual entanglement between host and viruses, Cell. This is a ... Chemically defined cytokine-free expansion of human haematopoietic stem cells, Nature. Lineage Enters Into Option and License ...
Metabolic potential of a single cell belonging to one of the most abundant lineages in freshwater bacterioplankton. Published ... Metabolic potential of a single cell belonging to one of the most abundant lineages in freshwater bacterioplankton ... We thus set out to use single-cell genomics to gain insights into their genetic make-up, with the aim of learning about their ... We found that the acI-B1 cell had a small genome, with a rather low percentage of genes having no predicted functions (similar ...
Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage. ... Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage. In ... Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage. / ... Increased expression of CD27 on activated human memory B cells correlates with their commitment to the plasma cell lineage. ...
Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease: clinical significance and comparison ... Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease: clinical significance and comparison ... Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease: clinical significance and comparison ...
Differentiation of Rat Mesenchymal Stem Cells toward Osteogenic Lineage on Extracellular Matrix Protein Gradients. In: Advanced ... Differentiation of Rat Mesenchymal Stem Cells toward Osteogenic Lineage on Extracellular Matrix Protein Gradients. Advanced ... Differentiation of Rat Mesenchymal Stem Cells toward Osteogenic Lineage on Extracellular Matrix Protein Gradients. / Rasi ... title = "Differentiation of Rat Mesenchymal Stem Cells toward Osteogenic Lineage on Extracellular Matrix Protein Gradients", ...
However, the control of directing pluripotent cells into mesoderm lineage which gives rise to cardiac muscle cells remains poor ... Transgenic reporter mouse embryonic stem cells were used in this study. The reporter cell line shows the cellular endogenous ... Future studies with human pluripotent stem cells may transduce cells towards mesoderm and finally towards cardiac fate. ... Here in this work, the synergistic effect of chemical and mechanical signaling in driving cells towards mesoderm germ-layer was ...
A New Genetic Tool for Lineage Tracing of Mitotic Cells in Mice Research Grant ...
Mitochondrial and nuclear genome sequences from straight-tusked elephants indicated they were a sister lineage to African ... Single-Cell MRD Assay Helps Characterize Cells Surviving Acute Myeloid Leukemia Therapy ... Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, ... Additionally, they noted that the Palaeoloxodon, though few in samples, formed two lineages based on the site where they were ...
Parvoviral virions deploy a capsid-tethered lipolytic enzyme to breach the endosomal membrane during cell entry. Proc Natl Acad ... Distinct Lineages of Bufavirus in Wild Shrews and Nonhuman Primates. Emerging Infectious Diseases. 2015;21(7):1230-1233. doi: ... Distinct Lineages of Bufavirus in Wild Shrews and Nonhuman Primates On This Page ... Sasaki, M., Orba, Y., Anindita, P. D., Ishii, A., Ueno, K., Hangombe, B. M....Sawa, H. (2015). Distinct Lineages of Bufavirus ...
... indicating that the lineage giving rise to SARS-CoV-2 has been circulating unnoticed in bats for decades. In this manuscript, ... Our results indicate the presence of a single lineage circulating in bats with properties that allowed it to infect human cells ... Green boxplots show the TMRCA estimate for the RaTG13/SARS-CoV-2 lineage and its most closely related pangolin lineage ( ... Green boxplots show the TMRCA estimate for the RaTG13/SARS-CoV-2 lineage and its most closely related pangolin lineage ( ...
From Erythroblast Progenitors to Mature Red Blood Cell (International Journal of Molecular Sciences) ... 24, Pages 9715: Physiology of Red Cell Lineage: From Erythroblast Progenitors to Mature Red Blood Cell (International Journal ... 24, Pages 9715: Physiology of Red Cell Lineage: From Erythroblast Progenitors to Mature Red Blood Cell (International Journal ...
About Cell Lineage] [To Lineage- Before] [To Lineage - Now] [4D Embryo Development] [Cell Types in Body Plan] [WORMBASE Cell ...
A bone found in a cave by an international team of anthropologists in France may represent a previously unknown lineage of Homo ... How many living cells on Earth?. Dec 3, 2023. And Now, here comes COVID-19 version BA.2, BA.4, BA.5,.... Dec 2, 2023 ... Hip bone found in cave in France may represent a previously unknown lineage of Homo sapiens. by Bob Yirka , Phys.org ... A bone found in a cave by an international team of anthropologists in France may represent a previously unknown lineage of Homo ...