... induces cytotoxicity in a dose-dependent manner in cancer cell lines. Cell cycle analysis suggested activation of apoptosis, ... inhibition of tumor growth and a 3-fold increase in the life span of tumor bearing animals compared to untreated tumor mice. ... without arresting cell cycle progression. Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts ... potentiate apoptosis rather than necrosis in cancer cells. Loss of mitochondrial membrane potential, upregulation of ...
... were expressed in all tumor cell lines. In contrast, fucosyl-GM1 was not found to restrict to small cell lung carcinoma cells. ... To characterize biomarkers in neural tumors, we analyzed the acidic lipid fractions of 13 neural tumor cell lines using enzyme- ... Antigens in Neural Tumor Cell Lines and Anti-Glycosphingolipid Antibodies in Sera of Patients with Neural Tumors Subject Area: ... Antigens in Neural Tumor Cell Lines and Anti-Glycosphingolipid Antibodies in Sera of Patients with Neural Tumors. Neurosignals ...
... showed greater efficacy in eliciting antibody-dependent cellular phagocytosis of EGFR wild-type and KRAS-mutant tumor cells ... Innate Cell Engager Demonstrates Evidence of Improved EGFR Inhibition in Tumor Cell Lines. November 12, 2021. Caroline Seymour ... "AFM24 enhances macrophage-mediated antibody-dependent cellular phagocytosis of various EGFR-expressing tumor cell lines, ... Tetravalent, bispecific innate cell engager (ICE®) AFM24 enhances macrophage mediated tumor cell phagocytosis. Presented at: ...
The EL4-hCD19-LZ clonal cell line expresses high levels of human CD19. ... Humanized EL4-hCD19-LZ Reporter Tumor Cell Line. Design of the EL4-hCD19-LZ cell line. The EL-4 cell line was established from ... Human CD19 expression was assessed in EL4 parental cell line (left), human control cells - PBMC (center), and EL4-hCD19-LZ cell ... Tumor size (mm3) = (width²*length)/2.. Right figure. Medium (200 mm3) and large (800 mm3) tumors were collected and tumor ...
Application of this stratification to four CRC cell line panels comprising 74 different cell lines, showed that the tumor ... Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines. Title Subtypes of ... tumor subtyping. cell lines. targeted therapy. To reference this document use: http://resolver.tudelft.nl/uuid:538a9813-5214- ... primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines. ...
... activity and the radiosensitising effect of gemcitabine was investigated in eight different human tumour cell lines. Tumour ... The degree of radiosensitisation was also cell line dependent and seemed to correlate with the sensitivity of the cell line to ... our cell lines varied considerably and differed up to three fold from 5 to 15 pmol/h/mg protein between the tested cell lines. ... A clear concentration-dependent radiosensitising effect of dFdC was observed in all cell lines. ...
Tumor: insulinoma. - By clicking on the cell line name, you will retrieve the detailed description of the cell line - By ... Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines.. Nucleic Acids ... Home - Cell Index - Search - Web Sites Species - Tissues - Tumors - Pathologies - Tr. Agents Collections - Laboratories - ... you will retrieve the list of all relevant cell lines CRI-D11 (rat, NEDH) - IZSBS. For information, get in touch with: IRCCS ...
However, whether the anti-inflammatory effect of berberine contributes to its anti-tumor effect on colitis-associated ... The anti-inflammatory and anti-tumor effects of berberine, a traditional Chinese medicine, were separately discovered in ... and tumor necrosis factor-alpha (TNF-α) expression in colonic macrophages. An in vitro study on cell lines identified that ... berberine treatment of Raw 264.7 macrophages resulted in conditioned media with fewer proliferative effects on a cell line with ...
Results: TLR3 activation increased cell death in the TLR3(+) SNU182 HCC cell line (30.5% vs 8.5%, P = .03) and promoted NK-cell ... NK-cell activation and tumor infiltration, and proliferation of tumor-infiltrating T and NK cells. Proliferation of tumor ... and T-cell tumor infiltration, and inversely correlated with tumor parenchyma cell viability. TLR3 expression was also ... The effect of TLR3 on the tumor parenchyma and infiltrating immune cells was investigated in a spontaneous liver tumor mouse ...
All NSCLC cell lines and the colorectal cancer tumor cell lines HCT-116, HT-29, HCT-15, Colo201, and Colo205 were determined to ... These two targeted agents act synergistically to inhibit cell growth in 12 of 22 cell lines, including all five cell lines ( ... Cell Lines. The cell lines H460, Calu6, SW1573, H1703, H292, H358, HCT-116, HT-29, FET, GEO, HCT-15, Colo201, Colo205, CBS, ... Cell proliferation was determined using the Cell Titer Glo assay (Promega, Madison, WI). Cell lines were seeded at a density of ...
Gene expression analysis of NK cells after tumor coculture. Following 4 hours of coculture with the 786O tumor cell line and NK ... The basis of our study was to coculture activated NK cells with tumor cells to model tumor-experienced NK cells within the TME ... Unlike peripheral blood NK cells and tumor-infiltrating T cells, tumor-infiltrating NK cells expressed significantly higher ... NK cells were cocultured with tumor cell lines for 4 or 16 hours before cell sorting and FACS analysis. ...
Home , Products , Immune System Tumor Cell Lines , Immune System Tumor Cell Lines. ... Human T Lymphocyte Leukemia Cells. The A3 subclone was from the Jurkat cell line. Jurkat cells were treated with Fas antibodies ... GFP or RFP Expressing Cells - Human Primary Cells *- Motion System Primary Cells ... Human Megakaryocyte Leukemia Cells. A new human megakaryocyte (Dami) was established from the blood of a megakaryotic leukemia ...
January 1998). "6-Aminonicotinamide sensitizes human tumor cell lines to cisplatin". Clinical Cancer Research. 4 (1): 117-30. ... Pyruvate kinase type M2 or PKM2 is present in embryonic, adult stem cells. It is also expressed by many tumor cells. The ... Hypoxic adaptation by cancer cells is essential for survival and progression of a tumor. In addition to cell-autonomous changes ... it gives advantage in both growth and survival of the cell. It has also been seen that metabolic phenotype of tumor cells ...
We found that DKK3 expression levels were low in GBC patients and cell lines. Treatment of GBC cell lines with demethylating ... We observed low expression of DKK3 in gallbladder adenocarcinoma tumors and highly invasive GBC cell lines. We showed that ... and colony forming ability of GBC cells. Our data thus demonstrated the DKK3 gene is a potential tumor suppressor gene in GBC ... Loss of DKK3 gene is associated with a possible tumor suppressor role in human cancers. The role and regulation of DKK3 in GBC ...
LINE-1 are poorly expressed in normal cells and abundantly in cancer cells. Decreasing RT activity in cancer cells, by either ... LINE-1 are poorly expressed in normal cells and abundantly in cancer cells. Decreasing RT activity in cancer cells, by either ... RNA hybrid molecules in cancer but not in normal cells. Remarkably, hybrid molecules fail to form in tumor cells treated with ... RNA hybrid molecules in cancer but not in normal cells. Remarkably, hybrid molecules fail to form in tumor cells treated with ...
... cells correlates with GET treatment and an increase of long-term memory T cells results from animals with complete tumor ... a moderate tumor growth inhibition or heterogenous tumor regressions with survival improvement. Further studies are warranted ... The goal of this study was to examine the activity of IL-15/IL-15Rα complex (IL-15cx) to CD8+ T cells and evaluate its ... The goal of this study was to examine the activity of IL-15/IL-15Rα complex (IL-15cx) to CD8+ T cells and evaluate its ...
Tumor-native ST6GAL1 promotes tumor cell behaviors such as invasion and resistance to cell stress and chemo- and radio- ... The impact of this non-canonical extrinsic mechanism of ST6GAL1 on tumor cell pathobiology is not known. We hypothesize that ... ST6GAL1 expression resulted in decreased ST6GAL1 cargo in the exosome-like vesicles as well as decreased breast tumor cell ... data indicate that extracellular ST6GAL1 from remote sources can compensate for cellular ST6GAL1-mediated aggressive tumor cell ...
Gupta S, Dwarakanath BS, Muralidhar K, Jain V. Role of apoptosis in photodynamic sensitivity of human tumour cell lines. Indian ... Role of apoptosis in photodynamic sensitivity of human tumour cell lines. Seema Gupta, B. S. Dwarakanath, K. Muralidhar, Viney ... Role of apoptosis in photodynamic sensitivity of human tumour cell lines. In: Indian Journal of Experimental Biology. 2003 ; ... Role of apoptosis in photodynamic sensitivity of human tumour cell lines. / Gupta, Seema; Dwarakanath, B. S.; Muralidhar, K. et ...
Cell Line, Tumor; Cell Plasticity; Flow Cytometry; Humans; Melanoma; Neoplastic Stem Cells; Phenotype; Tumor Stem Cell Assay; ... Furthermore, there is an absence of a cellular hierarchy in cell lines and all cells in culture are able to drive tumor ... and CD133 was analyzed in UM cell lines and primary UM short-term cultures (STCs) established from tumor samples. Additionally ... and CD133 does not select for a subpopulation of stem-like cells in either UM cell lines or UM STCs. ...
Results Most HNSCC cell lines induced migration of monocytes, B cells and CD4+ T-cells up to maximal 12%, whereas CD8+ T-cells ... 935 Attraction of immune cells by head and neck cancer cell lines and primary tumor-conditioned supernatants ... 935 Attraction of immune cells by head and neck cancer cell lines and primary tumor-conditioned supernatants ... We analyzed the immune cell subsets attracted by HNSCC cell lines and by tumor-conditioned supernatants. ...
Cancer stemness and metastatic potential of the novel tumor cell line K3: an inner mutated cell of bone marrow-derived ... and the new tumor cell line, K3, was isolated from the neoplasm. The K3 cells expressed surface antigens and pluripotent genes ... Moreover, the K3 cells contained side population cells (SP) like cancer stem cells (CSCs), which might contribute to K3 ... Keywords: mesenchymal stem cell, side population cells, cancer stem cell, metastasis, epithelial-mesenchymal transition ...
Tumors exhibit significant myeloid cell infiltrates, which are actively recruited to the tumor microenvironment. Myeloid cells ... we discuss the role of myeloid cells in promoting tumor angiogenesis. Furthermore, we describe a subset of myeloid cells with ... on the mechanisms regulating myeloid cell recruitment to the tumor microenvironment and on the potential of myeloid cells as ... promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites ...
Bladder cancer often starts from the cells lining the bladder. These cells are called transitional cells. ... Tumors are also grouped based on how they appear under a microscope. This is called grading the tumor. A high-grade tumor is ... The TNM (tumor, nodes, metastasis) staging system is used to stage bladder cancer:. *Ta -- The cancer is in the lining of the ... Papillary tumors look like warts and are attached to a stalk.. *Carcinoma in situ tumors are flat. They are much less common. ...
Cell lines and cell culture. MCF7, T47D, MDA-MB-436, MDA-MB-157, and Hs578T breast cancer cells were obtained from the American ... For the MCF7 and T47D cell lines, we performed single-cell cloning for each FLCN guide RNA, and once FLCN-KO cells were ... Loss of FLCN in luminal breast cancer cells enhances tumor growth. (A) Growth curves of tumors of WT (blue), FLCN-knockout ( ... A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell. 2006;10(6):515- ...
Culture of cell line. Human gist cell line (GIST-882 cell) was purchased from cosmobio company in Japan. The cells were ... Plate cell clonogenesis experiment. The GIST-882 cell lines of different intervention groups were made into cell suspension and ... Cell proliferation experiment. Cell morphology observation and cell counting method: the cells in the logarithmic growth period ... The EC50 of IR in this study is much higher than the effective radiation dose (5-40Gy) of other tumor cell lines, which fully ...
Cell Lines Embryonic, Fibroblast Cell Lines and Lymphoid Tumor Cell Lines. X. laevis LG15 cloned adult injected sc. with 10,000 ... Characteristics of Tumor Cell Lines. Name of tumor cell line. BB7. ff-2. 15/0. 15/40. ... All these cell lines express specific T-cell lineage markers (CD8, CD5 and XT-1 pan T-cell), and immature thymocytes CTX marker ... true lymphoid tumors have been discovered and cell lines have been obtained opening new avenues for tumor biology and tumor ...
These cells later become sperm in the testicles or eggs in the ovaries. This summary is about germ cell tumors that form in ... A germ cell is a type of cell that forms as a fetus develops. ... Childhood extracranial germ cell tumors form from germ cells in ... Cancer cells are not found in fluid taken from the abdomen. Cancer is not seen in lymph nodes or tissue that lines the abdomen ... Mixed germ cell tumors. Mixed germ cell tumors are made up of at least two types of malignant germ cell tumor. They can form in ...
In this work, we confirmed that overexpressed miR-381-3p repressed biological functions of glioma cells. Additionally, we also ... Compared with NHA, ANTXR1 was upregulated in U87, H4, T98G, and U251 cell lines (Figure 3(b)). Thereafter, reduced levels of ... cells were pictured at 0 h and 24 h, and wound-healing rate was calculated. . ... glioma cells were seeded into 6-well plates. After 90% confluence of cells was reached, a scratch was made on cells with a ...
... and bat cell lines (amplicon = 237 bp); murine GAPDH for mouse and rat cell lines (796 bp); and bovine GAPDH for bovine, ovine ... mouse mammary tumor virus; lane 7, Mason-Pfizer monkey virus; lane 8, murine leukemia virus; lane 9, feline leukemia virus; ... known BLV-negative cell line), negative control; lane 12, simian T-cell leukemia virus; lane 13, human T-cell leukemia virus 1 ... and feline cell lines (857 bp)Lane 1, molecular weight marker (HyperLadder IV; Bioline, Taunton, MA, USA), lane 2, fetal lamb ...
NCI60 testing is performed in two parts: first a single concentration is tested in all 60 cell lines at a single dose of 10 -5 ... If the results obtained meet selection criteria, then the compound is tested again in all 60 cell lines in 5 x 10 fold ... For 5-dose 60 cell testing: On the day of drug addition to growing cells in tissue culture, 90 µl DMSO is added to each well ( ... For 1-dose 60 cell testing: On the day of or the day before drug addition to growing cells in tissue culture, a strip of ...