*  Abstract 18478: Deletion of E2f1 Promotes Bone-marrow Progenitor Cell Differentiation and Ischemic Cardiac Repair | Circulation
Since an increase in oxidative phosphorylation in stem/progenitor cells is often associated with cell differentiation, we ... progenitor cells is markedly lower than those in WT cells (P,0.01, n=4). After culture in the EPC differentiation medium for 7 ... Abstract 18478: Deletion of E2f1 Promotes Bone-marrow Progenitor Cell Differentiation and Ischemic Cardiac Repair. Shiyue Xu, ... Abstract 18478: Deletion of E2f1 Promotes Bone-marrow Progenitor Cell Differentiation and Ischemic Cardiac Repair ...
  http://circ.ahajournals.org/content/130/Suppl_2/A18478
*  3/26 Webinar: Tips and Techniques for Serum-free Expansion of hMSCs
... in cell therapy and tissue engineering due to their self-renewal, multi-lineage differentiation, immunomodulation, and trophic ... Brian has over 10 years experience in cell biology and industrial scale cGMP manufacturing of both liquid and powder cell ... Serum-free mammalian cell culture media, in particular, require optimization of the expansion protocols. Even subtle changes in ... One of the challenges faced in the clinical application of hMSCs is the need for efficient expansion of these cells in vitro ...
  https://www.corning.com/worldwide/en/products/life-sciences/news-events/events/2015/03/newsevent-66395.html
*  A new class of stem cells in South Africa: iPS cells
How are iPS cells made?. When cell differentiation occurs, the cell follows a process of changes in gene activity whereby ... The end result of this differentiation 'programme' is a specialised cell of one type or another (e.g. cardiac muscle cells or ... iPS cells have been derived from a wide range of cell types and differentiated into an equally broad range of cell types ... Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell ...
  http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S0256-95742013000100012&lng=es&nrm=iso&tlng=en
*  Pleiotrophin antagonizes Bromodomain-containing protein 2 (Brd2) during neuronal differentiation | Journal of Cell Science
To shed light on the role of Brd2 in the transition from cell proliferation to differentiation we have looked for Brd2 ... Ptn-mediated antagonism of Brd2 has been assessed in a cell differentiation model and in two embryonic processes associated ... The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. ... on cell motility. A Travelling Fellowship from Journal of Cell Science allowed her to spend time in Prof Maddy Parson's lab at ...
  http://jcs.biologists.org/content/early/2014/03/31/jcs.147462
*  OPC differentiation assay<...
Following 5 days of differentiation, cells are stained and imaged in high-content ArrayScan™ reader in multiple channels. ... OPC differentiation assay. Renovo's OPC differentiation assay is used to identify compounds that promote the production of ... Cells were imaged in a high-content ArrayScan reader using a 10x objective. Green, PLP-EGFP+ oligodendrocytes; blue, Hoechst- ... Differentiation of OPCs into EGFP+ oligodendrocytes: CTL, no treatment; T3, treatment with thyroid hormone T3. OPCs were ...
  http://www.renovoneural.com/services/cell-based-assays/opc-differentiation-assay/
*  Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation. | CHAVI-ID
Bcl6 is required for CD4 T cell differentiation into T follicular helper cells (Tfh). In this study, we examined the role of IL ... Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation.. Thu, 05/16/ ... IL-6 mediated STAT3 activation is important for downregulation of IL-2Rα to limit Th1 cell differentiation in an acute viral ... Home » Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation. ...
  http://chavi-id.org/publications/cutting-edge-stat1-required-il-6-mediated-bcl6-induction-early-follicular-helper-cell
*  Integrins regulate epithelial cell differentiation by modulating Notch activity | Journal of Cell Science
However, in some cell types, a modified cell cycle occurs during differentiation, in which the DNA is replicated without ... 2007). A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev. Cell 12, 631-643 ... The processes of cell proliferation and differentiation have been studied independently, but the cell cycle is intimately ... The coordination of cell proliferation with the gradual differentiation of different cell types is essential for proper ...
  http://jcs.biologists.org/content/127/21/4667
*  β-Catenin signaling is required for neural differentiation of embryonic stem cells | Development
Neural differentiation of ES cells is regulated by cell density. ES cells were induced to differentiate by the 4-/4+ protocol ... Cells were seeded at high (106 cells/ml, HD) or low densities (105 cells/ml, LD) and treated with or without RA (cells in ... Cell density. Introduction. Embryonic stem (ES) cells are pluripotent cells derived from the inner cell mass of the blastocyst ... Neural differentiation of ES cells is inhibited at high density. To define the effects of cell density on neuronal lineage ...
  http://dev.biologists.org/content/131/15/3545
*  springerlink, sciencedirect, wileyinterscience, z8OoqYUZwowyMHOpM6SRMRM1M0c: Three differentiation states risk-stratify bladder...
We investigated whether a molecular classification of tumor cell differentiation, based on a developmental biology approach, ... Three differentiation states risk-stratify bladder cancer into distinct subtypes. *Jens-Peter Volkmera,b,c,1,2, ... iDepartment of Molecular and Cellular Biology, Dan L. Duncan Cancer Center, Center for Cell Gene and Therapy, Baylor College of ... Our data indicate that BC can be subclassified into three subtypes, on the basis of their differentiation states: basal, ...
  http://journalaccess.blogspot.com/2012/02/three-differentiation-states-risk.html
*  iPSC to Hepatocyte Differentiation System Overview
The process of generating hiPS cell-derived hepatocytes begins with the directed differentiation of hiPS cells into definitive ... Functional, disease-specific hepatocytes from patient-derived cell lines. The Cellartis iPS Cell to Hepatocyte Differentiation ... undifferentiated stem cell population is ideal. The iPS Cell to Hepatocyte Differentiation System promotes high-quality ... hiPS cells were differentiated into functional hepatocytes using the Cellartis iPS Cell to Hepatocyte Differentiation System. ...
  http://www.clontech.com/US/Products/Stem_Cell_Research/Resources/iPS_to_Hepatocyte_Differentiation_Overview?sitex=10020:22372:US&PEBCL1=q8DIRG9bPvMbTPhbC49c9ONqG5&PEBCL1_pses=ZG7AFC907621D7D9B47296560AA304D443226DB8FD4546DE161C4122758BE6DAF83AA0A21DAD20AEFF0C559D6E161D0F78B40BF35311019719
*  Functional characterization of Nurr1 and Pin1 in neuronal progenitor cell differentiation | ScholarBank@NUS
neuronal progenitor cell (NT2/D1), differentiation, Nurr1, cell cycle, Pin1, dopaminergic neuron. ... However, the mechanism by which Nurr1 promotes dopamine cell differentiation has remained unknown. In this study, I have used a ... DONG BEIBEI (2006-02-28). Functional characterization of Nurr1 and Pin1 in neuronal progenitor cell differentiation. ... and Pin1 was identified and the possible mechanism whereby Pin1 affects the progression of cell cycle and cell differentiation ...
  http://scholarbank.nus.edu.sg/handle/10635/15062
*  Movassagh M and Philpott A (2008), Cardiac differentiation in Xenopus requires the... - Xenbase Paper
We show that cell-cycling post-gastrulation is not essential for cardiac differentiation in Xenopus embryos, and conversely ... Figure 5. The requirement for Xic1 in cardiomyocyte differentiation is distinct from its ability to arrest the cell cycle. ... plays a role in neuronal and myotome differentiation beyond its ability to arrest the cell cycle. Thus, we investigated whether ... these results suggest that CDKIs play an important direct role in driving cardiomyocyte differentiation in addition to cell- ...
  http://www.xenbase.org/literature/article.do?method=display&articleId=37634
*  Reduction of Prep1 Levels Affects Differentiation of Normal and Malignant B Cells and Accelerates Myc Driven Lymphomagenesis -...
Reduction of Prep1 Levels Affects Differentiation of Normal and Malignant B Cells and Accelerates Myc Driven Lymphomagenesis ... Moreover, we show that Prep1 is in fact required for the differentiation of Pro-B and Pre-B cells into IgM+ lymphocytes and-or ... Reduction of Prep1 Levels Affects Differentiation of Normal and Malignant B Cells and Accelerates Myc Driven Lymphomagenesis. ... Reduction of Prep1 Levels Affects Differentiation of Normal and Malignant B Cells and Accelerates Myc Driven Lymphomagenesis - ...
  http://libros.duhnnae.com/2017/jun7/149818268845-Reduction-of-Prep1-Levels-Affects-Differentiation-of-Normal-and-Malignant-B-Cells-and-Accelerates-Myc-Driven-Lymphomagenesis.php
*  The Wnt/β-catenin pathway directs neuronal differentiation of cortical neural precursor cells | Development
The cells were incubated for 2 days with Fgf2, and the percentage of TuJ1+ cells among GFP+ cells was determined. *P, 0.02 and ... The cells were then incubated for 3 days in the absence of Fgf2. (A) The percentage of TuJ1+ cells among GFP+ cells was ... cell number (Fig. 2A). Most of the TuJ1- cells were Nestin+ and when the cells were cultured 3 days longer, many of them became ... DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev. Cell 1,749 -758. ...
  http://dev.biologists.org/content/131/12/2791
*  Telomere Length Influences Cancer Cell Differentiation
... promotes the differentiation of cancer cells, probably reducing malignancy, which is strongly associated with a loss of cell ... differentiation. They report their findings in a manuscript published online ahead of print, in the journal Molecular and ... promotes the differentiation of cancer cells, probably reducing malignancy, which is strongly associated with a loss of cell ... Cancer cells have shorter telomeres compared to healthy cells, but they guard their immortality by maintaining these telomeres ...
  https://www.asm.org/index.php/asm-newsroom/journal-tip-sheets/88-news-room/journal-tipsheets/91725-telomere-length-influences-cancer-cell-differentiation
*  Frontiers | Regulators of Tfh Cell Differentiation | Immunology
Tfh cells are also generated from the conversion of other effector T cells as exemplified by Th1 cells converting into Tfh ... Tfh cells are also generated from the conversion of other effector T cells as exemplified by Th1 cells converting into Tfh ... Tfh cells are generated from naïve CD4 T cells with sequential steps involving cytokine signaling (IL-21, IL-6, IL-12, activin ... Tfh cells are generated from naïve CD4 T cells with sequential steps involving cytokine signaling (IL-21, IL-6, IL-12, activin ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00520/full
*  Phys.org - stem cell differentiation
Phys.org internet news portal provides the latest news on science including: Physics, Space Science, Earth Science, Health and Medicine
  https://phys.org/tags/stem+cell+differentiation/sort/liverank/1w/
*  Cell differentiation - Biology-Online Dictionary
It is the process in which a cell changes into another cell type. During cell differentiation, the changes may include cell ... A cell that underwent differentiation is described as differentiated. A differentiated cell means a cell that has changed in ... Cell differentiation refers to the normal process by which a less specialized cell goes through development and maturation in ... An undifferentiated cell therefore would be a primitive cell or a progenitor cell that is yet to undergo cellular ...
  https://www.biology-online.org/dictionary/Cell_differentiation
*  Dissecting teleost B cell differentiation using transcription factors.
In the absence of serological reagents, an alternative approach to dissecting teleost B cell development is to use ... B cell developmental pathways in teleost fishes are poorly understood. ... Cell Differentiation / genetics, immunology. Cell Separation. Fishes / immunology. Flow Cytometry. Gene Expression Regulation, ... B cell developmental pathways in teleost fishes are poorly understood. In the absence of serological reagents, an alternative ...
  http://www.biomedsearch.com/nih/Dissecting-teleost-B-cell-differentiation/21251922.html
*  Scientists Map Epigenetic Changes During Blood Cell Differentiation - 08/16/2010
... a Johns Hopkins-led team of scientists has produced the first-ever epigenetic landscape map for tissue differentiation. ... Having charted the occurrence of a common chemical change that takes place while stem cells decide their fates and progress ... Scientists Map Epigenetic Changes During Blood Cell Differentiation. Potential Application For Stem Cell Therapies ... The team could tell which types of stem cells the blood cells had come from, because epigenetically those blood cells had not ...
  https://www.hopkinsmedicine.org/news/media/releases/scientists_map_epigenetic_changes_during_blood_cell_differentiation
*  Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation | Nature Immunology
T cell differentiation, regulated the formation of terminal-effector cell fates and memory-precursor cell fates, respectively. ... Differentiation and persistence of memory CD8+ T cells depend on T cell factor 1. . Immunity 33, 229-240 (2010). ... T cell differentiation. *Bingfei Yu1. n2*, Kai Zhang ORCID: orcid.org/0000-0003-3454-73572. n2*, J Justin Milner1. *, Clara ... YY1 inhibits differentiation and function of regulatory T cells by blocking Foxp3 expression and activity. . Nat. Commun. 7, ...
  http://www.nature.com/articles/ni.3706?error=cookies_not_supported&code=c6e39a06-ad79-4ec5-8873-ead56d59bfc6
*  Interplay of matrix stiffness and protein tethering in stem cell differentiation. - PubMed - NCBI
Interplay of matrix stiffness and protein tethering in stem cell differentiation.. Wen JH1, Vincent LG1, Fuhrmann A2, Choi YS1 ... Our findings imply that the stiffness of planar matrices regulates stem cell differentiation independently of protein tethering ... osteogenic and adipogenic differentiation of human adipose-derived stromal cells and marrow-derived mesenchymal stromal cells. ... also regulates stem cell differentiation. By modulating substrate porosity without altering stiffness in polyacrylamide gels, ...
  https://www.ncbi.nlm.nih.gov/pubmed/25108614?access_num=25108614&link_type=MED&dopt=Abstract
*  Epigenetics in stem-cell differentiation - Wikipedia
LIF inhibits cell differentiation, and its removal allows the cell lines to go through cell differentiation. The cell lines ... In embryonic stem cells, DNMT1 depletion within the undifferentiated progenitor cell compartment led to cell cycle arrest, ... following the initiation of in vitro embryonic stem cell differentiation. Differentiation was triggered by the removal of ... "Hematopoietic commitment during embryonic stem cell differentiation in culture". Molecular Cell Biology. 13: 473-486. doi: ...
  https://en.wikipedia.org/wiki/Epigenetics_in_stem-cell_differentiation
*  IFN-β Inhibits Human Th17 Cell Differentiation | The Journal of Immunology
IFN-β-1a directly inhibits Th17 cell differentiation. A direct effect of IFN-β-1a on Th17 cell differentiation was investigated ... IFN-β-1a directly inhibits Th17 cell differentiation. A, IFN-β-1a inhibits RORc gene expression in CD4+CD45RA+ T cells cultured ... Dendritic cells transduced with SOCS-3 exhibit a tolerogenic/DC2 phenotype that directs type 2 Th cell differentiation in vitro ... and the Th17 cell surface marker IL-23R. The IFN-β-1a-mediated suppression of Th17 cell differentiation is also supported by ...
  http://www.jimmunol.org/content/183/8/5418?ijkey=7ddbecc251ce7249d4f5f8fcd06fdb702cf45964&keytype2=tf_ipsecsha
*  The Mesenchyme Controls the Timing of Pancreatic β-Cell Differentiation | Diabetes
... a master gene controlling endocrine cell-fate decisions in progenitor cells; then β-cell differentiation occurred. In the ... If differentiation occurs too early, the stem-cell pool remains small, and the final number of differentiated cells is ... β-cells did not develop (Figs. 4A, b and 7B, b). These results indicate that the mesenchyme modulates β-cell differentiation ... β-cell differentiation occurred, and the number of β-cells increased, as shown by in situ hybridization (Fig. 1A-E). Here, we ...
  http://diabetes.diabetesjournals.org/content/55/3/582