Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal cancers worldwide, partly because methods are lacking to ... We also generated a 5-miRNA signature that discriminated between 21 malignant (high-grade dysplasia and invasive carcinoma) and ... The signature contained novel miRNAs and miRNAs previously implicated in pancreatic carcinogenesis that had 2- to 4-fold higher ...http://cancerpreventionresearch.aacrjournals.org/content/early/2015/08/27/1940-6207.CAPR-15-0094
Telomerase elevation in pancreatic ductal carcinoma compared to nonmalignant pathological states. | Clinical Cancer Research
Telomerase elevation in pancreatic ductal carcinoma compared to nonmalignant pathological states.. N Suehara, K Mizumoto, T ... Telomerase elevation in pancreatic ductal carcinoma compared to nonmalignant pathological states.. N Suehara, K Mizumoto, T ... Telomerase elevation in pancreatic ductal carcinoma compared to nonmalignant pathological states.. N Suehara, K Mizumoto, T ... Telomerase elevation in pancreatic ductal carcinoma compared to nonmalignant pathological states. Message Subject (Your Name) ...http://clincancerres.aacrjournals.org/content/3/6/993
Radiosensitization and Stromal Imaging Response Correlates for the HIF-1 Inhibitor PX-478 Given with or without Chemotherapy in...
... of human pancreatic ductal carcinoma but in only 16% of normal pancreas. Stroma adjacent to the pancreatic ductal carcinoma ... Pancreatic cancer is the most hypoxic of all solid tumors and remains refractory to current chemoradiotherapy. We have seen ... We investigated the novel selective HIF-1α inhibitor PX-478 on in vitro and in vivo radiation response of human pancreatic ... In mice with Panc-1, CF-PAC-1, or SU.86.86 pancreatic xenografts, concurrent administration of PX-478 potentiated the antitumor ...http://mct.aacrjournals.org/content/early/2010/06/24/1535-7163.MCT-09-0768
Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas: it's Histopathologic Difference Between 2 Major Types Shinichi...
... which is the common precursor of invasive carcinomas ... types different mode of spreading through the pancreatic ductal ... The distinction between IPMN and pancreatic intraepithelial neoplasia (PanIN) , ... Both have genetic alterantions associated with ductal carcinoma, ex: K-ras, p53, DPC4/Smad4, p16 (more common in Low-grade ... Squamoid Cyst of Pancreatic Ducts: A Distinct Type of Cystic Lesion in the Pancreas Mohammad Othman, MD,* Olca Basturk, MD,* ...http://slideplayer.com/slide/3862138/
STAT3 Plays a Critical Role in KRAS-Induced Pancreatic Tumorigenesis | Cancer Research
Pancreatic ductal cells. Pancreatic ductal cells where isolated from 9-week-old Pdx1-Cre;LSL-KRASG12D mice as previously ... Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res 1997;57:1731-4. ... Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 2003;4:437-50. ... Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the United States and carries a dismal 5 ...http://cancerres.aacrjournals.org/content/71/14/5020
γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation. - Nuffield Department of Orthopaedics,...
... of tumor-infiltrating T cells in human pancreatic ductal adenocarcinoma (PDA). Recruitment and activation of γδT cells was ... Inflammation is paramount in pancreatic oncogenesis. We identified a uniquely activated γδT cell population, which constituted ... T-Lymphocytes, Cells, Cultured, Epithelial Cells, Animals, Mice, Inbred C57BL, Humans, Mice, Carcinoma, Pancreatic Ductal, ... of tumor-infiltrating T cells in human pancreatic ductal adenocarcinoma (PDA). Recruitment and activation of γδT cells was ...https://www.ndorms.ox.ac.uk/publications/642267
... which acts downstream of TGFβ and is frequently deleted in pancreatic ductal carcinoma (PDAC). To elucidate the mechanism by ... These findings also provide an explanation for the frequent inactivation of SMAD4, but not TGFβ receptors, in pancreatic cancer ... and accelerated pancreatic carcinogenesis in SMAD4-wild-type cells, raising the unexpected possibility that EMT precedes ...http://cancerdiscovery.aacrjournals.org/content/early/2016/03/01/2159-8290.CD-RW2016-036
September 2010 - Volume 252 - Issue 3 : Annals of Surgery
HuR Status is a Powerful Marker for Prognosis and Response to Gemcitabine-Based Chemotherapy for Resected Pancreatic Ductal ... Risk of Colorectal Adenoma and Carcinoma After Colectomy for Colorectal Cancer in Patients Meeting Amsterdam Criteria. Kalady, ... This study supports the notion that cytoplasmic HuR status can help guide the treatment of pancreatic ductal adenocarcinoma. ... is an mRNA binding protein previously described as a predictive biomarker for selecting pancreatic ductal adenocarcinoma ...http://journals.lww.com/annalsofsurgery/toc/2010/09000
Gastric gland mucin‐specific O‐glycan expression decreases with tumor progression from precursor lesions to pancreatic cancer -...
MUC6 and MUC5AC in pancreatic neoplasms and compare them with progression from PanIN to invasive ductal adenocarcinoma (IDAC) ( ... the PanIN-IDAC sequence; 20 cases) and from IPMN to IPMN with associated invasive carcinoma (IPMNAIC) (the IPMN-IPMNAIC ... MUC6 is also expressed in pancreatic neoplasms, including PanIN and IPMN, but the role of αGlcNAc expression in pancreatic ... Pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) are major precursors of ...https://www.semanticscholar.org/paper/Gastric-gland-mucin-specific-O-glycan-expression-d-Ohya-Yamanoi/643f98c6374f3b516eccb1e4f422eb4a2d71c994
... arise in the pancreatic ductal system and are distinct mucin-producing cystic precursor lesions of pancreatic ductal ... Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays. Cancer Res 2003; ... Normal pancreatic ductal epithelial cells were selectively microdissected from frozen sections adjacent to IPMN, pancreatic ... 5 with IPMNs and 30 with an associated invasive pancreatic ductal adenocarcinomas) and 8 patients with benign pancreatic ...http://clincancerres.aacrjournals.org/content/18/3/700
Although PTEN aberrations are present in many cancer types, it is thought to play little role in pancreatic ductal ... In 8 primary cutaneous squamous cell carcinomas (cSCC), the authors show that TP53 mutation was an early event and was followed ... PTEN Is a Tumor Suppressor in Human Pancreatic Ductal Adenocarcinoma. See article by Ying et al., p. 158 ... In addition, the PTEN/PI3K/AKT axis and NF-κB itself may be drug targets in pancreatic cancer. ...http://cancerdiscovery.aacrjournals.org/content/1/2/91
Abstract 1543: Clinical significance of ZNF185 intracellular localization in pancreatic ductal carcinoma | Cancer Research
Abstract 1543: Clinical significance of ZNF185 intracellular localization in pancreatic ductal carcinoma. Daisuke Furukawa, ... Clinical significance of ZNF185 intracellular localization in pancreatic ductal carcinoma. [abstract]. In: Proceedings of the ... Abstract 1543: Clinical significance of ZNF185 intracellular localization in pancreatic ductal carcinoma ... Abstract 1543: Clinical significance of ZNF185 intracellular localization in pancreatic ductal carcinoma ...http://cancerres.aacrjournals.org/content/76/14_Supplement/1543
Identification and validation of differential expressed apoptotic genes in microdissected pancreatic ductal carcinomas | Cancer...
Identification and validation of differential expressed apoptotic genes in microdissected pancreatic ductal carcinomas. ... Identification and validation of differential expressed apoptotic genes in microdissected pancreatic ductal carcinomas ... Identification and validation of differential expressed apoptotic genes in microdissected pancreatic ductal carcinomas ... Identification and validation of differential expressed apoptotic genes in microdissected pancreatic ductal carcinomas ...http://cancerres.aacrjournals.org/content/67/9_Supplement/3581
Carcinoma, Pancreatic ductal M384 - Pathway Predesigned Plate | Life Science Research | Bio-Rad
Carcinoma, Pancreatic ductal M384. Predesigned 384-well panel for use with SYBR® Green ...http://www.bio-rad.com/en-us/prime-pcr-assays/predesigned-plate/sybr-green-carcinoma-pancreatic-ductal-m384
pancreatic ductal carcinoma
Build: Fri Jul 27 09:23:34 EDT 2018 (commit: a5c8d99). National Center for Advancing Translational Sciences (NCATS), 6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-435-0888. ...https://pharos.nih.gov/idg/diseases/DOID:3587
The Neurotrophin-Trk Receptor Axes Are Critical for the Growth and Progression of Human Prostatic Carcinoma and Pancreatic...
... have been implicated in the development and progression of human prostatic carcinoma and pancreatic ductal adenocarcinoma. We ... The human prostate carcinoma cell line PC-3, the human prostatic/bladder carcinoma TSU-Pr1, and the human ovarian carcinoma ... pancreatic, lung, and medullary thyroid carcinoma (5, 6, 7, 8, 9, 10) . Specifically, human prostatic carcinoma cells have been ... RT-PCR detection of trkA expression in PC-3 prostatic, CFPAC pancreatic, and SK-OV-3 ovarian carcinoma tumor cell lines but not ...http://clincancerres.aacrjournals.org/content/8/6/1924
"Proteomic profiling of pancreatic ductal carcinoma cell lines treated with trichostatin-A" | IRIS...
"Proteomic profiling of pancreatic ductal carcinoma cell lines treated with trichostatin-A". ... "Proteomic profiling of pancreatic ductal carcinoma cell lines treated with trichostatin-A" ... A pancreatic adenocarcinoma cell line (Paca44) was treated with trichostatin-A (TSA), a potent inhibitor of histone ... A pancreatic adenocarcinoma cell line (Paca44) was treated with trichostatin-A (TSA), a potent inhibitor of histone ...https://iris.univr.it/handle/11562/301231
July 2013 - Volume 37 - Issue 7 : The American Journal of Surgical Pathology
Pancreatic Intraglandular Metastasis Predicts Poorer Outcome in Postoperative Patients With Pancreatic Ductal Carcinoma. Oguro ... Most Nonparotid "Acinic Cell Carcinomas" Represent Mammary Analog Secretory Carcinomas. Bishop, Justin A.; Yonescu, Raluca; ... Signet Ring Cell Colorectal Carcinoma: A Distinct Subset of Mucin-poor Microsatellite-stable Signet Ring Cell Carcinoma ... Clear Cell Odontogenic Carcinomas Show EWSR1 Rearrangements: A Novel Finding and a Biological Link to Salivary Clear Cell ...http://journals.lww.com/ajsp/toc/2013/07000
PEGPH20 Plus Nab-Paclitaxel Plus Gemcitabine Compared With Nab-Paclitaxel Plus Gemcitabine in Subjects With Stage IV Untreated...
pancreatic ductal carcinoma(PDA). Pancreatic ductal carcinoma. PEGPH20. Gemcitabine. Nab-paclitaxel. Additional relevant MeSH ... Non metastatic pancreatic ductal adenocarcinoma. *Evidence of deep vein thrombosis (DVT) or pulmonary embolism (PE) or other ... Subjects must have newly diagnosed stage 4 untreated metastatic pancreatic ductal cancer diagnosed by a standard of Care CT ... Histologically confirmed Stage IV pancreatic ductal adenocarcinoma w/ documented disseminated neoplasm to liver and /or lung. ...https://clinicaltrials.gov/ct2/show?term=pegph20&rank=3
Identificação de fatores diabetogênicos associados ao adenocarcinoma de pâncreas
Pancreatic ductal carcinoma. S100 proteins. Resumo em inglês. Pancreatic ductal adenocarcinoma is closely related to diabetes ... Pancreatic adenocarcinoma patients who had diabetes mellitus had higher HOMA-IR (p < 0.05) and a trend to lower HOMA-beta ... Of these, 25 were five times more expressed in diabetic patients? pancreatic adenocarcinomas. Three genes were chosen for RT- ... Clinical and laboratorial data of 33 patients with pancreatic adenocarcinoma were evaluated, and tumor gene expression was ...http://www.teses.usp.br/teses/disponiveis/5/5135/tde-30102006-152027/pt-br.php
A Study of Napabucasin Plus Nab-Paclitaxel With Gemcitabine in Adult Patients With Metastatic Pancreatic Adenocarcinoma - Full...
Pancreatic Ductal. Carcinoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Neoplasms. Carcinoma, Ductal. ... Carcinoma, Pancreatic Ductal Drug: Napabucasin Drug: Nab-paclitaxel Drug: Gemcitabine Phase 3 ... Neoplasms, Ductal, Lobular, and Medullary. Pancreatic Neoplasms. Digestive System Neoplasms. Neoplasms by Site. Endocrine Gland ... Must have histologically or cytologically confirmed advanced pancreatic ductal adenocarcinoma (PDAC) that is metastatic. The ...https://clinicaltrials.gov/ct2/show/study/NCT02993731?term=CanStem111P&rank=1&show_locs=Y
Durvalumab and Tremelimumab in Combination With First-Line Chemotherapy in Advanced Solid Tumors - Full Text View -...
Carcinoma, Pancreatic Ductal Esophageal Squamous Cell Carcinoma Drug: paclitaxel + carboplatin Drug: carboplatin + etoposide ... Carcinoma, Pancreatic Ductal. Triple Negative Breast Neoplasms. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic ... small cell lung carcinoma (SCLC), and gastric/gastro-esophageal junction (GEJ) cancer, pancreatic ductal adenocarcinoma (PDAC) ... Small Cell Lung Carcinoma Carcinoma, Squamous Cell of Head and Neck Stomach Neoplasms Triple Negative Breast Neoplasms Ovarian ...https://clinicaltrials.gov/ct2/show/NCT02658214
Biomarkers Discovery through Multivariate Statistical Methods: A Review of Recently Developed Methods and Applications in...
Pancreatic ductal carcinoma cells Effect of Trichostatin A 2D-PAGE PCA  ... the effect of Trichostatin A on pancreatic ductal carcinoma cells ; the development of a special class of aptamers , ... Hepatocellular carcinoma: 81 patients with hepatitis B-related carcinoma and 80 controls. SELDI-TOF CART. Sgand Spg89.6%. Model ... Samples, reported on the x-axis, belong to two pancreatic cancer cell lines (T3M4 and PACA44) treated or not with Throchostatin ...https://www.omicsonline.org/open-access/biomarkers-discovery-through-multivariate-statistical-methods-jpb.S3-003.php?aid=33716
Ductal carcinoma - Wikipedia
Types include: Mammary Ductal carcinoma in situ Invasive ductal carcinoma Pancreatic ductal carcinoma. ... Ductal carcinoma is a type of tumor that primarily presents in the ducts of a gland. ...https://en.wikipedia.org/wiki/Ductal_carcinoma
Bevacizumab, Gemcitabine, and Oxaliplatin in Treating Patients With Metastatic Pancreatic Cancer - Full Text View -...
No other malignancy within the past 5 years except basal cell or squamous cell skin cancer, carcinoma in situ of the cervix, or ... Histologically or cytologically confirmed ductal cell or undifferentiated adenocarcinoma of the pancreas ... Bevacizumab, Gemcitabine, and Oxaliplatin in Treating Patients With Metastatic Pancreatic Cancer. The safety and scientific ... Pancreatic Neoplasms. Digestive System Neoplasms. Neoplasms by Site. Neoplasms. Endocrine Gland Neoplasms. Digestive System ...https://clinicaltrials.gov/ct2/show/study/NCT00112528?show_locs=Y