Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell...
Drug: Busulfan 0.8 mg/kg/dose q6hrs or 1.1 mg/kg/dose q6hrs, IV, Day -9 to Day -6 pre-HCT ... A Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell ... Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell ... Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell ...https://clinicaltrials.gov/ct2/show/record/NCT01596699
Busulfan upregulated the microRNA-200 (miR-200) family | Open-i
Busulfan upregulated the microRNA-200 (miR-200) family and modulated its target genes in osteosarcoma. (a,b) Messenger RNA from ... Dose-dependent and time-dependent effect of busulfan on the activation of miR-429. Busulfan (150 μM) seemed to be efficient for ... Dose-dependent and time-dependent effect of busulfan on the activation of miR-429. Busulfan (150 μM) seemed to be efficient for ... Bottom Line: Busulfan has been widely used to treat CML.Moreover, a series of loss-of-function and gain-of-function experiments ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4317920_cas0105-0755-f2&req=4
Busulfan in Infant to Adult Hematopoietic Cell Transplant Recipients: A Population Pharmacokinetic Model for Initial and...
High busulfan exposure is associated with worse outcomes in a daily i.v. busulfan and fludarabine allogeneic transplant regimen ... The alkylating agent busulfan is an integral part of many hematopoietic cell transplant conditioning regimens. Busulfan has a ... busulfan (15). Their simulations revealed that only 44% of children would achieve a busulfan Css of 615 to 1,025 ng/mL when EMA ... busulfan concentrations over a wide range of body weights and ages (Fig. 1); (ii) i.v. busulfan clearance, scaled to size (i.e ...http://clincancerres.aacrjournals.org/content/20/3/754.long
PRO#1278: Fludarabine and Busulfan vs. Fludarabine, Busulfan and Total Body Irradiation (FLUBUTBI) | Aplastic Anemia and MDS...
... busulfan and low dose total body irradiation in patients undergoing allogeneic stem cell transplantation. A study population of ... This is a single institution study of fludarabine and busulfan versus fludarabine, ... Drug: Fludarabine and Busulfan plus/minus Total Body Irradiation (low dose) Fludarabine 40mg/m2 and Busulfan 130mg/m2 on days - ... This is a single institution study of fludarabine and busulfan versus fludarabine, busulfan and low dose total body irradiation ...http://www.aamds.org/node/4766
Busulfan and Fludarabine in Patients With AML and MDS - Full Text View - ClinicalTrials.gov
Experimental: Busulfan + Fludarabine Once a day for four days, Busulfan 130 mg/m^2 through intravenous catheter over 3 hours ... Busulfan and Fludarabine in Patients With AML and MDS. The safety and scientific validity of this study is the responsibility ... Drug: Busulfan 130 mg/m^2 injected through the intravenous catheter over three hours, once a day, for four days, starting ... High-dose Busulfan will be injected through the catheter over three hours, once a day, for four days, starting immediately ...https://clinicaltrials.gov/ct2/show/NCT00502905
Targeted Busulfan, Fludarabine Conditioning Regimen for Hematopoietic Stem Cell Transplantation in Chronic Granulomatous...
Drug: Busulfan First dose: busulfan (120 mg/m2 ivs once daily) (if age,1 yr: 80 mg/ m2) Second to forth dose: according to the ... Experimental: Busulfan First dose: busulfan (120 mg/m2 ivs once daily) (if age,1 yr: 80 mg/ m2) Second to forth dose: according ... Busulfan is a highly toxic drug with narrow therapeutic window. In this study we plan to use optimal busulfan dose through ... Busulfan. Alkylating Agents. Molecular Mechanisms of Pharmacological Action. Immunosuppressive Agents. Immunologic Factors. ...https://clinicaltrials.gov/ct2/show/NCT01338675?recr=Open&cond=%22Granulomatous+Disease%2C+Chronic%22&rank=5
busulfan | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
busulfan ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ...http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=structure&ligandId=7136
Study With Intravenous Busulfan And Fludarabine Myeloablative Conditioning Regimen For HLA Identical Sibling Donor HSCT - Full...
on days -6 to -3 (total dose 160 mg/m2), followed by Busulfan 3,2 mg/kg once daily i.v. in 180 min. in the same days (total ... Drug Information available for: Busulfan Fludarabine Genetic and Rare Diseases Information Center resources: Myeloid Leukemia ... Study With Intravenous Busulfan And Fludarabine Myeloablative Conditioning Regimen For HLA Identical Sibling Donor HSCT (BUFLU) ... Analyze the results of conditioning with once-daily dose intravenous busulfan and fludarabine in patients undergoing HLA ...https://clinicaltrials.gov/ct2/show/NCT01683123
Busulfan IC50 - Drug Resistance to EGFR Inhibitors in Lung Cancer
Posts Tagged: Busulfan IC50 Purpose In multiple cell metazoans, the ability of polarized epithelial cells On November 11, 2017 ... For example, the building-up Busulfan IC50 of mesenchymal indicators and shedding of epithelial indicators such as deposition ... Busulfan IC50 2007b). Under fibrosis, nevertheless, overproduction of extracellular matrix by myofibroblasts extracted from ... These cells undergo EMT additional generate Busulfan IC50 mesoderm and endoderm then. Mesoderm and ectoderm of an adult patient ...http://elevateblogconference.com/tag/busulfan-ic50/
Busulfan - Biology-Online Dictionary
Busulfan (Science: chemical) An alkylating agent having a selective immunosuppressive effect on bone marrow. It has been used ... According to the fourth annual report on carcinogens (ntp 85-002, 1985), busulfan is listed as a known carcinogen. ... Busulfan. Revision as of 21:16, 3 October 2005 by WikiConvertor (Talk) ... Retrieved from "http://www.biology-online.org/bodict/index.php?title=Busulfan&oldid=18914" ...http://www.biology-online.org/bodict/index.php?title=Busulfan&oldid=18914
Alemtuzumab, Busulfan, and Cyclophosphamide Followed By a Donor Stem Cell Transplant in Treating Patients With Hematologic...
Drug Information available for: Busulfan Alemtuzumab Genetic and Rare Diseases Information Center resources: Childhood Acute ... Alemtuzumab, Busulfan, and Cyclophosphamide Followed By a Donor Stem Cell Transplant in Treating Patients With Hematologic ... Chemotherapy: Patients receive alemtuzumab IV over 2 hours on days -10 to -6, busulfan IV over 3 hours on days -7 to -4, and ... PURPOSE: This phase I/II trial is studying the best dose of alemtuzumab when given together with busulfan and cyclophosphamide ...https://clinicaltrials.gov/show/NCT00555048
Busulfan and Etoposide Followed by Peripheral Blood Stem Cell Transplant and Low-Dose Aldesleukin in Treating Patients With...
Drug: busulfan Drug: etoposide Biological: aldesleukin Procedure: peripheral blood stem cell transplantation Phase 2 ... Busulfan and Etoposide Followed by Peripheral Blood Stem Cell Transplant and Low-Dose Aldesleukin in Treating Patients With ... Drug Information available for: Busulfan Etoposide Aldesleukin Etoposide phosphate Genetic and Rare Diseases Information Center ... PREPARATIVE REGIMEN: Patients receive busulfan IV over 2 hours or PO every 6 hours on days -7 to -4 and etoposide IV on day -3. ...https://clinicaltrials.gov/ct2/show/NCT00003875
Busulfan - Wikipedia
Concomitant use of acetaminophen within 72 hours of busulfan use can reduce busulfan clearance (resulting in increased busulfan ... Phenytoin increases hepatic clearance of busulfan (resulting in decreased busulfan AUC). However, clinical studies of busulfan ... Fludarabine + busulfan is a typical example of this use. Toxicity may include interstitial pulmonary fibrosis ("busulfan lung ... Busulfex is supplied as an intravenous solution with 6 mg/ml busulfan. Busulfex has proved equally effective as oral busulfan, ...https://en.wikipedia.org/wiki/Busulfan
Busulfan Drug Interactions - Drugs.com
306 medications are known to interact with busulfan. Includes Acidophilus (lactobacillus acidophilus), AmBisome (amphotericin b ... Show all medications in the database that may interact with busulfan.. Check for interactions with busulfan. Type in a drug ... A total of 306 drugs (1693 brand and generic names) are known to interact with busulfan. ... Common medications checked in combination with busulfan. *Acidophilus (lactobacillus acidophilus). *AmBisome (amphotericin b ...https://www.drugs.com/drug-interactions/busulfan.html
DailyMed - BUSULFEX- busulfan injection
Busulfan (UNII: G1LN9045DK) (Busulfan - UNII:G1LN9045DK). Busulfan. 6 mg in 1 mL. ... The solubility of busulfan in water is 0.1 g per L and the pH of BUSULFEX diluted to approximately 0.5 mg per mL busulfan in ... Busulfan primarily binds to albumin (Mean ± standard deviation=32.4 ± 2.2%). Metabolism: Busulfan is predominantly metabolized ... Oral Busulfan Literature Review: Four publications of randomized, controlled trials that evaluated a high-dose oral busulfan- ...https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e03a2579-fb59-4c77-b487-0a72cb8cd76e
Busulfan facts, information, pictures | Encyclopedia.com articles about Busulfan
Make research projects and school reports about Busulfan easy with credible articles from our FREE, online encyclopedia and ... Busulfan Gale Encyclopedia of Cancer COPYRIGHT 2002 The Gale Group Inc.. Busulfan. Definition. Busulfan (also known by the ... Busulfan, when used for bone marrow transplants, is dosed by patient body weight. Busulfan is usually given at a dose of 4mg ... Busulfan is taken orally and comes in tablet form.. Recommended dosage. Busulfan can be taken following several different ...https://www.encyclopedia.com/medicine/drugs/pharmacology/busulfan
Busulfan (Intravenous Route) Description and Brand Names - Mayo Clinic
Information about this busulfan-intravenous-route. Pregnancy Category. Explanation. All Trimesters. D. Studies in pregnant ... Thalassemia-Busulfan may cause increased pressure within the heart in children. Proper Use. A nurse or other trained health ... Busulfan must be given slowly, so the needle will remain in place for 2 hours. You may also receive medicines to help prevent ... Busulfan belongs to the group of medicines known as alkylating agents. It seems to act by interfering with the function of the ...https://www.mayoclinic.org/drugs-supplements/busulfan-intravenous-route/description/DRG-20067303?p=1
Busulfan (By mouth) | Lima Memorial Health System
Busulfan (By mouth). Busulfan (bue-SUL-fan). Treats certain kinds of leukemia.. Brand Name(s): Myleran. There may be other ... Do not use it if you had an allergic reaction to busulfan, or if you are pregnant.. How to Use This Medicine: Tablet. * ... Some medicines can affect how busulfan works. Tell your doctor if you are taking itraconazole or thioguanine. ...http://www.limamemorial.org/health-library/Thomson%20DrugNotes/45/0960
Gemcitabine/Clofarabine/Busulfan and Allogeneic Transplantation for Aggressive Lymphomas
Test doses are used to study how your body breaks down busulfan. and decide the dose of busulfan that you will receive. You may ... dose of busulfan by vein over 3 hours. If for any reason you could not have the PK tests. performed, you will receive the ... Gemcitabine/Clofarabine/Busulfan and Allogeneic Transplantation for Aggressive Lymphomas. Trial Phase:. Phase 1/Phase 2. ... to be performed, you will receive the standard dose of busulfan.. On Day -9 or Day -7, you will be admitted to the hospital and ...http://www.knowcancer.com/cancer-trials/NCT01701986/
Busulfan/fludarabine/melphalan/tacrolimus | Springer for Research & Development
Busulfan/fludarabine/melphalan/tacrolimus. Fatal pulmonary haemorrhage associated with immune reaction: case report ...https://rd.springer.com/article/10.2165/00128415-200711790-00030
Busulfan chemotherapy drug molecule - Stock Image F012/9871 - Science Photo Library
Busulfan cancer chemotherapy drug molecule (alkylating agent). Atoms are represented as spheres with conventional colour coding ... Keywords: alkyl, alkylating, antineoplastic, artwork, atomic, busulfan, busulfane, cancer, cgi, chemical, chemistry, ... Caption: Busulfan cancer chemotherapy drug molecule (alkylating agent). Atoms are represented as spheres with conventional ...http://www.sciencephoto.com/media/723405/view
Medicine for busulfan allergy - Things You Didn't Know
Busulfan (Definition) Busulfan is an addiction reducing agent which is a kind of psychiatric drug. ...Read more ... Myleran allergy: Myleran (Busulfan) is a chemotherapy medication used in the treatment of some types of leukemia. An allergy ...https://www.healthtap.com/topics/medicine-for-busulfan-allergy
IJMS | Free Full-Text | Gosha-Jinki-Gan Recovers Spermatogenesis in Mice with Busulfan-Induced Aspermatogenesis
After busulfan treatment, the weight of the testes and the epididymal sperm count progressively decreased in the normal diet ... Male 4-week-old C57BL/6J mice were administered a single intraperitoneal injection of busulfan, and they were then fed a normal ... These results suggest that busulfan-induced aspermatogenesis is irreversible if appropriate treatment is not administered. ... to mice suffering from severe aspermatogenesis after busulfan treatment to determine whether TJ107 can recover spermatogenesis ...http://www.mdpi.com/1422-0067/19/9/2606