*  Hypertrophic osteodystrophy - Wikipedia
... bone formation) and necrosis and inflammation of cancellous bone. The disease is usually bilateral in the limb bones, ... LaFond E, Breur G, Austin C (2002). "Breed susceptibility for developmental orthopedic diseases in dogs". J Am Anim Hosp Assoc ... Hypertrophic Osteodystrophy (HOD) is a bone disease that occurs in fast-growing large and giant breed dogs. The disorder is ... Other bones may be affected, particularly the ribs, the metacarpal bones, the mandible, and the scapula. Lameness may present ...
  https://en.wikipedia.org/wiki/Hypertrophic_osteodystrophy
*  theological moments: September 2011
A missing skull bone and tumor, cafe-au-lait spots, freckling in the skin folds and iris-these are features of his NF1. Do I ... Labels: about NF, about NF1, developmental delays, Fear, God waiting, learning disabilities, motor skills, neurofibromin, ... and Huntington's Disease combined. NF has three main types: NF1, NF2, and Schwannomatosis. Separate genes on different ... Surgery proves to be the only option to treat his bone dysplasia in the skull, brain tumor, and left eye. I wait for science. ...
  http://theologicalmoments.blogspot.com/2011/09/
*  Bone disease - Developmental abnormalities and hereditary conditions | Britannica.com
Developmental abnormalities and hereditary conditions: Many diseases of the skeletal system are congenital in the sense that ... Developmental abnormalities and hereditary conditions. Congenital bone diseases. Many diseases of the skeletal system are ... human disease: Diseases of senescence. …joints are changes involving the bone itself. The bone of elderly persons is known to ... More About Bone disease. 13 references found in Britannica articles. Assorted References. *arthritis* In human disease: ...
  https://www.britannica.com/science/bone-disease/Developmental-abnormalities-and-hereditary-conditions
*  Nebivolol Versus Losartan Versus Nebivolol+Losartan Against Aortic Root Dilation in Genotyped Marfan Patients - Full Text View ...
Disease. Pathologic Processes. Pathological Conditions, Anatomical. Bone Diseases, Developmental. Bone Diseases. ... Heart Diseases. Abnormalities, Multiple. Congenital Abnormalities. Genetic Diseases, Inborn. Connective Tissue Diseases. Limb ... Musculoskeletal Diseases. Heart Defects, Congenital. Cardiovascular Abnormalities. Cardiovascular Diseases. ... Condition or disease Intervention/treatment Phase Marfan Syndrome Drug: Losartan and nebivolol Drug: Losartan Drug: Nebivolol ...
  https://clinicaltrials.gov/ct2/show/NCT00683124?term=Marfan+Syndrome&rank=12
*  Short Stature Related Distress - Full Text View - ClinicalTrials.gov
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Genetic Diseases, Inborn. Endocrine System Diseases. ... Condition or disease Intervention/treatment Phase Idiopathic Short Stature Self Image Drug: GH treatment (Genotropin) Drug: 1 ...
  https://clinicaltrials.gov/ct2/show/NCT01246219?cond=%22metatropic+dysplasia%22+OR+%22Dwarfism%22&rank=7
*  Phase III Randomized Study of Interferon Gamma in Children With Severe, Congenital Osteopetrosis - Full Text View -...
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Interferons. Interferon-gamma. Calcitriol. ... Patients may continue treatment in the absence of toxicity and disease progression. If disease progression is diagnosed in the ... Compare the number of adverse events or clinical manifestations of disease progression occurring in these patients. ... Biologic therapy: No prior/concurrent bone marrow transplantation No prior interferon gamma No other investigational biologic ...
  https://clinicaltrials.gov/ct2/show/NCT00004402
*  Versartis Trial in Children to Assess Long-Acting Growth Hormone - Full Text View - ClinicalTrials.gov
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Bone Diseases, Endocrine. Hypopituitarism. Pituitary ... Hypothalamic Diseases. Brain Diseases. Central Nervous System Diseases. Nervous System Diseases. Hormones. Hormones, Hormone ... Condition or disease Intervention/treatment Phase Pediatric Growth Hormone Deficiency Drug: Experimental: VRS-317 Phase 1 Phase ... Genetic and Rare Diseases Information Center resources: Growth Hormone Deficiency Isolated Growth Hormone Deficiency ...
  https://clinicaltrials.gov/ct2/show/study/NCT01718041?show_locs=Y
*  Study of Skeletal Disorders and Short Stature - Full Text View - ClinicalTrials.gov
Bone Diseases. Dwarfism. Osteochondrodysplasias. Bone Diseases, Developmental. Musculoskeletal Diseases. Genetic Diseases, ... DISEASE CATEGORY I:. Individuals and family members with a suspected or an established diagnosis of any FGFR3 disorder, type II ... DISEASE CATEGORY II:. Individuals and family members with a suspected or an established diagnosis of a skeletal dysplasia in ... If a gene change is found that is responsible for the bone disorder or growth problem in the family, arrangements will be made ...
  https://clinicaltrials.gov/ct2/show/NCT00001754?term=%22spondylocostal+dysostosis%22+%5BDISEASE%5D+OR+NCT00001754+%5BID-NUMBER%5D+OR+NCT00854828+%5BID-NUMBER%5D+OR+NCT01087034+%5BID-NUMBER%5D&rank=3
*  A Study of Two Vismodegib Regimens in Participants With Multiple Basal Cell Carcinomas - Full Text View - ClinicalTrials.gov
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Jaw Diseases. Stomatognathic Diseases. Abnormalities, ... Genetic and Rare Diseases Information Center resources: Nevoid Basal Cell Carcinoma Syndrome Basal Cell Carcinoma, Multiple ...
  https://clinicaltrials.gov/ct2/show/NCT01815840?recr=Open&cond=%22Carcinoma%2C+Basal+Cell%22&rank=16
*  Botox Clinical Trial - Full Text View - ClinicalTrials.gov
Bone Diseases, Developmental. Bone Diseases. Pathological Conditions, Anatomical. onabotulinumtoxinA. Botulinum Toxins, Type A ... Bone lengthening is achieved by surgically breaking the bone and with the use of an extending device, commonly placed on the ... To re start the process means the child has to have a further general anaesthetic to enable the bone to be re osteotomised (re ... The drawback with this is the potential for the bone ends to start fusing and prevent further lengthening once the process is ...
  https://clinicaltrials.gov/ct2/show/NCT00624299
*  Hematopoietic Stem Cell Transplantation for Malignant Infantile Osteopetrosis - Full Text View - ClinicalTrials.gov
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Cyclophosphamide. Methotrexate. Fludarabine phosphate. ... Condition or disease Intervention/treatment Phase Osteopetrosis Drug: Busulfan, Cyclophosphamide, Thymoglobulin, Fludarabine ( ...
  https://clinicaltrials.gov/ct2/show/NCT01087398?term=survival+and+GVHD+after+allogeneic+HSCT+for+osteopetrosis&rank=1
*  Effect of Somatropin on Left Ventricular Mass in Growth Hormone Deficient Adult Patients - Full Text View - ClinicalTrials.gov
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Bone Diseases, Endocrine. Hypopituitarism. Pituitary ... Hypothalamic Diseases. Brain Diseases. Central Nervous System Diseases. Nervous System Diseases. Endocrine System Diseases. ... Condition or disease Intervention/treatment Phase Growth Hormone Disorder Adult Growth Hormone Deficiency Drug: somatropin Drug ... Bone mineral density and body composition assessed by DEXA (Dual Energy X-Ray Absorptiometry). *Quality of life using EQ5D ( ...
  https://www.clinicaltrials.gov/ct2/show/NCT01562834?term=SOMATROPIN&rank=38
*  Evaluation of rhGH Replacement Therapy in Patients With Pseudohypoparathyroidism Type Ia (PHP Ia) - Full Text View -...
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Bone Diseases, Endocrine. Hypopituitarism. Pituitary ... Central Nervous System Diseases. Nervous System Diseases. Endocrine System Diseases. Genetic Diseases, Inborn. Bone Diseases, ... Condition or disease Intervention/treatment Pseudohypoparathyroidism Growth Hormone Deficiency, Dwarfism Drug: recombinant ... Genetic and Rare Diseases Information Center resources: Growth Hormone Deficiency Isolated Growth Hormone Deficiency ...
  https://clinicaltrials.gov/show/NCT00497484
*  Free Fatty Acids, Body Weight, and Growth Hormones Secretion in Children - Full Text View - ClinicalTrials.gov
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Bone Diseases, Endocrine. Hypopituitarism. Pituitary ... Brain Diseases. Central Nervous System Diseases. Nervous System Diseases. Endocrine System Diseases. Genetic Diseases, Inborn. ... Condition or disease Intervention/treatment Phase Obesity Short Stature Growth Hormone Deficiency Drug: Niacin Drug: Placebo ... Hepatic disease with elevated liver function tests (ALT or AST)greater than or equal to 1.5 the upper limits of normal. ...
  https://clinicaltrials.gov/ct2/show/NCT01237041?recr=Open&intr=%22Niacin%22&rank=14
*  An Efficacy and Safety Study of Palovarotene for the Treatment of MO - Full Text View - ClinicalTrials.gov
Bone Diseases. Musculoskeletal Diseases. Neoplasms, Bone Tissue. Neoplasms, Connective Tissue. Neoplasms, Connective and Soft ... Genetics Home Reference related topics: Ollier disease Hereditary multiple osteochondromas Genetic and Rare Diseases ... Condition or disease Intervention/treatment Phase Exostoses, Multiple Hereditary Drug: Palovarotene 2.5 mg Drug: Palovarotene ... A bone age at screening of 14 years or less.. *Symptomatic MO, defined as a new or enlarged osteochondroma that occurred in the ...
  https://clinicaltrials.gov/ct2/show/NCT03442985?term=clementia&rank=4
*  Study of the Molecular Basis in the Pathophysiology of Food Intake and Growth in Children - Full Text View - ClinicalTrials.gov
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Genetic Diseases, Inborn. Endocrine System Diseases. ... Group 5: children with no endocrine diseases and without obesity or short stature. ...
  https://clinicaltrials.gov/ct2/show/NCT00830141
*  Circulating Transforming Growth Factor Beta (TGF-β) in Individuals With Marfan Syndrome - Full Text View - ClinicalTrials.gov
Disease. Pathologic Processes. Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Heart Defects, Congenital ... Cardiovascular Diseases. Heart Diseases. Abnormalities, Multiple. Congenital Abnormalities. Genetic Diseases, Inborn. ... Genetic and Rare Diseases Information Center resources: Camurati-Engelmann Disease Marfan Syndrome ... TGF-β levels play a major role in the pathogenesis of Marfan syndrome, a disease characterized by disproportionate height, long ...
  https://clinicaltrials.gov/show/NCT01361087
*  Nautilus: Dynamic Craniotomy; New Surgical Technique and Preliminary Results - Full Text View - ClinicalTrials.gov
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Craniofacial Abnormalities. Musculoskeletal ... If you do not receive fixation, however, trace the helicoid of the bone osteotomy can turn on a spring that can expand or ... Being the craniostenoses sutural basically a disease, the fact that the brain being trapped in an enclosure that does not have ... This form of osteotomy was therefore chosen by the authors to induce bone compliance areas of secondary defect that should ...
  https://clinicaltrials.gov/ct2/show/NCT01672619
*  Blood Loss and Transfusion Requirement in Infants Treated With Tranexamic Acid - Full Text View - ClinicalTrials.gov
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Craniofacial Abnormalities. Musculoskeletal ... Patient or family history of thromboembolic disease as there may be potential risk of thrombosis ...
  https://clinicaltrials.gov/ct2/show/NCT01094977?cond=%22craniosynostoses%22+OR+%22muenke+syndrome%22&rank=5
*  Clinical Variability in Marfan Syndrome - Full Text View - ClinicalTrials.gov
Disease. Pathologic Processes. Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Heart Defects, Congenital ... Heart Diseases. Abnormalities, Multiple. Congenital Abnormalities. Genetic Diseases, Inborn. Connective Tissue Diseases. Limb ... Condition or disease Intervention/treatment Marfan Syndrome Procedure: skin punch biopsy and molecular biology Other: ... modulates the clinical expression of the disease in individuals from families with clinical variability (intrafamilial) and in ...
  https://clinicaltrials.gov/ct2/show/NCT01707563?cond=%22Marfan+syndrome%22&rank=7
*  Efficacy and Safety Evaluation of Recombinant Human Growth Hormone (r-hGH), Saizen®, on a Population of Children With...
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Genetic Diseases, Inborn. Endocrine System Diseases. ... Bone age at Month 36 or Month 60 is compatible with treatment prolongation according to investigator opinion ... Bone age less than or equal to 11 years for girls and 13 years for boys ... Spinal Diseases. Musculoskeletal Abnormalities. Congenital Abnormalities. Hormones. Hormones, Hormone Substitutes, and Hormone ...
  https://clinicaltrials.gov/ct2/show/NCT01111019?cond=%22Skeletal+dysplasias%22&rank=3
*  Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia - Full Text View - ClinicalTrials...
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Bone Diseases, Endocrine. Pituitary Diseases. ... Hypothalamic Diseases. Brain Diseases. Central Nervous System Diseases. Nervous System Diseases. Nervous System Malformations. ... Genetic and Rare Diseases Information Center resources: Growth Hormone Deficiency Isolated Growth Hormone Deficiency ... Endocrine System Diseases. Dwarfism, Pituitary. Hypopituitarism. Septo-Optic Dysplasia. Dwarfism. ...
  https://clinicaltrials.gov/ct2/show/NCT00140413?recr=Open&cond=%22Pituitary+Diseases%22&rank=15
*  Efficacy, Safety and Pharmacokinetics of Oral LDE225 in Treatment of Patients With Nevoid Basal Cell Carcinoma Syndrome (NBCCS)...
Bone Diseases, Developmental. Bone Diseases. Musculoskeletal Diseases. Jaw Diseases. Stomatognathic Diseases. Abnormalities, ... Condition or disease Intervention/treatment Phase Basal Cell Carcinoma Gorlin Syndrome Nevoid Basal Cell Carcinoma Syndrome ... Measure: Disease Burden by BCC Tumor Counts [ Time Frame: Baseline, day 85, and day 113 ]. BCC tumor counts were performed ... Genetic and Rare Diseases Information Center resources: Nevoid Basal Cell Carcinoma Syndrome Focal Dermal Hypoplasia ...
  https://clinicaltrials.gov/ct2/show/NCT01350115?recr=Open&cond=%22Jaw+Diseases%22&rank=7