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*  CAS 485-49-4 (+)-Bicuculline - BOC Sciences
We offer qualified products for 485-49-4((+)-Bicuculline),please inquire us for 485-49-4((+)-Bicuculline). ... Bicuculline (CAS: 485-49-4) (+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+ ... Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels. ... present study was to examine panic-like elaborated defensive behaviour evoked through GABAA receptor blockade with bicuculline ...
  http://www.bocsci.com/bicuculline-cas-485-49-4-item-84-92982.html
*  Bicuculline (ab120107)参考文献| Abcam中国官方网站
Bicuculline,引用Abcam's (+)-Bicuculline (ab120107)的参考文献列表。为您列举引用本产品
  http://www.abcam.cn/-bicuculline-ab120107-references.html
*  Bicuculline - Wikipedia
Sensitivity to bicuculline is defined by IUPHAR as a major criterion in the definition of GABAA receptors Picrotoxin Manske, R ... The action of bicuculline is primarily on the ionotropic GABAA receptors, which are ligand-gated ion channels concerned chiefly ... Bicuculline is a phthalide-isoquinoline compound that is a light-sensitive competitive antagonist of GABAA receptors. It was ... The half-maximal inhibitory concentration (IC50) of bicuculline on GABAA receptors is 3 μM. In addition to being a potent GABAA ...
  https://en.wikipedia.org/wiki/Bicuculline
*  Bicuculline - LKT Labs
Bicuculline is a neuromodulatory GABA-A receptor antagonist used to study regional variation of GABA receptors and the role of ... Coadministration of bicuculline and NMDA induces paraplegia in the rat. Brain Res. 2012 Apr 27;1451:27-33. PMID: 22445063 ... Through its inhibition of GABA-A receptors, bicuculline potentiates activation at NMDA receptors and produces membrane ... bicuculline and penicillin. Brain Res. 1982 Jan 28;232(1):41-56. PMID: 7055710. ...
  https://www.lktlabs.com/product/bicuculline/
*  Bicuculline, pentobarbital and diazepam modulate spontaneous GABA(A) channels in rat hippocampal neurons.
... Birnir, Bryndis John ... Exposure of the patches to 100 microM bicuculline caused a gradual decrease on the single-channel conductance of the ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:560703
*  Regional and differential expression of gelatinases in rat brain after systemic kainic acid or bicuculline administration
... ... Treatment with the GABAA antagonist, bicuculline, resulted in increased levels of MMP-9, 12 h after drug administration, but no ... No obvious degeneration was detected in kainate-treated, non-convulsive rats or bicuculline-treated animals. These data ...
  https://insights.ovid.com/ejnrs/199810110/00009274-199810110-00006
*  Bicuculline-Induced Seizures: A Challenge for Optical and Biochemical Modeling of the Cytochrome Oxidase CuA Nirs Signal |...
At the highest bicuculline doses (0.25 mg/animal) the maximum values recorded were: ΔHbO2 = +19 ± 7 μM; ΔHHb = -12 ± 4 μM; ... Bicuculline-Induced Seizures: A Challenge for Optical and Biochemical Modeling of the Cytochrome Oxidase CuA Nirs Signal. ... Cooper C.E., Cope M., Elwell C.E., Delpy D.T. (2009) Bicuculline-Induced Seizures: A Challenge for Optical and Biochemical ... The changes induced by bicuculline provide an interesting challenge to the physics and biochemistry of using NIRS to study ...
  https://rd.springer.com/chapter/10.1007/978-0-387-85998-9_20
*  Effects of low doses of bicuculline on N-methyl-D-aspartate single-channel kinetics are not evident in whole-cell currents. |...
Effects of low doses of bicuculline on N-methyl-D-aspartate single-channel kinetics are not evident in whole-cell currents.. J ... Effects of low doses of bicuculline on N-methyl-D-aspartate single-channel kinetics are not evident in whole-cell currents.. J ... Effects of low doses of bicuculline on N-methyl-D-aspartate single-channel kinetics are not evident in whole-cell currents.. J ... Bicuculline methiodide (BIC-Mel) (10-100 microM) altered the kinetics of N-methyl-D-aspartate (NMDA) responses in single- ...
  http://molpharm.aspetjournals.org/content/41/5/900
*  Modulation of Ligands Binding To the Benzodiazepine Receptor By An Endogenous Inhibitor (gaba-modulin) and Bicuculline | DIAL...
Modulation of Ligands Binding To the Benzodiazepine Receptor By An Endogenous Inhibitor (gaba-modulin) and Bicuculline. In: ... Modulation of Ligands Binding To the Benzodiazepine Receptor By An Endogenous Inhibitor (gaba-modulin) and Bicuculline Primary ... Home» Modulation of Ligands Binding To the Benzodiazepine Receptor By An Endogenous Inhibitor (gaba-modulin) and Bicuculline ...
  https://dial.uclouvain.be/pr/boreal/object/boreal:53966
*  Plus it
... bicuculline (0.4 mm), was microinjected into the vlPAG (n = 25). Injection of bicuculline caused inhibition of firing of Aδ- ... Bicuculline methiodide, 0.4 mm, pH 6.0, and a 2% solution of Pontamine Sky Blue (both Sigma-Aldrich) were diluted in aqueous ... The effects of bicuculline are transient and reversed after 30 min, and a further 30 min washout period was allowed. After ... Bicuculline injection into the vlPAG. To identify functional inhibitory projections from the vlPAG to the TCC and to indicate ...
  http://www.jneurosci.org/content/33/37/14869
*  Lab Rotator at Thomas Scientific
Bicuculline LKT Labs. …anxiety, and memory. Through its inhibition of GABA-A receptors, bicuculline potentiates activation at ...
  https://www.thomassci.com/scientific-supplies/Lab-Rotator
*  Proteins, Peptides, Small Molecules & Other Biomolecules - 2B Scientific
Bicuculline. £74.00 SKU:. T2850-10mg. Size:. 10mg. Suppl:. TargetMol. Add to order Added to order View basket ...
  https://www.2bscientific.com/Ranges/Proteins
*  GABA Receptors - Neuronal Signaling
Bicuculline GABAA antagonist (+)-Bicuculline is a classical GABAA antagonist. A12993 Zaleplon - Zaleplon is a non- ...
  http://www.adooq.com/gaba-receptors.html
*  Plus it
Induction of prolonged corticothalamic bursts by 4-AP and bicuculline. Application of 4-AP and bicuculline elicited prolonged ... 1998) Effect of bicuculline on thalamic activity: a direct blockade of IAHP in reticularis neurons. J Neurophysiol 79:2911-2918 ... From P2 in layer VI, P7 in VP, and P8 in RTN, joint application of 4-AP and bicuculline elicited prolonged depolarizations ... In mouse thalamocortical slices in vitro, the potassium channel blocker 4-AP and GABAA receptor antagonist bicuculline together ...
  http://www.jneurosci.org/content/19/8/2865
*  Phenibut - Wikipedia
Phenibut also binds to and blocks α2δ subunit-containing VDCCs, similarly to gabapentin and pregabalin, and hence is a gabapentinoid.[9][16] Both (R)-phenibut and (S)-phenibut display this action with similar affinity (Ki = 23 and 39 μM, respectively).[9] Moreover, (R)-phenibut possesses 4-fold greater affinity for this site than for the GABAB receptor (Ki = 92 μM), while (S)-phenibut does not bind significantly to the GABAB receptor (Ki , 1 mM).[9] As such, based on the results of this study, phenibut would appear to have much greater potency in its interactions with α2δ subunit-containing VDCCs than with the GABAB receptor (between 5- to 10-fold).[9] For this reason, the actions of phenibut as a α2δ subunit-containing voltage-gated calcium channel blocker or gabapentinoid may be its true primary mechanism of action, and this may explain the differences between phenibut and its close relative baclofen (which, in contrast, has essentially insignificant activity as a gabapentinoid; Ki = 6 ...
  https://en.wikipedia.org/wiki/Phenibut
*  Pregnanolone - Wikipedia
Pregnanolone, also known as eltanolone (INN), is an endogenous neurosteroid that is biosynthesized from progesterone.[1] It is a positive allosteric modulator of the GABAA receptor,[1] as well as a negative allosteric modulator of the glycine receptor,[2] and is known to have sedative, anxiolytic, anesthetic, and anticonvulsant effects.[1][2][3] It was investigated for clinical use as a general anesthetic, but produced unwanted side effects such as convulsions on occasion, and for this reason was never marketed.[2][4] During pregnancy, pregnanolone and allopregnanolone are involved in sedation and anesthesia of the fetus.[5][6] ...
  https://en.wikipedia.org/wiki/Eltanolone
*  Ciprofloxacin - Wikipedia
Ciprofloxacin is used to treat a wide variety of infections, including infections of bones and joints, endocarditis, gastroenteritis, malignant otitis externa, respiratory tract infections, cellulitis, urinary tract infections, prostatitis, anthrax, and chancroid.[2]. Ciprofloxacin only treats bacterial infections; it does not treat viral infections such as the common cold. For certain uses including acute sinusitis, lower respiratory tract infections and uncomplicated gonorrhea, ciprofloxacin is not considered a first-line agent.. Ciprofloxacin occupies an important role in treatment guidelines issued by major medical societies for the treatment of serious infections, especially those likely to be caused by Gram-negative bacteria, including Pseudomonas aeruginosa. For example, ciprofloxacin in combination with metronidazole is one of several first-line antibiotic regimens recommended by the Infectious Diseases Society of America for the treatment of community-acquired abdominal infections in ...
  https://en.wikipedia.org/wiki/Cipro
*  5α-Dihydroprogesterone - Wikipedia
5α-Dihydroprogesterone (5α-DHP), also known as allopregnanedione,[1] as well as 5α-pregnane-3,20-dione, is an endogenous progestogen and neurosteroid that is synthesized from progesterone.[2][3] It is also an intermediate in the synthesis of allopregnanolone and isopregnanolone from progesterone. 5α-DHP is an agonist of the progesterone receptor and a positive allosteric modulator of the GABAA receptor (albeit with an affinity for this receptor that is regarded as relatively low (in comparison to 3α-hydroxylated progesterone metabolites such as allopregnanolone and pregnanolone)).[2][3][4][5] It has also been found to act as a negative allosteric modulator of the GABAA-rho receptor.[6] In addition, it is a weak agonist of the pregnane X receptor (PXR) (EC50 ,10,000 µM)), with approximately six-fold lower potency relative to its 5β-isomer, 5β-dihydroprogesterone.[7]. ...
  https://en.wikipedia.org/wiki/5-alpha-dihydroprogesterone
*  gamma-Aminobutyric acid - Wikipedia
Antagonists/negative allosteric modulators: bicuculline, cicutoxin, flumazenil, furosemide, gabazine, oenanthotoxin, picrotoxin ...
  https://en.wikipedia.org/wiki/Gamma_amino_butyric_acid
*  On the regulation of ischaemia-induced glutamate efflux from rat cortex by GABA; in vitro studies with GABA, clomethiazole and...
The effect of bicuculline (Bic; 10 μM) on the inhibitory effect of pentobarbitone (300 μM) on glutamate efflux is also shown. ... Bicuculline (10 μM) did not antagonize the inhibition of glutamate efflux induced by clomethiazole (Figure 4). In contrast, ... The experiments with bicuculline and picrotoxin further demonstrate that the effect is not due to an action of clomethiazole at ... Results shown as mean±s.e.mean (n=4-9). **Different from Ischaemia (P,0.01). Addition of bicuculline or picrotoxin abolished ...
  http://onlinelibrary.wiley.com/doi/10.1038/sj.bjp.0703398/full
*  IJMS | Free Full-Text | Modeling Natural Anti-Inflammatory Compounds by Molecular Topology | HTML
Hsu, D.Z.; Liu, M.Y. Bicuculline methiodide attenuates hepatic injury and decreases mortality in septic rats: Role of cytokines ...
  http://www.mdpi.com/1422-0067/12/12/9481/htm