*  Benzazepine - Wikipedia
Benzazepines are heterocyclic chemical compounds consisting of a benzene ring fused to an azepine ring. Examples include: ... Benazepril Fenoldopam GSK-189,254 Ivabradine Lorcaserin Semagacestat Varenicline Benzodiazepine Dibenzazepine Benzazepines at ...
  https://en.wikipedia.org/wiki/Benzazepine
*  2,3,4,5-Tetrahydro-1,5-methano-1H-3-benzazepine - Wikipedia
2,3,4,5-Tetrahydro-1,5-methano-1H-3-benzazepine is a drug originally researched as a potential opioid analgesic, but was found ... 5-methano-1H-3-benzazepine, it seems unlikely that this is actually the compound being sold. Corey lactone 4-phenylbenzoate ... 5-methano-1H-3-benzazepines". Journal of Medicinal Chemistry. 22 (4): 455-7. doi:10.1021/jm00190a020. PMID 430484. Singer, R. A ... 5-methano-1H-3-benzazepine via Oxidative Cleavage and Reductive Amination Strategies". Synthesis. 2004 (11): 1755. doi:10.1055/ ...
  https://en.wikipedia.org/wiki/2,3,4,5-Tetrahydro-1,5-methano-1H-3-benzazepine
*  Decreased striatal dopamine efflux after intrastriatal application of benzazepine-class D1 agonists is not mediated via...
The present experiments employed in vivo microdialysis to further examine the ability of widely used benzazepine-class D1 ... The present data suggest that the ability of intrastriatally applied benzazepine-class D1 agonists to decrease striatal ... The present experiments employed in vivo microdialysis to further examine the ability of widely used benzazepine-class D1 ... Decreased striatal dopamine efflux after intrastriatal application of benzazepine-class D1 agonists is not mediated via ...
  https://www.semanticscholar.org/paper/Decreased-striatal-dopamine-efflux-after-of-D1-is-Zackheim-Abercrombie/38ddc9cb7322d95a0223321cb4b2094d239169fa
*  Indian Patents. 223202:METAL SALTS OF BENZAZEPINE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF
METAL SALTS OF BENZAZEPINE COMPOUNDS AND PROCESS FOR PREPARATION THEREOF. Abstract. The invention provides a compound of the ... Preferred benzazepines are the compounds wherein Ri is a phenylethyl group or a 1-naphtylethyl group, R2 and Rs are both ... Benzazepines with the above formula are known from EP 0733642, EP 0830863, WO00/48601 and WO01/03699. EP 0733642 is related to ... 19 g of the S-methylbenzyl amine salt of 1H-1-Benzazepine-1-acetic. acid, 3-[[[1-[(2R)-2-. 2,3,4,5-tetrahydro-2-oxo-, (3S)- ...
  http://www.allindianpatents.com/patents/223202-metal-salts-of-benzazepine-compounds-and-process-for-preparation-thereof
*  4-Fluoro-2,3,4,5-tetrahydro-1H-2-benzazepine hcl - Alfa Chemistry
We offer qualified products for 360054-82-6(4-FLUORO-2,3,4,5-TETRAHYDRO-1H-2-BENZAZEPINE HCL),please inquire us for 360054-82-6 ... Home > Product > Heterocyclic Organic Compounds > 4-Fluoro-2,3,4,5-tetrahydro-1H-2-benzazepine hcl ... 4-Fluoro-2,3,4,5-tetrahydro-1H-2-benzazepine hcl , CAS Number: 360054-82-6. ...
  http://www.alfa-chemistry.com/cas_360054-82-6.htm
*  7-[[4-[(4-Chlorophenyl)methoxy]phenyl]sulfonyl]-2,3,4,5-tetrahydro-8-methoxy-3-methyl-1H-3-benzazepine(2Z)-2-butenedioate -...
5-tetrahydro-8-methoxy-3-methyl-1H-3-benzazepine(2Z)-2-butenedioate/ACM853402956 can be provided in Alfa Chemistry. We are ... 7-[[4-[(4-Chlorophenyl)methoxy]phenyl]sulfonyl]-2,3,4,5-tetrahydro-8-methoxy-3-methyl-1H-3-benzazepine(2Z)-2-butenedioate , CAS ... 7-[[4-[(4-Chlorophenyl)methoxy]phenyl]sulfonyl]-2,3,4,5-tetrahydro-8-methoxy-3-methyl-1H-3-benzazepine(2Z)-2-butenedioate ... 7-[[4-[(4-chlorophenyl)methoxy]phenyl]sulfonyl]-2,3,4,5-tetrahydro-8-methoxy-3-methyl-1H-3-Benzazepine (2Z)-2-butenedioate; ...
  http://www.alfa-chemistry.com/cas_853402-95-6.htm
*  R)-(+)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine - Alfa Chemistry
R)-(+)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine/AFI253446150 can be provided in Alfa Chemistry. We ... Home > Product > Heterocyclic Organic Compounds > (R)-(+)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine ... R)-(+)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine , CAS Number: 253446-15-0. ... R(+)-SKF-81297 hydrobromide, R-(+)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide, 253446-15- ...
  http://www.alfa-chemistry.com/cas_253446-15-0.htm
*  7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepine 313673-94-8 H-NMR | C-NMR Spectral Analysis NMR Spectrum
5-tetrahydro-1H-1-benzazepine H-NMR spectral analysis, 7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepine C-NMR spectral analysis ect ...
  http://www.molbase.com/en/hnmr_313673-94-8-moldata-23855.html
*  Captodiame - Wikipedia
Captodiame (INN), also known as captodiamine, is an antihistamine sold under the trade names Covatine, Covatix, and Suvren which is used as a sedative and anxiolytic. The structure is related to diphenhydramine.[1] A 2004 study suggested captodiame may be helpful in preventing benzodiazepine withdrawal syndrome in people discontinuing benzodiazepine treatment.[1] In addition to its actions as an antihistamine, captodiamine has been found to act as a 5-HT2C receptor antagonist and σ1 receptor and D3 receptor agonist.[2] It produces antidepressant-like effects in rats.[2] However, captodiamine is unique among antidepressant-like drugs in that it increases brain-derived neurotrophic factor (BDNF) levels in the hypothalamus but not in the frontal cortex or hippocampus.[2] This unique action may be related to its ability to attenuate stress-induced anhedonia and corticotropin-releasing factor (CRF) signaling in the hypothalamus.[2] ...
  https://en.wikipedia.org/wiki/Captodiame
*  Domperidone - Wikipedia
The hormone prolactin stimulates lactation (production of breast milk). Dopamine, released by the hypothalamus stops the release of prolactin from the pituitary gland. Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation (that is, it is a galactogogue). In some nations, including Australia, domperidone is used off-label, based on uncertain and anecdotal evidence of its usefulness, as a therapy for mothers who are having difficulty breastfeeding.[24][25] In the United States, domperidone is not approved for this or any other use.[26][27] A study called the EMPOWER trial was designed to assess the effectiveness and safety of domperidone in assisting mothers of preterm babies to supply breast milk for their infants.[28] The study randomized 90 mothers of preterm babies to receive either domperidone 10 mg orally three times daily for 28 days (Group A) or placebo 10 mg orally three times daily for 14 days followed by domperidone ...
  https://en.wikipedia.org/wiki/Domperidone
*  WAY-100635 - Wikipedia
WAY-100635 has also been found to increase the analgesic effects of opioid drugs in a dose-dependent manner, in contrast to 5-HT1A agonists such as 8-OH-DPAT which were found to reduce opioid analgesia.[22][23] However, since 5-HT1A agonists were also found to reduce opioid-induced respiratory depression and WAY-100635 was found to block this effect,[24] it is likely that 5-HT1A antagonists might worsen this side effect of opioids. Paradoxically, chronic administration of the very high efficacy 5-HT1A agonist befiradol results in potent analgesia following an initial period of hyperalgesia, an effect most likely linked to desensitisation and/or downregulation of 5-HT1A receptors (i.e. analogous to a 5-HT1A antagonist-like effect).[25][26][27] As with other 5-HT1A silent antagonists such as UH-301 and robalzotan, WAY 100635 can also induce a head-twitch response in rodents.[28] ...
  https://en.wikipedia.org/wiki/WAY-100635
*  Dopamine receptor - Wikipedia
The present meta-analysis was conducted to estimate the magnitude of the effects of methylphenidate and amphetamine on cognitive functions central to academic and occupational functioning, including inhibitory control, working memory, short-term episodic memory, and delayed episodic memory. In addition, we examined the evidence for publication bias. Forty-eight studies (total of 1,409 participants) were included in the analyses. We found evidence for small but significant stimulant enhancement effects on inhibitory control and short-term episodic memory. Small effects on working memory reached significance, based on one of our two analytical approaches. Effects on delayed episodic memory were medium in size. However, because the effects on long-term and working memory were qualified by evidence for publication bias, we conclude that the effect of amphetamine and methylphenidate on the examined facets of healthy cognition is probably modest overall. In some situations, a small advantage may be ...
  https://en.wikipedia.org/wiki/Dopamine_receptor
*  Bromocriptine - Wikipedia
Most frequent side effects are nausea, orthostatic hypotension, headaches, and vomiting through stimulation of the brainstem vomiting centre.[9] Vasospasms with serious consequences such as myocardial infarction and stroke that have been reported in connection with the puerperium, appear to be extremely rare events.[10] Peripheral vasospasm (of the fingers or toes) can cause Raynaud's Phenomenon. Bromocriptine use has been anecdotally associated with causing or worsening psychotic symptoms (its mechanism is in opposition of most antipsychotics, whose mechanisms generally block dopamine).[11] Pulmonary fibrosis has been reported when bromocriptine was used in high doses for the treatment of Parkinson's disease.[12] Use to suppress milk production after childbirth was reviewed in 2014 and it was concluded that in this context a causal association with serious cardiovascular, neurological or psychiatric events could not be excluded with an overall incidence rate estimated to range between 0.005% ...
  https://en.wikipedia.org/wiki/Bromocriptine
*  Raclopride - Wikipedia
Raclopride is a synthetic compound that acts as a selective antagonist on D2 dopamine receptors.[1] Its selectivity to the cerebral D2 receptors is characterized by its respective Ki-values, which are as follows: 1.8, 3.5, 2400 and 18000 nM for D2, D3, D4 and D1 receptors respectively. It can be radiolabelled with radioisotopes, e.g. 3H or 11C and used as a tracer for in vitro imaging (autoradiography) as well as in vivo imaging positron emission tomography (PET). Images obtained by cerebral PET scanning (e.g. PET/CT or PET/MRI) allow the non-invasive assessment of the binding capacity of the cerebral D2 dopamine receptor, which can be useful for the diagnosis of movement disorders. In particular, cerebral D2 receptor binding as measured by carbon-11-raclopride (11C-raclopride) has shown to reflect disease severity of Huntington's disease, a genetical disease characterized by selective degeneration of cerebral D2 receptors.[2] Other studies have investigated the relationship of D2 receptor ...
  https://en.wikipedia.org/wiki/Raclopride
*  L-DOPA - Wikipedia
L-DOPA crosses the protective blood-brain barrier, whereas dopamine itself cannot. Thus, L-DOPA is used to increase dopamine concentrations in the treatment of Parkinson's disease and dopamine-responsive dystonia. This treatment was made practical and proven clinically by George Cotzias and his coworkers, for which they won the 1969 Lasker Prize.[4][5] Once L-DOPA has entered the central nervous system, it is converted into dopamine by the enzyme aromatic L-amino acid decarboxylase, also known as DOPA decarboxylase. Pyridoxal phosphate (vitamin B6) is a required cofactor in this reaction, and may occasionally be administered along with L-DOPA, usually in the form of pyridoxine.. Besides the central nervous system, L-DOPA is also converted into dopamine from within the peripheral nervous system. Excessive peripheral dopamine signaling causes many of the adverse side effects seen with sole L-DOPA administration. To bypass these effects, it is standard clinical practice to coadminister (with ...
  https://en.wikipedia.org/wiki/L-dopa
*  Efficacy of I(f) inhibition with ivabradine in different subpopulations with stable angina pectoris.
Benzazepines / administration & dosage*. Coronary Artery Bypass / methods. Cyclic Nucleotide-Gated Cation Channels / drug ... 0/Benzazepines; 0/Cyclic Nucleotide-Gated Cation Channels; 155974-00-8/ivabradine ...
  http://www.biomedsearch.com/nih/Efficacy-If-inhibition-with-ivabradine/19468225.html
*  Involvement of cyclin B1 in progesterone-mediated cell growth inhibition, G2/M cell cycle arrest, and apoptosis in human...
Benzazepines / pharmacology. Blotting, Western. Cell Cycle / physiology*. Cell Differentiation / drug effects. Cell Division / ... 0/Benzazepines; 0/Coloring Agents; 0/Cyclin B1; 0/Indoles; 0/Tetrazolium Salts; 0/Thiazoles; 0/alsterpaullone; 298-93-1/ ...
  http://www.biomedsearch.com/nih/Involvement-cyclin-B1-in-progesterone/19968870.html
*  Concerns about 'Comparative adverse cardiac effects of pimobendan and benazepril monotherapy in dogs with mild degenerative...
Benzazepines / administration & dosage*. Cardiotonic Agents / adverse effects*. Dog Diseases / drug therapy*. Dogs. Ethics, ... 0/Antihypertensive Agents; 0/Benzazepines; 0/Cardiotonic Agents; 0/Pyridazines; 74150-27-9/pimobendan; 86541-75-5/benazepril ...
  http://www.biomedsearch.com/nih/Concerns-about-Comparative-adverse-cardiac/18371019.html
*  Self-administration of the D1 agonist SKF 82958 is mediated by D1, not D2, receptors.
Benzazepines / administration & dosage, pharmacology*. Conditioning, Operant / drug effects. Dopamine Agonists / administration ... 0/Benzazepines; 0/Dopamine Agonists; 0/Dopamine Antagonists; 0/Receptors, Dopamine D1; 0/Receptors, Dopamine D2; 0/ ...
  http://www.biomedsearch.com/nih/Self-administration-D1-agonist-SKF/8867867.html
*  Tranylcypromine - The Full Wiki
Benzazepines: 6-Br-APB • Fenoldopam • SKF-38,393 • SKF-77,434 • SKF-81,297 • SKF-82,958 • SKF-83,959; Ergot-derivatives: ...
  http://www.thefullwiki.org/Tranylcypromine
*  6-Br-APB - The Full Wiki
Benzazepines: 6-Br-APB • Fenoldopam • SKF-38,393 • SKF-77,434 • SKF-81,297 • SKF-82,958 • SKF-83,959; Ergot-derivatives: ... R)-3-allyl-6-bromo-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine ... 5-tetrahydro-1H-3-benzazepine and its 6-bromo analogue". Journal of Medicinal Chemistry 35 (8): 1466-71. PMID 1533424. ...
  http://www.thefullwiki.org/6-Br-APB
*  RG-4733 - DrugBank
Benzazepines. Sub Class. Dibenzazepines. Direct Parent. Dibenzazepines. Alternative Parents. N-acyl-alpha amino acids and ...
  https://www.drugbank.ca/drugs/DB11870
*  Alcaftadine - DrugBank
Benzazepines. Sub Class. Not Available. Direct Parent. Benzazepines. Alternative Parents. Carbonylimidazoles / Azepines / Aryl- ... Benzazepine / Azepine / Imidazole-4-carbonyl group / Aryl-aldehyde / N-substituted imidazole / Piperidine / Benzenoid / ... This compound belongs to the class of organic compounds known as benzazepines. These are organic compounds containing a benzene ... 6,11-Dihydro-11-(1-Methyl-4-piperidinylidene)-5H-iMidazo[2,1-b][3]benzazepine-3-carboxaldehyde ...
  https://www.drugbank.ca/drugs/DB06766
*  Ecopipam - DrugBank
Benzazepines. Sub Class. Not Available. Direct Parent. Benzazepines. Alternative Parents. Tetralins / Azepines / Aralkylamines ... Benzazepine / Tetralin / 1-hydroxy-2-unsubstituted benzenoid / Azepine / Aralkylamine / Aryl chloride / Aryl halide / Benzenoid ... This compound belongs to the class of organic compounds known as benzazepines. These are organic compounds containing a benzene ...
  https://www.drugbank.ca/drugs/DB12273
*  Eslicarbazepine acetate - DrugBank
Benzazepines. Sub Class. Dibenzazepines. Direct Parent. Dibenzazepines. Alternative Parents. Azepines / Benzenoids / Ureas / ...
  https://www.drugbank.ca/drugs/DB09119