Azasteroids Summary Report | CureHunter
Azasteroids: Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with ... Azasteroids. Subscribe to New Research on Azasteroids Steroidal compounds in which one or more carbon atoms in the steroid ring ...http://www.curehunter.com/public/keywordSummaryD001378.do
Indian Patents. 250632:'PROCESS FOR THE PREPARATION OF 4-AZASTEROIDS'
Process for the preparation of 4-azasteroids. The invention relates to a process for the preparation of 4-azasteroids of the ... PROCESS FOR THE PREPARATION OF 4-AZASTEROIDS'. Abstract. The invention relates to a process for the preparation of 4-steroids ... 1. A process for the preparation of 4-azasteroids of the formula. (Formula Removed). wherein. R1and R2 are independently ... Compounds of formula I are key intermediates for the production of pharmaceutically active 4-azasteroids, e.g. 17-substituted-4 ...http://www.allindianpatents.com/patents/250632-process-for-the-preparation-of-4-azasteroids
Category:Steroids - Wikimedia Commons
The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases
3) 10-azasteroids, for example, AS97004, are competitive 5α-RI with a similar mechanism of action to 6-azasteroids . ... 3-azasteroids, 19-nor-10-azasteroids, and diazasteroids .. 8.2. Nonsteroidal Inhibitors [9, 30, 46]. Several pharmaceutical ... 2) 6-Azasteroids (e.g., GIlS7669X) have a heterocyclic B ring (nitrogen atom at position 6) and a Δ4,5 bond in the A ring and ... d)Pyridines lack B and C rings.(e)Benzo[c]quinolinones tricyclic compounds derived from 6-azasteroids (no D ring, aromatic ring ...https://www.hindawi.com/journals/au/2012/530121/
Discovery and development of 5α-reductase inhibitors - Wikipedia
Azasteroids are a type of steroid derivatives which have nitrogen atoms replaced at various positions for one of the carbon ... Two 4-azasteroids, finasteride and dutasteride are marketed as 5-ARIs. Finasteride (Proscar or Propecia) was the first ... Two of them are 4-azasteroids and will be covered here. As mentioned above, the third one, epristeride is only marketed in ... The main problems for 4-azasteroids is the rapid conversion into inactive 4,5-dihydro form, which is done by the enzyme. ...https://en.wikipedia.org/wiki/Discovery_and_development_of_5%CE%B1-reductase_inhibitors
Candocuronium iodide - Wikipedia
"Neuromuscular and other blocking actions of a new series of mono and bisquaternary aza steroids". J Pharm Phamacol. 26 (11): ... "The neuromuscular and autonomic blocking effects of azasteroids containing choline or acetylcholine fragments". J Pharm ...https://en.wikipedia.org/wiki/Candocuronium_iodide
Azasteroid - Wikipedia
Two azasteroids, finasteride and dutasteride, are used clinically as 5α-reductase inhibitors. Some of the 6-azasteroids may ... "6-Azasteroids: Potent dual inhibitors of human type 1 and 2 steroid 5.alpha.-reductase". Journal of Medicinal Chemistry. 36 (26 ... "6-Azasteroids: Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5.alpha.-Reductase and Human Adrenal 3. ...https://en.wikipedia.org/wiki/Azasteroid
Patent US5679521 - Steroid 5A-reductases - Google Patents
The 4-azasteroids, 4-MA (17α-N,N-diethylcarbamoyl-4-methyl-4-aza-5α-androtane-3-one) and MK-906 (17β-N-t-butylcarbamoyl-4-aza-5 ... 4-aza steroids (Andersson and Russell, 1990). Prior to the current invention, there remained many outstanding questions ...http://www.google.co.uk/patents/US5679521
... azasteroids, reductase inhibitors, and enzyme inhibitors to identify randomized trials. Eight studies met the inclusion ...https://www.cancer.gov/types/prostate/hp/prostate-prevention-pdq
MK-386 - Wikipedia
... and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase". J. Med. Chem. 37 (23): 3871-4. PMID ...https://en.wikipedia.org/wiki/MK-386
Aza- - Wikipedia
While the above figure gives examples of 4-aza steroids, 6-aza steroids have also been developed by GSK, although none of these ...https://en.wikipedia.org/wiki/Aza-
Satinder Vir Kessar - Wikipedia
Through his later day researches, he built the infrastructure of solanum alkaloids, accomplished the synthesis of azasteroids ...https://en.wikipedia.org/wiki/Satinder_Vir_Kessar
List of MeSH codes (D04) - Wikipedia
... azasteroids MeSH D04.808.925.100.250 --- finasteride. ...https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D04)
May 30, 2017 - mk-2866 Cycle
A novel series of ostarine gw1516 results gtx-024 16-substituted-4-azasteroids has been identified as potential tissue- ...http://mk2866cycle.com/2017/05/30/
Dutasteride - DrugBank
3-oxo-5-alpha-steroids / 3-oxo-4-azasteroids / 4-azasteroids and derivatives / Trifluoromethylbenzenes / Anilides / N- ...https://www.drugbank.ca/drugs/DB01126
Finasteride - DrugBank
3-hydroxysteroids / 4-azasteroids and derivatives / Cyclic carboximidic acids / Propargyl-type 1,3-dipolar organic compounds / ...https://www.drugbank.ca/drugs/DB01216
3-hydroxy-13-amino-13,17-secoandrostan-17-oic-13,17-lactam p-bis(2-chloroethyl)amino phenyl acetate Summary Report |...
Azasteroids: 1*3-hydroxy-13-amino-13,17-secoandrostan-17-oic-13,17-lactam p-bis(2-chloroethyl)amino phenyl acetate: 3 ...http://www.curehunter.com/public/keywordSummaryC515329-3-hydroxy-13-amino-13-17-secoandrostan-17-oic-13-17-lactam-p-bis-2-chloroethyl-amino-phenyl-acetate.do
Heterocyclic Steroids Summary Report | CureHunter
Azasteroids: 1. *1,6-dithiabenz(3,4)estra-3,5(10),8,14-tetraen-17-one ...http://www.curehunter.com/public/keywordSummaryD013260-Heterocyclic-Steroids.do
Human Metabolome Database: Showing metabocard for Solanidine (HMDB0003236)
A phase II, 28-day, randomized, parallel-group, open-label study evaluating the efficacy and safety of twice daily oral doses...
This trial will compare the efficacy, tolerability and pharmacokinetics of testosterone (150, 250 and 400mg) when administered alone or in combination withhttps://adisinsight.springer.com/trials/700019827?error=cookies_not_supported&code=61ed301c-4a93-42ad-9428-724232a5346e
A Multicenter, Randomized, Double-blind, Clinical Study to Investigate the Efficacy and Safety of Treatment With Tamsulosin 0...
This study will investigate the effects of tamsulosin +/- finasteride on lower urinary tracts symptoms in patients with benign prostate hyperplasia.https://adisinsight.springer.com/trials/700226705?error=cookies_not_supported&code=58dbc661-60b6-4a60-b274-f3f772bbf67a
Open Label, Randomized Comparative Study to Evaluate the Pharmacokinetic Characteristics Between Coadministered Finasteride...
This study investigated the pharmacokinetics of single pill combination finasteride/tamsulosin [GL PharmTech] versus co-administered finasteride and tamsulosinhttps://adisinsight.springer.com/trials/700231717?error=cookies_not_supported&code=0553af64-2446-4245-aafd-a494414c81e4
FDC116115: A prospective study of sexual function in sexually active men treated for BPH - AdisInsight
This trial is investigating the effects of dutasteride/tamsulosin [Duodart, GlaxoSmithKline] on sexual function in sexually active men with at least moderatehttp://adisinsight.springer.com/trials/700224392?error=cookies_not_supported&code=9e80c24f-fb7c-4921-a739-633397079dbf
Pharmacokinetics of topical (0.25% solution bid) and oral (1 mg od) finasteride after single and 7 days multiple dose in male...
This study compared the pharmacokinetics and tolerability of finasteride following single-dose and multiple-dose, topical versus oral administration in men withhttp://adisinsight.springer.com/trials/700235600?error=cookies_not_supported&code=f037cb7e-8291-4d92-9cf5-cfe53597c227
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