*  Dutasteride - DrugBank
3-oxo-5-alpha-steroids / 3-oxo-4-azasteroids / 4-azasteroids and derivatives / Trifluoromethylbenzenes / Anilides / N- ...
  https://www.drugbank.ca/drugs/DB01126
*  Azasteroids Summary Report | CureHunter
Azasteroids: Steroidal compounds in which one or more carbon atoms in the steroid ring system have been substituted with ... Azasteroids. Subscribe to New Research on Azasteroids Steroidal compounds in which one or more carbon atoms in the steroid ring ...
  http://www.curehunter.com/public/keywordSummaryD001378.do
*  Indian Patents. 250632:'PROCESS FOR THE PREPARATION OF 4-AZASTEROIDS'
Process for the preparation of 4-azasteroids. The invention relates to a process for the preparation of 4-azasteroids of the ... PROCESS FOR THE PREPARATION OF 4-AZASTEROIDS'. Abstract. The invention relates to a process for the preparation of 4-steroids ... 1. A process for the preparation of 4-azasteroids of the formula. (Formula Removed). wherein. R1and R2 are independently ... Compounds of formula I are key intermediates for the production of pharmaceutically active 4-azasteroids, e.g. 17-substituted-4 ...
  http://www.allindianpatents.com/patents/250632-process-for-the-preparation-of-4-azasteroids
*  The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases
3) 10-azasteroids, for example, AS97004, are competitive 5α-RI with a similar mechanism of action to 6-azasteroids [9]. ... 3-azasteroids, 19-nor-10-azasteroids, and diazasteroids [9].. 8.2. Nonsteroidal Inhibitors [9, 30, 46]. Several pharmaceutical ... 2) 6-Azasteroids (e.g., GIlS7669X) have a heterocyclic B ring (nitrogen atom at position 6) and a Δ4,5 bond in the A ring and ... d)Pyridines lack B and C rings.(e)Benzo[c]quinolinones tricyclic compounds derived from 6-azasteroids (no D ring, aromatic ring ...
  https://www.hindawi.com/journals/au/2012/530121/
*  Discovery and development of 5α-reductase inhibitors - Wikipedia
Azasteroids are a type of steroid derivatives which have nitrogen atoms replaced at various positions for one of the carbon ... Two 4-azasteroids, finasteride and dutasteride are marketed as 5-ARIs. Finasteride (Proscar or Propecia) was the first ... Two of them are 4-azasteroids and will be covered here. As mentioned above, the third one, epristeride is only marketed in ... The main problems for 4-azasteroids is the rapid conversion into inactive 4,5-dihydro form, which is done by the enzyme. ...
  https://en.wikipedia.org/wiki/Discovery_and_development_of_5%CE%B1-reductase_inhibitors
*  Candocuronium iodide - Wikipedia
"Neuromuscular and other blocking actions of a new series of mono and bisquaternary aza steroids". J Pharm Phamacol. 26 (11): ... "The neuromuscular and autonomic blocking effects of azasteroids containing choline or acetylcholine fragments". J Pharm ...
  https://en.wikipedia.org/wiki/Candocuronium_iodide
*  Azasteroid - Wikipedia
Two azasteroids, finasteride and dutasteride, are used clinically as 5α-reductase inhibitors. Some of the 6-azasteroids may ... "6-Azasteroids: Potent dual inhibitors of human type 1 and 2 steroid 5.alpha.-reductase". Journal of Medicinal Chemistry. 36 (26 ... "6-Azasteroids: Structure-Activity Relationships for Inhibition of Type 1 and 2 Human 5.alpha.-Reductase and Human Adrenal 3. ...
  https://en.wikipedia.org/wiki/Azasteroid
*  urinary tract neoplasms benign drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-major] Azasteroids / therapeutic use. Enzyme Inhibitors / therapeutic use. Prostatic Hyperplasia / drug therapy ... Azasteroids / therapeutic use. Dihydrotestosterone / blood. Dutasteride. Enzyme Inhibitors / therapeutic use. Finasteride / ... Chemical-registry-number] 0 / 5-alpha Reductase Inhibitors; 0 / Azasteroids; 0 / Enzyme Inhibitors; 0 / Sulfonamides; ...
  http://www.bmlsearch.com/?kwr=urinary+tract+neoplasms+benign+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1
*  MK-386 - Wikipedia
... and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase". J. Med. Chem. 37 (23): 3871-4. PMID ...
  https://en.wikipedia.org/wiki/MK-386
*  Low-dose oral cholecalciferol is associated with higher numbers of Helios+ and total Tregs than oral calcitriol in renal...
Regulatory T cells (Tregs) are a cornerstone of graft acceptance. High numbers of Tregs are associated with better long-term graft survival. Recently, Vitamin D was suggested as an immunomodulator, in addition to its classical role in calcium metabolism. Vitamin D modulates Tregs and might, thereby, promote graft acceptance and long-term graft survival. One hundred twenty-three renal allograft recipients attending either Heidelberg nephrology or Giessen internal medicine clinic were enrolled in this cross- sectional study. Sixteen healthy controls were studied in addition. Sixty-nine patients were receiving no vitamin D, 38 calcitriol, and 16 cholecalciferol supplementations. We evaluated whether there was a difference in the absolute numbers of Helios+, Helios−, CTLA-4+, IFNg+, and total Tregs among the patient groups. Cholecalciferol supplementation was associated with higher absolute numbers of Helios+, CTLA-4+, and total Tregs than calcitriol (p < 0.001, p = 0.004, p = 0.001 respectively). Helios+
  https://bmcpharmacoltoxicol.biomedcentral.com/articles/10.1186/s40360-016-0066-9
*  Aza- - Wikipedia
While the above figure gives examples of 4-aza steroids, 6-aza steroids have also been developed by GSK, although none of these ...
  https://en.wikipedia.org/wiki/Aza-
*  Satinder Vir Kessar - Wikipedia
Through his later day researches, he built the infrastructure of solanum alkaloids, accomplished the synthesis of azasteroids ...
  https://en.wikipedia.org/wiki/Satinder_Vir_Kessar
*  Patent US5679521 - Steroid 5A-reductases - Google Patents
The 4-azasteroids, 4-MA (17α-N,N-diethylcarbamoyl-4-methyl-4-aza-5α-androtane-3-one) and MK-906 (17β-N-t-butylcarbamoyl-4-aza-5 ... 4-aza steroids (Andersson and Russell, 1990). Prior to the current invention, there remained many outstanding questions ...
  http://www.google.co.uk/patents/US5679521
*  https://www.cancer.gov/types/prostate/hp/prostate-prevention-pdq
... azasteroids, reductase inhibitors, and enzyme inhibitors to identify randomized trials. Eight studies met the inclusion ...
  https://www.cancer.gov/types/prostate/hp/prostate-prevention-pdq
*  May 30, 2017 - mk-2866 Cycle
A novel series of ostarine gw1516 results gtx-024 16-substituted-4-azasteroids has been identified as potential tissue- ...
  http://mk2866cycle.com/2017/05/30/
*  The effect of 5alpha-reductase inhibition with dutasteride and finasteride on semen parameters and serum hormones in healthy...
Azasteroids/pharmacology*. *Double-Blind Method. *Dutasteride. *Enzyme Inhibitors/pharmacology*. *Finasteride/pharmacology*. * ...
  https://www.ncbi.nlm.nih.gov/pubmed/17299062
*  Finasteride - DrugBank
3-hydroxysteroids / 4-azasteroids and derivatives / Cyclic carboximidic acids / Propargyl-type 1,3-dipolar organic compounds / ...
  https://www.drugbank.ca/drugs/DB01216
*  Quantitative Structure - Activity Relationships Study of Carbonic Anhydrase Inhibitors Using Logistic Regression Model
37] Bakken G.A., Jurs P.C., QSARs for 6-Azasteroids as Inhibitors of Human Type 1 5r-Reductase: Prediction of Binding Affinity ...
  http://www.ijcce.ac.ir/article_5864.html
*  In vivo efficacy of STX213, a second-generation steroid sulfatase inhibitor, for hormone-dependent breast cancer therapy. -...
Animals, Azasteroids, Breast Neoplasms, Enzyme Inhibitors, Estradiol, Female, Humans, Liver, Mice, Mice, Nude, Models, ...
  https://pharm.ox.ac.uk/publications/678639
*  Human Metabolome Database: Showing metabocard for Solanidine (HMDB0003236)
InChI=1S/C27H43NO/c1-16-5-8-23-17(2)25-24(28(23)15-16)14-22-20-7-6-18-13-19(29)9-11-26(18,3)21(20)10-12-27(22,25)4/h6,16-17,19-25,29H,5,7-15H2,1-4H3/t16-,17+,19-,20+,21-,22-,23+,24-,25-,26-,27-/m0/ ...
  http://www.hmdb.ca/metabolites/HMDB03236