Azaserine - Wikipedia
Azaserine has a solubility of 50 mg/mL in water, a melting point of 146-162 °C, a vapor pressure of 1.53x10−10mmHg at 25 °C, ... Azaserine also downregulates the expression of VCAM-1 and ICAM-1 in response to TNF-α, and research indicates that it may have ... Azaserine inhibits the rate limiting step of the metabolic hexosamine pathway and irreversibly inhibits γ-glutamyltransferase ... Azaserine is a naturally occurring serine derivative diazo compound with antineoplastic and antibiotic properties deriving from ...
Metabolites | April 2021 - Browse Articles
Azaserine-treated HUVEC primarily showed 13C enrichment differences in UDP-GlcNAc. 13C MFA estimated decreased pentose ... In contrast, 13C MFA estimated increases in both pentose phosphate pathway and TCA activity in azaserine-treated cells. These ... We observed two to three times higher glutamine uptake in fidarestat and azaserine-treated cells. Fidarestat and DHEA-treated ... azaserine) pathways alters endothelial metabolism. Glucose, glutamine, and a four-carbon input to the malate shuttle were ...
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Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions<...
As a result, HBP inhibitor azaserine reduced CD133-positive subpopulation and CD133 expression under high glucose condition. ... As a result, HBP inhibitor azaserine reduced CD133-positive subpopulation and CD133 expression under high glucose condition. ... As a result, HBP inhibitor azaserine reduced CD133-positive subpopulation and CD133 expression under high glucose condition. ... As a result, HBP inhibitor azaserine reduced CD133-positive subpopulation and CD133 expression under high glucose condition. ...
metabolism of purine and pyrimidine nucleotides
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Azaserine-induced pancreatic carcinogenesis in rats: Promotion by a diet rich in saturated fat and inhibition by a standard ... The role of cholecystokinin in dietary fat-promoted pancreatic carcinogenesis was investigated in azaserine-treated rats, using ... Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats ...
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Avipoxvirus B4.909.204.783.160.100 Avoidance Learning F2.463.785.373.173 Avulavirus B4.909.777.455.600.650.70 Azaserine D12.125 ... Avipoxvirus B4.909.204.783.160.100 Avoidance Learning F2.463.785.373.173 Avulavirus B4.909.777.455.600.650.70 Azaserine D12.125 ... Avipoxvirus B4.909.204.783.160.100 Avoidance Learning F2.463.785.373.173 Avulavirus B4.909.777.455.600.650.70 Azaserine D12.125 ... Avipoxvirus B4.909.204.783.160.100 Avoidance Learning F2.463.785.373.173 Avulavirus B4.909.777.455.600.650.70 Azaserine D12.125 ...
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Glutamine analogs like azaserine (Aza) and 6-diazo-5-oxo-L-norleucine (DON) can inhibit the HBP and show anti-tumor activity in ... are reduced following Azaserine (a glutamine analog and GFAT1 inhibitor) treatment as well as glucose deprivation, and this ...