A Switch in Retrograde Signaling from Survival to Stress in Rapid-Onset Neurodegeneration | Journal of Neuroscience
Axonal transport is significantly inhibited in a mouse model of familial ALS. To examine the contribution of axonal transport ... Differential transport of signaling molecules in neurodegenerative disease models. To determine how retrograde axonal transport ... Model correlating changes in axonal transport balance with disease severity and time course: slowing of retrograde transport is ... 2007) Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria ...http://www.jneurosci.org/content/29/31/9903.full?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&andorexacttitle=and&andorexacttitleabs=and&fulltext=kinexus&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT
Download Axonal Transport in Neuronal Growth and Regeneration by Sidney Ochs (auth.), John S. Elam, Paul Cancalon (eds.) PDF -...
Download Axonal Transport in Neuronal Growth and Regeneration by Sidney Ochs (auth.), John S. Elam, Paul Cancalon (eds.) PDF. ... Download Axonal Transport in Neuronal Growth and Regeneration by Sidney Ochs (auth.), John S. Elam, Paul Cancalon (eds.) PDF. ... Although fast axonal transport is often used to refer solely to the movement of materials at the fastest orthograde rate, there ... Download Axonal Transport in Neuronal Growth and Regeneration by Sidney Ochs (auth.), John S. Elam, Paul Cancalon (eds.) PDF. ...http://redecorayvende.com/lib/axonal-transport-in-neuronal-growth-and-regeneration
Enhanced Sensitivity of Striatal Neurons to Axonal Transport Defects Induced by Mutant Huntingtin | Journal of Neuroscience
2006) The genetics of axonal transport and axonal transport disorders. PLoS Genet 2:e124. ... In contrast, mutant huntingtin affects axonal transport of APP and retrograde transport of BDNF in primary striatal neurons ( ... huntingtin affects axonal transport of all or only a subset of cargoes and whether mutant huntingtin affects axonal transport ... enhances axonal transport of cargoes other than BDNF and whether the effect of huntingtin overexpression on axonal transport is ...http://www.jneurosci.org/content/28/50/13662
Axonal Transport Impaired in HD | Huntington's Disease Lighthouse Families
Axonal transport is critical for the survival of neurons. Proteins are synthesized in the cell body and then are transported in ... Axonal Transport Impaired in HD. Marsha L. Miller, Ph.D., Sun, 09/20/2009 ... If the mutant protein impairs such a critical function as axonal transport, then why do neurons remain healthy for years? As we ... JNK3 phosphorylates kinesin-1, the motor protein of the axonal transport system which moves the cargo toward the ends of the ...http://hdlf.org/node/493
Publication | The Zhang Lab - University of Illinois at Urbana-Champaign
11. K. Zhang, H. V. Mudrakola, L. Chen, M. Vrljic, and B. Cui "Single molecule imaging of NGF axonal transport in a ... H. V. Mudrakola, C. Wu, K. Zhang, and B. Cui, "Single Molecule Imaging of Axonal Transport in Live Neurons", in Laser Science ... W. J. Xie, K. Zhang, B. Cui "Functional characterization and axonal transport of quantum dot labeled BDNF", Integrative Biology ... P.D. Chowdary, D. Che, K. Zhang, B. Cui "Retrograde NGF axonal transport - coordination of opposite polarity motors near ...http://publish.illinois.edu/kaizhanglab/publication/
Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases | Molecular Neurodegeneration | Full...
Axonal transport is critical for maintaining axonal integrity. Anterograde axonal transport supplies the axon with proteins ... Axonal transport is ATP-dependent  and in vitro assays show that the motors that mediate axonal transport hydrolyze 1 ... Anterograde vesicle transport was more susceptible to peroxide inhibition than retrograde transport. Axonal transport partially ... causes an inhibition of axonal transport several hours before any signs of axonal degeneration occur. The transport of ...https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/1750-1326-7-29
retrograde axonal transport
Tag: retrograde axonal transport. Posted on November 23, 2015. May 6, 2016. ...http://www.virologyhighlights.com/tag/retrograde-axonal-transport/
ALZFORUM | NETWORKING FOR A CURE
Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport. Biochim Biophys ...http://www.alzforum.org/papers/effects-als-related-sod1-mutants-dynein-and-kif5-mediated-retrograde-and-anterograde-axonal
Drosophila Models of Human Disease: Fly research and neurodegenerative diseases
Axonal transport defects are a common phenotype in Drosophila models of ALS. Hum Mol Genet. 2016 Jun 15;25(12):2378-2392. Epub ... Defective axonal transport is hypothesized to be a key factor in the selective vulnerability of motor nerves ... Here, we ... These results further support defects in axonal transport as a common factor in models of ALS that may contribute to the ... assessed the axonal transport of different cargos in multiple Drosophila models of ALS. ... ...http://flydiseasemodels.blogspot.com/2017/07/baldwin-kr-godena-vk-hewitt-vl.html
Research 2016 | ARSACS
Characterizing and Ameliorating Axonal Transport Defects in ARSACS Mice'- Dr. Thomas Schwartz. April 2, 2016. ... The objective is to identify compounds that will improve axonal transport in neurons carrying the mutation. The compounds we ... The first will be to examine transport in detail in multiple neuronal cell types and developmental stages in order to find a ... "Hits" identified in this screen that increase transport will be tested on the sacsin mutant neurons to see if they can restore ...http://arsacs.com/research-2016/
Though axonal transport has a special name, it is not fundamentally different from the pathways of intracellular traffic found ... This movement is called axonal transport. Cargoes originating from the cell body move out towards the axon tip and cargoes ... Chapter on Axonal Transport in Neuroscience in the 21st century, an online encyclopedia of neuroscience ... A fundamental principle of axonal transport, which is generalizable to all intracellular traffic, is that all macromolecular ...http://neurofilament.osu.edu/research/axonal-transport/
Axonal Transport: A Weak Link in Parkinson Disease? | ALZFORUM
Retrolinkin, a membrane protein, plays an important role in retrograde axonal transport. Proc Natl Acad Sci U S A. 2007 Feb 13; ... 1-Methyl-4-phenylpyridinium affects fast axonal transport by activation of caspase and protein kinase C. Proc Natl Acad Sci U S ... The Skinny on FAT: APP's Role in Fast Axonal Transport 31 Oct 2006. ... The Skinny on FAT: APP's Role in Fast Axonal Transport 31 Oct 2006. ...http://www.alzforum.org/news/research-news/axonal-transport-weak-link-parkinson-disease
IJMS | Free Full-Text | Computational Analysis of Axonal Transport: A Novel Assessment of Neurotoxicity, Neuronal Development...
In order to better characterize the mechanisms involved in axonal transport, we formulate a novel computer-assisted monitoring ... Despite its importance, however, the molecular mechanisms of axonal transport remain mostly unknown because a simple and ... system of axonal transport. Potential uses of this system and implications for future studies will be discussed. ... Axonal transport plays a crucial role in neuronal morphogenesis, survival and function. ...http://www.mdpi.com/1422-0067/13/3/3414/xml
Center for Nonlinear Dynamics » Publication » Endogenous GSK-3/Shaggy regulates bidirectional axonal transport of the Amyloid...
Defective axonal transport causes abnormal axonal cargo accumulations and is connected to neurodegenerative diseases, including ... Endogenous GSK-3/Shaggy regulates bidirectional axonal transport of the Amyloid Precursor Protein. ... has been proposed to be a central player in AD and to regulate axonal transport by the MT motor protein kinesin-1. Using ... nd that endogenous GSK-3 is a required negative regulator of both kinesin-1-mediated and dynein-mediated axonal transport of ...https://chaos.utexas.edu/publications/endogenous-gsk-3shaggy-regulates-bidirectional-axonal-transport-of-the-amyloid-precursor-protein
Erratum: GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila (Molecular Psychiatry ...
Erratum: GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila (Molecular Psychiatry ( ... Erratum: GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila (Molecular Psychiatry ( ...https://www.psych.ox.ac.uk/publications/290489
How did the research in axonal transport of proteins metamorphosed into cargo moving in multitracks - The pathology of a...
Most axonal proteins are synthesized in the nerve cell body and are transported along axons by mechanisms of axonal transport. ... How did the research in axonal transport of proteins metamorphosed into cargo moving in multitracks. ankitraj14 Uncategorized ... A mathematical model was developed by Craciun et al. that determines the profile and velocity of the population of transported ... Reaction-Diffusion-Hyperbolic Systems in Neurofilament Transport in Axon. ...https://thebenignoath.wordpress.com/2015/11/08/how-did-the-research-in-axonal-transport-of-proteins-metamorphosed-into-cargo-moving-in-multitracks/
Axonal transport - Wikipedia
The basic mechanism of fast axonal transport has been understood for decades but the mechanism of slow axonal transport is only ... and in those cases it is likely that axonal transport is a key player in mediating pathology. Dysfunctional axonal transport is ... Axonal transport, also called axoplasmic transport or axoplasmic flow, is a cellular process responsible for movement of ... Retrograde transport shuttles molecules/organelles away from axon termini toward the cell body. Retrograde axonal transport is ...https://en.wikipedia.org/wiki/Axonal_transport
blocking axonal transport in rats
... Eriko Terao terao at bani.ucl.ac.be Mon Jun 2 06:24:41 EST 1997 *Previous message: platinum- ... We are currently trying to block axonal transport in the facial nerve of adult rats. We have tried both vincristine and ...http://www.bio.net/bionet/mm/neur-sci/1997-June/028837.html
Recent Mathematical Models of Axonal Transport | SpringerLink
Aluminum effect on slow axonal transport: a novel impairment of neurofilament transport. J. Neurosci. 4(3), 722-731 (1984) ... N. Hirokawa, Axonal transport and the cytoskeleton. Curr. Opin. Neurobiol. 3(5), 724-731 (1993)CrossRefGoogle Scholar ... J.J. Blum, M.C. Reed, A model for fast axonal transport. Cell Motil. 5(6), 507-527 (1985)CrossRefGoogle Scholar ... S.I. Rubinow, J.J. Blum, A theoretical approach to the analysis of axonal transport. Biophys. J. 30(1), 137-147 (1980)CrossRef ...https://link.springer.com/chapter/10.1007/978-3-319-62627-7_12
Interganglionic axonal transport of neuropeptides in Aplysia | Journal of Neuroscience
All the peptides were transported by fast axonal transport as judged by the distance transported and/or the sensitivity to ... Interganglionic axonal transport of neuropeptides in Aplysia. PE Lloyd. Journal of Neuroscience 1 September 1989, 9 (9) 3243- ... Interganglionic axonal transport of neuropeptides in Aplysia Message Subject (Your Name) has forwarded a page to you from ... The transport of neuropeptides between central ganglia was studied in Aplysia. Peptide transport was determined by incubating ...http://www.jneurosci.org/content/9/9/3243
Toxics | Free Full-Text | Axonal Transport Impairment in Chemotherapy-Induced Peripheral Neuropathy
... together with fast axonal transport. Indeed, this bidirectional cargo-specific transport has a pivotal role in neuronal ... In this paper, we will examine the effect of the main old and new chemotherapeutic drug categories on axonal transport, with ... Literature data demonstrate that, despite different mechanisms of action, all antineoplastic agents impair the axonal ... to some extent and the severity of the neuropathy correlates with the degree of damage on this bidirectional transport. ...http://www.mdpi.com/2305-6304/3/3/322
Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments | JCB
Neurofilaments are transported rapidly but intermittently in axons: implications for slow axonal transport. J. Neurosci. 20: ... Tables S1, S2, and S3 show data from the vesicle transport assay, the NF transport assay, and the MT transport assay, ... vesicle transport, and NF transport. In neurons cotransfected with control siRNA, the majority of moving MTs was transported in ... Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments. Yan He, Franto Francis, Kenneth A. Myers ...http://jcb.rupress.org/content/168/5/697
Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons. | JCB
Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons.. R L Morris, P J Hollenbeck ... These data indicate that axonal organelle transport can occur along both MTs and MFs in vivo, but with different velocities and ... Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons. ... A large body of evidence indicates that microtubules (MTs) conduct organelle transport in axons, but recent studies on extruded ...http://jcb.rupress.org/content/131/5/1315?ijkey=ff78239f2c711e2b1239f0adb532877043c8f76d&keytype2=tf_ipsecsha
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Bioengineering, Issue 84, Drosophila melanogaster, Live Imaging, Microfluidics, axonal injury, axonal degeneration, calcium ... These events include the rapid transport of organelles in axons, calcium responses to injury, and time-lapse studies of the ... Another application of the chip is to study regenerative and degenerative responses to axonal injury, so the second part of ... It applies the Fermi simplification to Fokker-Plank solution of the photon transport equation, combined with geometrical optics ...https://www.jove.com/visualize/abstract/23300962/long-term-in-vivo-imaging-of-multiple-organs-at-the-single-cell-level
Protocols and Video Articles Authored by Rohini Kuner (Translated to Italian)
An activation of Plexin-B1 via its ligand, semaphorin 4D (Sema4D), produces an acute collapse of axonal growth cones in ... It is transported to axon terminals via small translucent vesicles and secreted in both spontaneous and depolarization-induced ... Thus, our results show that Sema4D-Plexin-B interactions modulate dendritic and axonal arborizations of developing neurons by ... The Semaphorin 4D-plexin-B Signalling Complex Regulates Dendritic and Axonal Complexity in Developing Neurons Via Diverse ...https://www.jove.com/author/Rohini_Kuner?language=Italian