An Astrocytic Basis for Humanity - Ben Barres
Astrocytes are a major cell type in the brain that constitute at least one third of rodent and human brain cells. Long thought ... 2017) Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells. Neuron 95:779- ... First we will use next generation RNA-Seq sequencing to determine and compare the transcriptomes of mouse and human astrocytes ... Human genes that strongly control synapse formation or function will then be expressed in mouse astrocytes in transgenic mice ...
Cytokine Regulation of Ciita and Class II MHC in Glia - Etty Benveniste
2008) Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes. J Immunol 181:3167-76 ... Molecular basis of oncostatin M-induced SOCS-3 expression in astrocytes. Glia 56:1250-62 ...
Sodium Entry Into Amiloride-Sensitive Epithelia - Dale Benos
2011) Interaction of ASIC1 and ENaC subunits in human glioma cells and rat astrocytes. Am J Physiol Cell Physiol 300:C1246-59 ...
Sigma-1 Receptor Provides Neuroprotection Against Optic Neuropathy - Kathryn Bollinger
... activation on RGCs and optic nerve head astrocytes (ONHAs) under glaucomatous cond... ... Astrocytes are the major glial constituent of the optic nerve head (ONH), which is the site of initial glaucomatous injury. At ... S1R is a ligand-operated, transmembrane protein that is expressed in RGCs and astrocytes throughout the visual system. A major ... Interplay between neuroprotective pathways, HIV, and astrocytes. *A whole systems approach to implementing standardized dental ...
Pilot Project - Gene Regulation in Vasopressin Neurons During Aging - Celia Sladek
2001) Two-dimensional gel analysis of secreted proteins induced by interleukin-1 beta in rat astrocytes. Neurochem Int 39:349- ...
Role of NKCC1 on Brain Tumor Stem Cell Migration After EGF and Slit-2 Stimulation - Alfredo Quinones-Hinojosa
2016) Blast shockwaves propagate Ca(2+) activity via purinergic astrocyte networks in human central nervous system cells. Sci ...
Investigating a Role for Glutamate Transport in Epilepsy - Margaret Sutherland
The EAAT2 protein is tagged with GFP (green fluorescent protein) and expression is driven by the astrocyte-specific GFAP ...
Role of Protease Activated Receptors in Spinal Cord Injury and Repair - Isobel Scarisbrick
2017) Astrocyte heterogeneity across the brain and spinal cord occurs developmentally, in adulthood and in response to ... Yoon, Hyesook; Radulovic, Maja; Scarisbrick, Isobel A (2018) Kallikrein-related peptidase 6 orchestrates astrocyte form and ... astrocytes and oligodendroglia and their sensitivity to neurotoxic agents in vitro. In Aim 3, we will dissect the molecular ...
Targeting the mitochondrial pyruvate carrier to treat neurodegenerative disease - Anne Murphy
Aim 1 : Characterize the response of primary neurons and astrocytes to mild MPC inhibition with further studies of glucose ... using a battery of follow-on assays in neurons and astrocytes to further optimize a potential lead compound. This Multi-PI ...
The protective role of microglia in preventing hypoxic disruption of blood-brain barrier integrity and VCID - D Milner
Interestingly, microglial depletion profoundly increased vascular leak and this was associated with astrocyte-vascular ...
Infrastructure for Translational Neuroscience Center - Avindra Nath
... human neural stem cells and human NSC-derived neurons along with some astrocyte cultures (with M. Rao, CRM). Weve established ...
Core - Mutagenesis, Expression and Cell Culture
This Core on mutagenesis, expression and cell culture will provide a heavily relied upon service to the center, providing most of the experimental material for...
Isolation and Expression of Coccidioides T-Cell Antigens - Garry Cole
Astrocyte-microglial communication in developmental synapse formation. *Investigating aryl hydrocarbon receptor-cofactor ...
Mechanisms Underlying the Cerebellar Contribution to Autism in Mouse Models of Tu - Peter Tsai
Autism is a devastating neurodevelopmental disorder characterized by social impairment, restrictive thinking/repetitive behaviors, and communication impairment...
Virus Vector Shared Resource - Kristoffer Valerie
Astrocyte-neuron interactions in visual cortex circuits. *Polyadenylation and Translational Control. *Gas-phase Bio-conjugation ...
Training of the Pediatric Physician-Scientist - Gary Silverman
Hypothalamic astrocyte-neuron relationship links overnutrition to hypertension. *HIV Center for Clinical and Behavioral Studies ...
Partial Differential Equations in Several Complex Variables - Mei-Chi Shaw
Expression of CPLA2 in Reactive Astrocytes in Alzheimers Disease. *Toxic Effects of Organoselenium Compounds ...
Shared Resource 09: Leukemia Tissue Bank (LTBSR) - Lapo Alinari
? LEUKEMIA TISSUE BANK SHARED RESOURCE (LTBSR) The LTBSR is a longstanding biobank, established in 1997, that procures, processes, and stores biologic material...
Developing Targeted Therapeutic Nanosystems to Treat Metastatic Colon Cancer - Martin Conda Sheridan
Decoding Astrocyte Signaling in Neural Circuitry with Novel Computational Modeling and Analytical Tools ... Decoding Astrocyte Signaling in Neural Circuitry with Novel Computational Modeling and Analytical Tools ...