*  Discontinuation of low dose aspirin and risk of myocardial infarction: case-control study in UK primary care | The BMJ
A major strength of this study is that use of The Health Improvement Network enabled analysis of an extensive sample that was representative of the UK primary care population and had age and sex distributions similar to those in the national population. Also, the network includes all patients in participating practices who have been diagnosed as having a primary cardiovascular event and prescribed low dose aspirin to prevent a secondary event in primary care, supporting the broad external validity of these findings. Moreover, we observed the increased risk of non-fatal myocardial infarction in patients who were truly non-adherent but not in those who were found to be taking over the counter aspirin, which reinforces the internal validity of this study.. A potential limitation of the study is that use of aspirin might have been misclassified in some cases. For example, the recording of a prescription for low dose aspirin in The Health ...
  http://www.bmj.com/content/343/bmj.d4094.long
*  Study Adds to Evidence Daily Aspirin Linked to Lower Cancer Mortality | 3BL Media
3BL Media) Atlanta, GA - August 31, 2012 - A large new observational study finds more evidence of an association between daily aspirin use and modestly lower cancer mortality, but suggests any reduction may be smaller than that observed in a recent analysis. The study, appearing early online in the Journal of the National Cancer Institute (JNCI), provides additional support for a potential benefit of daily aspirin use for cancer mortality, but the authors say important questions remain about the size of the potential benefit.. A recent analysis pooling results from existing randomized trials of daily aspirin for prevention of vascular events found an estimated 37% reduction in cancer mortality among those using aspirin for five years or more. But uncertainty remains about how much daily aspirin use may lower cancer mortality, as the size of this pooled analysis was limited and two very large randomized trials of ...
  http://3blmedia.com/theCSRfeed/Study-Adds-Evidence-Daily-Aspirin-Linked-Lower-Cancer-Mortality
*  Low Dose Aspirin for the Prevention of Preeclampsia - Full Text View - ClinicalTrials.gov
Preeclampsia is one of the three leading causes of maternal morbidity and mortality all over the world. The use of low dose aspirin has been mentioned in several studies with promising results. The investigators decided to evaluate the use of low dose aspirin, starting between 13 and 16 weeks of pregnancy, based on clinical characteristics only to reduce the incidence of preeclampsia ...
  https://clinicaltrials.gov/ct2/show/NCT01890005?recr=Open&cond=%22Stillbirth%22&rank=11
*  Molecules | Free Full-Text | Nitric Oxide-Releasing Aspirin Suppresses NF-κB Signaling in Estrogen Receptor Negative Breast...
Estrogen receptor negative (ER(−)) breast cancer is aggressive, responds poorly to current treatments and has a poor prognosis. The NF-κB signaling pathway is implicated in ER(−) tumorigenesis. Aspirin (ASA) is chemopreventive against ER(+) but not for ER(−) breast cancers. Nitric oxide-releasing aspirin (NO-ASA) is a safer ASA where ASA is linked to an NO-releasing moiety through a spacer. In vitro, we investigated anti-proliferation effects of NO-ASA (para- and meta-isomers) against ER(−) breast cancer cells MDA-MB-231 and SK-BR-23, effects on NF-κB signaling, and reactive oxygen species by standard techniques. In vivo, effects of NO-ASA were evaluated in a mouse xenograft model using MDA-MB-231 cells. p-NO-ASA inhibited the growth of MDA-MB-231 and SK-BR-3 cells at 24 h, the respective IC50s were 13 ± 2 and 17 ± 2 μM; ASA had an IC50 of |3000 μM in both cell lines. The IC50s for m-NO-ASA in MDA-MB-231 and SK-BR-3 were 173 ± 15 and 185 ± 12 μM, respectively, therefore, ...
  http://www.mdpi.com/1420-3049/20/7/12481
*  Daily aspirin therapy: Understand the benefits and risks - Mayo Clinic
The U.S. Preventive Services Task Force recently recommended daily aspirin therapy if you're age 50 to 59 years, you're not at increased bleeding risk, and you have an increased risk of heart attack or stroke of 10 percent or greater over the next 10 years. If you're age 60 to 69, you aren't at increased bleeding risk, and you have a high risk of heart attack or stroke of 10 percent or greater over the next 10 years, talk to your doctor about daily aspirin therapy. More research is needed to determine the benefits and risks of daily aspirin use in adults younger than age 50 and older than age 70 before a recommendation can be made for or against aspirin use to prevent cardiovascular disease and colorectal cancer for these age groups.. Although aspirin has been recommended in the past for certain groups of people without a history of heart attack, there's some disagreement among experts about whether the benefits of ...
  https://www.mayoclinic.org/diseases-conditions/heart-disease/in-depth/daily-aspirin-therapy/art-20046797?p=1
*  1999 - Low-dose aspirin reduced combined 3-month risk for stroke, MI, and death after carotid endarterectomy | 2000...
The U.S. Food and Drug Administration recently ruled that low-dose aspirin may be used to prevent stroke in patients with a previous stroke or transient ischemic attack. The ACE trial is likely to fuel the move toward this use of low-dose aspirin. Unlike other aspirin studies, the ACE trial is restricted to the period after CE and shows that low-dose aspirin should now be used at the time of CE. Should low-dose aspirin be used for all stroke prevention? The ACE trial data do not directly answer this question. However, support for high-dose aspirin is mainly based on greater reductions in stroke risk in studies using higher aspirin doses than in studies using lower doses (1) or on secondary analyses (2) and not on randomized controlled trials. The ACE trial is the first randomized study to show a differential effect among aspirin doses and suggests that low-dose ...
  http://acpjc.org/Content/132/1/issue/ACPJC-2000-132-1-010.htm
*  Quitting daily aspirin therapy may increase second heart attack, stroke risk - A Woman's Health - Women Magazine
Low-dose aspirin therapy is a simple and inexpensive treatment," said Johan Sundstrom, M.D., Ph.D., lead author and professor of epidemiology at Uppsala University in Sweden. "As long as there's no bleeding or any major surgery scheduled, our research shows the significant public health benefits that can be gained when patients stay on aspirin therapy.". Studies have suggested patient's experience a "rebound effect" after stopping aspirin treatment, this is possibly due to increased clotting levels from the loss of aspirin's blood-thinning effects. Because of the large number of patients on aspirin and the high number who stop treatment, the importance of a rebound effect may be significant, Sundstrom said.. "We hope our research may help physicians, healthcare providers and patients make informed decisions on whether or not to stop aspirin use," Sundstrom said.. The American Heart Association recommends ...
  http://awomanshealth.com/quitting-daily-aspirin-therapy-may-increase-second-heart-attack-stroke-risk/
*  Health News Report: NIH study finds regular aspirin use may reduce ovarian cancer risk
Among study participants who reported whether or not they used aspirin regularly: 18 percent used aspirin, 24 percent used non-aspirin NSAIDs, and 16 percent used acetaminophen. The researchers determined that participants who reported daily aspirin use had a 20 percent lower risk of ovarian cancer than those who used aspirin less than once per week. For non-aspirin NSAIDs, which include a wide variety of drugs, the picture was less clear: the scientists observed a 10 percent lower ovarian cancer risk among women who used NSAIDs at least once per week compared with those who used NSAIDs less frequently. However, this finding did not fall in a range that was significant statistically. In contrast to the findings for aspirin and NSAIDs, use of acetaminophen, which is not an anti-inflammatory agent, was not associated with reduced ovarian cancer risk ...
  http://healthnewsreport.blogspot.com/2014/02/nih-study-finds-regular-aspirin-use-may.html
*  Daily Dose Aspirin Extremely Grievous For Your Health Concerns - In NewsWeekly
Too much use of Aspirin can cause severe affect on your health and can be the reason of Cancer and Heart Attack. In- Details:. According the health research laboratories daily aspirin therapy is reason behind the increasing number of cases for heart attack and cancer diseases.. NHS Researcher found the risk more than its benefits; they told that It can bleed your brain and stomach.. Doctors advice you aspirin therapy after first stroke or first heart attack, which can make your blood in flow steadily in your veins, this therapy is not good for all patients. Mostly more 50 years old patients are recommended for low dose Aspirin.. Daily dose recommended to those patient who have heart disease because the aspirin remove the blood clots by diluting it into the smooth blood .. If you don't have any heart diseases then and you are regularly taking this dose can affective for your health and you may be get strokes or heart attack. ...
  https://innewsweekly.com/daily-dose-aspirin-extremely-grievous-for-your-health-concerns/
*  Study: Aspirin increases risk of age-related macular degeneration - JunkScience.com
A very small study - with very little credibility.. Media release below.. ###. Study suggests link between regular aspirin use, increased risk of age-related macular degeneration. CHICAGO - Regular aspirin use appears to be associated with an increased risk of neovascular age-related macular degeneration (AMD), which is a leading cause of blindness in older people, and it appears to be independent of a history of cardiovascular disease and smoking, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication.. Aspirin is one of the most widely used medications in the world and is commonly used in the prevention of cardiovascular disease, such as myocardial infarction (heart attack) and ischemic stroke. While a recent study suggested that regular aspirin use was associated with AMD, particularly the more visually devastating neovascular (wet) form, other studies have reported inconsistent findings. ...
  https://junkscience.com/2013/01/study-aspirin-increases-risk-of-age-related-macular-degeneration/
*  Danish Aspirin Resistance Trial - Pilot Study - Tabular View - ClinicalTrials.gov
Platelets play a major role in arterial thrombus formation - the cause of cardiovascular death, acute myocardial infarction and ischemic stroke and the number one killer in the Western World. Binding the COX enzyme platelet aggregation is inhibited by aspirin, and as prophylaxis against death, myocardial infarction and stroke aspirin is the most widely used drug worldwide. Low dose aspirin has been shown to improve outcome in patients with ischemic heart disease, but approximately 12% of these patients will suffer from a vascular event during a 2 year follow-up period despite aspirin therapy. It has been speculated that these patients might be 'resistant' to the antiaggregatory effect of aspirin, and a diminished response to aspirin has been correlated with a less favourable outcome. However, at present no international consensus exists on how to measure 'aspirin resistance'.. Comparisons: ...
  https://clinicaltrials.gov/ct2/show/record/NCT00389129
*  Aspirin treatment and risk of first incident cardiovascular diseases in patients with type 2 diabetes : an observational study...
Objectives To investigate the benefits and risks associated with aspirin treatment in patients with type 2 diabetes and no previous cardiovascular disease (CVD) in clinical practice. Design Population-based cohort study between 2005 and 2009, mean follow-up 3.9years. Setting Hospital outpatient clinics and primary care in Sweden. Participants Men and women with type 2 diabetes, free from CVD, including atrial fibrillation and congestive heart failure, at baseline, registered in the Swedish National Diabetes Register, with continuous low-dose aspirin treatment (n=4608) or no aspirin treatment (n=14038). Main outcome measures Risks of CVD, coronary heart disease (CHD), stroke, mortality and bleedings, associated with aspirin compared with no aspirin, were analysed in all patients and in subgroups by gender and estimated cardiovascular risk. Propensity scores were used to adjust for several baseline risk factors and ...
  http://umu.diva-portal.org/smash/record.jsf?pid=diva2:696967
*  Time-Dependent Effects of Aspirin on Blood Pressure and Morning Platelet Reactivity | Hypertension
Aspirin is used for cardiovascular disease (CVD) prevention by millions of patients on a daily basis. Previous studies suggested that aspirin intake at bedtime reduces blood pressure compared with intake on awakening. This has never been studied in patients with CVD. Moreover, platelet reactivity and CVD incidence is highest during morning hours. Bedtime aspirin intake may attenuate morning platelet reactivity. This clinical trial examined the effect of bedtime aspirin intake compared with intake on awakening on 24-hour ambulatory blood pressure measurement and morning platelet reactivity in patients using aspirin for CVD prevention. In this randomized open-label crossover trial, 290 patients were randomized to take 100 mg aspirin on awakening or at bedtime during 2 periods of 3 months. At the end of each period, 24-hour blood pressure and morning platelet reactivity were measured. The primary analysis ...
  http://hyper.ahajournals.org/content/early/2015/02/17/HYPERTENSIONAHA.114.04980
*  Rite Aid: As low as ONLY $.75 each for St. Joseph Low Dose Aspirin with BOGO Free Sale & Coupon!
Right now at Rite Aid, select St. Joseph Low Dose Aspirin products are on sale for BOGO Free!! Just add in a manufacturer's coupons to pay as low as ONLY $.75 each! Check it out:. At Rite Aid through 2/21:. #1 ...
  https://www.couponaholic.net/2015/02/rite-aid-as-low-as-only-75-each-for-st-joseph-low-dose-aspirin-with-bogo-free-sale-coupon/
*  Prevalence of gastroduodenal ulcers-erosions in patients taking low-dose aspirin with either 15 mg-day of lansoprazole or 40 mg...
Prevalence of gastroduodenal ulcers-erosions in patients taking low-dose aspirin with either 15 mg-day of lansoprazole or 40 mg-day of famotidine: The OITA-GF study 2. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
  http://libros.duhnnae.com/2017/jul3/149901275855-Prevalence-of-gastroduodenal-ulcers-erosions-in-patients-taking-low-dose-aspirin-with-either-15mg-day-of-lansoprazole-or-40mg-day-of-famotidine-T.php
*  HON - News : Low-Dose Aspirin May Lower Risk for Common Breast Cancer by 20 Percent
MONDAY, May 1, 2017 (HealthDay News) -- Score yet another point for low-dose aspirin: Regularly taking "baby" aspirin appears to protect women from the most common type of breast cancer, new research suggests.. Use of low-dose aspirin at least three times a week was linked to a 20 percent risk reduction for cancers known as hormone-receptor positive, HER2 negative -- the most common breast cancer subtype, said study senior author Leslie Bernstein.. That's a "moderate" reduction in risk, said Bernstein, a professor at the City of Hope Cancer Center in Duarte, Calif. It's "maybe not as good as exercise," she said, but she added that more people might adhere to an aspirin regimen than an exercise routine.. However, the study doesn't establish a direct cause-and-effect relationship, and Bernstein said it's too early to recommend taking daily aspirin for breast-cancer risk reduction.. Many adults already take low-dose ...
  http://www.healthonnet.org/News/HSN/722157.html
*  Aspirin May Reduce Mortality Rate in Colon Cancer Patients
Though research into using aspirin to prevent cancer and heart disease has been ongoing for many years, a recently published study found that daily aspirin use may help to reduce the overall chances of mortality in colon cancer patients. The ten-year study, conducted in Holland, showed that colon cancer patients could reduce their chances of dying by as much as 33 percent by taking 80mg of aspirin every day for at least 9 months.. Life-saving Potential. Though aspirin should not be used in lieu of other treatments for colon cancer, this is the first time the over-the-counter medicine has come into discussion as a potentially useful drug for complementing other cancer treatment procedures. Aspirin is by no means a treatment of cancer in and of itself.. A Few Caveats. More research is needed before experts can definitively recommend daily aspirin use to all older patients of colon cancer. The study's results ...
  https://lacolon.com/blog/research-daily-aspirin-use-may-reduce-mortality-in-colon-cancer-patients
*  Prevention of Recurrent Ulcer Bleeding in High-risk Users of Low-dose Aspirin - Full Text View - ClinicalTrials.gov
Low-dose aspirin is increasingly used for the prophylaxis against coronary heart disease and stroke. However, it is also an important cause of peptic ulcer bleeding worldwide. In England and Wales, low-dose aspirin is estimated to account for about 10% of ulcer bleeding in people aged 60 and over [Weil 1995]. The problem of aspirin-related ulcer disease is expanding with the increasing use of aspirin for cardiovascular prophylaxis.. No dose of aspirin is entirely free of risk. Using a daily dose of aspirin as low as 75 mg, the risk of ulcer bleeding doubles that of non-users [Weil 1995]. Previous ulcer disease and concurrent major medical illnesses are important risk factors for ulcer bleeding with low-dose aspirin. Among aspirin users, those with previous ulcer disease have a 5-fold increased risk of ulcer bleeding [Lanas 2000]. Recently the investigators have shown that ...
  https://clinicaltrials.gov/ct2/show/NCT01278550
*  Effects of regular aspirin on long-term cancer incidence and metastasis: A systematic comparison of evidence from observational...
Background: Long-term follow-up of randomised trials of aspirin in prevention of vascular events showed that daily aspirin reduced the incidence of colorectal cancer and several other cancers and reduced metastasis. However, statistical power was inadequate to establish effects on less common cancers and on cancers in women. Observational studies could provide this information if results can be shown to be reliable. We therefore compared effects of aspirin on risk and outcome of cancer in observational studies versus randomised trials. Methods: For this systematic review, we searched for case-control and cohort studies published from 1950 to 2011 that reported associations between aspirin use and risk or outcome of cancer. Associations were pooled across studies by meta-analysis and stratified by duration, dose, and frequency of aspirin use and by stage of cancer. We compared associations from observational studies with the ...
  https://www.neuroscience.ox.ac.uk/publications/329820
*  JPPP: Low-Dose Aspirin For Primary Prevention of CV Events in Elderly Patients With Multiple Atherosclerotic Risk Factors -...
The study was led by Yasuo Ikeda, MD, of the Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan, and looked at 14,464 patients aged 60 to 85 years, presenting with hypertension, dyslipidemia, or diabetes mellitus recruited by primary care physicians at 1,007 clinics in Japan between March 2005 and June 2007, and were followed up for up to 6.5 years. Patients were randomized 1:1 to enteric-coated aspirin 100 mg/d or no aspirin in addition to ongoing medications. The composite primary outcome was death from cardiovascular causes, nonfatal stroke and nonfatal myocardial infarction.. The study was terminated early after a median follow-up of 5.02 years based on likely futility. In both the aspirin and no aspirin groups, 56 fatal events occurred. Patients with an occurrence of nonfatal stroke totaled 114 in the aspirin group and 108 in the no aspirin group; of nonfatal myocardial ...
  http://www.acc.org/latest-in-cardiology/articles/2014/11/17/11/45/low-dose-aspirin-for-primary-prevention-of-cv-events-in-elderly-patients
*  Aspirin, ibuprofen and stroke - Effect Measure
Stroke patients who use ibuprofen for arthritis pain or other conditions while taking aspirin to reduce the risk of a second stroke undermine aspirin's ability to act as an anti-platelet agent, researchers at the University at Buffalo have shown. In a group of patients seen by physicians at two offices of the Dent Neurologic Institute, 28 patients were identified as taking both aspirin and ibuprofen [Motrin, Advil] (a nonsteroidal anti-inflammatory drug, or NSAID) daily and all were found to have no anti-platelet effect from their daily aspirin. Thirteen of these patients were being seen because they had a second stroke/TIA while taking aspirin and a NSAID, and were platelet non-responsive to aspirin (aspirin resistant) at the time of that stroke. The researchers found that when 18 of the 28 patients returned for a second neurological visit after discontinuing NSAID use and were tested ...
  http://scienceblogs.com/effectmeasure/2008/03/17/aspirin-ibuprofen-and-stroke/
*  Who should - and who shouldn't - take daily aspirin | UC Davis Health System
Cardiologist Ezra Amsterdam specializes in helping patients manage acute ischemic syndromes, chest pain, post-myocardial infarction risk and coronary artery disease. He is frequently called upon to help establish and update national standards for treating and preventing cardiac disease.. The greater the risk for a heart attack or stroke, the more likely the benefits of aspirin will outweigh the risks. Risk is highest in those who have had a heart attack, ischemic stroke (caused by a clot) or TIA (so-called "mini" or "warning" stroke), and doctors usually advise daily aspirin for these individuals to help prevent a second event. Aspirin is also standard therapy in patients who have had a stent placed in a coronary artery.. Those who cannot tolerate aspirin's side effects may be asked to try enteric-coated aspirin instead, add a proton pump inhibitor (PPI) to reduce GI symptoms or substitute clopidogrel (Plavix), which also ...
  http://www.ucdmc.ucdavis.edu/welcome/features/2015-2016/05/20160531_aspirin.html
*  2006 - Clopidogrel plus aspirin did not differ from aspirin alone for reducing MI, stroke, and CV death in high-risk...
Aspirin, which blocks the platelet cyclooxygenase pathway, is effective for preventing vascular events (1). Recent short-term studies combining aspirin with clopidogrel, another antiplatelet drug that blocks the adenosine diphosphate P2Y12 receptor, have shown significant benefit in patients with acute coronary syndromes and those undergoing percutaneous revascularization (2). The CHARISMA trial by Bhatt and colleagues was designed to determine if long-term therapy with aspirin plus clopidogrel was better than aspirin alone in patients at high risk for atherothrombosis. Overall, there was no benefit in using dual therapy over aspirin alone for the primary outcome and only a small benefit for the secondary outcome. However, it is logical that if dual therapy is effective for short-term therapy in acute coronary syndromes, there may be some patients for whom long-term therapy might also be beneficial. To address this ...
  http://acpjc.org/Content/145/2/issue/ACPJC-2006-145-2-033.htm
*  Aspirin and cancer prevention | The BMJ
When Eichengrün and colleagues at dye manufacturer Friedrich Bayer & Co synthesised acetylsalicylic acid in 1897 the success story of aspirin began,1 and its potential applications are still being revealed. It is well established that aspirin reduces pain, limits the inflammatory response, and reduces cardiovascular disease but that it can lead to major bleeding events and gastrointestinal upset. For several years increasing numbers of studies have suggested a benefit of aspirin on the occurrence of polyps and colorectal cancer.2 3 Potential beneficial effects on other common cancer types have also been reported.4 Two recently published large scale studies have provided additional evidence that low dose aspirin reduces the incidence of cancer, death from cancer, and cancer metastasis.5 6. The first, an analysis of the short term effects of daily aspirin (,300 mg) use on various cancer related outcomes in 51 randomised ...
  http://www.bmj.com/content/344/bmj.e2480?etoc=&ga=w_ga_mpopular
*  Low-Dose Acetylsalicylic Acid in Treating Patients With Stage I-III Non-Small Cell Lung Cancer - Full Text View -...
PRIMARY OBJECTIVES:. I. To determine whether ASA (acetylsalicylic acid) 325 mg inhibits prostaglandin E2 (PGE2) biosynthesis in patients with early stage non-small cell lung cancer (NSCLC). Cyclooxygenase (COX) catalytic activity will be determined by measuring the metabolite of PGE2, 11alpha-hydroxy-9,12-dioxo-2,3,4,5-tetranor-prostane-1,20 dioic acid (PGE-M) in urine pre- and post-ASA 325 mg as a surrogate of systemic PGE2 biosynthesis.. SECONDARY OBJECTIVES:. I. To determine whether COX-2 protein has a slow turnover in adenocarcinoma of the lung. COX turnover will be determined by measuring urinary PGE-M levels daily for 7 days after discontinuing ASA 325 mg. COX-2 and Prostaglandin expression will also be measured in tumor samples of patients taken at the time of surgery.. OUTLINE:. Patients receive acetylsalicylic acid orally (PO) for 7 days and urine is collected for 7 days post therapy. ...
  https://clinicaltrials.gov/ct2/show/NCT01707823?recr=Open&cond=%22Lung+Neoplasms%22&rank=18