Arecoline is a base, and its conjugate acid has a pKa ~ 6.8. Arecoline is volatile in steam, miscible with most organic ... Arecoline has also been used medicinally as an antihelmintic (a drug against parasitic worms). Arecoline has also been shown to ... Arecoline also inhibits AMPK through generation of ROS in several types of cells. Arecoline promotes excitation and decreases ... Arecoline is metabolized by both kidneys and liver. Currently, 11 metabolites of arecoline are documented among which N- ...

The aim of this study was to establish an arecoline-induced epithelial-mesenchymal transformation (EMT) model of OSCC … ... Arecoline, the main alkaloid of areca nut, is well known for its role in inducing submucosal fibrosis and oral squamous cell ... Arecoline induces EMT and promotes metastasis of oral cancer by upregulation of SAA1. As shown in the graph, arecoline induces ... Arecoline promoted metastasis of OSCC in vivo. CAL33 cells treated with or without arecoline were inoculated into the tongues ...

... www.iarc.fr/news-events/iarc-monographs-evaluation-of-the-carcinogenicity-of-acrolein-crotonaldehyde-and-arecoline/ ... Arecoline, which has a mild psychoactive effect, was also classified as possibly carcinogenic to humans (Group 2B). Arecoline ... The International Agency for Research on Cancer evaluates carcinogenicity of acrolein, crotonaldehyde, and arecoline ...

This study investigated the effectiveness of arecoline hydrobromide (AH) on the functions of rheumatoid arthritis fibroblast- ... Arecoline hydrobromide suppresses PI3K/AKT pathway in rheumatoid arthritis synovial fibroblasts and relieves collagen-induced ... This study investigated the effectiveness of arecoline hydrobromide (AH) on the functions of rheumatoid arthritis fibroblast- ...

Similarly, ROS scavengers could block the effects of arecoline.. Conclusions: This study demonstrated that arecoline induced ... Keywords: Arecoline, Glycolysis, ROS, Calcium ion, Anoikis. Citation styles. APA Copy. Cheng, H.L., Chang, W.T., Hu, Y.C., ... Cheng, H.L.; Chang, W.T.; Hu, Y.C.; Hsieh, B.S.; Huang, T.C.; Chong, I.W.; Huang, L.W.; Chang, K.L. Arecoline Increases ... Arecoline Increases Glycolysis and Modulates pH Regulator Expression in HA22T/VGH Hepatoma Cells, Leading to Increase of ...

Arecoline is the primary active ingredient of the areca nut, which is carcinogenic to humans (Group 1). Areca nut is chewed for ... IARC Monographs Volume 128: Acrolein, Crotonaldehyde, and Arecoline. The International Agency for Research on Cancer (IARC) is ... and crotonaldehyde and arecoline are possibly carcinogenic to humans (Group 2B). ... pleased to announce that Volume 128 of the IARC Monographs, Acrolein, crotonaldehyde, and arecoline, is now available online. ...

arecoline, Arecaline, Arecholine, Methylarecaiden, Methylarecaidin, Arecolin, Arekolin, Arecoline base, Arecaidine methyl ester ...

Arecoline is the primary active ingredient of the areca nut, which is carcinogenic to humans (Group 1). At least 10% of the ... Arecoline has been used medicinally as an anthelmintic and is still applied in the form of areca-nut preparations in ... Acrolein, Crotonaldehyde, and Arecoline. IARC Monographs on the Identification of Carcinogenic Hazards to Humans Volume 128. ...

Organophosphate (OP) compounds are a diverse group of chemicals used in both domestic and industrial settings. Examples of organophosphates include insecticides (malathion, parathion, diazinon, fenthion, dichlorvos, chlorpyrifos, ethion), nerve gases (soman, sarin, tabun, VX), ophthalmic agents (echothiophate, isoflurophate), and antihelminti...

Organophosphate (OP) compounds are a diverse group of chemicals used in both domestic and industrial settings. Examples of organophosphates include insecticides (malathion, parathion, diazinon, fenthion, dichlorvos, chlorpyrifos, ethion), nerve gases (soman, sarin, tabun, VX), ophthalmic agents (echothiophate, isoflurophate), and antihelminti...

Arecoline; carbon disulphide; electronic nicotine delivery systems and nicotine; human cytomegalovirus; parabens. Agents ...

...

Analysis of the cholinergic activity of the areca alkaloids indicates that while arecoline and guvacoline are both activators ... Review of the pharmacological activities of arecoline including effects on central nervous system, cardiac, digestive and ... While areca catechu nut has multiple components, its major alkaloid is arecoline which is believed to be the active component ... The pharmacology, toxicology and potential applications of arecoline: a review. Pharm Biol. 2016;54:2753-2760. [PubMed: ...

Alkaloids Muscarine Pilocarpine Arecoline ...

Wen, X.M.; Zhang, Y.L.; Liu, X.M.; Guo, S.X.; Wang, H. Immune responses in mice to arecoline mediated by lymphocyte muscarinic ...

Interestingly, c-myc promoter activity was also induced by arecoline. MiR-22 expression in arecoline-treated OSCC cells was ... Arecoline, the major alkaloid of areca nut, is known to induce oral carcinogenesis, however, its mechanism is still needed to ... Effects of arecoline on proliferation of oral squamous cell carcinoma cells by dysregulating c-Myc and miR-22, directly ... In arecoline-treated OSCC cells, oncostatin M (OSM) expression was significantly upregulated and inversely correlated with miR- ...

Arecoline derivative. Target. CHRM3 [HSA:1131] [KO:K04131]. Pathway. hsa04080 Neuroactive ligand-receptor interaction. ...

Selvan R and Rao A (2008) Influence of Arecoline on Immune System: III. Suppression of B Cell-Mediated Immune Response in Mice ...

Arecoline N-oxide: its mutagenicity and possible role as ultimate carcinogen in areca oral carcinogenesis.. Lin KH; Lin CY; Liu ... 2. Arecoline, a major alkaloid of areca nut, inhibits p53, represses DNA repair, and triggers DNA damage response in human ... Enhancement of the genotoxicity of benzo[a]pyrene by arecoline through suppression of DNA repair in HEp-2 cells.. Huang JL; Lu ... 1. On the in vitro N-nitrosation of arecoline.. Wenke G; Hoffmann D. Carcinogenesis; 1983; 4(2):169-72. PubMed ID: 6825205. [ ...

The study shows that the nuts active ingredient, arecoline, acts on the same receptor proteins in the brain as nicotine. This ...

Research dating back to 1957 demonstrated that the naturally occurring mAChR agonist arecoline, when given to patients with ... In the 1990s, a synthetic structural analogue of arecoline, xanomeline, was characterized and ultimately studied in patients ... schizophrenia, resulted in "lucid intervals."6 Notably, arecoline occurs naturally in the betel nut, which is chewed in some ...

ARECOLINE. ARSANILIC ACID AND ITS SALTS. ASPARAGINASE. ATROPINE AND ITS SALTS. AVERMECTINS, THEIR SALTS AND. DERIVATIVES. ...

Arecoline is the active ingredient in betel nut and inhibits the growth of periodontal fibroblasts. Therefore, betel quid ...

... arecoline, arsenic trioxide, arsine, aspidium, astropine. ...

... and arecoline may be responsible for their enhanced expression. [18, 19, 20] Further studies have shown that arecoline is an ... Arecoline, an active alkaloid found in betel nuts, stimulates fibroblasts to increase production of collagen by 150%. [16] In ... Arecoline, an alkaloid found in the areca nut, promotes salivation, stains saliva red, and is a stimulant. ... Raised keratinocyte growth factor-1 expression in oral submucous fibrosis in vivo and upregulated by arecoline in human buccal ...

Arecoline_Hydrobromide,create,28-MAR-08,(null),(null) C72705,Asenapine,create,28-MAR-08,(null),(null) C72706,Aspoxicillin, ...

It contains three major alkaloids: arecoline, pilocarpine, and muscarine. ? USES 1. It is used to refresh the mouth. 2. It ...

Strickland, SS; (2002) Anthropological perspectives on use of the areca nut. Addiction biology, 7 (1). pp. 85-97. ISSN 1355-6215 DOI: https://doi.org/10.1080/13556210120091446 Full text not available from this repository ...