Apomorphine - DrugBank
Apomorphine has been shown to improve motor function in an animal model of Parkinson's disease. In particular, apomorphine ... Apomorphine may increase the hypertensive activities of Droxidopa.. Approved, Investigational. Duloxetine. Apomorphine may ... Apomorphine may increase the hypotensive activities of Lacidipine.. Approved, Investigational. Landiolol. Apomorphine may ... Amoxapine may decrease the antihypertensive activities of Apomorphine.. Approved. Amphetamine. The metabolism of Apomorphine ...https://www.drugbank.ca/drugs/DB00714
A review of intermittent subcutaneous apomorphine injections for the rescue management of motor fluctuations associated with...
Following administration of apomorphine, the decrease in daily 'off' time from baseline ranged from 2.6 to 4 hours (6 studies) ... In the double-blind trials, all of the studies except one reported a statistically significant difference between apomorphine ... Chen J J, Obering C. A review of intermittent subcutaneous apomorphine injections for the rescue management of motor ... This review assessed the efficacy of intermittent subcutaneous apomorphine injections for the management of 'off' episodes in ...http://www.crd.york.ac.uk/crdweb/ShowRecord.asp?LinkFrom=OAI&ID=12006000532
apomorphine | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY
apomorphine ligand page. Quantitative data and detailed annnotation of the targets of licensed and experimental drugs. ... pEC50 5.1 Apomorphine blocks TRPA1 at 100µM  Description: Calcium imaging, patch clamp Conditions: HEK293 cells transfected ...http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?tab=biology&ligandId=33
Apomorphine | Memorial Sloan Kettering Cancer Center
If you have an allergy to apomorphine or any other part of this drug. ...https://www.mskcc.org/cancer-care/patient-education/apomorphine?glossary=on
apomorphine - WellSpan Health Library
Apomorphine is used to treat 'wearing-off' episodes (muscle stiffness, loss of muscle control) in people with advanced ... Apomorphine has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of ... Ask your doctor how to safely stop using apomorphine.. If you stop using apomorphine for 7 days or longer, ask your doctor ... What is apomorphine?. Apomorphine has some of the same effects as a chemical called dopamine, which occurs naturally in your ...http://www.wellspan.org/health-library/Document.aspx?id=d04991a1
Apomorphine definition and meaning | Collins English Dictionary
Apomorphine definition: a white crystalline alkaloid , derived from morphine , that is used medicinally as an... , Meaning, ... apomorphine is in the lower 50% of commonly used words in the Collins dictionary ...https://www.collinsdictionary.com/dictionary/english/apomorphine
A 10 year retrospective audit of long-term apomorphine use in Parkinson's disease | SpringerLink
Objectives Apomorphine is a potent dopamine agonist useful in the treatment of Parkinson's disease patients with disabling ... after sometime on apomorphine). Sixteen patients have stopped using apomorphine completely. Thirteen have stopped the pump, but ... Subcutaneous apomorphine is easy for patients to use, is well tolerated and has a low incidence of side effects, especially ... Steiger MJ, Quinn NP, Marsden CD (1992) The clinical use of apomorphine in Parkinson's disease. J Neurol 239:389-393PubMed ...https://link.springer.com/article/10.1007%2Fs00415-004-0547-4
Motor response to apomorphine and levodopa in asymmetric Parkinson's disease
Motor response to apomorphine; Counselling of patients and liaison with the general practitioner; Benefits of apomorphine; ... Apomorphine, a short-acting dopamine D1 and D2 receptor agonist, was the first dopamine receptor agonist used to treat ... Apomorphine/levodopa. // Reactions Weekly;9/19/2009, Issue 1270, p8 The article describes a case of psychiatric disorders ... Subcutaneous Apomorphine. Deleu, Dirk; Hanssens, Yolande; Northway, Margaret G. // Drugs & Aging;2004, Vol. 21 Issue 11, p687 ...http://connection.ebscohost.com/c/articles/66105793/motor-response-apomorphine-levodopa-asymmetric-parkinsons-disease
Apomorphine - Wikipedia
LD50 Apomorphine is colourless as a liquid but stains green, therefore care must be taken to avoid splashes. Apomorphine does ... This, along with the use of sublingual apomorphine tablets, led to a renewed interest in the use of apomorphine as a treatment ... "Apomorphine - A forgotten treatment for alcoholism". apomorphine.info. Retrieved 2018-01-24. Neves SR, Ram PT, Iyengar R (2002 ... Tompkins, James (1899). "Apomorphine in Acute Alcoholic Delirium". Medical Record. "APOMORPHINE AS A HYPNOTIC". The Lancet. 155 ...https://en.wikipedia.org/wiki/Apomorphine
Haloperidol and apomorphine differentially affect neuropeptidase activity. | Journal of Pharmacology and Experimental...
Haloperidol and apomorphine differentially affect neuropeptidase activity.. S M Waters, C S Konkoy and T P Davis ... Haloperidol and apomorphine differentially affect neuropeptidase activity.. S M Waters, C S Konkoy and T P Davis ... Haloperidol and apomorphine differentially affect neuropeptidase activity.. S M Waters, C S Konkoy and T P Davis ... Haloperidol and apomorphine differentially affect neuropeptidase activity. Message Subject (Your Name) has forwarded a page to ...http://jpet.aspetjournals.org/content/277/1/113
Effects of apomorphine and L-dopa on the parkinsonian bladder - Aranda - 1993 - Neurourology and Urodynamics - Wiley Online...
Effects of apomorphine and L-dopa on the parkinsonian bladder. Authors. *. Bernard Aranda,. Corresponding author. *Department ... Miguel Rosa-Grilo, Mubasher A. Qamar, Andrew Evans, K. Ray Chaudhuri, The efficacy of apomorphine - A non-motor perspective, ... Whereas hyperreflexic patients improved with apomorphine, and to a lesser extent with L dopa, these drugs had no effect on ... We compared the results of cystometry and urethral profilometry with and without apomorphine (and L dopa) in 12 idiopathic ...http://onlinelibrary.wiley.com/doi/10.1002/nau.1930120302/abstract
A Study That Compares the Extent to Which Apomorphine Becomes Available in the Body After Taking Either an Investigational Drug...
A Study That Compares the Extent to Which Apomorphine Becomes Available in the Body After Taking Either an Investigational Drug ... Containing Apomorphine or Apomorphine That is Injected Under the Skin in People With PD Complicated by ... Apomorphine Becomes Available in the Body After Taking Either an Investigational Drug Containing Apomorphine or Apomorphine ... taking either an investigational drug containing apomorphine or apomorphine that is injected under the skin in people with PD ...http://www.centerwatch.com/clinical-trials/listings/126162/parkinson-disease-study-that-compares-extent/?&radius=50
Enhancement of apomorphine-induced penile erection in the rat by a selective alpha(1D)-adrenoceptor antagonist.
... Mizusawa, ... A-322312, prazosin, or yohimbine did not enhance erections induced by apomorphine. None of the alpha(1)-AR antagonists ... A-322312, prazosin, or yohimbine did not enhance erections induced by apomorphine. None of the alpha(1)-AR antagonists ... Effects of intracavernous (i.c.) or intraperitoneal (i.p.) administration of alpha(1)-AR antagonists on apomorphine-induced ...https://lup.lub.lu.se/search/publication/109057
Development of a gas chromatographic/mass spectrometric method to quantify R(-)-apomorphine, R(-)-apocodeine and R(-)...
A method was developed and validated for the analysis of R(-)-apomorphine, (R-)-apocodeine and R(-)-norapomorphine in human ... The quantification limits were 1 ng/ml for apomorphine and apocodeine and 25 ng/ml for norapomorphine. Calibration curves were ... Variation in intraday and interday precision was below 10%. This method was applied to study apomorphine bioavailability in ... Development of a gas chromatographic/mass spectrometric method to quantify R(-)-apomorphine, R(-)-apocodeine and R(-)- ...https://www.sigmaaldrich.com/catalog/papers/16285020
Deep brain stimulation of the subthalamic nucleus: effectiveness in advanced Parkinson's disease patients previously reliant on...
... apomorphine can be very effective.2 Longer term infusion of apomorphine over several hours a day is often required in patients ... Total daily apomorphine dose was reduced by 68.9% (p,0.05) and apomorphine infusion via a pump was no longer required in four ... Subcutaneous apomorphine in the treatment of Parkinson's disease. J Neurol Neurosurg Psychiatry1990;53:96-101. ... Of importance in this series, is that four of six patients no longer required apomorphine infusion via a pump and the patient ...http://jnnp.bmj.com/content/74/2/170
Apomorphine | CTD
Anhydrous Apomorphine Hydrochloride , Anhydrous, Apomorphine Hydrochloride , Apokinon , Apomorphine Chloride , Apomorphine ... Apomorphine , Hydrochloride, Anhydrous Apomorphine , Hydrochloride, Apomorphine , Hydrochloride, Hemihydrate Apomorphine ... Apomorphine 2.. Chemicals ← Heterocyclic Compounds ← Heterocyclic Compounds, Fused-Ring ← Heterocyclic Compounds, 2-Ring ← ... Apomorphine 3.. Chemicals ← Heterocyclic Compounds ← Heterocyclic Compounds, Fused-Ring ← Heterocyclic Compounds, 4 or More ...http://ctdbase.org/detail.go?type=chem&acc=D001058
The effect of amitriptyline treatment on the growth hormone response to apomorphine. - Department of Psychiatry
The way in which amitriptyline attenuates the effect of apomorphine is not clear. Direct blockade of dopamine receptors in the ... Amitriptyline treatment significantly reduced the growth hormone response to apomorphine, confirming the findings of an earlier ... The growth hormone response to subcutaneous administration of the dopamine agonist apomorphine (0.005 mg/kg) was assessed in ... The way in which amitriptyline attenuates the effect of apomorphine is not clear. Direct blockade of dopamine receptors in the ...https://www.psych.ox.ac.uk/publications/185948
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months ...https://www.apexbt.com/r-apomorphine-hydrochloride.html
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DMOZ - Health: Pharmacy: Drugs and Medications: A: Apomorphine
Official pharmaceutical website with information for patients and health professionals. ...http://dmoztools.net/Health/Pharmacy/Drugs_and_Medications/A/Apomorphine/
Clozapine effects on neuroendocrine response to apomorphine challenge testing in chronic neuroleptic nonresponsive...
Clozapine effects on neuroendocrine response to apomorphine challenge testing in chronic neuroleptic nonresponsive ... The Blunted Plasma Cortisol Response to Apomorphine and Its Relationship to Treatment Response in Patients with Schizophrenia. ... Clozapine effects on neuroendocrine response to apomorphine challenge testing in chronic neuroleptic nonresponsive ...https://www.semanticscholar.org/paper/Clozapine-effects-on-neuroendocrine-response-to-in-Szymanski-Lieberman/486dc72d9bc20d84e1dc4345a96f0c94e9e1c5bc
Apomorphine for Treatment of Advanced Symptoms of PARKINSON'S DISEASE - Parkinson Research Foundation
Many pharmaceutical companies have tried for many years to find a viable formulation and delivery method to make Apomorphine ... Apomorphine for Treatment of Advanced Symptoms of PARKINSON'S DISEASE. ... Apomorphine for Treatment of Advanced Symptoms of PARKINSON'S DISEASE. Apomorphine has been available for many years as a " ... Apomorphine needs to be injected under the skin, which is painful and causes scaring. Once injected, it causes immediate nausea ...http://parkinsonhope.org/apomorphine-treatment-advanced-symptoms-parkinsons-disease/