Apamin (ap) blocks an initial component of the IAHP in all of the genotypes except SK2 Δ/Δ mice, which lack the apamin- ... 2B). In slices from wild-type mice, apamin blocked an early component of the IAHP and the apamin-sensitive component of the ... In particular, the IsAHP in mice lacking the least apamin-sensitive SK subunit, SK1, is similar to wild type and is not apamin ... It is interesting that SK2 channels, required for the apamin-sensitive ImAHP, may also be responsible for the effects of apamin ...http://www.jneurosci.org/content/24/23/5301
Apamin dictionary definition | apamin defined
Apamin-sensitive, non-nitric oxide (NO) endothelium-dependent...
Apamin-sensitive, non-nitric oxide (NO) endothelium-dependent relaxations to bradykinin in the bovine isolated coronary artery ... Apamin-sensitive, non-nitric oxide (NO) endothelium-dependent relaxations to bradykinin in the bovine isolated coronary artery ... Both the high [K(+)](o)/apamin-sensitive relaxation to BK, and the relaxation to the K(ATP) channel-opener, levcromakalim (0.6 ... or apamin (0.3 microM). Ouabain (1 microM), an inhibitor of Na(+)/K(+)-ATPase, decreased the sensitivity to BK without ...https://www.mysciencework.com/publication/show/apamin-sensitive-non-nitric-oxide-endothelium-dependent-relaxations-bradykinin-bovine-isolated-coronary-artery-role-cyt-b311e30e
Apamin - Wikipedia
Apamin is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom). Dry bee venom consists of 2-3% of apamin. Apamin ... Apamin is an element in bee venom. You can come into contact with apamin through bee venom, so the symptoms that are known are ... Apamin was first isolated by Habermann in 1965 from Apis mellifera, the Western honey bee. Apamin was named after this bee. Bee ... Apamin is the only neurotoxin acting purely on the central nervous system. The symptoms of apamin toxicity are not well known, ...https://en.wikipedia.org/wiki/Apamin
Apamin from bee venom, ≥95% (HPLC) | Sigma-Aldrich
Apamin for your research needs. Find product specific information including CAS, MSDS, protocols and references. ...https://www.sigmaaldrich.com/catalog/product/sigma/a1289?lang=en®ion=US
RCSB PDB - 1DU9: SOLUTION STRUCTURE OF BMP02, A NATURAL SCORPION TOXIN WHICH BLOCKS APAMIN-SENSITIVE CALCIUM-ACTIVATED...
A NATURAL SCORPION TOXIN WHICH BLOCKS APAMIN-SENSITIVE CALCIUM-ACTIVATED POTASSIUM CHANNELS, 25 STRUCTURES ... SOLUTION STRUCTURE OF BMP02, A NATURAL SCORPION TOXIN WHICH BLOCKS APAMIN-SENSITIVE CALCIUM-ACTIVATED POTASSIUM CHANNELS, 25 ... which had been demonstrated to be a weak blocker of apamin-sensitive calcium-activated potassium channels. Two-dimensional NMR ... which had been demonstrated to be a weak blocker of apamin-sensitive calcium-activated potassium channels. Two-dimensional NMR ...http://www.rcsb.org/structure/1DU9
Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: Potent, non-peptidic blockers of the...
... non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel. JOURNAL OF MEDICINAL CHEMISTRY , 43 (3) pp. 420-431. ... non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel ... non-peptidic blockers of the apamin-sensitive Ca2+-activated K+ channel. ...http://discovery.ucl.ac.uk/25432/
Therapeutically Relevant Concentrations of Raloxifene Dilate Pressurized Rat Resistance Arteries via Calcium-Dependent...
Effect of CTX Plus Apamin. A combined treatment with CTX plus apamin (each at 50 nmol/L) did not reduce raloxifene-induced ... Raloxifene-induced dilatations were unaffected by treatment with CTX plus apamin, a recipe widely used to block K+-dependent ... Acetylcholine, phenylephrine, l-NAME, apamin, and CTX were purchased from Sigma (St. Louis, Mo.). ICI 182,780, 1400W, LY 294002 ... CTX plus apamin (n=4) (C), and by wortmannin or LY294002 (n=4 to 5) (D). Results are means±SEM of n experiments. The ...http://atvb.ahajournals.org/content/30/5/992
Frontiers | Small-Conductance Ca2+-Activated K+ Channel 2 in the Dorsal Horn of Spinal Cord Participates in Visceral...
1-EBIO or CyPPA effect could be prevented by SK2 channel blocker apamin. CRD could induce an increase in c-Fos protein ... 1-EBIO or CyPPA effect could be prevented by SK2 channel blocker apamin. CRD could induce an increase in c-Fos protein ... Apamin decreased the amplitude of IAHP in rats that experienced neonatal CRD (p , 0.01, n = 6 neurons per group). (E) Apamin ... which could be blocked by SK2 channel blocker apamin (5 ng/10 μL) (p , 0.05; Figure 4C). Apamin (100 nM) decreased IAHP current ...https://www.frontiersin.org/articles/10.3389/fphar.2018.00840/full
The drugs tested included apamin (100 nm; n = 5), TTX (300 nm; n = 4), a mixture of NBQX (AMPA antagonist; 5 μm), MK-801 (NMDA ... Consistent with the previous report on SMHs in DA neurons (Seutin et al., 1998), SMOCs were completely eliminated by apamin ( ... C, Summary bar graph depicting the effects of apamin, TTX, and various neurotransmitter antagonists on SMOCs. The SMOC ... Seutin V, Massotte L, Scuvee-Moreau J, Dresse A (1998) Spontaneous apamin-sensitive hyperpolarizations in dopaminergic neurons ...http://www.jneurosci.org/content/24/49/11079
Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice | JEM
Indo, indomethacin; CTx, charybdotoxin; Apm, apamin. *, P , 0.05; **, P , 0.01. Relative contribution of EDHF in male (I) and ... and 1 μM apamin (an inhibitor of small-conductance KCa channels), indicating a primary role of EDHF in endothelium-dependent ... and a combination of charybdotoxin and apamin, respectively (14, 21). To examine the effect of NOS uncoupling on EDHF-mediated ...http://jem.rupress.org/content/205/9/2053
However, 100 nM apamin had no significant effect on the firing rate of these eight PVN neurons (Fig. 7C). At 500 nM, apamin ... C, summary data showing the differential effect of 100 and 500 nM apamin and 20 μM bicuculline on the firing activity of eight ... We found that bicuculline methiodide, but not apamin, significantly increased the firing activity of labeled PVN neurons. ... we determined the effect of apamin, a specific blocker of SK channels, on the firing activity of labeled PVN neurons. Bath ...http://jpet.aspetjournals.org/content/316/2/733
US20120302639A1 - Omega 3 formulations for treatment of risk factors for cardiovascular disease and protection against sudden...
In addition, the combination of L-NA plus TRAM 34 and apamin abolished the endothelium-dependent relaxation to EPA:DHA 6:1 (. ... c. TRAM 34 (100 nM) and apamin (100 nM) inhibitors of Ca2+-activated potassium channels (IKCa and SKCa) respectively, to ... TRAM 34 and apamin (inhibitors of Ca2+-dependent potassium channels of intermediate and low conductance IKCa and SKCa, ... Apamin+TRAM 34) and the formation of vasoactive prostanoids (indomethacin). The relaxation induced by EPA:DHA 6:1 was ...https://patents.google.com/patent/US20120302639A1/en
COMPOSITIONS AND METHODS FOR THE TREATMENT OF SINONASAL DISORDERS - OTONOMY, INC.
... apamin; amiodarone; azimilide; bretylium; clofilium; tedisamil; ibutilide; sematilide; nifekalant; tamulustoxin and ...http://www.sumobrain.com/patents/wipo/Compositions-methods-treatment-sinonasal-disorders/WO2011049960.html
... and apamin (to block SK channels). None of these compounds changed the WT firing pattern to that of du2J/du2J PCs. TEA (1 mm) ... blocking SK channels with apamin (100 nm) or blocking BK channels with Penitrem A (10 μm) also increased the rate of firing in ... penitrem A and apamin (Alomone Labs); SR95531 [2-(3-carboxypropyl)-3-amino-6-(4-methoxyphenyl)pyridazinium bromide], NBQX, and ...http://www.jneurosci.org/content/26/48/12576
ICSD for WWW
MIN apa : MINeral name contains apa eg apatite.. *PDF 32-77 (PDF number contains 32-77) ...http://icsd.ill.fr/icsd/index.php?action=Search&nb_rows=10&authors=%22Cornelius,+A.L.%22
Pandinus imperator toxin (Pi4) - Wikipedia
Pi4 competes with apamin, another SK-channel toxin. IC50 is 0.5 ± 0.2 µM. Scorpion venoms can be toxic for mammals, insects, ...https://en.wikipedia.org/wiki/Pandinus_imperator_toxin_(Pi4)
Schmidt sting pain index - Wikipedia
... apamin, and MCD peptide. Melittin is the main toxin of bee venom, and it damages red blood cells and white blood cells. Apamin ...https://en.wikipedia.org/wiki/Schmidt_sting_pain_index
Tamapin - Wikipedia
However, Tamapin displaces Apamin in binding assays and is therefore a stronger toxin with respect to Apamin. SK 1 and SK 3 are ... Its sequence similarity to other toxins that can compete with the binding site of apamin is much lower. It is 31 amino acids ... Despite completely different sequences, Apamin (a bee venom toxin) and Tamapin share at least in part, the same binding sites ... Tamapin-2 can also compete very effectively with apamin for binding to synaptosomes. The target of Tamapin is the small ...https://en.wikipedia.org/wiki/Tamapin
MCD peptide - Wikipedia
Gmachl, M; Kreil, G (1995). "The precursors of the bee Venom Constituents Apamin and MCD Peptide Are Encoded by two Genes in ... In addition to MCD peptide, melittin and apamin have also been identified in this venom and are also described as voltage- ... Although the MCD peptide sequence shows similarity with apamin, they have different toxic properties. MCD peptide belongs to a ...https://en.wikipedia.org/wiki/MCD_peptide
SK channel - Wikipedia
In addition, SK channels (SK1-SK3) but not SK4 (IK) are sensitive to blockade by the bee toxin apamin, and the scorpion venoms ... Experiments using apamin have shown that specifically blocking SK channels can increase learning and long-term potentiation. In ... Blatz AL, Magleby KL (1986). "Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal ...https://en.wikipedia.org/wiki/SK_channel
Scyllatoxin - Wikipedia
This toxin shows similarity in its physiological activity and binding specificity to apamin, but both toxins show no structural ... potent inhibitor of apamin binding from Leiurus quinquestriatus hebraeus venom". J. Biol. Chem. 263 (21): 10192-7. PMID 2839478 ...https://en.wikipedia.org/wiki/Scyllatoxin
Tetraethylammonium - Wikipedia
"Tetraethylammonium blockade of apamin-sensitive and insensitive Ca2+-activated K+ channels in a pituitary cell line." J. ... Inhibition of the electrogenic Na,K pump and Na,K-ATPase activity by tetraethylammonium, tetrabutylammonium, and apamin. ...https://en.wikipedia.org/wiki/Tetraethylammonium