Amplyx - Advancing Novel Therapeutic Solutions for life-threatening fungal infections.
"There hasn't been a new class of antifungal drug approved since 2001, and many existing antifungal agents are difficult to use ... Amplyx Pharmaceuticals is developing novel, broad-spectrum antifungal agents for the treatment of life-threatening invasive ... Amplyx was founded on a mission to develop a new class of antifungal medicine that would overcome the severe limitations of ... Amplyx Pharmaceuticals Initiates Dosing in Phase 1 Clinical Trial of APX001, a Novel Antifungal Product Candidate for Treatment ...http://amplyx.com
Anti-Candida albicans activity, cytotoxicity and interaction with antifungal drugs of essential oils and extracts from aromatic...
Natural products and antifungal drug discovery. In: Ernst EJ, Rogers PD, editors. Antifungal agents: Methods and protocols. ... Vitale RG, Afeltra J, Dannaoui E. Antifungal combinations. In: Ernst EJ, Rogers PD, editors. Antifungal agents: Methods and ... Screening by using in vitro evaluation is a useful tool for the discovery of new potential antifungal agents from natural ... Important antifungal agents such as polyenes, echinocandins/ pneumocandins, aureobasidins and sordarins had their origin in ...http://www.scielo.org.co/scielo.php?pid=S0123-93922011000300004&script=sci_arttext
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Voriconazole belongs to the family of medications called antifungals. It is used to treat certain types of invasive (inside the ... Voriconazole oral suspension should not be mixed with any other medication or flavouring agent and it should not be further ... Allergy: It is not clear whether people who have previously had an allergic reaction to another 'azole' antifungal will have an ... antifungal medications [e.g., ketoconazole, fluconazole, and itraconazole] will also be allergic to voriconazole.) ...http://www.pharmasave.com/medications/teva-voriconazole/
SCYNEXIS Presents New Data Further Supporting SCY-078 as a Potential Treatment for Aspergillus and Candida Infections at IDWeek...
SCY-078 is an antifungal agent in clinical development for the treatment of fungal infections caused by Candida and Aspergillus ... By belonging to a chemical class distinct from other antifungals, SCY-078 has shown in vitro and in vivo activity against multi ... resistance observed in Candida and Aspergillus species to available therapies create an urgent need for novel antifungal agents ... The second poster, "Assessment of the In Vitro Antifungal Activity of SCY-078 Against a Collection of Candida parapsilosis ...http://ir.scynexis.com/news-releases/news-release-details/scynexis-presents-new-data-further-supporting-scy-078-potential
Voriconazole: a highly potent treatment for fungal infections
Voriconazole is an antifungal agent which has been approved for treatment of a broad range of fungal infections, including ... response to these antifungal agents in vitro, and also to check for resistance to voriconazole. ... The aim was to compare the effectiveness of voriconazole with other agents, by studying the yeasts' ... They also note that the activity of the agent in vitro may help predict the response of patients to treatment. ...http://www.innovations-report.com/html/reports/medicine-health/voriconazole-a-highly-potent-treatment-fungal-124423.html
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ASMscience | Antifungal Drugs: The Current Armamentarium and Development of New Agents
Despite the paucity of new classes of antifungals that have come to market in recent years, it is clear that by leveraging ... We discuss state-of-the-art approaches to discover novel chemical matter with antifungal activity and highlight some of the ... We feature the benefits of combination therapy as a strategy to expand our current repertoire of antifungals and discuss the ... The efficacy of these agents is compromised by host toxicity, fungistatic activity, or the emergence of drug resistance in ...http://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.FUNK-0002-2016
Antifungal Pharmacokinetics and Pharmacodynamics | Aspergillus & Aspergillosis Website
Antifungal pharmacokinetics and pharmacodynamics (PK-PD) has been used to develop currently available antifungal agents, and ... As knowledge improves, antifungal PK-PD will become a critical component for the development of new agents. ... The PK-PD of currently available antifungal drug classes and agents within those classes are reviewed. ... This chapter describes the tools that have been developed and are available for antifungal PK-PD. ...http://aspergillus.org.uk/content/antifungal-pharmacokinetics-and-pharmacodynamics
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Search of: 'Antifungal Agents' - List Results - ClinicalTrials.gov
Short and Long-term Safety of Micafungin and Other Parenteral Antifungal Agents. *Systemic Fungal Infections ... Hygienic Socks With Antifungal Agent-loaded Microcapsules for Patients With Tinea Pedis. *Tinea Pedis ... Antifungal Use in Oncohematological Neutropenic Patients. *Invader Fungal Infection. *Drug: Antifungal drug. VORICONAZOL. ( ... PEACE: Pediatric Antifungal Comparative Effectiveness. *Pediatric Invasive Candidiasis. *Drug: Observational antifungal therapy ...https://clinicaltrials.gov/ct2/results?intr=%22Antifungal+Agents%22
Antifungal Agents | Springer for Research & Development
... methods for finding novel drug targets and evaluating antifungal resistance have become more ... With the growing frequency of fungal infections even as resistance to existing antifungal agents increases, ... In Antifungal Agents: Methods and Protocols, expert scientists describe in detail the state-of-the-art molecular methods they ... With the growing frequency of fungal infections even as resistance to existing antifungal agents increases, methods for finding ...https://rd.springer.com/book/10.1385/1592599435
1859961452 - Antifungal Agents: Discovery and Mode of Action - AbeBooks
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Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents
H. L. Hoffman, E. J. Ernst, and M. E. Klepser, "Novel triazole antifungal agents," Expert Opinion on Investigational Drugs, vol ... M. K. Kathiravan, A. B. Salake, A. S. Chothe et al., "The biology and chemistry of antifungal agents: a review," Bioorganic & ... E. S. D. Ashley, R. Lewis, J. S. Lewis, C. Martin, and D. Andes, "Pharmacology of systemic antifungal agents," Clinical ... D. Sanglard and F. C. Odds, "Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences ...https://www.hindawi.com/journals/bmri/2013/204237/ref/
Optimal Use of the Newer Antifungal Agents | Cancer Network | The Oncology Journal
While some of these agents offer better efficacy, others are proving their value more in improved tolerability, said John R. 1 ... and treatment of invasive fungal infections is being improved by the relatively recent introduction of new antifungal agents. ... improved by the relatively recent introduction of new antifungal. agents. While some of these agents offer better efficacy, ... spectrum of antifungal activity, improved bioavailability, and fewer. drug interactions.. Other new generations of antifungal ...http://www.cancernetwork.com/articles/optimal-use-newer-antifungal-agents
Global Antifungal Agents Market Professional Survey Overview, Research, Size And Forecast 2017 | Medgadget
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Candidiasis in Emergency Medicine Medication: Antifungals, azole, Antifungals, polyenes, Antimetabolite, Antifungals,...
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United States Antifungal Agents Market Report 2017, Trends, Share, Size Research Report
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Frontiers | Screening of Pharmacologically Active Small Molecule Compounds Identifies Antifungal Agents Against Candida...
Therefore, this screening reveals agent, CV-3988 that was previously unknown to be antifungal agent, which could be a novel ... using an antifungal susceptibility test (AST). To investigate the antifungal effects of the hit compounds, ASTs were conducted ... using an antifungal susceptibility test (AST). To investigate the antifungal effects of the hit compounds, ASTs were conducted ... The current antifungal therapies either have toxic side effects or are insufficiently effect. The aim of this study is develop ...https://www.frontiersin.org/articles/10.3389/fmicb.2015.01453/full
Symptoms of Antifungal agent-induced liver damage -- Saramycetin - RightDiagnosis.com
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Green Route for Efficient Synthesis of Novel Amino Acid Schiff Bases as Potent Antibacterial and Antifungal Agents and...
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TMC125-TiDP2-C187: A Phase I, Open-label Trial to Investigate the Pharmacokinetic Interaction Between TMC125 and Two Antifungal...
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IJMS | Free Full-Text | Synthesis, Antifungal Activities and Qualitative Structure Activity Relationship of Carabrone...
... which led to the improved activities for carabrone and its analogues and further confirmed their potential as antifungal agents ... The result revealed that all the derivatives synthesized exhibited considerable antifungal activities in vitro and in vivo, ... synthesized and their antifungal activities against Botrytis cinerea and Colletotrichum lagenarium were evaluated. ... Antifungal Activity. All the derivatives exhibited significant antifungal activities in spore germination assay with IC50 (50% ...http://www.mdpi.com/1422-0067/15/3/4257/htm
Molecular cloning and biochemical characterization of Candida albicans acyl-CoA:sterol acyltransferase, a potential target of...
... a potential target of antifungal agents.. [Ki-Young Kim, Yu-Kyong Shin, Jong-Chul Park, Jung-Ho Kim, Hongyuan Yang, Dong-Min ...https://www.sigmaaldrich.com/catalog/papers/15184069