Amplyx - Advancing Novel Therapeutic Solutions for life-threatening fungal infections.
"There hasn't been a new class of antifungal drug approved since 2001, and many existing antifungal agents are difficult to use ... Amplyx Pharmaceuticals is developing novel, broad-spectrum antifungal agents for the treatment of life-threatening invasive ... Amplyx was founded on a mission to develop a new class of antifungal medicine that would overcome the severe limitations of ... Amplyx Pharmaceuticals Initiates Dosing in Phase 1 Clinical Trial of APX001, a Novel Antifungal Product Candidate for Treatment ...http://amplyx.com
Anti-Candida albicans activity, cytotoxicity and interaction with antifungal drugs of essential oils and extracts from aromatic...
Natural products and antifungal drug discovery. In: Ernst EJ, Rogers PD, editors. Antifungal agents: Methods and protocols. ... Vitale RG, Afeltra J, Dannaoui E. Antifungal combinations. In: Ernst EJ, Rogers PD, editors. Antifungal agents: Methods and ... Screening by using in vitro evaluation is a useful tool for the discovery of new potential antifungal agents from natural ... Important antifungal agents such as polyenes, echinocandins/ pneumocandins, aureobasidins and sordarins had their origin in ...http://www.scielo.org.co/scielo.php?pid=S0123-93922011000300004&script=sci_arttext
SCYNEXIS Presents New Data Further Supporting SCY-078 as a Potential Treatment for Aspergillus and Candida Infections at IDWeek...
SCY-078 is an antifungal agent in clinical development for the treatment of fungal infections caused by Candida and Aspergillus ... By belonging to a chemical class distinct from other antifungals, SCY-078 has shown in vitro and in vivo activity against multi ... resistance observed in Candida and Aspergillus species to available therapies create an urgent need for novel antifungal agents ... The second poster, "Assessment of the In Vitro Antifungal Activity of SCY-078 Against a Collection of Candida parapsilosis ...http://ir.scynexis.com/news-releases/news-release-details/scynexis-presents-new-data-further-supporting-scy-078-potential
Voriconazole: a highly potent treatment for fungal infections
Voriconazole is an antifungal agent which has been approved for treatment of a broad range of fungal infections, including ... response to these antifungal agents in vitro, and also to check for resistance to voriconazole. ... The aim was to compare the effectiveness of voriconazole with other agents, by studying the yeasts' ... They also note that the activity of the agent in vitro may help predict the response of patients to treatment. ...http://www.innovations-report.com/html/reports/medicine-health/voriconazole-a-highly-potent-treatment-fungal-124423.html
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Clade related antifungal resistance among South African candida albicans isolates
Background: Azoles and polyenes are antifungal agents used for treatment and/or prophylaxis of C. albicans infections, and a ... Continued antifungal surveillance is needed to predict the evolution of resistance in a particular population and to take ... Clade related antifungal resistance among South African candida albicans isolates. Molepo, Julitha ... Evaluation of colony phenotypes and their antifungal susceptibilities in C. albicans isolates is recommended as this may be ...http://ulspace.ul.ac.za/handle/10386/265
ASMscience | Antifungal Drugs: The Current Armamentarium and Development of New Agents
Despite the paucity of new classes of antifungals that have come to market in recent years, it is clear that by leveraging ... We discuss state-of-the-art approaches to discover novel chemical matter with antifungal activity and highlight some of the ... We feature the benefits of combination therapy as a strategy to expand our current repertoire of antifungals and discuss the ... The efficacy of these agents is compromised by host toxicity, fungistatic activity, or the emergence of drug resistance in ...http://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.FUNK-0002-2016
Optimal Use of the Newer Antifungal Agents | Cancer Network | The Oncology Journal
While some of these agents offer better efficacy, others are proving their value more in improved tolerability, said John R. 1 ... and treatment of invasive fungal infections is being improved by the relatively recent introduction of new antifungal agents. ... improved by the relatively recent introduction of new antifungal. agents. While some of these agents offer better efficacy, ... spectrum of antifungal activity, improved bioavailability, and fewer. drug interactions.. Other new generations of antifungal ...http://www.cancernetwork.com/articles/optimal-use-newer-antifungal-agents
Antifungal Pharmacokinetics and Pharmacodynamics | Aspergillus & Aspergillosis Website
Antifungal pharmacokinetics and pharmacodynamics (PK-PD) has been used to develop currently available antifungal agents, and ... As knowledge improves, antifungal PK-PD will become a critical component for the development of new agents. ... The PK-PD of currently available antifungal drug classes and agents within those classes are reviewed. ... This chapter describes the tools that have been developed and are available for antifungal PK-PD. ...http://aspergillus.org.uk/content/antifungal-pharmacokinetics-and-pharmacodynamics
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antifungal agent (CHEBI:35718)
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Search of: 'Antifungal Agents' - List Results - ClinicalTrials.gov
Short and Long-term Safety of Micafungin and Other Parenteral Antifungal Agents. *Systemic Fungal Infections ... Hygienic Socks With Antifungal Agent-loaded Microcapsules for Patients With Tinea Pedis. *Tinea Pedis ... Antifungal Use in Oncohematological Neutropenic Patients. *Invader Fungal Infection. *Drug: Antifungal drug. VORICONAZOL. ( ... PEACE: Pediatric Antifungal Comparative Effectiveness. *Pediatric Invasive Candidiasis. *Drug: Observational antifungal therapy ...https://clinicaltrials.gov/ct2/results?intr=%22Antifungal+Agents%22
Antifungal Agents | Springer for Research & Development
... methods for finding novel drug targets and evaluating antifungal resistance have become more ... With the growing frequency of fungal infections even as resistance to existing antifungal agents increases, ... In Antifungal Agents: Methods and Protocols, expert scientists describe in detail the state-of-the-art molecular methods they ... With the growing frequency of fungal infections even as resistance to existing antifungal agents increases, methods for finding ...https://rd.springer.com/book/10.1385/1592599435
1859961452 - Antifungal Agents: Discovery and Mode of Action - AbeBooks
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Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents
4. Need of New Antifungal Agents. Potential pharmacological strategies include the use of (i) new formulations of antifungals, ... A second general source of antifungal agents comprises nonpolymeric synthetic agents, which can be classified into four groups ... 3. Mechanisms of Resistance against Antifungal Agents. Antifungal resistance is based on different mechanisms, namely, (i) ... only few classes of antifungal agents are currently available in oral and intravenous forms. Additionally antifungal resistance ...https://www.hindawi.com/journals/bmri/2013/204237/
Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents
H. L. Hoffman, E. J. Ernst, and M. E. Klepser, "Novel triazole antifungal agents," Expert Opinion on Investigational Drugs, vol ... M. K. Kathiravan, A. B. Salake, A. S. Chothe et al., "The biology and chemistry of antifungal agents: a review," Bioorganic & ... E. S. D. Ashley, R. Lewis, J. S. Lewis, C. Martin, and D. Andes, "Pharmacology of systemic antifungal agents," Clinical ... D. Sanglard and F. C. Odds, "Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences ...https://www.hindawi.com/journals/bmri/2013/204237/ref/
Global Antifungal Agents Market Professional Survey Overview, Research, Size And Forecast 2017 | Medgadget
... we at Orbis Research present the 2017 Global Antifungal Agents Market professional su ... 1.1.1 Definition of Antifungal Agents. 1.1.2 Specifications of Antifungal Agents. 1.2 Classification of Antifungal Agents. 1.2. ... Chapter One: Industry Overview of Antifungal Agents. 1.1 Definition and Specifications of Antifungal Agents. ... Global Antifungal Agents Market Professional Survey Overview, Research, Size And Forecast 2017. May 8th, 2017 orbisresearch.com ...https://www.medgadget.com/2017/05/global-antifungal-agents-market-professional-survey-overview-research-size-and-forecast-2017.html
Global Topical Antifungal Agents Sales Market Report 2017 : ReportsnReports
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Candidiasis in Emergency Medicine Medication: Antifungals, azole, Antifungals, polyenes, Antimetabolite, Antifungals,...
Antifungal agent that is a water-miscible base consisting of pegoxol 7 stearate, peglicol 5 oleate, mineral oil, benzoic acid, ... Antifungal agent of the echinocandin class. Inhibits synthesis of 1,3-beta-D-glucan, an essential component of fungal cell ... Broad-spectrum antifungal agent that inhibit yeast growth by altering cell membrane permeability, which causes fungal cell ... Imidazole broad-spectrum antifungal agent. Nizoral impairs synthesis of ergosterol (the main sterol of fungal cell membranes), ...https://emedicine.medscape.com/article/781215-medication
United States Antifungal Agents Market Report 2017, Trends, Share, Size Research Report
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Frontiers | Screening of Pharmacologically Active Small Molecule Compounds Identifies Antifungal Agents Against Candida...
Therefore, this screening reveals agent, CV-3988 that was previously unknown to be antifungal agent, which could be a novel ... using an antifungal susceptibility test (AST). To investigate the antifungal effects of the hit compounds, ASTs were conducted ... using an antifungal susceptibility test (AST). To investigate the antifungal effects of the hit compounds, ASTs were conducted ... The current antifungal therapies either have toxic side effects or are insufficiently effect. The aim of this study is develop ...https://www.frontiersin.org/articles/10.3389/fmicb.2015.01453/full
Symptoms of Antifungal agent-induced liver damage -- Saramycetin - RightDiagnosis.com
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A Polysaccharide Extracted From Sphagnum Moss as Antifungal Agent in Archaeological Conservation
... ... The antifungal effect of Sphagnum extract was tested by the disk-diffusion method on the spores of seventeen fungal species. ... it was concluded that Sphagnum moss and Sphagnum products can be recommended for use in art conservation as antifungal agents. ... As an example of the application of Sphagnum polysaccharides in art conservation, they were added as preservative agents to ...https://qspace.library.queensu.ca/handle/1974/5392
Green Route for Efficient Synthesis of Novel Amino Acid Schiff Bases as Potent Antibacterial and Antifungal Agents and...
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Multicenter, Randomized, Double-Blind, Double-Dummy, Phase 3 Study of the Safety and Efficacy of Elvitegravir Versus...
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