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*  Scientists Find Antibodies That Prevent Most HIV Strains From Infecting Human Cells - TheBody.com
Atomic structure of the antibody VRC01 (blue and green) binding to HIV (grey and red). The precise site of VRC01-HIV binding ( ... "The discovery of these exceptionally broadly neutralizing antibodies to HIV and the structural analysis that explains how they ... Rational design of envelope surface identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science. DOI: 10.1126 ... Antibody development begins with the mixing of genes into new combinations within the immune cells that make antibodies. ...
  http://www.thebody.com/content/art57342.html?nxtprv
*  Recent Articles | Broadly Cross-neutralizing Antibodies | The Scientist Magazine®
A family of broadly neutralizing antibodies from a chronically infected donor provides a schematic for designing vaccines and ... Unique Antibodies Open Path Toward New HIV Vaccines. By Amanda B. Keener , January 27, 2017 ... track the evolution of HIV in a single patient to understand what drives the production of broadly neutralizing antibodies. ... A synthetic antibody prevents infection in four monkeys injected with heavy doses of the virus. ...
  https://www.the-scientist.com/?articles.list/categoryNo/2625/category/The-Scientist/tagNo/2744/tags/broadly-cross-neutralizing-antibodies/
*  Recent Articles | Broadly Cross-neutralizing Antibodies And Immunology | The Scientist Magazine®| Page 4
tags: broadly cross-neutralizing antibodies x immunology x The Scientist. » broadly cross-neutralizing antibodies and ... A family of broadly neutralizing antibodies from a chronically infected donor provides a schematic for designing vaccines and ... Unique Antibodies Open Path Toward New HIV Vaccines. By Amanda B. Keener , January 27, 2017 ... Anti-Flavivirus Antibodies Enhance Zika Infection in Mice. By Anna Azvolinsky , March 30, 2017 ...
  https://www.the-scientist.com/?articles.list/tagNo/2744,12/tags/broadly-cross-neutralizing-antibodies,immunology/pageNo/4/
*  RCSB PDB - 4LSS: Crystal structure of broadly and potently neutralizing antibody VRC01 in complex with HIV-1 clade A strain KER...
Crystal structure of broadly and potently neutralizing antibody VRC01 in complex with HIV-1 clade A strain KER_2018_11 gp120 ...
  https://www.rcsb.org/structure/4lss
*  IMMUNOGEN DESIGN TO INDUCE HIV NEUTRALIZING ANTIBODIES | CROI Conference
Induction of broadly neutralizing antibodies (bnAbs) is a major HIV vaccine goal. We hypothesize that consistent bnAb ... to shepherd antibody maturation toward bnAb development. To test this hypothesis, we have focused our initial immunogen design ...
  http://www.croiconference.org/sessions/immunogen-design-induce-hiv-neutralizing-antibodies
*  Cell Based Neutralizing Antibody Assays
... Cell-based anti-drug neutralizing antibody (NAb) assays for safety and efficacy ... Experienced cell-based neutralizing antibody assay capabilities. Our experts, based in Good Laboratory Practice (GLP) compliant ... Cell-based neutralizing antibody assays can be difficult to develop as the selection of the most suitable assay type (indirect ... Cell-based assays mimic the mechanism by which the neutralizing antibodies (NAbs) exert their effect in vivo and are the ...
  http://www.intertek.com/pharmaceutical/immunochemistry/cell-based-assays/
*  Broadly neutralizing antibodies to prevent HIV-1 | Science
These are referred to as broadly neutralizing antibodies (bnAbs). Such antibodies can be detected in about 25% of persons with ... Studies show the potential of synthetic and combinations of broadly neutralizing antibodies ... Studies show the potential of synthetic and combinations of broadly neutralizing antibodies ... Advances in technology-especially single-cell antibody cloning techniques-have led to the isolation and characterization of ...
  http://science.sciencemag.org/content/358/6359/46.summary
*  Neutralizing Antibodies Summary Report | CureHunter
Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus. ... Neutralizing Antibodies. Subscribe to New Research on Neutralizing Antibodies Antibodies that reduce or abolish some biological ... of anti-PE neutralizing antibodies in vivo and was less susceptible to inactivation by anti-PE neutralizing antibodies compared ... highly neutralizing antibody response in the clearance of Hepatitis C virus (HCV) infection. ". 10/01/2015 - "Neutralizing ...
  http://www.curehunter.com/public/keywordSummaryD057134-Neutralizing-Antibodies.do
*  Broadly Neutralizing Antibodies in HIV Patients | The Scientist Magazine®
... and the infection itself that influence whether a person with HIV will produce broadly neutralizing antibodies. ... broadly neutralizing antibodies. disease/medicine. HIV. HIV vaccine. infectious disease. vaccination. vaccine. ... Broadly Neutralizing Antibodies in HIV Patients. Researchers identify aspects of the patient, the virus, and the infection ... WIKIMEDIA, BRUCEBLAUSEOnly about 1 percent of HIV-infected people will generate the broadly neutralizing antibodies that target ...
  https://www.the-scientist.com/the-nutshell/broadly-neutralizing-antibodies-in-hiv-patients-32797
*  Broadly Neutralizing Antibodies in HIV Patients | The Scientist Magazine®
Broadly Neutralizing Antibodies in HIV Patients. Broadly Neutralizing Antibodies in HIV Patients. Researchers identify aspects ... broadly neutralizing antibodies. disease/medicine. HIV. HIV vaccine. infectious disease. vaccination. vaccine. ... WIKIMEDIA, BRUCEBLAUSEOnly about 1 percent of HIV-infected people will generate the broadly neutralizing antibodies that target ... Thirdly, different virus subtypes appeared more or less likely to trigger the production of broadly neutralizing antibodies. ...
  https://www.the-scientist.com/the-nutshell/broadly-neutralizing-antibodies-in-hiv-patients-32797/amp
*  Broadly Neutralizing Antibodies - IAVI - International AIDS Vaccine Initiative
... referred to as broadly neutralizing antibodies (bNAbs). These antibodies are effective against the majority of HIV isolates ... scientists have also determined precisely how and where these broadly neutralizing antibodies interact with the virus. This ... These antibodies can neutralize a wide range of genetically variable HIV isolates in laboratory tests, and studies show that ... Antibody immunoprophylaxis, if effective, could augment existing HIV prevention strategies and help limit the spread of the ...
  https://www.iavi.org/our-science/broadly-neutralizing-antibodies
*  Link Between Apobec3 Gene, Neutralizing Antibody Revealed | EmaxHealth
A single gene controls the ability of mice to make neutralizing antibodies against this retrovirus and to recover from the ... "This research delineates a potential genetic mechanism behind the production of neutralizing antibodies to HIV, which are ... Given that Apobec3 seems to help the immune system make neutralizing antibodies against retroviruses, the destruction of ... Antibodies are key to warding off viral infections, and most vaccines against viral diseases stimulate the body to make ...
  https://www.emaxhealth.com/2/24/24596.html
*  The rise of broadly neutralizing antibodies | EATG
Research on broadly neutralizing antibodies (bNAbs) is taking the field of HIV prevention science in new directions, with ...
  http://www.eatg.org/news/the-rise-of-broadly-neutralizing-antibodies/
*  Broadly Neutralizing Antibodies | A&U Magazine
Broadly neutralizing antibodies (bNAbs) hold the potential of being a component of an HIV functional cure regimen, an HIV ... Broadly neutralizing antibodies aim for a diverse effect against HIV types. by Jeannie Wraight and David Miller ... recently identified monoclonal antibodies that appear capable of a broadly neutralizing effect on a diverse range of HIV ... more than any other broadly neutralizing antibodies previously discovered.. The most promising bNAbs of the group will be ...
  https://aumag.org/2018/09/07/broadly-neutralizing-antibodies/
*  JCI - Towards HIV-1 remission: potential roles for broadly neutralizing antibodies
Recently discovered broadly neutralizing antibodies (bNAbs) exhibit remarkable breadth and potency in their ability to ... bNAbs can prevent infection by directly neutralizing cell-free virions, which prevents infection and accelerates viremia ... decline through antibody-mediated viral clearance. (. B. ) bNAbs can potentially bind to infected cells and mediate antiviral ...
  https://www.jci.org/articles/view/80561/figure/1
*  Viruses | Free Full-Text | Recombinant Sheep Pox Virus Proteins Elicit Neutralizing Antibodies
Virus-neutralizing activity against SPPV in lamb kidney cell culture was detected for polyclonal antisera raised to SPPV-060, ... To our knowledge, this is the first report demonstrating the virus-neutralizing activities of antisera raised to SPPV-060, SPPV ... The aim of this work was to evaluate the immunogenicity and neutralizing activity of sheep pox virus (SPPV; genus Capripoxvirus ... Recombinant Sheep Pox Virus Proteins Elicit Neutralizing Antibodies. Olga V. Chervyakova 1. ...
  http://www.mdpi.com/1999-4915/8/6/159
*  Abstract 1602: Generation of anti-IL-17B antibodies neutralizing IL-17B-mediated alterations of the immune microenvironment,...
Generation of anti-IL-17B antibodies neutralizing IL-17B-mediated alterations of the immune microenvironment, promotion of ... Abstract 1602: Generation of anti-IL-17B antibodies neutralizing IL-17B-mediated alterations of the immune microenvironment, ... Abstract 1602: Generation of anti-IL-17B antibodies neutralizing IL-17B-mediated alterations of the immune microenvironment, ... Abstract 1602: Generation of anti-IL-17B antibodies neutralizing IL-17B-mediated alterations of the immune microenvironment, ...
  http://cancerres.aacrjournals.org/content/77/13_Supplement/1602
*  Powerful HIV-Neutralizing Antibody s Pictures Revealed By Scripps Researchers
Researchers at The Scripps Research Institute have uncovered the surprising details of how a powerful anti-HIV antibody grabs ... in smaller concentrations of antibody molecules than any previously reported broadly neutralizing anti-HIV antibody. The new ... Powerful HIV-Neutralizing Antibody s Pictures Revealed By Scripps Researchers. by Tanya Thomas on October 16, 2011 at 3:12 PM ... Since the 1990s, Burton, Wilson, and other researchers have been searching for such "broadly neutralizing" antibodies against ...
  http://www.medindia.net/news/Powerful-HIV-Neutralizing-Antibodys-Pictures-Revealed-By-Scripps-Researchers-92031-1.htm
*  Combining Broadly Neutralizing Antibodies Shows Promise - TheBodyPRO.com
Results from the first human trials of a dual broadly neutralizing antibodies regimen appeared effective, safe, and well ... Slight Changes to Broadly Neutralizing HIV Antibody Yield Great Dividends No Proof of New HIV Cure, Despite Headlines -- Here's ... Slight Changes to Broadly Neutralizing HIV Antibody Yield Great Dividends No Proof of New HIV Cure, Despite Headlines -- Here's ... Rockefeller University presented evidence that early administration of a short course of two broadly neutralizing antibodies ( ...
  http://www.thebodypro.com/content/81404/combining-broadly-neutralizing-antibodies-shows-pr.html?ic=2005
*  Frontier Biotech licenses 3BNC117, a novel broad-spectrum HIV neutralizing antibody
... Tuesday, July 25, 2017 AIDS/HIV News ... 3BNC117, a novel broad-spectrum HIV neutralizing antibody, with albuvirtide for the treatment and prophylaxis of HIV infection ... 3BNC117 is one of the most effective broad-spectrum HIV neutralizing antibodies. Several phase 1 and phase 2 clinical trials ... www.prnewswire.com/news-releases/frontier-biotech-licenses-3bnc117-a-novel-broad-spectrum-hiv-neutralizing-antibody-300493440. ...
  http://www.medindia.net/health-press-release/Frontier-Biotech-licenses-3BNC117-a-novel-broad-spectrum-HIV-neutralizing-antibody-335092-1.htm
*  Recent Articles | Broadly Cross-neutralizing Antibodies And Genetics & Genomics | The Scientist Magazine®
tags: broadly cross-neutralizing antibodies x genetics & genomics x The Scientist. » broadly cross-neutralizing antibodies and ... Researchers Produce Alpaca Antibodies Using Yeast. By Catherine Offord , February 14, 2018 ... With multiple applications in biomedicine, the antibodies can now be made quickly, cheaply, and without the need for an alpaca ... Researchers identify antibodies for two commonly used Cas9 proteins in human blood. Investors take notice. ...
  https://www.the-scientist.com/?articles.list/categoryNo/2625/category/The-Scientist/tagNo/2744,9/tags/broadly-cross-neutralizing-antibodies,genetics--amp--genomics/
*  Biosimilar recombinant human erythropoietin induces the production of neutralizing antibodies
Sera from 23 of these patients were positive for r-HuEpo-neutralizing antibodies, and their bone marrow biopsies indicated pure ... Pure red cell aplasia (PRCA) due to neutralizing antibodies can rarely develop following treatment with epoetin. The treatment ... Sera and bone marrow biopsies from the remaining seven patients were negative for anti-r-HuEpo antibodies and red-cell aplasia ...
  http://connection.ebscohost.com/c/articles/61249144/biosimilar-recombinant-human-erythropoietin-induces-production-neutralizing-antibodies
*  Recent Articles | Hearing And Disease/Medicine | The Scientist Magazine®| Page 6
A memory B cell response to Zika virus in dengue-infected patients produced antibodies that were poorly neutralizing in vitro ... Cows injected with a protein that mimics HIV's envelope make broadly neutralizing antibodies that inhibit multiple strains of ... Immunized Cows Produce Anti-HIV Antibodies. By Jef Akst , July 20, 2017 ...
  https://www.the-scientist.com/?articles.list/tagNo/1887,6/tags/hearing,disease-medicine/pageNo/6/