*  Nucleosome Assembly Proteins Get SET to Defeat the Guardian of Chromosome Cohesion

Nagaoka SI, Hassold TJ, Hunt PA (2012) Human aneuploidy: mechanisms and new insights into an age-old problem. Nat Rev Genet 13 ... Chromosome segregation defects cause a range of problems, including chromosome instability and aneuploidy in cancer and, if ... 2011) Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science 333: 1039-1043 * View Article ... Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes. Curr Biol 20: 1522-1528 * ...

*  PLOS ONE: Tumor-Specific Chromosome Mis-Segregation Controls Cancer Plasticity by Maintaining Tumor Heterogeneity

Aneuploidy with chromosome instability is a cancer hallmark. We studied chromosome 7 (Chr7) copy number variation (CNV) in ... B, comparison of tumor heterogeneity with regard to chromosome 7 (Chr7) aneuploidy in the original tumor (T) and corresponding ...