Plus it
The β-amyloid (Aβ) peptide is the major constituent of amyloid plaques in Alzheimers disease (AD) brain and is likely to play ... 2004) Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1. J Biol Chem 279:10542-10550 ... 1997) Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1, amyloid precursor ... 2004) Processing amyloid precursor protein at the beta-site requires proper orientation to be accessed by BACE1. J Biol Chem ...
Plus it
2019b) Beta-amyloid pathology in human brain microvessel extracts from the parietal cortex: relation with cerebral amyloid ... 2010) Progressive accumulation of amyloid-beta oligomers in Alzheimers disease and in amyloid precursor protein transgenic ... KBASE Research Group (2021) Serum zinc levels and in vivo beta-amyloid deposition in the human brain. Alzheimers Res Ther 13: ... 2011b) Amyloid beta protein-induced zinc sequestration leads to synaptic loss via dysregulation of the ProSAP2/Shank3 scaffold ...
Correction for Rachel F. Lane et al., "Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for...
Correction: In "Diabetes-Associated SorCS1 Regulates Alzheimers Amyloid-β Metabolism: Evidence for Involvement of SorL1 and ... Correction for Rachel F. Lane et al., "Diabetes-Associated SorCS1 Regulates Alzheimers Amyloid-β Metabolism: Evidence for ... Correction for Rachel F. Lane et al., "Diabetes-Associated SorCS1 Regulates Alzheimers Amyloid-β Metabolism: Evidence for ... Correction for Rachel F. Lane et al., "Diabetes-Associated SorCS1 Regulates Alzheimers Amyloid-β Metabolism: Evidence for ...
Identification of NEEP21 as a β-Amyloid Precursor Protein-Interacting Protein In Vivo That Modulates Amyloidogenic Processing...
2010) Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines. ... 2005) BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production. J Biol Chem 280:30768- ... 1993) Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science 259:514-516. ... 2010) Amyloid beta from axons and dendrites reduces local spine number and plasticity. Nat Neurosci 13:190-196. ...
Accumulation of Amyloid Precursor Protein in the Mitochondrial Import Channels of Human Alzheimer's Disease Brain Is Associated...
2004) Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. J Biol Chem 279: ... 2005) Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-β1-42. J Neurosci 25:672-679. ... amyloid-β. Introduction. The neuropathological hallmarks of Alzheimers disease (AD) include extensive neuronal loss, the ... The major constituent of a senile plaque is β-amyloid (Αβ), which is a 40-43 amino acid peptide produced by the action of ...
Plus it
A major plaque component, β amyloid peptide (Aβ), derives from the amyloid precursor protein (APP). Human genetics supports the ... 2013) Amyloid-β oligomer detection by ELISA in cerebrospinal fluid and brain tissue. Anal Biochem 433:112-120, doi:10.1016/j.ab ... 2013) Evaluating amyloid-β oligomers in cerebrospinal fluid as a biomarker for Alzheimers disease. PLoS One 8:e66381, doi: ... 2013) Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls. Ann Neurol 73:104-119, doi:10.1002/ana ...
synaptogenesis | Journal of Neuroscience
Neurexin-β Mediates the Synaptogenic Activity of Amyloid Precursor Protein Vedrana Cvetkovska, Yuan Ge, Qin Xu, Shaokun Li, ...
Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic...
Assays for serum amyloid A (SAA), α2 antiplasmin (α2-AP), and complement 3 (C3) were performed as described previously ( ... Bharadwaj D, Mold C, Markham E, Du Clos TW (2001) Serum amyloid P component binds to Fc gamma receptors and opsonizes particles ... Mold C, Baca R, Du Clos TW (2002a) Serum amyloid P component and C-reactive protein opsonize apoptotic cells for phagocytosis ... Price DL, Borchelt DR, Sisodia SS (1993) Alzheimer disease and the prion disorders amyloid beta-protein and prion protein ...
Plus it
1995) The core Alzheimers peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger ... 1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 90 ... S87 lies within the highly hydrophobic non-amyloid component (NAC) region, which has been shown to play a critical role in ... Moreover, double immunostaining using human α-syn antibody and thioflavin S (ThS), a marker of β-sheet rich amyloid-like ...
A Tetra(Ethylene Glycol) Derivative of Benzothiazole Aniline Enhances Ras-Mediated Spinogenesis | Journal of Neuroscience
2011) Amyloid-dependent and amyloid-independent stages of Alzheimer disease. Arch Neurol 68:1062-1064, doi:10.1001/archneurol. ... 2010) Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines. ... 2010) Inhibitors of catalase-amyloid interactions protect cells from beta-amyloid-induced oxidative stress and toxicity. J Biol ... 2009) Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury. Nat Med 15:377-379, doi:10.1038/ ...
Plus it
SORLA directs APP away from endosomes, preventing excess production of β-amyloid. Disruption of this role likely explains why ... Loss of this regenerative function might exacerbate the detrimental effects of increased β-amyloid production when SORLA ... Cargoes guided by SORLA include amyloid precursor protein (APP), which is processed in different cellular compartments to ... produce β-amyloid and/or other cleavage products. ...
Plus it
1999) Neuronal apoptosis induced by beta-amyloid is mediated by caspase-8. Neurobiol Dis 6:440-449. ... 2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403:98-103. ...
Index by author - April 01, 2003, 23 (7) | Journal of Neuroscience
A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation Maria E. Bamberger, Meera E. Harris, ... A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation Maria E. Bamberger, Meera E. Harris, ... A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation Maria E. Bamberger, Meera E. Harris, ... A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation Maria E. Bamberger, Meera E. Harris, ...
Index by author - January 23, 2019, 39 (4) | Journal of Neuroscience
Alzheimers Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss Santiago V. Salazar, Timothy O. ... Alzheimers Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss Santiago V. Salazar, Timothy O. ... Alzheimers Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss Santiago V. Salazar, Timothy O. ... Alzheimers Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss Santiago V. Salazar, Timothy O. ...
Table of Contents - January 13, 2016, 36 (2) | Journal of Neuroscience
Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity Peng Yuan (袁鹏) and Jaime ... Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimers Disease ...
Lack of Neurodegeneration in Transgenic Mice Overexpressing Mutant Amyloid Precursor Protein Is Associated with Increased...
1994) Transthyretin sequesters amyloid β protein and prevents amyloid formation. Proc Natl Acad Sci USA 91:8368-8372. ... resulting in high β-amyloid (Aβ) levels in the brain. Despite this, amyloid plaques do not develop until 12 months of age, and ... 2001) Effect of the Alzheimer amyloid fragment Aβ25-35 on Akt/PKB kinase and survival of PC12 cells. J Neurochem 78:1000-1008. ... 1996) Increased amyloid-β4243 in brains of mice expressing mutant presenilin 1. Nature 383:710-713. ...
gene targeting | Journal of Neuroscience
Alzheimer Precursor Protein Interaction with the Nogo-66 Receptor Reduces Amyloid-β Plaque Deposition James H. Park, David A. ... Presenilin-1 P264L Knock-In Mutation: Differential Effects on Aβ Production, Amyloid Deposition, and Neuronal Vulnerability ...
Index by author - July 15, 2015, 35 (28) | Journal of Neuroscience
Network Disruption and Cerebrospinal Fluid Amyloid-Beta and Phospho-Tau Levels in Mild Cognitive Impairment Leonides Canuet, ... Network Disruption and Cerebrospinal Fluid Amyloid-Beta and Phospho-Tau Levels in Mild Cognitive Impairment Leonides Canuet, ... Network Disruption and Cerebrospinal Fluid Amyloid-Beta and Phospho-Tau Levels in Mild Cognitive Impairment Leonides Canuet, ... Network Disruption and Cerebrospinal Fluid Amyloid-Beta and Phospho-Tau Levels in Mild Cognitive Impairment Leonides Canuet, ...
Index by author - October 15, 1998, 18 (20) | Journal of Neuroscience
Protease Inhibitor Coinfusion with Amyloid β-Protein Results in Enhanced Deposition and Toxicity in Rat Brain Sally A. ... Protease Inhibitor Coinfusion with Amyloid β-Protein Results in Enhanced Deposition and Toxicity in Rat Brain Sally A. ... Protease Inhibitor Coinfusion with Amyloid β-Protein Results in Enhanced Deposition and Toxicity in Rat Brain Sally A. ... Protease Inhibitor Coinfusion with Amyloid β-Protein Results in Enhanced Deposition and Toxicity in Rat Brain Sally A. ...
Status Epilepticus-Induced Somatostatinergic Hilar Interneuron Degeneration Is Regulated by Striatal Enriched Protein Tyrosine...
1998) Beta-amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes. J ...
Plus it
2009) Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimers ... An attenuated immune response is sufficient to enhance cognition in an Alzheimers disease mouse model immunized with amyloid- ...
Table of Contents - December 01, 2010, 30 (48) | Journal of Neuroscience
Reduced Alzheimers Disease β-Amyloid Deposition in Transgenic Mice Expressing S-Palmitoylation-Deficient APH1aL and Nicastrin ...
The Effect of Body Posture on Brain Glymphatic Transport | Journal of Neuroscience
The glymphatic pathway expedites clearance of waste, including soluble amyloid β (Aβ) from the brain. Transport through this ...
Plus it
Frautschy SA, Baird A, Cole GM (1991) Effects of injected Alzheimer beta-amyloid cores in rat brain. Proc Natl Acad Sci USA 88 ... Kowall NW, McKee AC, Yankner BA, Beal MF (1992) In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment ... Mori H, Takio K, Ogawara M, Selkoe DJ (1992) Mass spectrometry of purified amyloid beta protein in Alzheimers disease. J Biol ... Delobette S, Privat A, Maurice T (1997) In vitro aggregation facilities β-amyloid peptide-(25-35)-induced amnesia in the rat. ...
Table of Contents - September 22, 2010, 30 (38) | Journal of Neuroscience
Fibrillar Amyloid-β-Activated Human Astroglia Kill Primary Human Neurons via Neutral Sphingomyelinase: Implications for ...
Table of Contents - March 16, 2011, 31 (11) | Journal of Neuroscience
Robust Amyloid Clearance in a Mouse Model of Alzheimers Disease Provides Novel Insights into the Mechanism of Amyloid-β ... Correction for Rachel F. Lane et al., "Diabetes-Associated SorCS1 Regulates Alzheimers Amyloid-β Metabolism: Evidence for ...
Constitutional Aneuploidy in the Normal Human Brain | Journal of Neuroscience
Podlisny MB, Lee G, Selkoe DJ (1987) Gene dosage of the amyloid β precursor protein in Alzheimers disease. Science 238: 669- ...
Table of Contents - March 09, 2005, 25 (10) | Journal of Neuroscience
β-Amyloid-Stimulated Microglia Induce Neuron Death via Synergistic Stimulation of Tumor Necrosis Factor α and NMDA Receptors ... Certain Inhibitors of Synthetic Amyloid β-Peptide (Aβ) Fibrillogenesis Block Oligomerization of Natural Aβ and Thereby Rescue ...
Plus it
... with a potential connection between the DMN metabolic rate and amyloid deposition (Buckner et al., 2005, 2009), it may be also ...
Table of Contents - February 15, 2001, 21 (4) | Journal of Neuroscience
β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and ... Use-Dependent Effects of Amyloidogenic Fragments of β-Amyloid Precursor Protein on Synaptic Plasticity in Rat Hippocampus In ...