*  Amyloid Fibril Composition as a Predictor of Development of Cardiomyopathy After Liver Transplantation for Hereditary...
Amyloid Fibril Composition as a Predictor of Development of Cardiomyopathy After Liver Transplantation for Hereditary ... The aim of this study was to investigate whether development of cardiomyopathy and heart failure in LTx ATTR amyloid patients ... Twenty-four patients with hereditary ATTR amyloidosis who had undergone LTx and have had their amyloid fibril type tested were ... is related to amyloid fibril composition.. Methods. ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:542919
*  Structure and Biomedical Applications of Amyloid Oligomer Nanoparticles
Amyloid oligomers are nonfibrillar polypeptide aggregates linked to diseases, such as Alzheimer's and Parkinson's. Here we show ... The amyloid oligomers are dynamic assemblies and are able to release their individual subunits. The small oligomeric size and ... Amyloid oligomers are nonfibrillar polypeptide aggregates linked to diseases, such as Alzheimer's and Parkinson's. Here we show ... Oligomer amyloids may provide a new biological nanomaterial for improved targeting, drug release, and medical imaging. ...
  http://www.bionity.com/de/fachpublikationen/731150/structure-and-biomedical-applications-of-amyloid-oligomer-nanoparticles.html
*  Cannabinoid Effects on β Amyloid Fibril and Aggregate Formation, Neuronal and Microglial-Activated Neurotoxicity In Vitro
In this study we compared the effects of a diverse set of CB ligands against β amyloid-mediated neuronal toxicity and activated ... Cannabinoid Effects on β Amyloid Fibril and Aggregate Formation, Neuronal and Microglial-Activated Neurotoxicity In Vitro. ... and compared this with a capacity to directly alter β amyloid (Aβ) fibril or aggregate formation. Neuroblastoma (SH-SY5Y) cells ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:649280
*  More Evidence for Transthyretin Amyloid to Associate with Osteoarthritis - Fight Aging!
Amyloid is better known for its role in Alzheimer's disease, but there are a number of types of amyloid, each a different ... We found that all of our patients with knee OA had amyloid deposits in the knee joints, especially in the meniscus, and those ... Amyloid deposition may therefore be a common histopathological feature associated with knee OA. Also, aging may induce ATTR ... One of our interesting observations concerned the different effects of aging on each type of amyloid formed. The frequency of ...
  https://www.fightaging.org/archives/2016/10/more-evidence-for-transthyretin-amyloid-to-associate-with-osteoarthritis/
*  Amyloid formation may link Alzheimer disease and type 2 diabetes
Islet amyloid can be found in islets of Langerhans in almost all patients with T2D. Islet amyloid is made up of islet amyloid ... Islet amyloid peptide found in human brain senile plaques with beta-amyloid, according to study published in The American ... After 10 months on a high-fat diet, tissue was analyzed using an amyloid-specific dye. The number of islets with amyloid was ... However, little is known about whether different forms of amyloid proteins interact or how amyloid formation begins in vivo. A ...
  http://www.innovations-report.com/html/reports/medicine-health/amyloid-formation-may-link-alzheimer-disease-and-type-2-diabetes.html
*  ASMscience | Bacterial Amyloids Appear To Play Role in Biofilms, Perhaps other Diseases
Amyloid structures, which consist of aggregated fibers of insoluble protein in web-like sheets, are a substantial part of what ... More and more microbiologists admit to being intrigued by amyloid structures. ... Because many types of bacteria depend on amyloid-rich curli to stick to host surfaces, disrupting these structures might open a ...
  http://www.asmscience.org/content/journal/microbe/10.1128/microbe.5.142.1
*  Alzheimer's-causing amyloid and bacteria trigger... UC Davis Health System Feature Story
Alzheimer's-causing amyloid and bacteria trigger same immune response. Amyloid plaques, bacteria biofilm both cause ... and the major protein found in amyloid plaques, (beta-amyloid) would trigger the TLR-2 response. They used cultures of ... Amyloid plaques are the sticky buildup of proteins that accumulate outside nerve cells. They are characteristic of several ... In a study published in the July issue of the journal Cell Host & Microbe, UC Davis researchers report that both amyloid ...
  http://www.ucdmc.ucdavis.edu/welcome/features/20090909_Alzheimers/index.html
*  Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in...
1998) Structural and kinetic features of amyloid β-protein fibrillogenesis. Amyloid 5:121-42. ... 1999) Quantifying amyloid β-peptide (Aβ) aggregation using the Congo red-Aβ (CR-aβ) spectrophotometric assay. Anal Biochem 266: ... 1997) Amyloid-β proteins activate Ca(2+)-permeable channels through calcium-sensing receptors. J Neurosci Res 47:547-554. ... 1992) Amyloid β-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell ...
  http://www.jneurosci.org/content/19/20/8876.long
*  Patent US5223482 - Recombinant Alzheimer's protease inhibitory amyloid protein and method of use - Google Patents
These sequences are used in producing or constructing recombinant β-amyloid core protein, β-amyloid-related proteins and ... DNA sequences encoding β-amyloid-related proteins associated with Alzheimer's disease are disclosed. Also provided herein is a ... The β-amyloid 751 protein cloned into a vaccinia virus as described in Example 3 was also examined for the nature of β-amyloid ... Expression of β-Amyloid-Related Protein (1-751) in Cultured Mammalian Cells. To facilitate the expression of β-amyloid-related ...
  http://www.google.com/patents/US5223482?dq=oakley+5,387,949
*  Localized amyloids important in diseases outside the brain : lessons from the islets of Langerhans and the thoracic aorta
Initial amyloid deposition occurs intracellularly and parts of this amyloid consist of proIAPP. Medin derived from lactadherin ... Localized amyloids important in diseases outside the brain: lessons from the islets of Langerhans and the thoracic aorta. ... It has long been understood that amyloids can be lethal in systemic diseases. More recently, it has been accepted that local ... In this review, we discuss two lesser known but common localized amyloid fibril-forming proteins: the polypeptide hormone islet ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:451533
*  Two-photon absorption of polyfluorene aggregates stabilized by insulin amyloid fibrils - RSC Advances (RSC Publishing)
The complexation is based on weak supramolecular interactions between amyloid fibrils and PFO in dissolved and aggregated forms ... and its binding to the amyloid-forming protein insulin. ... and its binding to the amyloid-forming protein insulin. The ... Two-photon absorption of polyfluorene aggregates stabilized by insulin amyloid fibrils P. Hanczyc, A. Justyniarski, D. A. ... complexation is based on weak supramolecular interactions between amyloid fibrils and PFO in dissolved and aggregated forms. In ...
  http://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C5RA08302H
*  The Culprit Is in the Cave : The Core Sites Explain the Binding Profiles of Amyloid-Specific Tracers
The Culprit Is in the Cave: The Core Sites Explain the Binding Profiles of Amyloid-Specific Tracers. Murugan, N. Arul AlbaNova ... The design of molecular probes and tracer molecules with specificity toward amyloid beta (A beta) fibrils is of paramount ... This requires a detailed understanding of the binding sites in amyloid targets, their number, and their binding mechanism for ... Our study reproduces the experimental results on the relative binding affinity of the tracers and amyloid binders and explains ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:1010278
*  Amyloid accumulation in the brain of Alzheimers patients results from altered - Synthesis and Structure-activity Relationship...
Amyloid accumulation in the brain of Alzheimers patients results from altered. Amyloid accumulation in the brain of Alzheimers ... On the basis of these studies we investigated the possibility that amyloid fibrils can induce synthesis of more APP and amyloid ... The creation of unwanted superoxide by amyloid- activated oxidative tension [12], [13] and (2) the development of amyloid ... Such a process would provide a synergistic mechanism whereby amyloid fibrils in blood circulation potentiate damage to the ...
  http://www.conferencedequebec.org/2018/01/08/amyloid-accumulation-in-the-brain-of-alzheimers-patients-results-from-altered/
*  amyloid
... Anti-TNF vs Alzheimer's mouse model. An experimental anti-inflammatory drug has positive effects on neuron function ... BioArt: amyloid in the heart. What Abstract Expressionist artist painted this? Jackson Pollock?. ... Amyloidosis of the heart is a set of complex diseases caused by the accumulation of cellular proteins that form an amyloid ... This image shows an amyloid plaque stained with Congo red stain and viewed through a polarized lens. The optical properties of ...
  http://www.emoryhealthsciblog.com/tag/amyloid/
*  Lysozyme Amyloidogenesis Is Accelerated by Specific Nicking and Fragmentation but Decelerated by Intact Protein Binding and...
Seeding of the amyloid fibril formation process using sonicated mature amyloid fibrils accelerates the fibril formation process ... assembly and conversion into amyloid fibrils are accounted for. Amyloid fibril formation of lysozyme has multiple kinetic ... Mature amyloid fibrils of HEWL are composed mainly of nicked HEWL in the early equilibrium phase but go through a "fibril ... We have revisited the well-studied heat and acidic amyloid fibril formation pathway (pH 1.6, 65 °C) of hen egg-white lysozyme ( ...
  http://liu.diva-portal.org/smash/record.jsf?pid=diva2:262849
*  Alzheimer's Brain Plaques - Alzheimer's Association
Explore an interactive diagram of beta-amyloid formation and how they contribute to the development of plaques in the ... Beta-amyloid is chemically "sticky" and gradually builds up into plaques.. The most damaging form of beta-amyloid may be groups ... Plaques form when protein pieces called beta-amyloid (BAY-tuh AM-uh-loyd) clump together. Beta-amyloid comes from a larger ...
  https://www.alz.org/braintour/plaques.asp
*  Amyloid | Newsroom - McGill University
Imagine if doctors could determine, many years in advance, who is likely to develop dementia. Such prognostic capabilities would give patients and their families time to plan and manage treatment.... ...
  https://mcgill.ca/newsroom/category/tags/amyloid
*  amyloid | Weizmann Institute of Science
Weizmann Institute of Science234 Herzl Street, Rehovot 7610001 IsraelTel: +972-8-934-9106 Terms of UseDisclaimerAccessibilitySite MapWeizmann CareersContact Us. ...
  http://www.weizmann.ac.il/pages/tags/amyloid
*  Apple Procyanidins Suppress Amyloid -Protein Aggregation
Apple Procyanidins Suppress Amyloid -Protein Aggregation. Toshihiko Toda,1,2 Tadahiro Sunagawa,3 Tomomasa Kanda,3 Motoyuki ... we investigated the antiaggregative activity of PC on amyloid β-protein (Aβ) aggregation, which is a pathological hallmark of ...
  https://www.hindawi.com/journals/bri/2011/784698/abs/
*  Amyloid Imaging and Beyond
Then to try to treat a patient based in findings with Amyloid Biomarkers as the florbetapir PET, or using ANY OTHER NEW amyloid ... Amyloid image and beyond(1). Carlos Oliveira. 9/28/2015 10:15:13 AM. As we can see in the articles bellow , it is proved that ... where they preferentially bind to amyloid plaques, and mark them-briefly-with emissions of mild radioactivity. Amyloid PET ... But amyloid beta plaques are just one feature of Alzheimer's. And although they build up early in the disease course, before ...
  http://dana.org/News/Amyloid_Imaging_and_Beyond/
*  Amyloid beta A4 protein (IPR028866) | InterPro | EMBL-EBI
Amyloid-beta is required for neuronal function, but can aggregate to form amyloid plaques that seem to disrupt brain cells by ... Two of the main isoforms, amyloid-beta40 (Abeta40) and amyloid-beta42 (Abeta42), are found prominently in the extracellular ... Amyloid beta A4 protein (also known as APP or A4) consists of a large N-terminal extracellular region containing heparin- ... The amyloid precursor protein and postnatal neurogenesis/neuroregeneration.. Biochem. Biophys. Res. Commun. 341 1-5 2006 ...
  http://www.ebi.ac.uk/interpro/entry/IPR028866
*  Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology
A. Abedini and D. P. Raleigh, "The role of His-18 in amyloid formation by human islet amyloid polypeptide," Biochemistry, vol. ... S. Gilead and E. Gazit, "The role of the 14-20 domain of the islet amyloid polypeptide in amyloid formation," Experimental ... P. Cao, L.-H. Tu, A. Abedini et al., "Sensitivity of amyloid formation by human islet amyloid polypeptide to mutations at ... P. Marek, A. Abedini, B. B. Song et al., "Aromatic interactions are not required for amyloid fibril formation by islet amyloid ...
  https://www.hindawi.com/journals/jdr/2016/2798269/ref/
*  Detection of Amyloid Plaques | SBIR.gov
A radiotracer that bound specifically to amyloid would be of great utility in diagnosis, monitoring treatment, and research of ... Specifically, this project poses the following specific aims AIM #1. Measure binding to amyloid protein of a group of ... AIM #2. Synthesize a defined library of halogenated heterocyclic analogs and screen for binding to amyloid protein. The working ... Nine candidates will be tested by in vitro homogenate displacement binding against radiolabeled ligand for amyloid protein. ...
  https://www.sbir.gov/sbirsearch/detail/238940
*  Beta-Amyloid 42/40 Ratio, CSF
... beta amyloid levels circulating in cerebrospinal fluid in different patients by using a ratio of beta-amyloid 42/beta-amyloid ... The test for CSF Beta-Amyloid by LC-MS/MS monitors both CSF beta-amyloid 40 (AB40) and 42 (AB42) endogenous peptides, rather ... The test for CSF Beta-Amyloid by LC-MS/MS monitors both CSF beta-amyloid 40 (AB40) and 42 (AB42) endogenous peptides, rather ... beta amyloid levels circulating in cerebrospinal fluid in different patients by using a ratio of beta-amyloid 42/beta-amyloid ...
  http://www.questdiagnostics.com/testcenter/TestDetail.action?ntc=94627
*  it's not a Beta-amyloid thing
it's definitely =not= a Beta-amyloid thing. I would say that neurodegeneration in Alzheimers mouse models was a beta- amyloid ... it's not a Beta-amyloid thing. the Beta-amyloid thing happens be-cause , 'normal' transcription is prematurely interrupted be- ... So yes it is curable but by addressing the beta-amyloid problems. *Previous message: it's not a Beta-amyloid thing ... it's not a Beta-amyloid thing. Kim kim at nospamclara.co.uk Fri Jun 28 09:58:25 EST 2002 *Previous message: it's not a Beta- ...
  http://www.bio.net/bionet/mm/neur-sci/2002-June/048767.html